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The map label for this gene is mscS [H]

Identifier: 39997453

GI number: 39997453

Start: 2576714

End: 2577760

Strand: Direct

Name: mscS [H]

Synonym: GSU2357

Alternate gene names: 39997453

Gene position: 2576714-2577760 (Clockwise)

Preceding gene: 39997452

Following gene: 39997454

Centisome position: 67.56

GC content: 57.88

Gene sequence:

>1047_bases
ATGACTATCCTTTCCGACATACAGAGTATTCTAAAGGCGGCGGGAATCCTTTCGTCCAGCCTCGTGGTCGGGCTCGTACT
CGACAAGGTAGTGCTGCGGCGGCTGAAAGTCCTCGCAAGCCGCACGCCGTGGGAGGGAGACGAGATCGTCGTCGACTCCC
TGCGGGGGCTGTTGTTGTACTCTGCCCTCTTGACAGGACTGTACGGCGTTGCGACGCAGGTTCCGATGACCGTAGGGCTG
CAGAGACTGGCGGGGAATATATTCCTCGTAACCATTATCCTTGTCGCTACTCTCTTCTTCATGAGGCTGGCTGCCGGCTT
TGTCACCCACTACGCGAAAAAGGCGGTACTGCCCTCCATTTCCATTTTCAGCAACCTTGCGAAAGTCTCCGTCTTTTCCA
TCGGCATCCTGATCATCCTCCAGTCTCTCGGAATCTCAATAGCTCCGATTCTCACCGCCCTCGGCGTCGGGGGCCTCGCC
GTTGCGCTCGCCCTCCAGGACACCCTGTCCAACATCTTTGCGGGGCTTCACATCATCGCGACCCGCCAGATCCGCCAGGG
CGACTACATCCGACTCGCCAGCGGAGAAGAGGGGTATGTGAACGACATAACCTGGCGCAACACCACCGTTCAGACCCTGC
CCAACAATATGGTCATCATCCCGAACTCAAAGCTGGCCGGCGCCATCGTTACGAACTACAACCTGCCTGACCGGGAAATG
GCGGTGCTCGTTCAGGTGGGAGTCAGTTACGCAAGCGACCTGGATCATGTGGAGCGGGTAACCATAGAGGTGGCCAGCGA
ACTGCTGCACGAGGTCCAGGGCGGAGCCAGCGGCTTTGACCCGTTCATCCGCTATCACACCTTTGCCGACTTCAGCATCA
ATTTCACCGTGATCCTGCGGGGCAAGGAATACGTGGACCAGCATCTCCTCAAGCATGAGTTCGTGAAACGCCTCCATCGG
CGTTATGCCAGGGAGAAAATCGAAATACCATTTCCGATCCGGACCCTCCACATCAAGCAGGAGGCGCCGGCACAGGAAGG
GGACTGA

Upstream 100 bases:

>100_bases
TACCGTCCGCTACAACCTCTTGAATTCATGAATAGTTATGAAAATAGTGGCCACGAATGGTTGATTTGTACACAAACTAT
TTATAGAATCGACACATTCC

Downstream 100 bases:

>100_bases
GATGACGCCGTGGTGCCTGGATATCGGAGCGACGCCCGTCACCGGAGGAGTTCACTTCAGGGTTTGGAGCCCCCTGGCCG
ATTCCGTCGAGGTCATCCGC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MTILSDIQSILKAAGILSSSLVVGLVLDKVVLRRLKVLASRTPWEGDEIVVDSLRGLLLYSALLTGLYGVATQVPMTVGL
QRLAGNIFLVTIILVATLFFMRLAAGFVTHYAKKAVLPSISIFSNLAKVSVFSIGILIILQSLGISIAPILTALGVGGLA
VALALQDTLSNIFAGLHIIATRQIRQGDYIRLASGEEGYVNDITWRNTTVQTLPNNMVIIPNSKLAGAIVTNYNLPDREM
AVLVQVGVSYASDLDHVERVTIEVASELLHEVQGGASGFDPFIRYHTFADFSINFTVILRGKEYVDQHLLKHEFVKRLHR
RYAREKIEIPFPIRTLHIKQEAPAQEGD

