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The map label for this gene is bdhA [H]

Identifier: 38234684

GI number: 38234684

Start: 2198998

End: 2200089

Strand: Reverse

Name: bdhA [H]

Synonym: DIP2135

Alternate gene names: 38234684

Gene position: 2200089-2198998 (Counterclockwise)

Preceding gene: 38234688

Following gene: 38234680

Centisome position: 88.41

GC content: 55.13

Gene sequence:

>1092_bases
ATGAAAGCAGCACGGTACTACGACCAAAAAGACATCCGAATTGAAGAAATCTCCGAGCAGCCACTGCTGCCAGGCACTGC
CCGCATCAAAGTAGCGTGGTGTGGCATTTGTGGCACCGACTTGCACGAGTTCCTCGAAGGTCCACTGTTCGTTCCAGAAC
ACCACCACCCGCACCCAGTCTCCGGCGAGGACTCCCCAGTGACCTTGGGGCATGAAATGTCCGGCGTGATCACAGAAGTC
GCCGAGGACGTGACCGATCTAGCCGTTGGCGACCACGTAGTAGTAGAGCCCTATTTGATTCACGATGATGTAGACACCTC
TGAAGCCAACCCCTTCTACCATCTTTCCCGCGACATGAACTTCATTGGTCTTGCCGGTGGCGGCGGTGGCTTGAGTGAAA
ACATTGTGGTCAAGCGGCGCTGGATCCACAAAATCTCCCCAGACCTGCCTCTCGACGAAGCAGCCCTCATCGAACCACTG
TCTGTGGGCTATCACGCAGTGGAACGTGCTGGGTTCGCCTCCGAAGAAGCAGCCAAGGGCAAGGTTGCACTTGTCGGCGG
TGCTGGACCTATTGGCTTGCTCACCGCCTCAGTACTCAAGGCTTTCGGCGCCACCGTGGTGATATCGGAACTATCCCCGC
TGCGTAGGAAGAAAGCACTCGATTCCGGTGCTGCCGACTACGCTCTCAACCCAGCAGAAGTGGATGTGGTTGAAGAAATT
GCCAAGCTTACCGACGGCAAAGGTGCCGACGTCGCCTTCGAATGCACCTCCGTCCAAGTAGTGCTGGACACCCTCATGGA
TGCTGTTCGCCCAGGGGCTGTGATCGTTGTGGTGTCTATCTGGTCTAAGCGCTCCAACTTTGACATCCATAAGTTGGTGA
TGAAGGAGATCGACCTGCGCGGCACGATTGCCTACTCCCATGCGCACCCGAACACCATCAAGCTGGTGGAATCCGGAAAG
ATTAACCTCAAGCCGTTTATCACCGGAAAGATTGCGCTTCAAGACATCGTGGATAAAGGTTTTGACACCCTCATTAACCA
CAATGAAACAGCAGTCAAGATCTTGGTATCCCCATCGGGCGTAGGCCTCTAG

Upstream 100 bases:

>100_bases
TGACACTATCTCAGGGACAAAAATCCCAATTTCTGGTGGTAATTTCGGGTTTAATCCCGCATGCAATAGTATGCAACAGT
CCGATTGAAGGAGAACTGCT

Downstream 100 bases:

>100_bases
CTGCTACGACAACGGCACAGTCCCCCTGGGACGTTGATCCCAATCCGTCATATCAGGGGAGGCTGTGCCTTTTATATTGT
TTGTTGAACGCTTAGCGGCT

Product: putative zinc-binding alcohol dehydrogenase

Products: NA

Alternate protein names: Acetoin reductase/2,3-butanediol dehydrogenase; AR/BDH [H]

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MKAARYYDQKDIRIEEISEQPLLPGTARIKVAWCGICGTDLHEFLEGPLFVPEHHHPHPVSGEDSPVTLGHEMSGVITEV
AEDVTDLAVGDHVVVEPYLIHDDVDTSEANPFYHLSRDMNFIGLAGGGGGLSENIVVKRRWIHKISPDLPLDEAALIEPL
SVGYHAVERAGFASEEAAKGKVALVGGAGPIGLLTASVLKAFGATVVISELSPLRRKKALDSGAADYALNPAEVDVVEEI
AKLTDGKGADVAFECTSVQVVLDTLMDAVRPGAVIVVVSIWSKRSNFDIHKLVMKEIDLRGTIAYSHAHPNTIKLVESGK
INLKPFITGKIALQDIVDKGFDTLINHNETAVKILVSPSGVGL

Sequences:

>Translated_363_residues
MKAARYYDQKDIRIEEISEQPLLPGTARIKVAWCGICGTDLHEFLEGPLFVPEHHHPHPVSGEDSPVTLGHEMSGVITEV
AEDVTDLAVGDHVVVEPYLIHDDVDTSEANPFYHLSRDMNFIGLAGGGGGLSENIVVKRRWIHKISPDLPLDEAALIEPL
SVGYHAVERAGFASEEAAKGKVALVGGAGPIGLLTASVLKAFGATVVISELSPLRRKKALDSGAADYALNPAEVDVVEEI
AKLTDGKGADVAFECTSVQVVLDTLMDAVRPGAVIVVVSIWSKRSNFDIHKLVMKEIDLRGTIAYSHAHPNTIKLVESGK
INLKPFITGKIALQDIVDKGFDTLINHNETAVKILVSPSGVGL
>Mature_363_residues
MKAARYYDQKDIRIEEISEQPLLPGTARIKVAWCGICGTDLHEFLEGPLFVPEHHHPHPVSGEDSPVTLGHEMSGVITEV
AEDVTDLAVGDHVVVEPYLIHDDVDTSEANPFYHLSRDMNFIGLAGGGGGLSENIVVKRRWIHKISPDLPLDEAALIEPL
SVGYHAVERAGFASEEAAKGKVALVGGAGPIGLLTASVLKAFGATVVISELSPLRRKKALDSGAADYALNPAEVDVVEEI
AKLTDGKGADVAFECTSVQVVLDTLMDAVRPGAVIVVVSIWSKRSNFDIHKLVMKEIDLRGTIAYSHAHPNTIKLVESGK
INLKPFITGKIALQDIVDKGFDTLINHNETAVKILVSPSGVGL

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=340, Percent_Identity=30, Blast_Score=139, Evalue=5e-33,
Organism=Escherichia coli, GI1788073, Length=340, Percent_Identity=27.0588235294118, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788407, Length=345, Percent_Identity=27.536231884058, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788075, Length=354, Percent_Identity=25.4237288135593, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1790718, Length=324, Percent_Identity=26.5432098765432, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI226510992, Length=336, Percent_Identity=28.5714285714286, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790045, Length=347, Percent_Identity=25.9365994236311, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787863, Length=317, Percent_Identity=26.1829652996845, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562876, Length=339, Percent_Identity=32.4483775811209, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17562878, Length=338, Percent_Identity=30.7692307692308, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6319258, Length=388, Percent_Identity=34.5360824742268, Blast_Score=210, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6319257, Length=390, Percent_Identity=32.8205128205128, Blast_Score=196, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6319955, Length=344, Percent_Identity=31.3953488372093, Blast_Score=152, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6322619, Length=344, Percent_Identity=31.3953488372093, Blast_Score=152, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6323099, Length=353, Percent_Identity=31.4447592067989, Blast_Score=147, Evalue=4e-36,
Organism=Drosophila melanogaster, GI17137530, Length=353, Percent_Identity=28.6118980169972, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI17737897, Length=353, Percent_Identity=28.6118980169972, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI221457811, Length=285, Percent_Identity=24.2105263157895, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45551930, Length=285, Percent_Identity=24.2105263157895, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45550770, Length=285, Percent_Identity=24.2105263157895, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.4 [H]

Molecular weight: Translated: 38943; Mature: 38943

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAARYYDQKDIRIEEISEQPLLPGTARIKVAWCGICGTDLHEFLEGPLFVPEHHHPHPV
CCCCCCCCCCCCCHHHCCCCCCCCCCCEEEEEEECCCHHHHHHHHCCCEECCCCCCCCCC
SGEDSPVTLGHEMSGVITEVAEDVTDLAVGDHVVVEPYLIHDDVDTSEANPFYHLSRDMN
CCCCCCEEECCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCCCEEECCCCC
FIGLAGGGGGLSENIVVKRRWIHKISPDLPLDEAALIEPLSVGYHAVERAGFASEEAAKG
EEEEECCCCCCCCCEEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHCCC
KVALVGGAGPIGLLTASVLKAFGATVVISELSPLRRKKALDSGAADYALNPAEVDVVEEI
CEEEEECCCCHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
AKLTDGKGADVAFECTSVQVVLDTLMDAVRPGAVIVVVSIWSKRSNFDIHKLVMKEIDLR
HHHCCCCCCCEEEEECHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHCCCC
GTIAYSHAHPNTIKLVESGKINLKPFITGKIALQDIVDKGFDTLINHNETAVKILVSPSG
EEEEEECCCCCEEEEEECCCEEEEEEEEHHHHHHHHHHCCHHHHHCCCCEEEEEEECCCC
VGL
CCC
>Mature Secondary Structure
MKAARYYDQKDIRIEEISEQPLLPGTARIKVAWCGICGTDLHEFLEGPLFVPEHHHPHPV
CCCCCCCCCCCCCHHHCCCCCCCCCCCEEEEEEECCCHHHHHHHHCCCEECCCCCCCCCC
SGEDSPVTLGHEMSGVITEVAEDVTDLAVGDHVVVEPYLIHDDVDTSEANPFYHLSRDMN
CCCCCCEEECCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCCCEEECCCCC
FIGLAGGGGGLSENIVVKRRWIHKISPDLPLDEAALIEPLSVGYHAVERAGFASEEAAKG
EEEEECCCCCCCCCEEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHCCC
KVALVGGAGPIGLLTASVLKAFGATVVISELSPLRRKKALDSGAADYALNPAEVDVVEEI
CEEEEECCCCHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
AKLTDGKGADVAFECTSVQVVLDTLMDAVRPGAVIVVVSIWSKRSNFDIHKLVMKEIDLR
HHHCCCCCCCEEEEECHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHCCCC
GTIAYSHAHPNTIKLVESGKINLKPFITGKIALQDIVDKGFDTLINHNETAVKILVSPSG
EEEEEECCCCCEEEEEECCCEEEEEEEEHHHHHHHHHHCCHHHHHCCCCEEEEEEECCCC
VGL
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9455482; 9384377 [H]