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The map label for this gene is cat1 [H]

Identifier: 39995285

GI number: 39995285

Start: 189553

End: 191115

Strand: Reverse

Name: cat1 [H]

Synonym: GSU0174

Alternate gene names: 39995285

Gene position: 191115-189553 (Counterclockwise)

Preceding gene: 39995289

Following gene: 39995277

Centisome position: 5.01

GC content: 63.98

Gene sequence:

>1563_bases
GTGTCGGAATTGCACAGAAGAATCAGGAAGACGAATCTCCATGAGCGGATCAGGACGGTAGAAGAGGTCATCCCCCTCTT
CCAGGACGGCATGAACCTGGGCTGGTCGGGCTTCACCCCCGCCGGCTACCCCAAGGCGGTACCCATCGCCCTGGCGGACC
ATGTGGAGAAGAACGGGCTGCAGGGGAAGCTGCGCTTCAACCTCTTCATCGGCGCCTCCGTGGGCGTCGAGACGGAAGAC
CGCTGGGCCTCCCTGGACATGATCGACCGCCGCTGGCCCTACCAGACCGGCAAGAACATCCAGGCCGGCATCAACTCCGG
CCGCATCCGCATGGGTGACCGCCACCTCTCAATGTTCGCCCAGGATTTGGGGTACGGCTTCTACACCAAGGAGAACGGCG
GCCGGCTGGATCTGGCCATCATCGAGTGCTCCGCCATCACCGAGAACGGCGGTCTGGTGCTGACCGCCTCCTGCGGCGCC
GTCCCCGAGATCGTCCAGATCGCCGACAAGATCATCATCGAGATCAACACCGCCATCCCCAACTATGAAGGCCTGCACGA
CATCATCGAACCCGTCAGCCCTCCCAACCGGCTCCCCTACCTCATCAGCCGGGTGGATGACCGGGCCGGATCTCCCTACG
TCCGCGTCGATACCGACAAGATCGTCGCCATCGTCGAGTCCACCCATCCGGACAACGGCCGCGCTTTTGCCGAGCAGGAC
GACACCTCCGAGGCCATTGCCAACAATATCCTGGACTTCTTCCAGGCAGAGGTGAAGGCGGGACGCCTCCCCAAGAACCT
GCTGCCGCTCCAGTCCGGCGTCGGCTCCATCGCCAACGCCGTTATCGGCGGTCTGGCCAAGGGCCCCTTCTCCGGCCTGA
GGGTCTGGACCGAGGTACTGCAGGACACCATGCTTGACCTCTTCGACTCCGGCAAGCTCGATTTCGCCTCCACCGTCTCC
CTCTCCTTCTCCGTGGACGGCTTCAAGCGCTTCTACGGCGACTGGGACAAGTACAGCGACAAGGTCATCATGCGCCCCCT
CTCCATCGCCAACCACCCGGAGCCCATCCGGCGCCTGGGATGCATTGCCATGAACACTCCCGTGGAGTTCGACATCTACG
CCCACGCCAACTCCACCCTGGTCGGCGGCACGCGCATGATCAACGGCATCGGCGGCTCCGGCGATTTCCTGCGCAACGCC
TACCTCTCCATCATGCACACCCCGTCGGCCCGCCCCACCAAGACCGACCCCACCGGCATCACCTGCGTCGTGCCCCACGT
CCCGCACGTTGACCATACCGAGCACGACCTTGACGTGCTGGTCACCGAGCAGGGCCTAGCCGACCTGCGGGGCCTGGCCC
CCAAGGACCGCGCCCGCGAGATCATCGCCAAGTGCGCCCACCCGGACTACAAGCCCCTCCTCACCGAGTACCTGGAGATG
GCCACCAGGGACTGCATGGCCCGCAAGGCGGGGCATGAGCCCCAGTTGCTGGACCGGGTGTTCAAGATGCAGGTGAACCT
GGCCAAGAACGGAACAATGAAGATCGACAACTGGGATATCTAG

Upstream 100 bases:

>100_bases
TCGAACGAACGTTCGATCATGTCGAGCGCTCGCATTCACCGACGACACCGCCAACCCGGTGCCACGGACAACACAATGCA
GGGTGAGGAGGAAGGGAACC

Downstream 100 bases:

>100_bases
TCGGTTGAAAGCAGATATTGATGTGACAACGGCGGCCTCCGGGCCGCCGTTTGCGTTTCTCGACGGCAACACGCGACAGG
CTGACGGCCGAGGATTTCGA

Product: acetyl-CoA hydrolase/transferase

Products: propionate; succinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MSELHRRIRKTNLHERIRTVEEVIPLFQDGMNLGWSGFTPAGYPKAVPIALADHVEKNGLQGKLRFNLFIGASVGVETED
RWASLDMIDRRWPYQTGKNIQAGINSGRIRMGDRHLSMFAQDLGYGFYTKENGGRLDLAIIECSAITENGGLVLTASCGA
VPEIVQIADKIIIEINTAIPNYEGLHDIIEPVSPPNRLPYLISRVDDRAGSPYVRVDTDKIVAIVESTHPDNGRAFAEQD
DTSEAIANNILDFFQAEVKAGRLPKNLLPLQSGVGSIANAVIGGLAKGPFSGLRVWTEVLQDTMLDLFDSGKLDFASTVS
LSFSVDGFKRFYGDWDKYSDKVIMRPLSIANHPEPIRRLGCIAMNTPVEFDIYAHANSTLVGGTRMINGIGGSGDFLRNA
YLSIMHTPSARPTKTDPTGITCVVPHVPHVDHTEHDLDVLVTEQGLADLRGLAPKDRAREIIAKCAHPDYKPLLTEYLEM
ATRDCMARKAGHEPQLLDRVFKMQVNLAKNGTMKIDNWDI

Sequences:

>Translated_520_residues
MSELHRRIRKTNLHERIRTVEEVIPLFQDGMNLGWSGFTPAGYPKAVPIALADHVEKNGLQGKLRFNLFIGASVGVETED
RWASLDMIDRRWPYQTGKNIQAGINSGRIRMGDRHLSMFAQDLGYGFYTKENGGRLDLAIIECSAITENGGLVLTASCGA
VPEIVQIADKIIIEINTAIPNYEGLHDIIEPVSPPNRLPYLISRVDDRAGSPYVRVDTDKIVAIVESTHPDNGRAFAEQD
DTSEAIANNILDFFQAEVKAGRLPKNLLPLQSGVGSIANAVIGGLAKGPFSGLRVWTEVLQDTMLDLFDSGKLDFASTVS
LSFSVDGFKRFYGDWDKYSDKVIMRPLSIANHPEPIRRLGCIAMNTPVEFDIYAHANSTLVGGTRMINGIGGSGDFLRNA
YLSIMHTPSARPTKTDPTGITCVVPHVPHVDHTEHDLDVLVTEQGLADLRGLAPKDRAREIIAKCAHPDYKPLLTEYLEM
ATRDCMARKAGHEPQLLDRVFKMQVNLAKNGTMKIDNWDI
>Mature_519_residues
SELHRRIRKTNLHERIRTVEEVIPLFQDGMNLGWSGFTPAGYPKAVPIALADHVEKNGLQGKLRFNLFIGASVGVETEDR
WASLDMIDRRWPYQTGKNIQAGINSGRIRMGDRHLSMFAQDLGYGFYTKENGGRLDLAIIECSAITENGGLVLTASCGAV
PEIVQIADKIIIEINTAIPNYEGLHDIIEPVSPPNRLPYLISRVDDRAGSPYVRVDTDKIVAIVESTHPDNGRAFAEQDD
TSEAIANNILDFFQAEVKAGRLPKNLLPLQSGVGSIANAVIGGLAKGPFSGLRVWTEVLQDTMLDLFDSGKLDFASTVSL
SFSVDGFKRFYGDWDKYSDKVIMRPLSIANHPEPIRRLGCIAMNTPVEFDIYAHANSTLVGGTRMINGIGGSGDFLRNAY
LSIMHTPSARPTKTDPTGITCVVPHVPHVDHTEHDLDVLVTEQGLADLRGLAPKDRAREIIAKCAHPDYKPLLTEYLEMA
TRDCMARKAGHEPQLLDRVFKMQVNLAKNGTMKIDNWDI

Specific function: Forms succinyl-CoA from succinate and acetyl-CoA [H]

COG id: COG0427

COG function: function code C; Acetyl-CoA hydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetyl-CoA hydrolase/transferase family [H]

Homologues:

Organism=Escherichia coli, GI1789287, Length=499, Percent_Identity=42.4849699398798, Blast_Score=381, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17538151, Length=320, Percent_Identity=27.5, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319456, Length=518, Percent_Identity=58.1081081081081, Blast_Score=617, Evalue=1e-178,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003702
- InterPro:   IPR006472
- InterPro:   IPR017821 [H]

Pfam domain/function: PF02550 AcetylCoA_hydro; PF04223 CitF [H]

EC number: NA

Molecular weight: Translated: 57439; Mature: 57308

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELHRRIRKTNLHERIRTVEEVIPLFQDGMNLGWSGFTPAGYPKAVPIALADHVEKNGL
CHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
QGKLRFNLFIGASVGVETEDRWASLDMIDRRWPYQTGKNIQAGINSGRIRMGDRHLSMFA
CEEEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECHHHHHHHH
QDLGYGFYTKENGGRLDLAIIECSAITENGGLVLTASCGAVPEIVQIADKIIIEINTAIP
HHHCCCEEECCCCCEEEEEEEEEEEEECCCCEEEEECCCCCHHHHHHHHHEEEEEECCCC
NYEGLHDIIEPVSPPNRLPYLISRVDDRAGSPYVRVDTDKIVAIVESTHPDNGRAFAEQD
CCCCHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEECCCEEEEEEECCCCCCCCCCCCCC
DTSEAIANNILDFFQAEVKAGRLPKNLLPLQSGVGSIANAVIGGLAKGPFSGLRVWTEVL
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
QDTMLDLFDSGKLDFASTVSLSFSVDGFKRFYGDWDKYSDKVIMRPLSIANHPEPIRRLG
HHHHHHHHCCCCCCEEEEEEEEEEHHHHHHHHCCHHHHCCCEEECCHHHCCCCHHHHHHC
CIAMNTPVEFDIYAHANSTLVGGTRMINGIGGSGDFLRNAYLSIMHTPSARPTKTDPTGI
CEEECCCEEEEEEECCCCEEECCHHEEECCCCCHHHHHHHHHHEEECCCCCCCCCCCCCE
TCVVPHVPHVDHTEHDLDVLVTEQGLADLRGLAPKDRAREIIAKCAHPDYKPLLTEYLEM
EEEECCCCCCCCCCCCCEEEEECCCHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
ATRDCMARKAGHEPQLLDRVFKMQVNLAKNGTMKIDNWDI
HHHHHHHHHCCCCHHHHHHHHHHHHEECCCCCEEECCCCC
>Mature Secondary Structure 
SELHRRIRKTNLHERIRTVEEVIPLFQDGMNLGWSGFTPAGYPKAVPIALADHVEKNGL
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
QGKLRFNLFIGASVGVETEDRWASLDMIDRRWPYQTGKNIQAGINSGRIRMGDRHLSMFA
CEEEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECHHHHHHHH
QDLGYGFYTKENGGRLDLAIIECSAITENGGLVLTASCGAVPEIVQIADKIIIEINTAIP
HHHCCCEEECCCCCEEEEEEEEEEEEECCCCEEEEECCCCCHHHHHHHHHEEEEEECCCC
NYEGLHDIIEPVSPPNRLPYLISRVDDRAGSPYVRVDTDKIVAIVESTHPDNGRAFAEQD
CCCCHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEECCCEEEEEEECCCCCCCCCCCCCC
DTSEAIANNILDFFQAEVKAGRLPKNLLPLQSGVGSIANAVIGGLAKGPFSGLRVWTEVL
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
QDTMLDLFDSGKLDFASTVSLSFSVDGFKRFYGDWDKYSDKVIMRPLSIANHPEPIRRLG
HHHHHHHHCCCCCCEEEEEEEEEEHHHHHHHHCCHHHHCCCEEECCHHHCCCCHHHHHHC
CIAMNTPVEFDIYAHANSTLVGGTRMINGIGGSGDFLRNAYLSIMHTPSARPTKTDPTGI
CEEECCCEEEEEEECCCCEEECCHHEEECCCCCHHHHHHHHHHEEECCCCCCCCCCCCCE
TCVVPHVPHVDHTEHDLDVLVTEQGLADLRGLAPKDRAREIIAKCAHPDYKPLLTEYLEM
EEEECCCCCCCCCCCCCEEEEECCCHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
ATRDCMARKAGHEPQLLDRVFKMQVNLAKNGTMKIDNWDI
HHHHHHHHHCCCCHHHHHHHHHHHHEECCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: propionyl-CoA; succinate [C]

Specific reaction: propionyl-CoA + succinate = propionate + succinyl-CoA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550525 [H]