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The map label for this gene is cysK [H]

Identifier: 38234460

GI number: 38234460

Start: 1940558

End: 1941493

Strand: Direct

Name: cysK [H]

Synonym: DIP1890

Alternate gene names: 38234460

Gene position: 1940558-1941493 (Clockwise)

Preceding gene: 38234458

Following gene: 38234461

Centisome position: 77.98

GC content: 56.52

Gene sequence:

>936_bases
ATGGCTAAAATTTACGACAGCATCCTCGACACCGTGGGCAATACCCCACTGATTAAGCTCAATCGCCTCGACAAATACCT
CCCCGGCAACGTTGTGGTCAAAGTTGAGTTTTTTAACCCTGCAAATTCTGTGAAAGACCGTATTGGTAAAGCAATCGTCG
ACGCAGCAGAAGCCTCCGGTGATCTCAAGCCAGGTGGCACCATCGTTGAAGCAACATCCGGCAACACCGGTATCGCTCTC
GCACTCGTCGGTGCTGCCCGCGGCTACAACGTTGTGCTCACCATGCCAGAAACGATGTCCCTCGAGCGCCGCGTCATGCT
ACGCGCCTATGGTGCAGAGATCGTTCTCACCTCTGGTGCAGCCGGAATGCAAGGCGCCGTAGACAAAGCAAACGAAATCG
TCGCTGAGCGCGACAACGCCATCCTCGCCAGCCAGTTCAAGAACGCCGCCAACCCAGAAATTCACCGTCGTACTACCGGC
GAAGAAATCTGGAACGACACCGACGGACAGGTCGACATCTTCGTCGCAGGCGTGGGTACCGGCGGAACCGTCACCGGCGC
TGGCGAAACCCTGAAGAAGCACAACCCAGAGATCAAGGTCTACGCCGTCGAGCCAGCAGCCTCCGCTCTCCTAACCACCG
GCAAGGCAGGCCCACACAAGATCCAAGGCCTCGGCGCAAACTTTATCCCAAGCGTTCTAAACCAGAAGGTCTACGAAGAA
GTCATTACCGTAACTAACGAGGACGCAATCTCCACCTCACGCCAGCTTGCCGCACAAGAAGGCATCCTAGGCGGCATTTC
TGCCGGCGCCAACCTCAAGGCAGCACTTGAGCTTGCAGCATTGCCAGAAAACGAGGGCAAGACCATCGTCACCGTCGTAC
CTGACTACGGCGAGCGCTACGTATCAACCGTCTTGTTCGACGACATCCGCGACTAA

Upstream 100 bases:

>100_bases
TTAAGCGTAGAGTAGACAGCCGATCCTACAAAAGGGAAGAAAAATACACCCTTTTGTGCAGGTCAACCGATAAACGCAAT
AAAATAAAGGACGTCATATC

Downstream 100 bases:

>100_bases
TCAACTCACCGTTGACACAACGCCCTGACCACCGAAACATAAGTGGTCAGGGCGTTTTTTCGTGCGTCGGGGCGTCGATA
AGCCCAAACTGATAGAGTCG

Product: putative cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MAKIYDSILDTVGNTPLIKLNRLDKYLPGNVVVKVEFFNPANSVKDRIGKAIVDAAEASGDLKPGGTIVEATSGNTGIAL
ALVGAARGYNVVLTMPETMSLERRVMLRAYGAEIVLTSGAAGMQGAVDKANEIVAERDNAILASQFKNAANPEIHRRTTG
EEIWNDTDGQVDIFVAGVGTGGTVTGAGETLKKHNPEIKVYAVEPAASALLTTGKAGPHKIQGLGANFIPSVLNQKVYEE
VITVTNEDAISTSRQLAAQEGILGGISAGANLKAALELAALPENEGKTIVTVVPDYGERYVSTVLFDDIRD

Sequences:

>Translated_311_residues
MAKIYDSILDTVGNTPLIKLNRLDKYLPGNVVVKVEFFNPANSVKDRIGKAIVDAAEASGDLKPGGTIVEATSGNTGIAL
ALVGAARGYNVVLTMPETMSLERRVMLRAYGAEIVLTSGAAGMQGAVDKANEIVAERDNAILASQFKNAANPEIHRRTTG
EEIWNDTDGQVDIFVAGVGTGGTVTGAGETLKKHNPEIKVYAVEPAASALLTTGKAGPHKIQGLGANFIPSVLNQKVYEE
VITVTNEDAISTSRQLAAQEGILGGISAGANLKAALELAALPENEGKTIVTVVPDYGERYVSTVLFDDIRD
>Mature_310_residues
AKIYDSILDTVGNTPLIKLNRLDKYLPGNVVVKVEFFNPANSVKDRIGKAIVDAAEASGDLKPGGTIVEATSGNTGIALA
LVGAARGYNVVLTMPETMSLERRVMLRAYGAEIVLTSGAAGMQGAVDKANEIVAERDNAILASQFKNAANPEIHRRTTGE
EIWNDTDGQVDIFVAGVGTGGTVTGAGETLKKHNPEIKVYAVEPAASALLTTGKAGPHKIQGLGANFIPSVLNQKVYEEV
ITVTNEDAISTSRQLAAQEGILGGISAGANLKAALELAALPENEGKTIVTVVPDYGERYVSTVLFDDIRD

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=315, Percent_Identity=40.6349206349206, Blast_Score=226, Evalue=1e-59,
Organism=Homo sapiens, GI295821200, Length=315, Percent_Identity=40.6349206349206, Blast_Score=226, Evalue=1e-59,
Organism=Homo sapiens, GI4557415, Length=315, Percent_Identity=40.6349206349206, Blast_Score=226, Evalue=1e-59,
Organism=Escherichia coli, GI1788754, Length=318, Percent_Identity=53.7735849056604, Blast_Score=295, Evalue=2e-81,
Organism=Escherichia coli, GI2367138, Length=302, Percent_Identity=39.0728476821192, Blast_Score=221, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI17535051, Length=303, Percent_Identity=51.4851485148515, Blast_Score=323, Evalue=8e-89,
Organism=Caenorhabditis elegans, GI17562970, Length=301, Percent_Identity=51.8272425249169, Blast_Score=321, Evalue=4e-88,
Organism=Caenorhabditis elegans, GI115535073, Length=301, Percent_Identity=54.8172757475083, Blast_Score=318, Evalue=3e-87,
Organism=Caenorhabditis elegans, GI32566674, Length=293, Percent_Identity=52.2184300341297, Blast_Score=313, Evalue=7e-86,
Organism=Caenorhabditis elegans, GI17561720, Length=301, Percent_Identity=51.4950166112957, Blast_Score=278, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI32566672, Length=215, Percent_Identity=50.2325581395349, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17534315, Length=322, Percent_Identity=37.5776397515528, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI25147552, Length=322, Percent_Identity=35.4037267080745, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17561716, Length=119, Percent_Identity=47.8991596638655, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321594, Length=321, Percent_Identity=36.7601246105919, Blast_Score=195, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6321449, Length=325, Percent_Identity=33.5384615384615, Blast_Score=133, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24643623, Length=316, Percent_Identity=37.0253164556962, Blast_Score=187, Evalue=6e-48,
Organism=Drosophila melanogaster, GI20129101, Length=316, Percent_Identity=37.0253164556962, Blast_Score=187, Evalue=6e-48,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32659; Mature: 32528

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIYDSILDTVGNTPLIKLNRLDKYLPGNVVVKVEFFNPANSVKDRIGKAIVDAAEASG
CCHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHCCC
DLKPGGTIVEATSGNTGIALALVGAARGYNVVLTMPETMSLERRVMLRAYGAEIVLTSGA
CCCCCCEEEEECCCCCCEEEEEEECCCCCEEEEECCCHHCHHHHHHHHHCCCEEEEECCC
AGMQGAVDKANEIVAERDNAILASQFKNAANPEIHRRTTGEEIWNDTDGQVDIFVAGVGT
CCCCCHHHHHHHHHHHCCCEEEHHHHCCCCCCCCCCCCCCHHHCCCCCCEEEEEEEEECC
GGTVTGAGETLKKHNPEIKVYAVEPAASALLTTGKAGPHKIQGLGANFIPSVLNQKVYEE
CCEECCCCHHHHHCCCCEEEEEECCHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHH
VITVTNEDAISTSRQLAAQEGILGGISAGANLKAALELAALPENEGKTIVTVVPDYGERY
HHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHEEEEEEECCCCCCCEEEEECCCCHHHH
VSTVLFDDIRD
HHHHHHHHCCC
>Mature Secondary Structure 
AKIYDSILDTVGNTPLIKLNRLDKYLPGNVVVKVEFFNPANSVKDRIGKAIVDAAEASG
CHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHCCC
DLKPGGTIVEATSGNTGIALALVGAARGYNVVLTMPETMSLERRVMLRAYGAEIVLTSGA
CCCCCCEEEEECCCCCCEEEEEEECCCCCEEEEECCCHHCHHHHHHHHHCCCEEEEECCC
AGMQGAVDKANEIVAERDNAILASQFKNAANPEIHRRTTGEEIWNDTDGQVDIFVAGVGT
CCCCCHHHHHHHHHHHCCCEEEHHHHCCCCCCCCCCCCCCHHHCCCCCCEEEEEEEEECC
GGTVTGAGETLKKHNPEIKVYAVEPAASALLTTGKAGPHKIQGLGANFIPSVLNQKVYEE
CCEECCCCHHHHHCCCCEEEEEECCHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHH
VITVTNEDAISTSRQLAAQEGILGGISAGANLKAALELAALPENEGKTIVTVVPDYGERY
HHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHEEEEEEECCCCCCCEEEEECCCCHHHH
VSTVLFDDIRD
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10710307 [H]