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The map label for this gene is norM [H]

Identifier: 38234055

GI number: 38234055

Start: 1493639

End: 1494958

Strand: Reverse

Name: norM [H]

Synonym: DIP1474

Alternate gene names: 38234055

Gene position: 1494958-1493639 (Counterclockwise)

Preceding gene: 38234056

Following gene: 38234054

Centisome position: 60.07

GC content: 52.35

Gene sequence:

>1320_bases
ATGAATACATCTCTCAACGACACCGCTGATCGCTCAGCGCATATTACCGCCGTTACAGTTCTTGCGCTGGCACTTCCTTC
TCTAGGAGTTCTTGCTGCGACACCACTGTATCTGTTATTGGACACTGCCGTTGTCGGTGGTCTTGGCACAGTCGCGCTTG
CAGCTTTGGGGGCGGGAACTGTAATTTACTCCCAAGTAACCACGCAGCTCACTTTTTTGTCTTACGGAACAACCGCAAGA
TCAGCGCGCTTGTATGGAGCAGGAAAACAGGGCGAAGCCGTGTATGAGGGGGTTCAAGCGACATGGATCGCATTGCTGGT
GGGGGCGGTGCTCGCAACTATTTTGTTCTTTGGTGCTCCCACATTCGCTTGGTGGCTCACAGGCAATCGAGAAGTTGCTA
ATAATGCTGGGCATTGGCTTCGTATCACTGCTTTCGGTGTGCCGCTGATTTTGGCCATTATGGCTGGTAACGGCTGGTTG
CGGGGGATCCAGAACACCCGAGCCCCCTTAGTTTTTACACTGGCTGGTGTTATTCCCGGCGCGTGTGCGGTGCCATTTTT
TGTGCATTGGTGGGGTCTGGTAGGTTCCGCATGGGCGAACCTTATGGGAACTTCGATCACAGCAGTGTTATTTGTGGGAT
GTTTAGCCCGCTATCATCGCGGAAGCTGGCGTCCGCAGTGGCGAATTATGAAGACACAGCTGGTATTGGGGCGCGATTTA
ATACTTCGCTCGTTTTCGTTTCAAGTGTCGTTTTTGTCTGCTGCTGCGGTAGCAGGACGTTTTGGCGCGGAATCGTTAGC
GGCACATCAGGTGCTTATGCAGTTGTGGGGTTTCCTCACTCTTGTTCTCGACTCACTAGCGATTGCGGGTCAAACTCTGA
CCGGTGCTGCTTTAGGCGCTGGAAGCGCAGCAGTTGCTCGAGCTGTTGGCGAAAAATCGATTCGGTACTCAACTTTTTTT
GGCGTTGTTTTAGCTGCTGTATTTGCGGTCGGGTGGTCGGTGATCCCACAGGTATTTACACGCGATACGAATGTTCTCAA
CGTTATGGCTGGTCCGTGGTGGCAACTCGTGGCATTGATTGCACTTGGTGGTGTGGTTTTTGCACTGGACGGGATTTTGT
TGGGTGCTTCTGATGCTGCGTTTTTGCGTACCGTTTCTATCGCATCGGTTGTCTGTGGATTCCTTCCAGGAGTATGGTTG
GCGCTCATTTTTGATGCTGGGCTGGTCGGCGTGTGGTGGGGTCTTATCGCTTTTCTATGTATTCGTTTGGGTACGTGTTG
GTGGCGTTTCCGCTCGATGAAATGGGCGGGGGTATCCTAA

Upstream 100 bases:

>100_bases
GTCATGTTCACGCCGCTGGCATGACCCTTCATGGGACTGAACAAGAAATAATTGGAAGCATTATGGCAGCAGTTGCAGCT
GCTGCCGAAACAGCAAAGTT

Downstream 100 bases:

>100_bases
AAGCATTCCTATAGGTTGTGGCGGGGTTGAAGGAGGTTGATCGACGATGGTTCAGACTTTGTGGGCTGTTGCAGATCTGC
ATGCTGCTGTACGAGCTAAT

Product: putative DNA-damage inducible protein

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MNTSLNDTADRSAHITAVTVLALALPSLGVLAATPLYLLLDTAVVGGLGTVALAALGAGTVIYSQVTTQLTFLSYGTTAR
SARLYGAGKQGEAVYEGVQATWIALLVGAVLATILFFGAPTFAWWLTGNREVANNAGHWLRITAFGVPLILAIMAGNGWL
RGIQNTRAPLVFTLAGVIPGACAVPFFVHWWGLVGSAWANLMGTSITAVLFVGCLARYHRGSWRPQWRIMKTQLVLGRDL
ILRSFSFQVSFLSAAAVAGRFGAESLAAHQVLMQLWGFLTLVLDSLAIAGQTLTGAALGAGSAAVARAVGEKSIRYSTFF
GVVLAAVFAVGWSVIPQVFTRDTNVLNVMAGPWWQLVALIALGGVVFALDGILLGASDAAFLRTVSIASVVCGFLPGVWL
ALIFDAGLVGVWWGLIAFLCIRLGTCWWRFRSMKWAGVS

Sequences:

>Translated_439_residues
MNTSLNDTADRSAHITAVTVLALALPSLGVLAATPLYLLLDTAVVGGLGTVALAALGAGTVIYSQVTTQLTFLSYGTTAR
SARLYGAGKQGEAVYEGVQATWIALLVGAVLATILFFGAPTFAWWLTGNREVANNAGHWLRITAFGVPLILAIMAGNGWL
RGIQNTRAPLVFTLAGVIPGACAVPFFVHWWGLVGSAWANLMGTSITAVLFVGCLARYHRGSWRPQWRIMKTQLVLGRDL
ILRSFSFQVSFLSAAAVAGRFGAESLAAHQVLMQLWGFLTLVLDSLAIAGQTLTGAALGAGSAAVARAVGEKSIRYSTFF
GVVLAAVFAVGWSVIPQVFTRDTNVLNVMAGPWWQLVALIALGGVVFALDGILLGASDAAFLRTVSIASVVCGFLPGVWL
ALIFDAGLVGVWWGLIAFLCIRLGTCWWRFRSMKWAGVS
>Mature_439_residues
MNTSLNDTADRSAHITAVTVLALALPSLGVLAATPLYLLLDTAVVGGLGTVALAALGAGTVIYSQVTTQLTFLSYGTTAR
SARLYGAGKQGEAVYEGVQATWIALLVGAVLATILFFGAPTFAWWLTGNREVANNAGHWLRITAFGVPLILAIMAGNGWL
RGIQNTRAPLVFTLAGVIPGACAVPFFVHWWGLVGSAWANLMGTSITAVLFVGCLARYHRGSWRPQWRIMKTQLVLGRDL
ILRSFSFQVSFLSAAAVAGRFGAESLAAHQVLMQLWGFLTLVLDSLAIAGQTLTGAALGAGSAAVARAVGEKSIRYSTFF
GVVLAAVFAVGWSVIPQVFTRDTNVLNVMAGPWWQLVALIALGGVVFALDGILLGASDAAFLRTVSIASVVCGFLPGVWL
ALIFDAGLVGVWWGLIAFLCIRLGTCWWRFRSMKWAGVS

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI1790477, Length=445, Percent_Identity=28.314606741573, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 46436; Mature: 46436

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTSLNDTADRSAHITAVTVLALALPSLGVLAATPLYLLLDTAVVGGLGTVALAALGAGT
CCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCH
VIYSQVTTQLTFLSYGTTARSARLYGAGKQGEAVYEGVQATWIALLVGAVLATILFFGAP
HHHHHHHHHHHHEECCCCHHCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TFAWWLTGNREVANNAGHWLRITAFGVPLILAIMAGNGWLRGIQNTRAPLVFTLAGVIPG
HHEEEECCCCHHCCCCCCEEEEEHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHCCC
ACAVPFFVHWWGLVGSAWANLMGTSITAVLFVGCLARYHRGSWRPQWRIMKTQLVLGRDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
ILRSFSFQVSFLSAAAVAGRFGAESLAAHQVLMQLWGFLTLVLDSLAIAGQTLTGAALGA
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCC
GSAAVARAVGEKSIRYSTFFGVVLAAVFAVGWSVIPQVFTRDTNVLNVMAGPWWQLVALI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHH
ALGGVVFALDGILLGASDAAFLRTVSIASVVCGFLPGVWLALIFDAGLVGVWWGLIAFLC
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
IRLGTCWWRFRSMKWAGVS
HHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNTSLNDTADRSAHITAVTVLALALPSLGVLAATPLYLLLDTAVVGGLGTVALAALGAGT
CCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCH
VIYSQVTTQLTFLSYGTTARSARLYGAGKQGEAVYEGVQATWIALLVGAVLATILFFGAP
HHHHHHHHHHHHEECCCCHHCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TFAWWLTGNREVANNAGHWLRITAFGVPLILAIMAGNGWLRGIQNTRAPLVFTLAGVIPG
HHEEEECCCCHHCCCCCCEEEEEHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHCCC
ACAVPFFVHWWGLVGSAWANLMGTSITAVLFVGCLARYHRGSWRPQWRIMKTQLVLGRDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
ILRSFSFQVSFLSAAAVAGRFGAESLAAHQVLMQLWGFLTLVLDSLAIAGQTLTGAALGA
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCC
GSAAVARAVGEKSIRYSTFFGVVLAAVFAVGWSVIPQVFTRDTNVLNVMAGPWWQLVALI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHH
ALGGVVFALDGILLGASDAAFLRTVSIASVVCGFLPGVWLALIFDAGLVGVWWGLIAFLC
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
IRLGTCWWRFRSMKWAGVS
HHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]