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The map label for this gene is zraS [H]

Identifier: 39997587

GI number: 39997587

Start: 2738467

End: 2740959

Strand: Direct

Name: zraS [H]

Synonym: GSU2492

Alternate gene names: 39997587

Gene position: 2738467-2740959 (Clockwise)

Preceding gene: 39997586

Following gene: 39997595

Centisome position: 71.8

GC content: 67.55

Gene sequence:

>2493_bases
ATGAACCGGCTCTCCCTGTTCCAGAAGATCCTGGTGGCCATGCTGACCCTGTCGCTGGTGCCGCTGCTGGTCTCTTCGGC
CATCCTCGCCCTGAACCTGGGCAGCGTGCGAGAGACCCTTGCCGACCGGATCGCCGATGCGGCCGACCGGCAGGCATCCG
AAAGCCTGCGCCTTCGGGCCGAGCAGGTGGCCGAGGGCATAGCCGGCTTCCTGCAGGACTGCGAGGCCGACCTGAAGCTC
TGCGTCACCCTCCCCCGCACCCCCGAAATCCTGACCGCCTTCTACGAGAGCCGCCACGGCGAGATCTGGCGGCGGGACGG
CACCGCCGCGGCCCCCCGCGAGGTGCGCGAGTCGATCCCGCGCTATGCCTCCCTGGCCGTGATCGATGCCAACGGCCGGG
AAACCTTCGTGATCCGCGAAGGGGCCATCGTGCCCGAAAGCGGGCTGCGCACCGTGGCCGACCCCGGCCAGACCGAGTTC
CTGCGGGAGGATTACTTCCAGCGCGCCCGGCAGCTCAAACGGGGCGAAATCCTCGTGACGCACGTCACCGGCTTCCACGT
GGGGAAAGAGGAGCAGCTGGCCGGCGCCCGGGAGCCTGAGGACGCCTACAGCGGCAGGGAATTTCGGGGTGTGGTCCGCT
TCGCCACCCCGCTGTTCGACAGGCGGGGCCGGTTCGACGGGGTCATGGTCCTGTCACTCGACCACCGCCACCTGATGGAA
TTCTCCCAGCATATCAGCCCCGGCCGGAACCGGGCCGTGGTCTTCCCCTCCTACCGCAGCGGCAACTATGCCTTCATCTT
CGACGACGAAGGGTGGATCATCACCCATCCCAAGTTCTGGGACATCCGGGGGGTGGACGCCGACGGCACCCTGGTCCCCC
CCTACACGAAGAACTCCCCCCCCGCCGACGTCGAGGCGGGCCGCATCCCCTTCAACCTGGACCACGCCGGCTTCATTCAC
CCCAACTACCCCCGGGTGGCCCAGCTGGTGCGGGAGCGCCAATCGGGCTACGTGGACATCACCAATGTTGGGGGCGCCAA
GAAGATCATGGCCTTCGCGCCGATCCCCTACTCCACCGGCGACTACACGCGCCACGGCATCTTCGGCGGGGTAACCATCG
GCTTCCAGGTGGACCAGTTCCATGAAACGGCCCGGGCCGGCTCCGCCGTCATCAATCTCCAGCTCCGGGAACACCTGCGG
CTTTCGGCCATCATCGTGGCCGCCACGTCCCTGATGGTGGTCATTTGTGCCTGGCTCCTCTCCCGGGGCGTCACCCGGCC
CCTGGCCCTGCTGACCGACGGGGTCAGGCGGCTGGCGGGGGGCGAATCCGGCGCCAAGGTGGAAGTGGCCGCGCGCGACG
AGGTGGGCGAGCTGGCCGACACCTTCAACCGGATGGCCGACGAGCTGGAACTTCGCAAGAACAGACTTCTCAAGACCCTG
GAGGAGCTGGAAGAATCGCGGCGGCACATCATGGATGAGCGCAACTTCAAGGAAAGCGTTCTGGAGAGCATCTCCAGCGC
CATCATGACGCTGTCGCCCGAGGGGTTGCTCACCTCGATCAACGGCACCGGTACGCGCCTGCTGGGGCCGGCCGCGGTCA
TCGGCGCCCCTTACCAAAAGGTGTTCAGCGAATGGAGCGACATGACCGGCCGGATCGCCGAGGCCCTGGCCGGCCGGCGC
GAGTACGGCCGCGAACCGCTCGTGCTCGGGACCGATGGCAAGGAACGGCATTTCGAGGTGGGCTTCTTCCCCATCTATGC
CGATCGCTCCGGCGGGCTCACCGTCACCATCCGGGACGAGACCGAGAAGGAAAGCTTTCGGGAGGAGATGACGCGGCTGG
ACCGGCTGGCCTCCCTGGGCAAGCTGGCCGCCGGCATCGCCCACGAGGTGCGCAACCCGCTCACGGGGGTGTCGCTGCTT
CTGGACGACCTCCACGATCGGGCCGGACTCGACGCCGAAAGCCAGGCAATGATGGGCAAGGCGCTCCAGGAGATCGAGCG
GGTGGAGCGGCTCGTGGCCGGGCTGCTCAACTTCTCCTCCCCGCCCAAGGCATTCCTGCGGGAGGCCGACCTGAACCGGG
TCATCCAGGATACGCTCCTGCTCCTGCGTCGGGAGTGCGAGAGCCGGAACGTGGCGCTCGGCTTCGAGCCCGGCGACGTG
CCGGTGTTCCGCATCGACGTGGAAAAGGTGCGGCAGGCCCTCCTGAACCTGGTGAAAAACGCCCTGGAGGCCATGCCCGA
CGGCGGATCGGTCCGGGTGACCACCGGCGTGGATGGTGACACTGCCGTGGTAACGGTGGCCGACACCGGCCCCGGCATCG
CCGATAACGACCTGCCGCTCATCTTCGAGCCCTTCTTCACCCGCAAGGGGGCGGGCACCGGGTTGGGGCTCTCCATCACC
CAGCGCATCGTCGAGGAGCACCACGGCAGGATCAGCGTGGAAAGCAGCGCCGGGGCAGGAACGACCTTCACCATCACTCT
TCCCATGGGCTAG

