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The map label for this gene is pncB [H]

Identifier: 39997387

GI number: 39997387

Start: 2506846

End: 2508291

Strand: Direct

Name: pncB [H]

Synonym: GSU2289

Alternate gene names: 39997387

Gene position: 2506846-2508291 (Clockwise)

Preceding gene: 39997384

Following gene: 39997388

Centisome position: 65.73

GC content: 63.0

Gene sequence:

>1446_bases
ATGCGCTACTCCCCCCTTCTCACCGACCTCTATCAGCTGACCATGCTCGCCGGCTACCTGGACGAAGGCATGGCGGAGAC
TCCGGCAGTCTTTGATCTCTTTTTTCGCCACAACCCTTTCCAGGGTGGCTATGCAGTCTTCGCCGGACTCGACACGGCCC
TCGACTTTCTCGAACACCTCGAGTTCAGCGAAGACGAGATCGAGTATCTCCAGGGGCTCGGTCTCTTCCGGCCGGCGTTC
ATCGATTTTCTCCGTTCGTTCCGTTTCAGGGGAAGGGTAACGGCCCCTCCCGAAGGAACGGTGGTCTTCGCCAATGAGCC
GCTGGTCACGGTGGATGCGCCCCTGGCCCAGGCCCAACTGGTGGAAACCGCGCTCCTCAATATCATCAACTTCCAGACGC
TCGTGGCCACGAAGGCCGCCCGGATCGTTCACGCGGCAGCGGACGGAACCGTTCTCGAGTTCGGCCTTCGACGCGCCCAG
GGCCCCGACGGCGGCCTGAGCGAAGCCAGGGCTGCCTACGTGGGAGGGGTACGCAGCACCAGCAACGTCCTGGCGGGCAA
GACCTTCGGCATCCCGGTGCGCGGCACTCACGCCCACAGCTGGATCATGGCCTTTTCCGACGAATTGACGGCGTTCAGGA
AATACGCTGAGGTCTTCCCCGACTCCTGCATTCTCCTGGTGGATACCTATGACACTCTCAGGAGCGGCCTGCCCAACGCA
ATCACCGTTGCGCGGGAGTTGCGGGCCAAGGGACACGAATTGGTCGGGGTACGGATCGACTCGGGCGATCTGGCCTACCT
CTCGCGCCAGGCACGGCGGCTGTTCGACGAAGCGGGGTTCCCCAATGTCCGGATCGTCGCCTCCAATGAGCTGGACGAAT
TCGTCATCGAGTCGATCCGGGCCGAAGGGGGATGTGTCGACATCTACGGCGTGGGAACCCGGCTCGCCACCTGTGCCGGG
GAGGGAGGAGGCGCCCTGGGAGGTGTCTACAAACTGGTCCGGATCGGCGATCGACCGCGGCTCAAGGTGACGAGTGACCT
GGCAAAGGCGACCCTGCCTGACCGGAAGCGGCTCCTGCGGGCCGTGGCGGCCGACGGCACCTTCATCCAGGACGTGATCT
GCCTGGATGGCGAAGAGGTGCTTCCCGGCCATACGGTCTTTGATCCGGCCAATCCTCTGCAGCATGTGACCATCCCGATG
AAGGCCCGCCTTGAAGACGTCCGTTCCGTTGCCATGGAGAACGGCAGGCGGACCGCCTCACGATCCGTTTCACTCGACCG
GATGGCCGATCGGTCACGGAATCAACTCGCCCTCCTCCCGCAGGGATGCCTTCGGTTCATCAACCCGCACCGCTACAAGG
TTTCCATCAGCCAAGGGCTCAATGACCTGCGACTTCGCCTCATGGAGGAGGTGCGGCACGGGTATCACGACATTGCCAAT
CCGTAA

Upstream 100 bases:

>100_bases
TCCGGAACGCCCCACCGCCGGCACGGTTACATCGATGAACCGGCCACGAGCGGCAGATGTGTGCTATACTCACGAAAAAT
CGAGCACGGAGGGCCGTTCC

Downstream 100 bases:

>100_bases
AGGAGCATATGCCATGGAAAACGATGCCGCCCTTCTCATCGTCGACGTCCAGAATGACTTCTGCCCAGGCGGAAGTCTGG
CCGTCCCCGAGGGGGACACC

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MRYSPLLTDLYQLTMLAGYLDEGMAETPAVFDLFFRHNPFQGGYAVFAGLDTALDFLEHLEFSEDEIEYLQGLGLFRPAF
IDFLRSFRFRGRVTAPPEGTVVFANEPLVTVDAPLAQAQLVETALLNIINFQTLVATKAARIVHAAADGTVLEFGLRRAQ
GPDGGLSEARAAYVGGVRSTSNVLAGKTFGIPVRGTHAHSWIMAFSDELTAFRKYAEVFPDSCILLVDTYDTLRSGLPNA
ITVARELRAKGHELVGVRIDSGDLAYLSRQARRLFDEAGFPNVRIVASNELDEFVIESIRAEGGCVDIYGVGTRLATCAG
EGGGALGGVYKLVRIGDRPRLKVTSDLAKATLPDRKRLLRAVAADGTFIQDVICLDGEEVLPGHTVFDPANPLQHVTIPM
KARLEDVRSVAMENGRRTASRSVSLDRMADRSRNQLALLPQGCLRFINPHRYKVSISQGLNDLRLRLMEEVRHGYHDIAN
P

Sequences:

>Translated_481_residues
MRYSPLLTDLYQLTMLAGYLDEGMAETPAVFDLFFRHNPFQGGYAVFAGLDTALDFLEHLEFSEDEIEYLQGLGLFRPAF
IDFLRSFRFRGRVTAPPEGTVVFANEPLVTVDAPLAQAQLVETALLNIINFQTLVATKAARIVHAAADGTVLEFGLRRAQ
GPDGGLSEARAAYVGGVRSTSNVLAGKTFGIPVRGTHAHSWIMAFSDELTAFRKYAEVFPDSCILLVDTYDTLRSGLPNA
ITVARELRAKGHELVGVRIDSGDLAYLSRQARRLFDEAGFPNVRIVASNELDEFVIESIRAEGGCVDIYGVGTRLATCAG
EGGGALGGVYKLVRIGDRPRLKVTSDLAKATLPDRKRLLRAVAADGTFIQDVICLDGEEVLPGHTVFDPANPLQHVTIPM
KARLEDVRSVAMENGRRTASRSVSLDRMADRSRNQLALLPQGCLRFINPHRYKVSISQGLNDLRLRLMEEVRHGYHDIAN
P
>Mature_481_residues
MRYSPLLTDLYQLTMLAGYLDEGMAETPAVFDLFFRHNPFQGGYAVFAGLDTALDFLEHLEFSEDEIEYLQGLGLFRPAF
IDFLRSFRFRGRVTAPPEGTVVFANEPLVTVDAPLAQAQLVETALLNIINFQTLVATKAARIVHAAADGTVLEFGLRRAQ
GPDGGLSEARAAYVGGVRSTSNVLAGKTFGIPVRGTHAHSWIMAFSDELTAFRKYAEVFPDSCILLVDTYDTLRSGLPNA
ITVARELRAKGHELVGVRIDSGDLAYLSRQARRLFDEAGFPNVRIVASNELDEFVIESIRAEGGCVDIYGVGTRLATCAG
EGGGALGGVYKLVRIGDRPRLKVTSDLAKATLPDRKRLLRAVAADGTFIQDVICLDGEEVLPGHTVFDPANPLQHVTIPM
KARLEDVRSVAMENGRRTASRSVSLDRMADRSRNQLALLPQGCLRFINPHRYKVSISQGLNDLRLRLMEEVRHGYHDIAN
P

