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The map label for this gene is pepA

Identifier: 38234212

GI number: 38234212

Start: 1670998

End: 1672500

Strand: Direct

Name: pepA

Synonym: DIP1637

Alternate gene names: 38234212

Gene position: 1670998-1672500 (Clockwise)

Preceding gene: 38234210

Following gene: 38234214

Centisome position: 67.15

GC content: 54.89

Gene sequence:

>1503_bases
GTGAGCGCACAGTTCTCACTGCCGGCGACCGGACTAGCTACTCAACTCGAGTTGTCTAAGAAACTCCCCGAGGATATTGA
TGCTCTTGTCGTCCCAACGTTTAAGGGCGAGGATGGTCTTGAACTCGCAGCCAGCGGTTTGTTCGATGAAAACCTTGAGA
TTGCCATTTGGGATTTACTCGTAGCAGTCGGAGCCACTGGTAAGCAGGGCGAAGTTGTACGCATCCCATCCATCGAGGGC
ATTGAGGTCGACTTCATCGTCGGCGTGGGCTTGGGGGATAACGATTCGCTTGACGACGACACCCTGCGTCGTGCAGCTGG
CGATGCAGCTCGAAGCTTGGCGGGTGTTCAGCATGTTGCTACGACGTTGGGAGCTTTCGGTCTGCAACCTGCTGTTGAGG
GCTTTGCACTGGGTGCTTATAACTACACCGGCGTGCGCTCGAAGCAAAAGAAGCCGCTGCCTTTGGAAAAGGTTACGTTC
ATTTCCCTTGGTGATAAAAAGGCTGCGAAAGAAGAATTCACCGTAGGCCAGATTATTGCGGAATCTGTGGCTTTGTGCCG
CGATCTAGTCAATGCGCCTTCCTCTCATCTCTACCCAGAGTCCTACGCGGCGATTATCCGAGACACTGCCGAGAAAATCG
GCCTCGGTGTAGAAATTTTGGATGAAAAGAAGCTGGAGAAGCAGGGCTTTGGCGGCATTTTGGCCGTGGGTACCGGCTCC
TCCCGTAAACCTCGTTTGGTCCGGTTGACCTGGGCACCAAAGAAGGCCAAAAAATCCATCGCGCTGGTGGGTAAAGGCAT
CACCTTCGATACCGGTGGAATTTCTCTCAAGCCAGGCGCTGGCATGGACGACATGATCTCCGATATGGGCGGCTCTGCCA
CCATGGTGGCCACGATCATTGCTGCGGCTCGTCTTGGAGTAAAGCTCAATGTCACAGCAACTATCCCGTTGGCGGAAAAT
ATGCCAGGCGGCAATGCTTTCCGCCCAGGTGATGTGATTACCCACTATGGCGGAATTACCTCGGAAATCCTTAATACTGA
TGCTGAGGGCCGCTTGGTGCTCGCGGACGCTATTGCACGCGCCAGCGAAGACAAGCCCGACTATTTGCTGAACGTCGCAA
CGCTGACGGGTGCACAAATCGTTGCACTCGGTGATCGCACCTCCGGAGTTATGGGATCCGATGAATTCCGTGATTCGGTA
GCTCTCACCGGTCGTACAGTTGGTGAACCAGCATGGGCAATGCCGCTGCCAGAGGAAATTGGCGAGGACGTAAAATCCCC
TGTTGCCGATATCCGTAACGTCACCGGTTCTCGTTCCGGCGGCATGATGGCAGCTGGCTGGTACCTCAGCCACTTCGTTG
GCGAAGGCATCGAATGGGCTCACGTCGATATTGCGGGACCTGCCTACAACAAAGCGGGCGTCTACGGATACATTCCTAAG
CGCGCCACGGGTGTACCTGTACGTACATTCGTGCAGGTGCTCTCTAACCTCGCTGAGCAGTAA

Upstream 100 bases:

>100_bases
CGTACACCAGACATCCTCGCATGCCATTGGCTAAGCTGGACAACACTAAAATTTTTCCTTGGCTTTTGCGCCAACTACCA
ACTTTTGGAGGTATATACCT

Downstream 100 bases:

>100_bases
CACCTAATAAGAATAAAGTGGTCAAGGATCTCTAGTCCTTGACCACTTTATTTTATTTATTTGCTATTGAGATTCCCCGC
GTTCTCTTTGTAATTTTTCG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MSAQFSLPATGLATQLELSKKLPEDIDALVVPTFKGEDGLELAASGLFDENLEIAIWDLLVAVGATGKQGEVVRIPSIEG
IEVDFIVGVGLGDNDSLDDDTLRRAAGDAARSLAGVQHVATTLGAFGLQPAVEGFALGAYNYTGVRSKQKKPLPLEKVTF
ISLGDKKAAKEEFTVGQIIAESVALCRDLVNAPSSHLYPESYAAIIRDTAEKIGLGVEILDEKKLEKQGFGGILAVGTGS
SRKPRLVRLTWAPKKAKKSIALVGKGITFDTGGISLKPGAGMDDMISDMGGSATMVATIIAAARLGVKLNVTATIPLAEN
MPGGNAFRPGDVITHYGGITSEILNTDAEGRLVLADAIARASEDKPDYLLNVATLTGAQIVALGDRTSGVMGSDEFRDSV
ALTGRTVGEPAWAMPLPEEIGEDVKSPVADIRNVTGSRSGGMMAAGWYLSHFVGEGIEWAHVDIAGPAYNKAGVYGYIPK
RATGVPVRTFVQVLSNLAEQ

Sequences:

>Translated_500_residues
MSAQFSLPATGLATQLELSKKLPEDIDALVVPTFKGEDGLELAASGLFDENLEIAIWDLLVAVGATGKQGEVVRIPSIEG
IEVDFIVGVGLGDNDSLDDDTLRRAAGDAARSLAGVQHVATTLGAFGLQPAVEGFALGAYNYTGVRSKQKKPLPLEKVTF
ISLGDKKAAKEEFTVGQIIAESVALCRDLVNAPSSHLYPESYAAIIRDTAEKIGLGVEILDEKKLEKQGFGGILAVGTGS
SRKPRLVRLTWAPKKAKKSIALVGKGITFDTGGISLKPGAGMDDMISDMGGSATMVATIIAAARLGVKLNVTATIPLAEN
MPGGNAFRPGDVITHYGGITSEILNTDAEGRLVLADAIARASEDKPDYLLNVATLTGAQIVALGDRTSGVMGSDEFRDSV
ALTGRTVGEPAWAMPLPEEIGEDVKSPVADIRNVTGSRSGGMMAAGWYLSHFVGEGIEWAHVDIAGPAYNKAGVYGYIPK
RATGVPVRTFVQVLSNLAEQ
>Mature_499_residues
SAQFSLPATGLATQLELSKKLPEDIDALVVPTFKGEDGLELAASGLFDENLEIAIWDLLVAVGATGKQGEVVRIPSIEGI
EVDFIVGVGLGDNDSLDDDTLRRAAGDAARSLAGVQHVATTLGAFGLQPAVEGFALGAYNYTGVRSKQKKPLPLEKVTFI
SLGDKKAAKEEFTVGQIIAESVALCRDLVNAPSSHLYPESYAAIIRDTAEKIGLGVEILDEKKLEKQGFGGILAVGTGSS
RKPRLVRLTWAPKKAKKSIALVGKGITFDTGGISLKPGAGMDDMISDMGGSATMVATIIAAARLGVKLNVTATIPLAENM
PGGNAFRPGDVITHYGGITSEILNTDAEGRLVLADAIARASEDKPDYLLNVATLTGAQIVALGDRTSGVMGSDEFRDSVA
LTGRTVGEPAWAMPLPEEIGEDVKSPVADIRNVTGSRSGGMMAAGWYLSHFVGEGIEWAHVDIAGPAYNKAGVYGYIPKR
ATGVPVRTFVQVLSNLAEQ

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=441, Percent_Identity=35.3741496598639, Blast_Score=228, Evalue=9e-60,
Organism=Homo sapiens, GI47155554, Length=379, Percent_Identity=34.5646437994723, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI1790710, Length=451, Percent_Identity=32.8159645232816, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI87082123, Length=362, Percent_Identity=38.3977900552486, Blast_Score=189, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17556903, Length=297, Percent_Identity=34.006734006734, Blast_Score=145, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17565172, Length=264, Percent_Identity=29.5454545454545, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21357381, Length=296, Percent_Identity=38.5135135135135, Blast_Score=182, Evalue=7e-46,
Organism=Drosophila melanogaster, GI221379063, Length=296, Percent_Identity=38.5135135135135, Blast_Score=182, Evalue=7e-46,
Organism=Drosophila melanogaster, GI221379062, Length=296, Percent_Identity=38.5135135135135, Blast_Score=182, Evalue=7e-46,
Organism=Drosophila melanogaster, GI24661038, Length=455, Percent_Identity=29.4505494505495, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI21355725, Length=455, Percent_Identity=29.4505494505495, Blast_Score=171, Evalue=8e-43,
Organism=Drosophila melanogaster, GI24662227, Length=425, Percent_Identity=31.0588235294118, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI20129969, Length=461, Percent_Identity=30.58568329718, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI161077148, Length=471, Percent_Identity=29.9363057324841, Blast_Score=158, Evalue=8e-39,
Organism=Drosophila melanogaster, GI20130057, Length=471, Percent_Identity=29.9363057324841, Blast_Score=158, Evalue=8e-39,
Organism=Drosophila melanogaster, GI21355645, Length=475, Percent_Identity=29.6842105263158, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24662223, Length=475, Percent_Identity=29.6842105263158, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI19922386, Length=485, Percent_Identity=29.0721649484536, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI20129963, Length=498, Percent_Identity=29.5180722891566, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI24646701, Length=383, Percent_Identity=26.8929503916449, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24646703, Length=383, Percent_Identity=26.8929503916449, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21358201, Length=383, Percent_Identity=26.8929503916449, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_CORDI (Q6NG90)

Other databases:

- EMBL:   BX248358
- RefSeq:   NP_939979.1
- ProteinModelPortal:   Q6NG90
- SMR:   Q6NG90
- GeneID:   2648683
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1637
- NMPDR:   fig|257309.1.peg.1570
- HOGENOM:   HBG742580
- OMA:   RSIAMMK
- PhylomeDB:   Q6NG90
- ProtClustDB:   PRK00913
- BioCyc:   CDIP257309:DIP1637-MONOMER
- BRENDA:   3.4.11.1
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 52372; Mature: 52241

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00631 CYTOSOL_AP; PS00277 STAPH_STREP_TOXIN_1

Important sites: ACT_SITE 277-277 ACT_SITE 351-351

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAQFSLPATGLATQLELSKKLPEDIDALVVPTFKGEDGLELAASGLFDENLEIAIWDLL
CCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHCCCCCCCCHHHHHHHH
VAVGATGKQGEVVRIPSIEGIEVDFIVGVGLGDNDSLDDDTLRRAAGDAARSLAGVQHVA
HHHCCCCCCCCEEECCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TTLGAFGLQPAVEGFALGAYNYTGVRSKQKKPLPLEKVTFISLGDKKAAKEEFTVGQIIA
HHHHHCCCCHHHCCEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHH
ESVALCRDLVNAPSSHLYPESYAAIIRDTAEKIGLGVEILDEKKLEKQGFGGILAVGTGS
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEECCHHHHHHCCCCCEEEECCCC
SRKPRLVRLTWAPKKAKKSIALVGKGITFDTGGISLKPGAGMDDMISDMGGSATMVATII
CCCCEEEEEEECCHHHCCCEEEEECCEEECCCCEEECCCCCHHHHHHHCCCCHHHHHHHH
AAARLGVKLNVTATIPLAENMPGGNAFRPGDVITHYGGITSEILNTDAEGRLVLADAIAR
HHHHCCEEEEEEEEEEECCCCCCCCCCCCCCHHHHCCCHHHHHHCCCCCCCEEEEHHHHH
ASEDKPDYLLNVATLTGAQIVALGDRTSGVMGSDEFRDSVALTGRTVGEPAWAMPLPEEI
CCCCCCCEEEEEEEECCCEEEEECCCCCCCCCCHHHHCCEEECCCCCCCCCCCCCCHHHH
GEDVKSPVADIRNVTGSRSGGMMAAGWYLSHFVGEGIEWAHVDIAGPAYNKAGVYGYIPK
HHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEECCC
RATGVPVRTFVQVLSNLAEQ
CCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SAQFSLPATGLATQLELSKKLPEDIDALVVPTFKGEDGLELAASGLFDENLEIAIWDLL
CCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHCCCCCCCCHHHHHHHH
VAVGATGKQGEVVRIPSIEGIEVDFIVGVGLGDNDSLDDDTLRRAAGDAARSLAGVQHVA
HHHCCCCCCCCEEECCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TTLGAFGLQPAVEGFALGAYNYTGVRSKQKKPLPLEKVTFISLGDKKAAKEEFTVGQIIA
HHHHHCCCCHHHCCEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHH
ESVALCRDLVNAPSSHLYPESYAAIIRDTAEKIGLGVEILDEKKLEKQGFGGILAVGTGS
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEECCHHHHHHCCCCCEEEECCCC
SRKPRLVRLTWAPKKAKKSIALVGKGITFDTGGISLKPGAGMDDMISDMGGSATMVATII
CCCCEEEEEEECCHHHCCCEEEEECCEEECCCCEEECCCCCHHHHHHHCCCCHHHHHHHH
AAARLGVKLNVTATIPLAENMPGGNAFRPGDVITHYGGITSEILNTDAEGRLVLADAIAR
HHHHCCEEEEEEEEEEECCCCCCCCCCCCCCHHHHCCCHHHHHHCCCCCCCEEEEHHHHH
ASEDKPDYLLNVATLTGAQIVALGDRTSGVMGSDEFRDSVALTGRTVGEPAWAMPLPEEI
CCCCCCCEEEEEEEECCCEEEEECCCCCCCCCCHHHHCCEEECCCCCCCCCCCCCCHHHH
GEDVKSPVADIRNVTGSRSGGMMAAGWYLSHFVGEGIEWAHVDIAGPAYNKAGVYGYIPK
HHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEECCC
RATGVPVRTFVQVLSNLAEQ
CCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910