Upstream 100 bases:

>100_bases
TCGCCTTTGCCACGGCCGGCGTGGGGGCGCTCACGGGGCCCATCTTCATGTGGTTGCTGCGCCGCTGCCCCGAGAGCTCG
CGCATGGCCGGGGGAAGGAA

Downstream 100 bases:

>100_bases
CCATAATCTCCAGCCCCCCGGTCATTAGCCTGGTTCTTTACCCTCTTTTTTTACGCAGCCCTCAGCGAACCTCGGACGTA
ACATTAACACAACCCAAGAA

Product: sensory box histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 830; Mature: 830

Protein sequence:

>830_residues
MNRLSLFQKILVAMLTLSLVPLLVSSAILALNLGSVRETLADRIADAADRQASESLRLRAEQVAEGIAGFLQDCEADLKL
CVTLPRTPEILTAFYESRHGEIWRRDGTAAAPREVRESIPRYASLAVIDANGRETFVIREGAIVPESGLRTVADPGQTEF
LREDYFQRARQLKRGEILVTHVTGFHVGKEEQLAGAREPEDAYSGREFRGVVRFATPLFDRRGRFDGVMVLSLDHRHLME
FSQHISPGRNRAVVFPSYRSGNYAFIFDDEGWIITHPKFWDIRGVDADGTLVPPYTKNSPPADVEAGRIPFNLDHAGFIH
PNYPRVAQLVRERQSGYVDITNVGGAKKIMAFAPIPYSTGDYTRHGIFGGVTIGFQVDQFHETARAGSAVINLQLREHLR
LSAIIVAATSLMVVICAWLLSRGVTRPLALLTDGVRRLAGGESGAKVEVAARDEVGELADTFNRMADELELRKNRLLKTL
EELEESRRHIMDERNFKESVLESISSAIMTLSPEGLLTSINGTGTRLLGPAAVIGAPYQKVFSEWSDMTGRIAEALAGRR
EYGREPLVLGTDGKERHFEVGFFPIYADRSGGLTVTIRDETEKESFREEMTRLDRLASLGKLAAGIAHEVRNPLTGVSLL
LDDLHDRAGLDAESQAMMGKALQEIERVERLVAGLLNFSSPPKAFLREADLNRVIQDTLLLLRRECESRNVALGFEPGDV
PVFRIDVEKVRQALLNLVKNALEAMPDGGSVRVTTGVDGDTAVVTVADTGPGIADNDLPLIFEPFFTRKGAGTGLGLSIT
QRIVEEHHGRISVESSAGAGTTFTITLPMG

Sequences:

>Translated_830_residues
MNRLSLFQKILVAMLTLSLVPLLVSSAILALNLGSVRETLADRIADAADRQASESLRLRAEQVAEGIAGFLQDCEADLKL
CVTLPRTPEILTAFYESRHGEIWRRDGTAAAPREVRESIPRYASLAVIDANGRETFVIREGAIVPESGLRTVADPGQTEF
LREDYFQRARQLKRGEILVTHVTGFHVGKEEQLAGAREPEDAYSGREFRGVVRFATPLFDRRGRFDGVMVLSLDHRHLME
FSQHISPGRNRAVVFPSYRSGNYAFIFDDEGWIITHPKFWDIRGVDADGTLVPPYTKNSPPADVEAGRIPFNLDHAGFIH
PNYPRVAQLVRERQSGYVDITNVGGAKKIMAFAPIPYSTGDYTRHGIFGGVTIGFQVDQFHETARAGSAVINLQLREHLR
LSAIIVAATSLMVVICAWLLSRGVTRPLALLTDGVRRLAGGESGAKVEVAARDEVGELADTFNRMADELELRKNRLLKTL
EELEESRRHIMDERNFKESVLESISSAIMTLSPEGLLTSINGTGTRLLGPAAVIGAPYQKVFSEWSDMTGRIAEALAGRR
EYGREPLVLGTDGKERHFEVGFFPIYADRSGGLTVTIRDETEKESFREEMTRLDRLASLGKLAAGIAHEVRNPLTGVSLL
LDDLHDRAGLDAESQAMMGKALQEIERVERLVAGLLNFSSPPKAFLREADLNRVIQDTLLLLRRECESRNVALGFEPGDV
PVFRIDVEKVRQALLNLVKNALEAMPDGGSVRVTTGVDGDTAVVTVADTGPGIADNDLPLIFEPFFTRKGAGTGLGLSIT
QRIVEEHHGRISVESSAGAGTTFTITLPMG
>Mature_830_residues
MNRLSLFQKILVAMLTLSLVPLLVSSAILALNLGSVRETLADRIADAADRQASESLRLRAEQVAEGIAGFLQDCEADLKL
CVTLPRTPEILTAFYESRHGEIWRRDGTAAAPREVRESIPRYASLAVIDANGRETFVIREGAIVPESGLRTVADPGQTEF
LREDYFQRARQLKRGEILVTHVTGFHVGKEEQLAGAREPEDAYSGREFRGVVRFATPLFDRRGRFDGVMVLSLDHRHLME
FSQHISPGRNRAVVFPSYRSGNYAFIFDDEGWIITHPKFWDIRGVDADGTLVPPYTKNSPPADVEAGRIPFNLDHAGFIH
PNYPRVAQLVRERQSGYVDITNVGGAKKIMAFAPIPYSTGDYTRHGIFGGVTIGFQVDQFHETARAGSAVINLQLREHLR
LSAIIVAATSLMVVICAWLLSRGVTRPLALLTDGVRRLAGGESGAKVEVAARDEVGELADTFNRMADELELRKNRLLKTL
EELEESRRHIMDERNFKESVLESISSAIMTLSPEGLLTSINGTGTRLLGPAAVIGAPYQKVFSEWSDMTGRIAEALAGRR
EYGREPLVLGTDGKERHFEVGFFPIYADRSGGLTVTIRDETEKESFREEMTRLDRLASLGKLAAGIAHEVRNPLTGVSLL
LDDLHDRAGLDAESQAMMGKALQEIERVERLVAGLLNFSSPPKAFLREADLNRVIQDTLLLLRRECESRNVALGFEPGDV
PVFRIDVEKVRQALLNLVKNALEAMPDGGSVRVTTGVDGDTAVVTVADTGPGIADNDLPLIFEPFFTRKGAGTGLGLSIT
QRIVEEHHGRISVESSAGAGTTFTITLPMG

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=228, Percent_Identity=38.5964912280702, Blast_Score=166, Evalue=5e-42,
Organism=Escherichia coli, GI1788549, Length=425, Percent_Identity=28.4705882352941, Blast_Score=158, Evalue=2e-39,
Organism=Escherichia coli, GI1786600, Length=352, Percent_Identity=26.4204545454545, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI145693157, Length=255, Percent_Identity=29.4117647058824, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1790346, Length=237, Percent_Identity=30.379746835443, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1786783, Length=254, Percent_Identity=31.1023622047244, Blast_Score=90, Evalue=6e-19,
Organism=Escherichia coli, GI1789808, Length=213, Percent_Identity=30.5164319248826, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1788393, Length=256, Percent_Identity=28.90625, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1790300, Length=352, Percent_Identity=25, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1788713, Length=233, Percent_Identity=27.8969957081545, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI48994928, Length=287, Percent_Identity=29.616724738676, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI87081816, Length=219, Percent_Identity=29.6803652968037, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1790567, Length=342, Percent_Identity=27.4853801169591, Blast_Score=70, Evalue=7e-13,
Organism=Escherichia coli, GI1787894, Length=235, Percent_Identity=28.0851063829787, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1790551, Length=202, Percent_Identity=30.1980198019802, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1789149, Length=225, Percent_Identity=31.5555555555556, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 91265; Mature: 91265

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRLSLFQKILVAMLTLSLVPLLVSSAILALNLGSVRETLADRIADAADRQASESLRLRA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQVAEGIAGFLQDCEADLKLCVTLPRTPEILTAFYESRHGEIWRRDGTAAAPREVRESIP
HHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHCC
RYASLAVIDANGRETFVIREGAIVPESGLRTVADPGQTEFLREDYFQRARQLKRGEILVT
CCEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEE
HVTGFHVGKEEQLAGAREPEDAYSGREFRGVVRFATPLFDRRGRFDGVMVLSLDHRHLME
EECCEECCCHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHH
FSQHISPGRNRAVVFPSYRSGNYAFIFDDEGWIITHPKFWDIRGVDADGTLVPPYTKNSP
HHHHCCCCCCCEEEEECCCCCCEEEEEECCCEEEECCCEEEEEECCCCCCCCCCCCCCCC
PADVEAGRIPFNLDHAGFIHPNYPRVAQLVRERQSGYVDITNVGGAKKIMAFAPIPYSTG
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCEEEEEECCCCCCC
DYTRHGIFGGVTIGFQVDQFHETARAGSAVINLQLREHLRLSAIIVAATSLMVVICAWLL
CCCCCCCCCCEEEEEEHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
SRGVTRPLALLTDGVRRLAGGESGAKVEVAARDEVGELADTFNRMADELELRKNRLLKTL
HCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EELEESRRHIMDERNFKESVLESISSAIMTLSPEGLLTSINGTGTRLLGPAAVIGAPYQK
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHEECCCCCEEECCCCCCCCCCCHHHHCCCHHH
VFSEWSDMTGRIAEALAGRREYGREPLVLGTDGKERHFEVGFFPIYADRSGGLTVTIRDE
HHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEEEEEEECCCCCEEEEECCC
TEKESFREEMTRLDRLASLGKLAAGIAHEVRNPLTGVSLLLDDLHDRAGLDAESQAMMGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
ALQEIERVERLVAGLLNFSSPPKAFLREADLNRVIQDTLLLLRRECESRNVALGFEPGDV
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
PVFRIDVEKVRQALLNLVKNALEAMPDGGSVRVTTGVDGDTAVVTVADTGPGIADNDLPL
CEEEECHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCCCE
IFEPFFTRKGAGTGLGLSITQRIVEEHHGRISVESSAGAGTTFTITLPMG
EECHHHCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCEEEEEEECCC
>Mature Secondary Structure
MNRLSLFQKILVAMLTLSLVPLLVSSAILALNLGSVRETLADRIADAADRQASESLRLRA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQVAEGIAGFLQDCEADLKLCVTLPRTPEILTAFYESRHGEIWRRDGTAAAPREVRESIP
HHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHCC
RYASLAVIDANGRETFVIREGAIVPESGLRTVADPGQTEFLREDYFQRARQLKRGEILVT
CCEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEE
HVTGFHVGKEEQLAGAREPEDAYSGREFRGVVRFATPLFDRRGRFDGVMVLSLDHRHLME
EECCEECCCHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHH
FSQHISPGRNRAVVFPSYRSGNYAFIFDDEGWIITHPKFWDIRGVDADGTLVPPYTKNSP
HHHHCCCCCCCEEEEECCCCCCEEEEEECCCEEEECCCEEEEEECCCCCCCCCCCCCCCC
PADVEAGRIPFNLDHAGFIHPNYPRVAQLVRERQSGYVDITNVGGAKKIMAFAPIPYSTG
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCEEEEEECCCCCCC
DYTRHGIFGGVTIGFQVDQFHETARAGSAVINLQLREHLRLSAIIVAATSLMVVICAWLL
CCCCCCCCCCEEEEEEHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
SRGVTRPLALLTDGVRRLAGGESGAKVEVAARDEVGELADTFNRMADELELRKNRLLKTL
HCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EELEESRRHIMDERNFKESVLESISSAIMTLSPEGLLTSINGTGTRLLGPAAVIGAPYQK
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHEECCCCCEEECCCCCCCCCCCHHHHCCCHHH
VFSEWSDMTGRIAEALAGRREYGREPLVLGTDGKERHFEVGFFPIYADRSGGLTVTIRDE
HHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEEEEEEECCCCCEEEEECCC
TEKESFREEMTRLDRLASLGKLAAGIAHEVRNPLTGVSLLLDDLHDRAGLDAESQAMMGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
ALQEIERVERLVAGLLNFSSPPKAFLREADLNRVIQDTLLLLRRECESRNVALGFEPGDV
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
PVFRIDVEKVRQALLNLVKNALEAMPDGGSVRVTTGVDGDTAVVTVADTGPGIADNDLPL
CEEEECHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCCCE
IFEPFFTRKGAGTGLGLSITQRIVEEHHGRISVESSAGAGTTFTITLPMG
EECHHHCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]