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The map label for this gene is atoC [H]

Identifier: 39997619

GI number: 39997619

Start: 2781835

End: 2783229

Strand: Direct

Name: atoC [H]

Synonym: GSU2524

Alternate gene names: 39997619

Gene position: 2781835-2783229 (Clockwise)

Preceding gene: 39997618

Following gene: 39997624

Centisome position: 72.93

GC content: 63.73

Gene sequence:

>1395_bases
ATGGAAAAGATTCTCATCATAGACGACGAGGCGTTCATCCGCGAAAACGTGGAGCGGATCCTCACCGACGACGGCTATCA
GGTTCTCTGCGCCGCCTCCGGCACGGAGGCCCGCGAGATCGTTGCCGACGAGGACGTTGACCTGGTCCTGCTGGACCTGA
ACCTGGGCACCGAGGACGGCATCGAGGTCCTCAAGGAGCTGAAACTCCTGGACCCGGAGCTCCTCGTCATCATCATAACC
GGCTTCGGCTCGGTGGAGAGCGCCGTGGACGCCCTGAAGCTGGGCGCGTTCCACTACATGAAGAAACCCTTCAAGGCGGA
CGCCCTGCGGGTCATCGTGAAACTGGCGCTCCAGACCCAGACCCTGCGGCGCGAGGTCCGCAATCTCCGCAAGGGGGATC
TGACCCTGTTCGAAAATGTCCCCCTGGTGGGGGCCGGCGAGGGGCTGAAGGAGATCATCCGCCAGGTCAAGGAGGTGGCC
CGCTTTCCCCTCTCCACGGTCCTCATCACCGGCGAGTCGGGCACCGGCAAGGAACTGGTGGCGCGCACCATTCACCACCT
TTCGGACCGGCGCGAGGCCCCCTTCGTCGCCATCAACTGCGCCTCCATGCCGGTTTCGCTGCTGGAAAGCGAACTCTTCG
GCCACGAGAAGGGGGCGTTCACCGATGCCAGCCAGCGCAAGCCGGGCCTTTTTGAAGAAGCCCACAAGGGGACCATCTTT
CTGGACGAGATCGGCGAGATGGATGTCTCCATCCAGGCCAAGCTGCTGCGGGTGCTGGAAGACCGGAAGATCAGGCGGGT
CGGCGGAACGCGGAACATCGACATCGACGTGCGGGTGATCGCCGCCACCAACCGCAACCTGCGCGACGCCATCCGCGAAG
GGAACTTCAGGGAAGACCTCTACTATCGTCTCAACGTGTTCCCCATCCACATCCCGCCGCTGCGGGAGCGGAAAGAGGAT
ATCCCGGTCCTGGCGAAATTCTACCTGGACCGTTACGGCCGCACCTTCAACCGCAGCTTCCAGATCATCTCGGCCGAGGC
CCTGCGGCTGCTGGAAACGCACCCCTGGCCCGGCAACATCCGCGAGATGAAAAACGTCATCGAGCGGATCTGCATCATGC
ACGACGGCCCGGAACTGACCCCGAACCACCTTCCGCCCGAAATCAAGCAGACCGAGGGGAGCGTTGCCCCGCCGGCCACG
GATGTAAGCGCGGATCTGGCCCAGGGGCTCGAAGCGGCCACCGACCGCTACGAAAAGCAGCTCATCGCTGCGGCCCTGGC
CATGACCGGCAACAACGTGCTGCAGGCGGCCCAGATTCTCAAGATTCCGCGCGGAACGCTACGCTACAAGATGACACGGC
ACGGATTGCACGGGGGGGGGAGCGACGGGGGATAG

Upstream 100 bases:

>100_bases
CGGCCGGGAACTCTCCCCCCCGGCAGTCGCCTTCATCGGCGAACTGACCGGAACCCGGCTCGCCTGACCCGCGGCTCGAC
GCTCCCTCCTATCGCGCACC

Downstream 100 bases:

>100_bases
GAAGCGGCAGGTACTGCGGAGTCAGAATTCAGCGACGATCAGCTCTGACAGGGGCTTGCGGTCCGAGTGGTGGGGGACCC
CGGACGGACGGCCCACGGCG

Product: sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MEKILIIDDEAFIRENVERILTDDGYQVLCAASGTEAREIVADEDVDLVLLDLNLGTEDGIEVLKELKLLDPELLVIIIT
GFGSVESAVDALKLGAFHYMKKPFKADALRVIVKLALQTQTLRREVRNLRKGDLTLFENVPLVGAGEGLKEIIRQVKEVA
RFPLSTVLITGESGTGKELVARTIHHLSDRREAPFVAINCASMPVSLLESELFGHEKGAFTDASQRKPGLFEEAHKGTIF
LDEIGEMDVSIQAKLLRVLEDRKIRRVGGTRNIDIDVRVIAATNRNLRDAIREGNFREDLYYRLNVFPIHIPPLRERKED
IPVLAKFYLDRYGRTFNRSFQIISAEALRLLETHPWPGNIREMKNVIERICIMHDGPELTPNHLPPEIKQTEGSVAPPAT
DVSADLAQGLEAATDRYEKQLIAAALAMTGNNVLQAAQILKIPRGTLRYKMTRHGLHGGGSDGG

Sequences:

>Translated_464_residues
MEKILIIDDEAFIRENVERILTDDGYQVLCAASGTEAREIVADEDVDLVLLDLNLGTEDGIEVLKELKLLDPELLVIIIT
GFGSVESAVDALKLGAFHYMKKPFKADALRVIVKLALQTQTLRREVRNLRKGDLTLFENVPLVGAGEGLKEIIRQVKEVA
RFPLSTVLITGESGTGKELVARTIHHLSDRREAPFVAINCASMPVSLLESELFGHEKGAFTDASQRKPGLFEEAHKGTIF
LDEIGEMDVSIQAKLLRVLEDRKIRRVGGTRNIDIDVRVIAATNRNLRDAIREGNFREDLYYRLNVFPIHIPPLRERKED
IPVLAKFYLDRYGRTFNRSFQIISAEALRLLETHPWPGNIREMKNVIERICIMHDGPELTPNHLPPEIKQTEGSVAPPAT
DVSADLAQGLEAATDRYEKQLIAAALAMTGNNVLQAAQILKIPRGTLRYKMTRHGLHGGGSDGG
>Mature_464_residues
MEKILIIDDEAFIRENVERILTDDGYQVLCAASGTEAREIVADEDVDLVLLDLNLGTEDGIEVLKELKLLDPELLVIIIT
GFGSVESAVDALKLGAFHYMKKPFKADALRVIVKLALQTQTLRREVRNLRKGDLTLFENVPLVGAGEGLKEIIRQVKEVA
RFPLSTVLITGESGTGKELVARTIHHLSDRREAPFVAINCASMPVSLLESELFGHEKGAFTDASQRKPGLFEEAHKGTIF
LDEIGEMDVSIQAKLLRVLEDRKIRRVGGTRNIDIDVRVIAATNRNLRDAIREGNFREDLYYRLNVFPIHIPPLRERKED
IPVLAKFYLDRYGRTFNRSFQIISAEALRLLETHPWPGNIREMKNVIERICIMHDGPELTPNHLPPEIKQTEGSVAPPAT
DVSADLAQGLEAATDRYEKQLIAAALAMTGNNVLQAAQILKIPRGTLRYKMTRHGLHGGGSDGG

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=456, Percent_Identity=42.5438596491228, Blast_Score=377, Evalue=1e-105,
Organism=Escherichia coli, GI1790437, Length=451, Percent_Identity=42.350332594235, Blast_Score=332, Evalue=3e-92,
Organism=Escherichia coli, GI1790299, Length=470, Percent_Identity=38.2978723404255, Blast_Score=313, Evalue=2e-86,
Organism=Escherichia coli, GI1788905, Length=453, Percent_Identity=38.6313465783664, Blast_Score=298, Evalue=6e-82,
Organism=Escherichia coli, GI87082117, Length=361, Percent_Identity=44.5983379501385, Blast_Score=274, Evalue=7e-75,
Organism=Escherichia coli, GI1789087, Length=362, Percent_Identity=44.475138121547, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI1789233, Length=320, Percent_Identity=44.375, Blast_Score=254, Evalue=9e-69,
Organism=Escherichia coli, GI87082152, Length=342, Percent_Identity=41.2280701754386, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI87081872, Length=318, Percent_Identity=38.3647798742138, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI1787583, Length=334, Percent_Identity=36.2275449101796, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1786524, Length=268, Percent_Identity=42.5373134328358, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI87081858, Length=312, Percent_Identity=33.3333333333333, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1789828, Length=250, Percent_Identity=34.8, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI1789809, Length=119, Percent_Identity=31.0924369747899, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1787229, Length=122, Percent_Identity=33.6065573770492, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51710; Mature: 51710

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKILIIDDEAFIRENVERILTDDGYQVLCAASGTEAREIVADEDVDLVLLDLNLGTEDG
CCEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCCCCEEEEEECCCCHHH
IEVLKELKLLDPELLVIIITGFGSVESAVDALKLGAFHYMKKPFKADALRVIVKLALQTQ
HHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
TLRREVRNLRKGDLTLFENVPLVGAGEGLKEIIRQVKEVARFPLSTVLITGESGTGKELV
HHHHHHHHHHCCCEEEEECCCCEECCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHH
ARTIHHLSDRREAPFVAINCASMPVSLLESELFGHEKGAFTDASQRKPGLFEEAHKGTIF
HHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCEEE
LDEIGEMDVSIQAKLLRVLEDRKIRRVGGTRNIDIDVRVIAATNRNLRDAIREGNFREDL
EECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCHHHHHHCCCCCCCE
YYRLNVFPIHIPPLRERKEDIPVLAKFYLDRYGRTFNRSFQIISAEALRLLETHPWPGNI
EEEEEEEEEECCCHHHHHCCCHHHHHHHHHHHCCHHCCCEEEEHHHHHHHHHCCCCCCCH
REMKNVIERICIMHDGPELTPNHLPPEIKQTEGSVAPPATDVSADLAQGLEAATDRYEKQ
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LIAAALAMTGNNVLQAAQILKIPRGTLRYKMTRHGLHGGGSDGG
HHHHHHHHCCCHHHHHHHHHHCCCCHHEEHHHHCCCCCCCCCCC
>Mature Secondary Structure
MEKILIIDDEAFIRENVERILTDDGYQVLCAASGTEAREIVADEDVDLVLLDLNLGTEDG
CCEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCCCCEEEEEECCCCHHH
IEVLKELKLLDPELLVIIITGFGSVESAVDALKLGAFHYMKKPFKADALRVIVKLALQTQ
HHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
TLRREVRNLRKGDLTLFENVPLVGAGEGLKEIIRQVKEVARFPLSTVLITGESGTGKELV
HHHHHHHHHHCCCEEEEECCCCEECCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHH
ARTIHHLSDRREAPFVAINCASMPVSLLESELFGHEKGAFTDASQRKPGLFEEAHKGTIF
HHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCEEE
LDEIGEMDVSIQAKLLRVLEDRKIRRVGGTRNIDIDVRVIAATNRNLRDAIREGNFREDL
EECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCHHHHHHCCCCCCCE
YYRLNVFPIHIPPLRERKEDIPVLAKFYLDRYGRTFNRSFQIISAEALRLLETHPWPGNI
EEEEEEEEEECCCHHHHHCCCHHHHHHHHHHHCCHHCCCEEEEHHHHHHHHHCCCCCCCH
REMKNVIERICIMHDGPELTPNHLPPEIKQTEGSVAPPATDVSADLAQGLEAATDRYEKQ
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LIAAALAMTGNNVLQAAQILKIPRGTLRYKMTRHGLHGGGSDGG
HHHHHHHHCCCHHHHHHHHHHCCCCHHEEHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]