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The map label for this gene is mapB [H]

Identifier: 38234075

GI number: 38234075

Start: 1519142

End: 1520026

Strand: Reverse

Name: mapB [H]

Synonym: DIP1496

Alternate gene names: 38234075

Gene position: 1520026-1519142 (Counterclockwise)

Preceding gene: 38234076

Following gene: 38234074

Centisome position: 61.08

GC content: 47.91

Gene sequence:

>885_bases
ATGGCTATTACTCGAGAACCTTTAAAACCTGGACATCCCACCCCGATTCGTGAGGTTCCGGCATACATTGATCGACCTGA
ATACGTTTGGAAAGATGAAGTTCAGGAGGCAATTGGAGAGCCTTTCATCCAGACTCCGGAAACAATCGAGGCTATGCGCG
AGGCTTCAAAGATCGCGGCAAATGCTTTGCACGTTGCCGGTGCTGCGGTAGCTCCTGGAGTTACCACTGATGAGATCGAC
CGAATTGCCCACGAGTACATGTGTGATCACGGTGCATACCCTTCGTGCTTGGGATATCGAGGATTCACAAAATCGTCGTG
TGTAAGTTTGAACGAGATCGTTTGTCATGGCATCCCGGATACCACGGTGATTCAAGATGGCGACATTGTGAACATTGACA
TCACGGCATACAAAAATGGTGTGCATGGAGACACTAACGCGACGTTTTTGGCGGGAAATGTTTCCGAAGAACATCGGTTG
CTCGTGGAGCGTACATACGAAGCGACGATGCGTGGAATTCGAGCAGCAAAACCTGGTCGTGAAATTAACGTCATTGGTCG
TGTCATCGAGTCGTATGCCAAGCGTTTTGGATACTCGGTGGTCACAGATTTCACCGGCCATGGCATTGGTACTACTTTCC
ACAACGGATTGGTAGTTTTGCACTACGATTCCGACGCATATCGTGATGTCTTAGAACCAGGCATGACACTGACGATCGAG
CCGATGATCAACCTAGGTGGGTTGGATTACCGTATTTGGGAAGACGGTTGGACTGTGCAAAATACGGACTTTAAGTTCAC
TGCTCAGTTTGAACACACTTTGGTTATTACTGACGATGGAAATGAAATTCTCAGCATCCCAGACGATGACGTTAAAGTAT
TCTAA

Upstream 100 bases:

>100_bases
AACTTTTTCACTACTCTTGATGATCTCAACGCAGGTATTGCAGTATCGGAGTAGTACCCCGTTGGTACCGGCAAAGCCTT
ATTAGGGTTAGCATAGTTTT

Downstream 100 bases:

>100_bases
TCTCAGTTGTGCATAACCATGACGGTTGTTTTTCTGCCTAAATAAGGGGGAGTAGCTACATCATGAAATCGTTCCTCGTC
GCTGGATGTACGTCGGATGC

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MAITREPLKPGHPTPIREVPAYIDRPEYVWKDEVQEAIGEPFIQTPETIEAMREASKIAANALHVAGAAVAPGVTTDEID
RIAHEYMCDHGAYPSCLGYRGFTKSSCVSLNEIVCHGIPDTTVIQDGDIVNIDITAYKNGVHGDTNATFLAGNVSEEHRL
LVERTYEATMRGIRAAKPGREINVIGRVIESYAKRFGYSVVTDFTGHGIGTTFHNGLVVLHYDSDAYRDVLEPGMTLTIE
PMINLGGLDYRIWEDGWTVQNTDFKFTAQFEHTLVITDDGNEILSIPDDDVKVF

Sequences:

>Translated_294_residues
MAITREPLKPGHPTPIREVPAYIDRPEYVWKDEVQEAIGEPFIQTPETIEAMREASKIAANALHVAGAAVAPGVTTDEID
RIAHEYMCDHGAYPSCLGYRGFTKSSCVSLNEIVCHGIPDTTVIQDGDIVNIDITAYKNGVHGDTNATFLAGNVSEEHRL
LVERTYEATMRGIRAAKPGREINVIGRVIESYAKRFGYSVVTDFTGHGIGTTFHNGLVVLHYDSDAYRDVLEPGMTLTIE
PMINLGGLDYRIWEDGWTVQNTDFKFTAQFEHTLVITDDGNEILSIPDDDVKVF
>Mature_293_residues
AITREPLKPGHPTPIREVPAYIDRPEYVWKDEVQEAIGEPFIQTPETIEAMREASKIAANALHVAGAAVAPGVTTDEIDR
IAHEYMCDHGAYPSCLGYRGFTKSSCVSLNEIVCHGIPDTTVIQDGDIVNIDITAYKNGVHGDTNATFLAGNVSEEHRLL
VERTYEATMRGIRAAKPGREINVIGRVIESYAKRFGYSVVTDFTGHGIGTTFHNGLVVLHYDSDAYRDVLEPGMTLTIEP
MINLGGLDYRIWEDGWTVQNTDFKFTAQFEHTLVITDDGNEILSIPDDDVKVF

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=293, Percent_Identity=44.0273037542662, Blast_Score=244, Evalue=8e-65,
Organism=Homo sapiens, GI40385867, Length=291, Percent_Identity=39.5189003436426, Blast_Score=219, Evalue=3e-57,
Organism=Escherichia coli, GI1786364, Length=250, Percent_Identity=47.6, Blast_Score=240, Evalue=7e-65,
Organism=Caenorhabditis elegans, GI71996291, Length=295, Percent_Identity=42.7118644067797, Blast_Score=231, Evalue=4e-61,
Organism=Saccharomyces cerevisiae, GI6323273, Length=285, Percent_Identity=40, Blast_Score=214, Evalue=1e-56,
Organism=Drosophila melanogaster, GI21355531, Length=284, Percent_Identity=43.3098591549296, Blast_Score=235, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24583427, Length=279, Percent_Identity=43.3691756272401, Blast_Score=229, Evalue=1e-60,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 32544; Mature: 32413

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAITREPLKPGHPTPIREVPAYIDRPEYVWKDEVQEAIGEPFIQTPETIEAMREASKIAA
CCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
NALHVAGAAVAPGVTTDEIDRIAHEYMCDHGAYPSCLGYRGFTKSSCVSLNEIVCHGIPD
HHHHHCCHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHCCHHHHHCCCCCC
TTVIQDGDIVNIDITAYKNGVHGDTNATFLAGNVSEEHRLLVERTYEATMRGIRAAKPGR
CEEEECCCEEEEEEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCC
EINVIGRVIESYAKRFGYSVVTDFTGHGIGTTFHNGLVVLHYDSDAYRDVLEPGMTLTIE
HHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEECCCEEEEEECCHHHHHHHCCCCEEEEE
PMINLGGLDYRIWEDGWTVQNTDFKFTAQFEHTLVITDDGNEILSIPDDDVKVF
ECCCCCCCEEEEECCCCEEECCCEEEEEEEEEEEEEECCCCEEEECCCCCEEEC
>Mature Secondary Structure 
AITREPLKPGHPTPIREVPAYIDRPEYVWKDEVQEAIGEPFIQTPETIEAMREASKIAA
CCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
NALHVAGAAVAPGVTTDEIDRIAHEYMCDHGAYPSCLGYRGFTKSSCVSLNEIVCHGIPD
HHHHHCCHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHCCHHHHHCCCCCC
TTVIQDGDIVNIDITAYKNGVHGDTNATFLAGNVSEEHRLLVERTYEATMRGIRAAKPGR
CEEEECCCEEEEEEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCC
EINVIGRVIESYAKRFGYSVVTDFTGHGIGTTFHNGLVVLHYDSDAYRDVLEPGMTLTIE
HHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEECCCEEEEEECCHHHHHHHCCCCEEEEE
PMINLGGLDYRIWEDGWTVQNTDFKFTAQFEHTLVITDDGNEILSIPDDDVKVF
ECCCCCCCEEEEECCCCEEECCCEEEEEEEEEEEEEECCCCEEEECCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]