Sequences:

>Translated_348_residues
MTILSDIQSILKAAGILSSSLVVGLVLDKVVLRRLKVLASRTPWEGDEIVVDSLRGLLLYSALLTGLYGVATQVPMTVGL
QRLAGNIFLVTIILVATLFFMRLAAGFVTHYAKKAVLPSISIFSNLAKVSVFSIGILIILQSLGISIAPILTALGVGGLA
VALALQDTLSNIFAGLHIIATRQIRQGDYIRLASGEEGYVNDITWRNTTVQTLPNNMVIIPNSKLAGAIVTNYNLPDREM
AVLVQVGVSYASDLDHVERVTIEVASELLHEVQGGASGFDPFIRYHTFADFSINFTVILRGKEYVDQHLLKHEFVKRLHR
RYAREKIEIPFPIRTLHIKQEAPAQEGD
>Mature_347_residues
TILSDIQSILKAAGILSSSLVVGLVLDKVVLRRLKVLASRTPWEGDEIVVDSLRGLLLYSALLTGLYGVATQVPMTVGLQ
RLAGNIFLVTIILVATLFFMRLAAGFVTHYAKKAVLPSISIFSNLAKVSVFSIGILIILQSLGISIAPILTALGVGGLAV
ALALQDTLSNIFAGLHIIATRQIRQGDYIRLASGEEGYVNDITWRNTTVQTLPNNMVIIPNSKLAGAIVTNYNLPDREMA
VLVQVGVSYASDLDHVERVTIEVASELLHEVQGGASGFDPFIRYHTFADFSINFTVILRGKEYVDQHLLKHEFVKRLHRR
YAREKIEIPFPIRTLHIKQEAPAQEGD

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=297, Percent_Identity=26.9360269360269, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787591, Length=269, Percent_Identity=26.7657992565056, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786670, Length=217, Percent_Identity=26.2672811059908, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 38136; Mature: 38005

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILSDIQSILKAAGILSSSLVVGLVLDKVVLRRLKVLASRTPWEGDEIVVDSLRGLLLY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
SALLTGLYGVATQVPMTVGLQRLAGNIFLVTIILVATLFFMRLAAGFVTHYAKKAVLPSI
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
SIFSNLAKVSVFSIGILIILQSLGISIAPILTALGVGGLAVALALQDTLSNIFAGLHIIA
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
TRQIRQGDYIRLASGEEGYVNDITWRNTTVQTLPNNMVIIPNSKLAGAIVTNYNLPDREM
HHHHCCCCEEEEECCCCCCCCCCCCCCCCCEECCCCEEEEECCCCCEEEEECCCCCHHHH
AVLVQVGVSYASDLDHVERVTIEVASELLHEVQGGASGFDPFIRYHTFADFSINFTVILR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHEEECCEEEEEEEEC
GKEYVDQHLLKHEFVKRLHRRYAREKIEIPFPIRTLHIKQEAPAQEGD
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCC
>Mature Secondary Structure 
TILSDIQSILKAAGILSSSLVVGLVLDKVVLRRLKVLASRTPWEGDEIVVDSLRGLLLY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
SALLTGLYGVATQVPMTVGLQRLAGNIFLVTIILVATLFFMRLAAGFVTHYAKKAVLPSI
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
SIFSNLAKVSVFSIGILIILQSLGISIAPILTALGVGGLAVALALQDTLSNIFAGLHIIA
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
TRQIRQGDYIRLASGEEGYVNDITWRNTTVQTLPNNMVIIPNSKLAGAIVTNYNLPDREM
HHHHCCCCEEEEECCCCCCCCCCCCCCCCCEECCCCEEEEECCCCCEEEEECCCCCHHHH
AVLVQVGVSYASDLDHVERVTIEVASELLHEVQGGASGFDPFIRYHTFADFSINFTVILR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHEEECCEEEEEEEEC
GKEYVDQHLLKHEFVKRLHRRYAREKIEIPFPIRTLHIKQEAPAQEGD
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12542086 [H]