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The map label for this gene is ygcM [C]

Identifier: 39996819

GI number: 39996819

Start: 1884164

End: 1884532

Strand: Direct

Name: ygcM [C]

Synonym: GSU1720

Alternate gene names: 39996819

Gene position: 1884164-1884532 (Clockwise)

Preceding gene: 39996817

Following gene: 39996820

Centisome position: 49.4

GC content: 56.1

Gene sequence:

>369_bases
ATGTATAGACTGACGATTCACACCTCGTTCGCCGCGGCACACTGCCTCATCAATTATCAGGGAGACTGCGAGAATCTGCA
CGGCCACAACTGGCGCGTAGAAGTATCGGTCACGGCCCGCGAACTGGACAAGGCCGGACTGGGTATCGATTTCAAGGTGC
TCAAGCAGGAAACCAACGGCCTGCTGCGGACCCTGGACCACAAGTACCTCAATGAACTGGAGCCGTTCAAAGAGATATCG
CCGTCGTCCGAAAACATCTCCCGCTACCTCTACCACGAGCTGTCCCGCCGCCTCAATGACGGCAACGTGACAGTTGAGAG
CATCACTGTCTGGGAATCGGACAACGCAGCGGCCACCTACTATGAGTAA

Upstream 100 bases:

>100_bases
TAAATATCTAAACAGTGCGGCGCGGCAGTCGCTTTTGCATTTTATGCATCCCCGTGGTACTATTCGCAGCGTTGACAACT
TCAGAATCAAGGATTGCGCC

Downstream 100 bases:

>100_bases
ACCCGGAGCCGAACTTGAGGAGGTTTTCTCCTCGGTCCAGGGGGAGGGGATGCTCATTGGCCTGCGCCAGGTATTCATCC
GATTCCGGGGGTGCAACCTG

Product: 6-pyruvoyl tetrahydrobiopterin synthase

Products: 6-pyruvoyl-5,6,7,8-tetrahydropterin; triphosphate

Alternate protein names: Queuosine Biosynthesis Protein QueD; 6-Pyruvoyl Tetrahydrobiopterin Synthase; 6-Pyruvoyl-Tetrahydropterin Synthase; 6-Pyruvoyl Tetrahydrobiopterin Synthase Family Protein; 6-Pyruvoyltetrahydropterin Synthase; Preq(0) Biosynthesis Protein Qued; 6-Carboxy-5 6 7 8-Tetrahydropterin Synthase; 6-Pyruvoyl Tetrahydropterin Synthase Family Protein; 6-Pyruvoyl Tetrahydrobiopterin Synthase-Like Protein; 6-Pyruvoyl Tetrahydropterin Synthase Superfamily; Queuosine Biosynthesis Protein; F0F1-Type ATP Synthase Subunit C; 6-Pyruvoyl Tetrahydrobiopterin Synthase Homolog

Number of amino acids: Translated: 122; Mature: 122

Protein sequence:

>122_residues
MYRLTIHTSFAAAHCLINYQGDCENLHGHNWRVEVSVTARELDKAGLGIDFKVLKQETNGLLRTLDHKYLNELEPFKEIS
PSSENISRYLYHELSRRLNDGNVTVESITVWESDNAAATYYE

Sequences:

>Translated_122_residues
MYRLTIHTSFAAAHCLINYQGDCENLHGHNWRVEVSVTARELDKAGLGIDFKVLKQETNGLLRTLDHKYLNELEPFKEIS
PSSENISRYLYHELSRRLNDGNVTVESITVWESDNAAATYYE
>Mature_122_residues
MYRLTIHTSFAAAHCLINYQGDCENLHGHNWRVEVSVTARELDKAGLGIDFKVLKQETNGLLRTLDHKYLNELEPFKEIS
PSSENISRYLYHELSRRLNDGNVTVESITVWESDNAAATYYE

Specific function: Tetrahydrobiopterin biosynthesis; second step. [C]

COG id: COG0720

COG function: function code H; 6-pyruvoyl-tetrahydropterin synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.2.3.12

Molecular weight: Translated: 14047; Mature: 14047

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRLTIHTSFAAAHCLINYQGDCENLHGHNWRVEVSVTARELDKAGLGIDFKVLKQETNG
CEEEEEECCHHEEEEEEECCCCCCCCCCCCEEEEEEEEHHHHHHCCCCCCHHHHHHHHHH
LLRTLDHKYLNELEPFKEISPSSENISRYLYHELSRRLNDGNVTVESITVWESDNAAATY
HHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCEEEC
YE
CC
>Mature Secondary Structure
MYRLTIHTSFAAAHCLINYQGDCENLHGHNWRVEVSVTARELDKAGLGIDFKVLKQETNG
CEEEEEECCHHEEEEEEECCCCCCCCCCCCEEEEEEEEHHHHHHCCCCCCHHHHHHHHHH
LLRTLDHKYLNELEPFKEISPSSENISRYLYHELSRRLNDGNVTVESITVWESDNAAATY
HHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCEEEC
YE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Mg2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 17.7 {6-(L-erythro-1,2-dihydroxypropyl} 5 {6-(L-erythro-1,2-dihydroxypropyl} 0.0091 {6-(L-erythro-1,2-dihydroxypropyl} 0.008 {6-(L-erythro-1,2-dihydroxypropyl} [C]

Substrates: 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin

Specific reaction: 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate

General reaction: Intramolecular redox reaction; P-O bond cleavage; Triphosphate elimination [C]

Inhibitor: (NH4)2SO4 [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA