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The map label for this gene is murC

Identifier: 38234172

GI number: 38234172

Start: 1626188

End: 1627621

Strand: Reverse

Name: murC

Synonym: DIP1597

Alternate gene names: 38234172

Gene position: 1627621-1626188 (Counterclockwise)

Preceding gene: 38234173

Following gene: 38234171

Centisome position: 65.4

GC content: 51.53

Gene sequence:

>1434_bases
ATGAATTCAATCGACTTAAGCCGTGTCCACATGATCGGAATCGGTGGAGCGGGAATGTCGGGAGTAGCGCGCATTTTGTT
GTCTTGCGGCAGCGTTGTGAGCGGTTCCGATGTTAAGGAATCTCGTCCGGTAGCTGCGCTTCGTGCAATGGGAGCAACGA
TTGCGGTAGGGCATAAAGCTGAAAACCTAGCAATCTCTGGTTCTATGCCGACGGTAGTTGTTACTTCCTTTGCTGCGATC
CCCCAAGATAACCCTGAGCTACAAGAAGCACGTGCCAATAACATTCCCGTTATTCGGCGATCGGACCTTTTGGGCGAGCT
CATGGAAGACCACCAGCAGGTTCTTATTGCTGGTACTCACGGCAAGACTTCGACGACATCTATGGCTGTGGTTGCGCTTC
AAGCGGCTGGGAAAGATCCTAGCTTTGCAATTGGTGGGCAGCTGAACAAAGCAGGAACGAATGCGCATGATGGCACCGGC
AAAGCCTTTGTGGCGGAGGCCGATGAATCGGATGCGTCTTTGCTGCGGTATAAGCCAGACATTGCAGTAGTTACTAATAT
CGAGCCGGATCACTTGGATTTCTTCAAAACATCTGAAGCATATTTCAAGGTGTTTGATGACTTTGCTGAGCGTGTGCAGC
CAGGCGGAACACTTGTTGTGTGTTTAGATGATCCGCACGCTGCGGCATTGGGGGAGAAGTTTAAAGATCGCATGACGGTT
CGCGGCTATGGGTCACCTGCTGCAGCGCAACAGTATCCAGATGTGGCCTTTACCGTTGTTGAGCACATGGAAGTTGGGCC
CGCTGGTACCCGCGCTCGAATCACAGTTGGTGACGATACAGTCGATGTGATCATGCGTATTCCTGGCCACCACATGGTGC
TCAACGCATGTGCAGCTTTGACTGCTGGTGTGACCGCTGGCGCCGAATTGGAACGACTTGCTGCTGGTATTAGCGACTTC
AGTGGTGTTCGCCGGCGTTTTGAATTCCATGGTCGTGTTTCCGGCGGAGCATTTCACGATGCAGAAGTCTATGACGACTA
CGCACATCATCCGACTGAGGTAACAGCCGTTCTTAAAGCTGCACGTCAACAGCAGGAAGCGCGCGGCATTGGGCGAGTAG
TGGTTGCTTTTCAGCCGCATCTATATTCTCGTACGATGGAATTTGCAGCTGAATTTGCTGAGGCATTATCGCTTGCCGAT
CATGCGGTGATCCTCGATATCTTTGGTGCACGTGAGCAGCCTGTTGAAGGCGTGGATTCCCGTATTATTTCGGACAAAAT
GACAATACCTGTAGTCTTTGAGCCCAATTTTTCAGCAGTTGCAGCACAGGTGAAAAAGATTGCTCAGCCCAACGATATTA
TCGTCACTATGGGTGCGGGTAGCGTGACCTTGCTTGCCGACGAAATCCTTACTGCGTTACGGGAGAGCGAATGA

Upstream 100 bases:

>100_bases
AGGAATCTGGCACCGCTAACGCTGCGGAGACGATTGCTGACATCATCTATTCCATTGTGAAAAATCACGATCGCAACAAA
TAAAACAGAAGAGATAGAAC

Downstream 100 bases:

>100_bases
AAAAGCGTATTGCCATTGTGAGTAGCATTGTGCTGCTTATTGTGGCGATTGCTGGCGGTTGTCTGTGGGCTTTTCCCGTC
ATGACCGTCCAAAAAATCGA

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MNSIDLSRVHMIGIGGAGMSGVARILLSCGSVVSGSDVKESRPVAALRAMGATIAVGHKAENLAISGSMPTVVVTSFAAI
PQDNPELQEARANNIPVIRRSDLLGELMEDHQQVLIAGTHGKTSTTSMAVVALQAAGKDPSFAIGGQLNKAGTNAHDGTG
KAFVAEADESDASLLRYKPDIAVVTNIEPDHLDFFKTSEAYFKVFDDFAERVQPGGTLVVCLDDPHAAALGEKFKDRMTV
RGYGSPAAAQQYPDVAFTVVEHMEVGPAGTRARITVGDDTVDVIMRIPGHHMVLNACAALTAGVTAGAELERLAAGISDF
SGVRRRFEFHGRVSGGAFHDAEVYDDYAHHPTEVTAVLKAARQQQEARGIGRVVVAFQPHLYSRTMEFAAEFAEALSLAD
HAVILDIFGAREQPVEGVDSRIISDKMTIPVVFEPNFSAVAAQVKKIAQPNDIIVTMGAGSVTLLADEILTALRESE

Sequences:

>Translated_477_residues
MNSIDLSRVHMIGIGGAGMSGVARILLSCGSVVSGSDVKESRPVAALRAMGATIAVGHKAENLAISGSMPTVVVTSFAAI
PQDNPELQEARANNIPVIRRSDLLGELMEDHQQVLIAGTHGKTSTTSMAVVALQAAGKDPSFAIGGQLNKAGTNAHDGTG
KAFVAEADESDASLLRYKPDIAVVTNIEPDHLDFFKTSEAYFKVFDDFAERVQPGGTLVVCLDDPHAAALGEKFKDRMTV
RGYGSPAAAQQYPDVAFTVVEHMEVGPAGTRARITVGDDTVDVIMRIPGHHMVLNACAALTAGVTAGAELERLAAGISDF
SGVRRRFEFHGRVSGGAFHDAEVYDDYAHHPTEVTAVLKAARQQQEARGIGRVVVAFQPHLYSRTMEFAAEFAEALSLAD
HAVILDIFGAREQPVEGVDSRIISDKMTIPVVFEPNFSAVAAQVKKIAQPNDIIVTMGAGSVTLLADEILTALRESE
>Mature_477_residues
MNSIDLSRVHMIGIGGAGMSGVARILLSCGSVVSGSDVKESRPVAALRAMGATIAVGHKAENLAISGSMPTVVVTSFAAI
PQDNPELQEARANNIPVIRRSDLLGELMEDHQQVLIAGTHGKTSTTSMAVVALQAAGKDPSFAIGGQLNKAGTNAHDGTG
KAFVAEADESDASLLRYKPDIAVVTNIEPDHLDFFKTSEAYFKVFDDFAERVQPGGTLVVCLDDPHAAALGEKFKDRMTV
RGYGSPAAAQQYPDVAFTVVEHMEVGPAGTRARITVGDDTVDVIMRIPGHHMVLNACAALTAGVTAGAELERLAAGISDF
SGVRRRFEFHGRVSGGAFHDAEVYDDYAHHPTEVTAVLKAARQQQEARGIGRVVVAFQPHLYSRTMEFAAEFAEALSLAD
HAVILDIFGAREQPVEGVDSRIISDKMTIPVVFEPNFSAVAAQVKKIAQPNDIIVTMGAGSVTLLADEILTALRESE

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=467, Percent_Identity=35.9743040685225, Blast_Score=232, Evalue=3e-62,
Organism=Escherichia coli, GI1790680, Length=482, Percent_Identity=27.5933609958506, Blast_Score=145, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_CORDI (P61677)

Other databases:

- EMBL:   BX248358
- RefSeq:   NP_939939.1
- ProteinModelPortal:   P61677
- SMR:   P61677
- GeneID:   2650786
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1597
- NMPDR:   fig|257309.1.peg.1530
- HOGENOM:   HBG476594
- OMA:   EPNFSAV
- PhylomeDB:   P61677
- ProtClustDB:   PRK00421
- BioCyc:   CDIP257309:DIP1597-MONOMER
- BRENDA:   6.3.2.8
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 50565; Mature: 50565

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSIDLSRVHMIGIGGAGMSGVARILLSCGSVVSGSDVKESRPVAALRAMGATIAVGHKA
CCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCEEEECCCC
ENLAISGSMPTVVVTSFAAIPQDNPELQEARANNIPVIRRSDLLGELMEDHQQVLIAGTH
CCEEEECCCCHHEEHHHHHCCCCCCHHHHHCCCCCCEEEHHHHHHHHHHCCCEEEEEECC
GKTSTTSMAVVALQAAGKDPSFAIGGQLNKAGTNAHDGTGKAFVAEADESDASLLRYKPD
CCCCCCCEEEEEEEECCCCCCEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEECCC
IAVVTNIEPDHLDFFKTSEAYFKVFDDFAERVQPGGTLVVCLDDPHAAALGEKFKDRMTV
EEEEECCCCCCCHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCEEE
RGYGSPAAAQQYPDVAFTVVEHMEVGPAGTRARITVGDDTVDVIMRIPGHHMVLNACAAL
EECCCCHHHHHCCCHHHHHHHHHCCCCCCCEEEEEECCCCEEHEEECCCCHHHHHHHHHH
TAGVTAGAELERLAAGISDFSGVRRRFEFHGRVSGGAFHDAEVYDDYAHHPTEVTAVLKA
HHCCCCCHHHHHHHHCHHHHHHHHHHHHHCCEECCCCCCCHHHHHHHCCCCHHHHHHHHH
ARQQQEARGIGRVVVAFQPHLYSRTMEFAAEFAEALSLADHAVILDIFGAREQPVEGVDS
HHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHH
RIISDKMTIPVVFEPNFSAVAAQVKKIAQPNDIIVTMGAGSVTLLADEILTALRESE
HHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCEEHHHHHHHHHHHCCC
>Mature Secondary Structure
MNSIDLSRVHMIGIGGAGMSGVARILLSCGSVVSGSDVKESRPVAALRAMGATIAVGHKA
CCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCEEEECCCC
ENLAISGSMPTVVVTSFAAIPQDNPELQEARANNIPVIRRSDLLGELMEDHQQVLIAGTH
CCEEEECCCCHHEEHHHHHCCCCCCHHHHHCCCCCCEEEHHHHHHHHHHCCCEEEEEECC
GKTSTTSMAVVALQAAGKDPSFAIGGQLNKAGTNAHDGTGKAFVAEADESDASLLRYKPD
CCCCCCCEEEEEEEECCCCCCEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEECCC
IAVVTNIEPDHLDFFKTSEAYFKVFDDFAERVQPGGTLVVCLDDPHAAALGEKFKDRMTV
EEEEECCCCCCCHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCEEE
RGYGSPAAAQQYPDVAFTVVEHMEVGPAGTRARITVGDDTVDVIMRIPGHHMVLNACAAL
EECCCCHHHHHCCCHHHHHHHHHCCCCCCCEEEEEECCCCEEHEEECCCCHHHHHHHHHH
TAGVTAGAELERLAAGISDFSGVRRRFEFHGRVSGGAFHDAEVYDDYAHHPTEVTAVLKA
HHCCCCCHHHHHHHHCHHHHHHHHHHHHHCCEECCCCCCCHHHHHHHCCCCHHHHHHHHH
ARQQQEARGIGRVVVAFQPHLYSRTMEFAAEFAEALSLADHAVILDIFGAREQPVEGVDS
HHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHH
RIISDKMTIPVVFEPNFSAVAAQVKKIAQPNDIIVTMGAGSVTLLADEILTALRESE
HHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCEEHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910