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=530, Percent_Identity=35.2830188679245, Blast_Score=266, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI71997947, Length=519, Percent_Identity=36.8015414258189, Blast_Score=325, Evalue=5e-89,
Organism=Caenorhabditis elegans, GI71997952, Length=519, Percent_Identity=36.8015414258189, Blast_Score=324, Evalue=7e-89,
Organism=Caenorhabditis elegans, GI71997955, Length=207, Percent_Identity=49.7584541062802, Blast_Score=208, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24581587, Length=535, Percent_Identity=37.9439252336449, Blast_Score=300, Evalue=2e-81,
Organism=Drosophila melanogaster, GI161076680, Length=277, Percent_Identity=41.5162454873646, Blast_Score=185, Evalue=7e-47,
Organism=Drosophila melanogaster, GI24581595, Length=277, Percent_Identity=41.5162454873646, Blast_Score=185, Evalue=7e-47,
Organism=Drosophila melanogaster, GI28574709, Length=277, Percent_Identity=41.5162454873646, Blast_Score=185, Evalue=7e-47,
Organism=Drosophila melanogaster, GI24581593, Length=277, Percent_Identity=41.5162454873646, Blast_Score=185, Evalue=7e-47,
Organism=Drosophila melanogaster, GI24581591, Length=277, Percent_Identity=41.5162454873646, Blast_Score=185, Evalue=7e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 52819; Mature: 52819

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYSPLLTDLYQLTMLAGYLDEGMAETPAVFDLFFRHNPFQGGYAVFAGLDTALDFLEHL
CCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHC
EFSEDEIEYLQGLGLFRPAFIDFLRSFRFRGRVTAPPEGTVVFANEPLVTVDAPLAQAQL
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCEEEECCCHHHHHH
VETALLNIINFQTLVATKAARIVHAAADGTVLEFGLRRAQGPDGGLSEARAAYVGGVRST
HHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCC
SNVLAGKTFGIPVRGTHAHSWIMAFSDELTAFRKYAEVFPDSCILLVDTYDTLRSGLPNA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHCCCCHH
ITVARELRAKGHELVGVRIDSGDLAYLSRQARRLFDEAGFPNVRIVASNELDEFVIESIR
HHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHH
AEGGCVDIYGVGTRLATCAGEGGGALGGVYKLVRIGDRPRLKVTSDLAKATLPDRKRLLR
CCCCEEEEEECCHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEHHHHHHHCCCHHHHHHH
AVAADGTFIQDVICLDGEEVLPGHTVFDPANPLQHVTIPMKARLEDVRSVAMENGRRTAS
HHHCCCCHHHHHHEECCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHCCCHHHH
RSVSLDRMADRSRNQLALLPQGCLRFINPHRYKVSISQGLNDLRLRLMEEVRHGYHDIAN
HCCCHHHHHCCCCCCEEECCHHHHHHCCCCEEEEEHHHCHHHHHHHHHHHHHHHHHHCCC
P
C
>Mature Secondary Structure
MRYSPLLTDLYQLTMLAGYLDEGMAETPAVFDLFFRHNPFQGGYAVFAGLDTALDFLEHL
CCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHC
EFSEDEIEYLQGLGLFRPAFIDFLRSFRFRGRVTAPPEGTVVFANEPLVTVDAPLAQAQL
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCEEEECCCHHHHHH
VETALLNIINFQTLVATKAARIVHAAADGTVLEFGLRRAQGPDGGLSEARAAYVGGVRST
HHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCC
SNVLAGKTFGIPVRGTHAHSWIMAFSDELTAFRKYAEVFPDSCILLVDTYDTLRSGLPNA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHCCCCHH
ITVARELRAKGHELVGVRIDSGDLAYLSRQARRLFDEAGFPNVRIVASNELDEFVIESIR
HHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHH
AEGGCVDIYGVGTRLATCAGEGGGALGGVYKLVRIGDRPRLKVTSDLAKATLPDRKRLLR
CCCCEEEEEECCHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEHHHHHHHCCCHHHHHHH
AVAADGTFIQDVICLDGEEVLPGHTVFDPANPLQHVTIPMKARLEDVRSVAMENGRRTAS
HHHCCCCHHHHHHEECCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHCCCHHHH
RSVSLDRMADRSRNQLALLPQGCLRFINPHRYKVSISQGLNDLRLRLMEEVRHGYHDIAN
HCCCHHHHHCCCCCCEEECCHHHHHHCCCCEEEEEHHHCHHHHHHHHHHHHHHHHHHCCC
P
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]