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The map label for this gene is proC [H]

Identifier: 39997636

GI number: 39997636

Start: 2804942

End: 2805754

Strand: Direct

Name: proC [H]

Synonym: GSU2541

Alternate gene names: 39997636

Gene position: 2804942-2805754 (Clockwise)

Preceding gene: 39997624

Following gene: 39997648

Centisome position: 73.54

GC content: 68.51

Gene sequence:

>813_bases
ATGCTGAAGGGAAGCACTCTCGGCTTCATCGGCGGCGGGAACATGGCTGAGGCGATCATCAAAGGGCTGCTGGCCGGCGG
GGTCGCGGCGGCGGACGTGATGGTGGCTGAACCGGTGGCAGCGCGGCGGGAATACCTGCACGGCACCTACGGCATCGACG
TCTGCGCCGACAACGGCCGGGTGGCCGCCGCTGCCGACGCCCTGGTCATGGCCGTAAAGCCCCAGGTGTTCCGTGGCATG
GTTGCGGCCCTGGGGCCGGCAGGGCTCGACGGCAAGCTGCTCATCTCCATCATGGCGGGGATTACCACCGCGGACATGGA
GGAGGTCTGCGGCAGCGCGGCCCGGGTGATCCGGGTGATGCCGAACACCCCGGCCCTGGTGCTGGAAGGGGCGTCCACCC
TCTGTCGCGGCAGGAACGCCACCGATGACGATCTGTTCTTTGCCACGGGAATCTTCGACCTGGTGGGGACCACCTGCGTG
GTGGAGGAAAAGCTCATGGACGCCGTCACCGGCGTCTCCGGCTGCGGCCCGGCCTACGTCTTCCTCTTCATGGAGGCCCT
TTCCGACGCCGGCGTGAAAAACGGCCTCCCCCGGGACGTGGCCACGAGACTGGCGGCCCAGACGGTACTGGGAGCTGCGA
GACTGCTCCTGGAGACCGGCGACCACCCAGGCGTCCTCAAGGAGAAGGTCACCTCCCCCGGCGGCAGCACCATCGCCGGC
ATCGCCTCCCTGGAGCGGGATGCCTTCCGCGGAGCGGTCATGGCCGCCGTGGACGCCGCTACTGCCCGCTCGGCGGAGCT
GGGCAAAAAATAA

Upstream 100 bases:

>100_bases
ACAAACCCGCAACATTCCGTCATGTTCGACTGATCACCGGCTTGACATTTTCCGGCGGATGCCGTAGGAAAAAGTATACT
ATTTTCGAGGAGGGACGAAG

Downstream 100 bases:

>100_bases
CGCTTCTTCGCCGCAGAGAATAACTCTCAACGCGTAACGGCGGCTGTCACGAATCCCGTAGCGATCAGGGTGGAGACGGC
GGAGATCCGGTGCTACTCTG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MLKGSTLGFIGGGNMAEAIIKGLLAGGVAAADVMVAEPVAARREYLHGTYGIDVCADNGRVAAAADALVMAVKPQVFRGM
VAALGPAGLDGKLLISIMAGITTADMEEVCGSAARVIRVMPNTPALVLEGASTLCRGRNATDDDLFFATGIFDLVGTTCV
VEEKLMDAVTGVSGCGPAYVFLFMEALSDAGVKNGLPRDVATRLAAQTVLGAARLLLETGDHPGVLKEKVTSPGGSTIAG
IASLERDAFRGAVMAAVDAATARSAELGKK

Sequences:

>Translated_270_residues
MLKGSTLGFIGGGNMAEAIIKGLLAGGVAAADVMVAEPVAARREYLHGTYGIDVCADNGRVAAAADALVMAVKPQVFRGM
VAALGPAGLDGKLLISIMAGITTADMEEVCGSAARVIRVMPNTPALVLEGASTLCRGRNATDDDLFFATGIFDLVGTTCV
VEEKLMDAVTGVSGCGPAYVFLFMEALSDAGVKNGLPRDVATRLAAQTVLGAARLLLETGDHPGVLKEKVTSPGGSTIAG
IASLERDAFRGAVMAAVDAATARSAELGKK
>Mature_270_residues
MLKGSTLGFIGGGNMAEAIIKGLLAGGVAAADVMVAEPVAARREYLHGTYGIDVCADNGRVAAAADALVMAVKPQVFRGM
VAALGPAGLDGKLLISIMAGITTADMEEVCGSAARVIRVMPNTPALVLEGASTLCRGRNATDDDLFFATGIFDLVGTTCV
VEEKLMDAVTGVSGCGPAYVFLFMEALSDAGVKNGLPRDVATRLAAQTVLGAARLLLETGDHPGVLKEKVTSPGGSTIAG
IASLERDAFRGAVMAAVDAATARSAELGKK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797095, Length=272, Percent_Identity=40.8088235294118, Blast_Score=184, Evalue=7e-47,
Organism=Homo sapiens, GI24797097, Length=272, Percent_Identity=40.8088235294118, Blast_Score=184, Evalue=9e-47,
Organism=Homo sapiens, GI198041662, Length=266, Percent_Identity=37.9699248120301, Blast_Score=178, Evalue=4e-45,
Organism=Homo sapiens, GI21361454, Length=272, Percent_Identity=37.8676470588235, Blast_Score=171, Evalue=5e-43,
Organism=Escherichia coli, GI1786585, Length=264, Percent_Identity=39.7727272727273, Blast_Score=188, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17569021, Length=266, Percent_Identity=41.3533834586466, Blast_Score=195, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17540664, Length=281, Percent_Identity=35.2313167259786, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320861, Length=289, Percent_Identity=29.4117647058824, Blast_Score=116, Evalue=3e-27,
Organism=Drosophila melanogaster, GI21358587, Length=266, Percent_Identity=43.984962406015, Blast_Score=213, Evalue=8e-56,
Organism=Drosophila melanogaster, GI24648116, Length=274, Percent_Identity=41.6058394160584, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24647700, Length=171, Percent_Identity=49.7076023391813, Blast_Score=159, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27383; Mature: 27383

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKGSTLGFIGGGNMAEAIIKGLLAGGVAAADVMVAEPVAARREYLHGTYGIDVCADNGR
CCCCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHCCCCCEEEECCCCC
VAAAADALVMAVKPQVFRGMVAALGPAGLDGKLLISIMAGITTADMEEVCGSAARVIRVM
EEHHHHHHHHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHEEEEC
PNTPALVLEGASTLCRGRNATDDDLFFATGIFDLVGTTCVVEEKLMDAVTGVSGCGPAYV
CCCCEEEECCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
FLFMEALSDAGVKNGLPRDVATRLAAQTVLGAARLLLETGDHPGVLKEKVTSPGGSTIAG
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHH
IASLERDAFRGAVMAAVDAATARSAELGKK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLKGSTLGFIGGGNMAEAIIKGLLAGGVAAADVMVAEPVAARREYLHGTYGIDVCADNGR
CCCCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHCCCCCEEEECCCCC
VAAAADALVMAVKPQVFRGMVAALGPAGLDGKLLISIMAGITTADMEEVCGSAARVIRVM
EEHHHHHHHHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHEEEEC
PNTPALVLEGASTLCRGRNATDDDLFFATGIFDLVGTTCVVEEKLMDAVTGVSGCGPAYV
CCCCEEEECCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
FLFMEALSDAGVKNGLPRDVATRLAAQTVLGAARLLLETGDHPGVLKEKVTSPGGSTIAG
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHH
IASLERDAFRGAVMAAVDAATARSAELGKK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]