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The map label for this gene is pphA [C]

Identifier: 39997724

GI number: 39997724

Start: 2901768

End: 2902451

Strand: Direct

Name: pphA [C]

Synonym: GSU2630

Alternate gene names: 39997724

Gene position: 2901768-2902451 (Clockwise)

Preceding gene: 39997720

Following gene: 39997725

Centisome position: 76.08

GC content: 65.64

Gene sequence:

>684_bases
GTGAACCATACGACCCATTCCCGCCGTTTCGTCATCCCCGACATCCATGGATGCGCTCTGACCCTTGACCGGCTTCTGTC
CGGGGTCCTGGGCCTGACGCGCCGGGATGACCTCTACCTGCTGGGGGATTACATCGACCGGGGCCCCCGGAGCCGCGAGG
TCATGGACCTGCTCATCTCCCTGTCGCTCAAGGGCTACCGGGTTCACACACTGCGGGGCAACCACGAGGAAATGTTCCTG
AACAGCTGCCGGGACCGGAACGCCTTCAGGCTCTGGACGCTGAACGGCGGTCTCGCCACCCTCGAAAGCTTCGGCGTCGA
GGACGCCTGCGAGATCCCCGCCCACTATCACCGCTTCATGGAGCAGATGCCCTGCTACCTGGTGCTGTCGGATTTCGTGC
TGGTCCACGCAAGCCTCGACTTCTCGCTCCCCGACCCGTTCGCCAATCGGGAGGCGATGCTCTGGAGCCGCTCCCTGGAG
GTGCGCAGGGAACGGCTCGGCGGGCGCCGGGTCATCGGCGGCCACACCCCCATGAACCGGCAGGAGATCGAGCGGGGGCT
GGCCACGGACCGGATCGTCCTCGACAACGGCTGCGTCTACCCGGAGCGGCCGGGGATGGGATCCCTGACGGCCCTGGAAC
TCGACACCATGACGCTCCATTTCCAGGAGAACATCGACCAATGA

Upstream 100 bases:

>100_bases
GCCGAGAATACAGGTTGACAATGGTCATGGCTTTACTCTCCGGATTCCCCCGTGCTATAAAAAATGCATCCAATCAATTA
TTTCCCGGTCAGGAGCCACG

Downstream 100 bases:

>100_bases
AACACTTCCGCAAGGAACTCTGGTTCGAGACACGCCAGCGCCGCCAGTTCATCAACATTACCCCGACGGTGCGGGAATGT
CTGCGGGAAAGCGGCATCCG

Product: serine/threonine protein phosphatase

Products: A Protein; Orthophosphate. [C]

Alternate protein names: Serine/Threonine Protein Phosphatase; Bis(5Nucleosyl)-Tetraphosphatase ApaH; Ser/Thr Protein Phosphatase Family Protein; Serine/Threonine Protein Phosphatase I; Serine/Threonine Protein Phosphatase Family Protein; Diadenosine Tetraphosphatase; Diadenosine Tetraphosphatase-Like Protein; Serinethreonine Protein Phosphatase; Serine/Threonine Specific Protein Phosphatase; Calcineurin-Like Phosphoesterase; Bis(5-Nucleosyl)-Tetraphosphatase; Protein Phosphatase

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MNHTTHSRRFVIPDIHGCALTLDRLLSGVLGLTRRDDLYLLGDYIDRGPRSREVMDLLISLSLKGYRVHTLRGNHEEMFL
NSCRDRNAFRLWTLNGGLATLESFGVEDACEIPAHYHRFMEQMPCYLVLSDFVLVHASLDFSLPDPFANREAMLWSRSLE
VRRERLGGRRVIGGHTPMNRQEIERGLATDRIVLDNGCVYPERPGMGSLTALELDTMTLHFQENIDQ

Sequences:

>Translated_227_residues
MNHTTHSRRFVIPDIHGCALTLDRLLSGVLGLTRRDDLYLLGDYIDRGPRSREVMDLLISLSLKGYRVHTLRGNHEEMFL
NSCRDRNAFRLWTLNGGLATLESFGVEDACEIPAHYHRFMEQMPCYLVLSDFVLVHASLDFSLPDPFANREAMLWSRSLE
VRRERLGGRRVIGGHTPMNRQEIERGLATDRIVLDNGCVYPERPGMGSLTALELDTMTLHFQENIDQ
>Mature_227_residues
MNHTTHSRRFVIPDIHGCALTLDRLLSGVLGLTRRDDLYLLGDYIDRGPRSREVMDLLISLSLKGYRVHTLRGNHEEMFL
NSCRDRNAFRLWTLNGGLATLESFGVEDACEIPAHYHRFMEQMPCYLVLSDFVLVHASLDFSLPDPFANREAMLWSRSLE
VRRERLGGRRVIGGHTPMNRQEIERGLATDRIVLDNGCVYPERPGMGSLTALELDTMTLHFQENIDQ

Specific function: Plays A Key Role In Signaling Protein Misfolding Via The Cpxr/Cpxa Transducing System. It Also Modulates The Phosphorylated Status Of Many Phosphoproteins In E. coli, Some Of Which Acting As Major Chaperones. Has Been Shown, In Vitro, To Act On Ser, Thr A

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.1.3.16 [C]

Molecular weight: Translated: 26012; Mature: 26012

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00125 SER_THR_PHOSPHATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHTTHSRRFVIPDIHGCALTLDRLLSGVLGLTRRDDLYLLGDYIDRGPRSREVMDLLIS
CCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEHHHCCCCCHHHHHHHHHH
LSLKGYRVHTLRGNHEEMFLNSCRDRNAFRLWTLNGGLATLESFGVEDACEIPAHYHRFM
HCCCCEEEEEECCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHCCCCCHHCCCHHHHHHH
EQMPCYLVLSDFVLVHASLDFSLPDPFANREAMLWSRSLEVRRERLGGRRVIGGHTPMNR
HHCCHHHHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCH
QEIERGLATDRIVLDNGCVYPERPGMGSLTALELDTMTLHFQENIDQ
HHHHHCCCCCEEEEECCCCCCCCCCCCCEEEEEEEEEEEEECCCCCC
>Mature Secondary Structure
MNHTTHSRRFVIPDIHGCALTLDRLLSGVLGLTRRDDLYLLGDYIDRGPRSREVMDLLIS
CCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEHHHCCCCCHHHHHHHHHH
LSLKGYRVHTLRGNHEEMFLNSCRDRNAFRLWTLNGGLATLESFGVEDACEIPAHYHRFM
HCCCCEEEEEECCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHCCCCCHHCCCHHHHHHH
EQMPCYLVLSDFVLVHASLDFSLPDPFANREAMLWSRSLEVRRERLGGRRVIGGHTPMNR
HHCCHHHHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCH
QEIERGLATDRIVLDNGCVYPERPGMGSLTALELDTMTLHFQENIDQ
HHHHHCCCCCEEEEECCCCCCCCCCCCCEEEEEEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Phosphoprotein; H2O [C]

Specific reaction: A Phosphoprotein + H2O = A Protein + Orthophosphate. [C]

General reaction: Phosphoric ester hydrolysis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA