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The map label for this gene is ftsI [H]

Identifier: 38234179

GI number: 38234179

Start: 1636021

End: 1638045

Strand: Reverse

Name: ftsI [H]

Synonym: DIP1604

Alternate gene names: 38234179

Gene position: 1638045-1636021 (Counterclockwise)

Preceding gene: 38234180

Following gene: 38234178

Centisome position: 65.82

GC content: 48.4

Gene sequence:

>2025_bases
GTGAATTCGAGCAACCCTGATCGATTCCACGGTAGACCTTCGTGGTCGAGTCGGGACCATTCGCATCGGTTCCCCACGAC
TCTAGGTGCGAAAAATCAGGATCTGAAAATTAAGCGCGAGGTCAATGCCCGGCAGCGTAGTACTCAAGACTCCGTAGTAT
CGCATCATCGATTTAGAGTTTTTCGTTTACTAGTTGTGCTGGTAGCGGCCATACTTATCGCGCGCCTTGGTTGGGTACAA
CTCGTTTGGGGACCGGATCTTTCAGAAAAAGCATCTGCACAGCGCACTCGAGTATTTGTCGATGCTGCACGTCGTGGCGA
GATTTATGACAACACGGGCCAATTGTTGGCATATACAATGCAAGCTCGATCGCTGACGGCGTCGCCAAAGCAATTGCGCA
AAGAGATTGAATACACTGCCAAGATCGAGCTGCAGGACGAAAAAGAGTATTCCAGTTGGGATGAAAATCAGAGGAAGAAA
AAGATTGAAGACAAGGTAGATAGCTACCTAGAAGAGTATTCAAACGAAATTCCGAAGATCATCAAAGACTCGGAAGCATC
TGCTAACGACATCAAGTCAAAAGATATTCTGAAAAAACTAAAAGCTGATACTAGCTATGAGGTTTTAGTACGAAACGTTG
ACCCAGATGTTGCCGAAAATATTGCGCAGAAATTTCATGGTATCGCCGCCGATCTCCAACAGATCCGTCAGTACCCGAAT
GGTGCTGTCGCAGAAAACGTGATTGGCAAGATTAGTCAAGATGGACAAGGTCAGTTTGGTTTCGAGTCATCGAATAATTC
TGTGCTTTCGGGGATTGACGGACGCAAAACTCTTGATGTCGCTGCGAGTGGAGAAGTAATCCCAGGTTCGCTACGCGATG
AAGTCCCCGCAACTAACGGGGCCAATGTCACTTTGACGTTAGACCTAGACATGCAGACCTATGTGCAGCAGCAATTGGAA
CAAGCAGTGTCCAATTCCGGTGCCCAAAGTGCCTCTGCAGTAGTGCTAGATGTGAAAACCGGAAAAGTTCTTACCATGGC
AAATTCCGGAACGATCAACCCAAATGGTGATATTGAAAAGCAGCTCAAAGACAATAAGTCTTTTGAAAACACCACCATTT
CTTCACCATTTGAGCCTGGGTCAGTTGCCAAGATCATTACCGCTGCGGGAGTTATTGAAGACGGCAAATCAACCCCAGAT
GAAGTTTTGCAAGTACCTGGCAGTATCGAGATGTCGGGCGTAAACGTGCGGGACGCGTGGGAGCATGGAACAGTTGGGTA
TACCACAACTGGCATCTTCGGTAAGTCCTCGAACGTCGGTACTCTTATGCTCGCGCAGCGATTAGGAGAGCAACGATTTA
ACGATCTTCTTCATCGCTTTGGAATCGGACAAAATACAGGTATCGAACTTCCCGTAGAGTCACAGGGCCTCCTACCCGAC
ATTTCCCAGTGGTCTGGCGGAACCTTTGCAAACCTCCCTATTGGACAGGGCATGTCTGTGACGCTGCTCCAAATGGCAGG
TATTTACCAAGCTTTGGCCAATGATGGGCAGCGAATCGAACCACGCATTATTGAAAAAGTAGTGGATTCCTCTGGAAACG
AAGTCGAACAACAGCCGCCTGCAGAAACCCGAGTCGTGTCTGCTCAAACCGCGCGTACTGTTGTTGATATGTTCCGTGGT
GTAGTGCAAAAAGATCCCACTGGAATCAATAGTGGTACTGGCGCAGGTGCAGCTGTTGATGGCTATCAAGTCAGTGGTAA
AACCGGCACTGCTCAGCAAGTAGATCCCAACACGGGTGCTTATTCGAATTCGAATTACTGGATTACTTTTGCGGGAATTG
CCCCAGCGGATAATCCGCGATTTGTAGTAGCGCTTATGCTCGACAAGCCTCATCGCGGTGTCCATGGCGAAGGAGGTCAA
TCGGCTGCGCCATTGTTCCACGATATCGCATCGTGGATCCTTGATCGTGATAATGTTCCACTTTCGCCACCAATGGAGGG
ACAACTTGTGTTGCAGGCTCAATAA

Upstream 100 bases:

>100_bases
CAATACGGGCGCAAATGAATCTGCGAACGGGTCAGTCGTTGCACCATACGCACCGACTGTTCATCGTTAAGCCAACCAAT
TTAGTGAGGCGGATCTAGGA

Downstream 100 bases:

>100_bases
CCAGAGAAGATGCAACGTCGTTCAGCTTTTTAACACACAACCTCGTGTTCACTTTGGAATTAAAGCTCCTGCCTATCCTC
GGCGAGAGCGTGTAGAAAGG

Product: putative penicillin-binding (cell division related) protein

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 674; Mature: 674

Protein sequence:

>674_residues
MNSSNPDRFHGRPSWSSRDHSHRFPTTLGAKNQDLKIKREVNARQRSTQDSVVSHHRFRVFRLLVVLVAAILIARLGWVQ
LVWGPDLSEKASAQRTRVFVDAARRGEIYDNTGQLLAYTMQARSLTASPKQLRKEIEYTAKIELQDEKEYSSWDENQRKK
KIEDKVDSYLEEYSNEIPKIIKDSEASANDIKSKDILKKLKADTSYEVLVRNVDPDVAENIAQKFHGIAADLQQIRQYPN
GAVAENVIGKISQDGQGQFGFESSNNSVLSGIDGRKTLDVAASGEVIPGSLRDEVPATNGANVTLTLDLDMQTYVQQQLE
QAVSNSGAQSASAVVLDVKTGKVLTMANSGTINPNGDIEKQLKDNKSFENTTISSPFEPGSVAKIITAAGVIEDGKSTPD
EVLQVPGSIEMSGVNVRDAWEHGTVGYTTTGIFGKSSNVGTLMLAQRLGEQRFNDLLHRFGIGQNTGIELPVESQGLLPD
ISQWSGGTFANLPIGQGMSVTLLQMAGIYQALANDGQRIEPRIIEKVVDSSGNEVEQQPPAETRVVSAQTARTVVDMFRG
VVQKDPTGINSGTGAGAAVDGYQVSGKTGTAQQVDPNTGAYSNSNYWITFAGIAPADNPRFVVALMLDKPHRGVHGEGGQ
SAAPLFHDIASWILDRDNVPLSPPMEGQLVLQAQ

Sequences:

>Translated_674_residues
MNSSNPDRFHGRPSWSSRDHSHRFPTTLGAKNQDLKIKREVNARQRSTQDSVVSHHRFRVFRLLVVLVAAILIARLGWVQ
LVWGPDLSEKASAQRTRVFVDAARRGEIYDNTGQLLAYTMQARSLTASPKQLRKEIEYTAKIELQDEKEYSSWDENQRKK
KIEDKVDSYLEEYSNEIPKIIKDSEASANDIKSKDILKKLKADTSYEVLVRNVDPDVAENIAQKFHGIAADLQQIRQYPN
GAVAENVIGKISQDGQGQFGFESSNNSVLSGIDGRKTLDVAASGEVIPGSLRDEVPATNGANVTLTLDLDMQTYVQQQLE
QAVSNSGAQSASAVVLDVKTGKVLTMANSGTINPNGDIEKQLKDNKSFENTTISSPFEPGSVAKIITAAGVIEDGKSTPD
EVLQVPGSIEMSGVNVRDAWEHGTVGYTTTGIFGKSSNVGTLMLAQRLGEQRFNDLLHRFGIGQNTGIELPVESQGLLPD
ISQWSGGTFANLPIGQGMSVTLLQMAGIYQALANDGQRIEPRIIEKVVDSSGNEVEQQPPAETRVVSAQTARTVVDMFRG
VVQKDPTGINSGTGAGAAVDGYQVSGKTGTAQQVDPNTGAYSNSNYWITFAGIAPADNPRFVVALMLDKPHRGVHGEGGQ
SAAPLFHDIASWILDRDNVPLSPPMEGQLVLQAQ
>Mature_674_residues
MNSSNPDRFHGRPSWSSRDHSHRFPTTLGAKNQDLKIKREVNARQRSTQDSVVSHHRFRVFRLLVVLVAAILIARLGWVQ
LVWGPDLSEKASAQRTRVFVDAARRGEIYDNTGQLLAYTMQARSLTASPKQLRKEIEYTAKIELQDEKEYSSWDENQRKK
KIEDKVDSYLEEYSNEIPKIIKDSEASANDIKSKDILKKLKADTSYEVLVRNVDPDVAENIAQKFHGIAADLQQIRQYPN
GAVAENVIGKISQDGQGQFGFESSNNSVLSGIDGRKTLDVAASGEVIPGSLRDEVPATNGANVTLTLDLDMQTYVQQQLE
QAVSNSGAQSASAVVLDVKTGKVLTMANSGTINPNGDIEKQLKDNKSFENTTISSPFEPGSVAKIITAAGVIEDGKSTPD
EVLQVPGSIEMSGVNVRDAWEHGTVGYTTTGIFGKSSNVGTLMLAQRLGEQRFNDLLHRFGIGQNTGIELPVESQGLLPD
ISQWSGGTFANLPIGQGMSVTLLQMAGIYQALANDGQRIEPRIIEKVVDSSGNEVEQQPPAETRVVSAQTARTVVDMFRG
VVQKDPTGINSGTGAGAAVDGYQVSGKTGTAQQVDPNTGAYSNSNYWITFAGIAPADNPRFVVALMLDKPHRGVHGEGGQ
SAAPLFHDIASWILDRDNVPLSPPMEGQLVLQAQ

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=610, Percent_Identity=31.6393442622951, Blast_Score=221, Evalue=9e-59,
Organism=Escherichia coli, GI1786854, Length=681, Percent_Identity=25.4038179148311, Blast_Score=121, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 73221; Mature: 73221

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSSNPDRFHGRPSWSSRDHSHRFPTTLGAKNQDLKIKREVNARQRSTQDSVVSHHRFRV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCHHHHHHHHHHHH
FRLLVVLVAAILIARLGWVQLVWGPDLSEKASAQRTRVFVDAARRGEIYDNTGQLLAYTM
HHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHEEEEEHHHCCCCCCCCCCEEEEEE
QARSLTASPKQLRKEIEYTAKIELQDEKEYSSWDENQRKKKIEDKVDSYLEEYSNEIPKI
HHHHCCCCHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IKDSEASANDIKSKDILKKLKADTSYEVLVRNVDPDVAENIAQKFHGIAADLQQIRQYPN
HCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCC
GAVAENVIGKISQDGQGQFGFESSNNSVLSGIDGRKTLDVAASGEVIPGSLRDEVPATNG
CHHHHHHHHHCCCCCCCCCCEECCCCCEEECCCCCEEEEEECCCCCCCCCHHHCCCCCCC
ANVTLTLDLDMQTYVQQQLEQAVSNSGAQSASAVVLDVKTGKVLTMANSGTINPNGDIEK
CEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCHHH
QLKDNKSFENTTISSPFEPGSVAKIITAAGVIEDGKSTPDEVLQVPGSIEMSGVNVRDAW
HHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEECCCCHHHCC
EHGTVGYTTTGIFGKSSNVGTLMLAQRLGEQRFNDLLHRFGIGQNTGIELPVESQGLLPD
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCC
ISQWSGGTFANLPIGQGMSVTLLQMAGIYQALANDGQRIEPRIIEKVVDSSGNEVEQQPP
CHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCC
AETRVVSAQTARTVVDMFRGVVQKDPTGINSGTGAGAAVDGYQVSGKTGTAQQVDPNTGA
CHHEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCEEECCCCCCCCCCCCCCCC
YSNSNYWITFAGIAPADNPRFVVALMLDKPHRGVHGEGGQSAAPLFHDIASWILDRDNVP
CCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
LSPPMEGQLVLQAQ
CCCCCCCCEEEEEC
>Mature Secondary Structure
MNSSNPDRFHGRPSWSSRDHSHRFPTTLGAKNQDLKIKREVNARQRSTQDSVVSHHRFRV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCHHHHHHHHHHHH
FRLLVVLVAAILIARLGWVQLVWGPDLSEKASAQRTRVFVDAARRGEIYDNTGQLLAYTM
HHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHEEEEEHHHCCCCCCCCCCEEEEEE
QARSLTASPKQLRKEIEYTAKIELQDEKEYSSWDENQRKKKIEDKVDSYLEEYSNEIPKI
HHHHCCCCHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IKDSEASANDIKSKDILKKLKADTSYEVLVRNVDPDVAENIAQKFHGIAADLQQIRQYPN
HCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCC
GAVAENVIGKISQDGQGQFGFESSNNSVLSGIDGRKTLDVAASGEVIPGSLRDEVPATNG
CHHHHHHHHHCCCCCCCCCCEECCCCCEEECCCCCEEEEEECCCCCCCCCHHHCCCCCCC
ANVTLTLDLDMQTYVQQQLEQAVSNSGAQSASAVVLDVKTGKVLTMANSGTINPNGDIEK
CEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCHHH
QLKDNKSFENTTISSPFEPGSVAKIITAAGVIEDGKSTPDEVLQVPGSIEMSGVNVRDAW
HHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEECCCCHHHCC
EHGTVGYTTTGIFGKSSNVGTLMLAQRLGEQRFNDLLHRFGIGQNTGIELPVESQGLLPD
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCC
ISQWSGGTFANLPIGQGMSVTLLQMAGIYQALANDGQRIEPRIIEKVVDSSGNEVEQQPP
CHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCC
AETRVVSAQTARTVVDMFRGVVQKDPTGINSGTGAGAAVDGYQVSGKTGTAQQVDPNTGA
CHHEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCEEECCCCCCCCCCCCCCCC
YSNSNYWITFAGIAPADNPRFVVALMLDKPHRGVHGEGGQSAAPLFHDIASWILDRDNVP
CCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
LSPPMEGQLVLQAQ
CCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]