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The map label for this gene is dxs

Identifier: 38233982

GI number: 38233982

Start: 1414718

End: 1416625

Strand: Reverse

Name: dxs

Synonym: DIP1397

Alternate gene names: 38233982

Gene position: 1416625-1414718 (Counterclockwise)

Preceding gene: 38233983

Following gene: 38233979

Centisome position: 56.92

GC content: 47.69

Gene sequence:

>1908_bases
ATGAGCATTCTTGAACACATCTCGTCACCTGCCGATGTCAAAACTTTAAGCTACGAACAATTAGATACATTAGCGAGCGA
GATCCGCGAATTTTTAGTGGAAAAGGTTTCGGCGACTGGAGGCCACTTAGGTCCGAACCTTGGGGTGGTCGAGCTGACAC
TTGCGATACATCGTGTGTTTTCTTCACCAAGTGATCCCATCATTTTTGATACCTCGCACCAGTCCTACGTTCATAAGATT
TTGACAGGTCGTGCAGGAGCTTTCGATACCCTTCGCCAAAAAGATGGATTGTCTGGATACACTTCTCGCGCTGAAAGCAA
CCATGATTGGACTGAATCATCGCATGCGTCAGCTTCGTTATCGTATGCGGATGGATTAGCGAAGGCTTTCCAACTAAAAG
GCGAAAAAGCTCGAAACGTGGTTGCAGTCGTCGGTGATGGCGCTCTAACTGGTGGTATGTGTTGGGAGGCCTTAAACAAT
ATTGCAACTGGGACCGAGCGCAATGTTGTTGTGGTCGTCAATGACAATGGGCGAAGCTATTCGCCGACCATTGGCGGTTT
TGCGGATAATTTAGCGGCGCTTCGGATGAAACCAAGCTATGACCGCGTGATGGAGCAAGGTAAAACTACTCTCAAATCCT
TAGGATGGGTAGGCGAGCGGACATTTGAAGCTCTTCATGCTTTTAAAGAAGGCGTTAAGTCAAGTGTCATACCTACAGAG
ATGTTCCCAGAATTGGGCATGAAGTATATTGGTCCAGTTAATGGACATAATACGAAAGCTGTAGAGGCCGCGTTACGCTA
TGGCCGAGATCATAAAGGTCCTCTGATTGTTCATGTGGTGACAGAAAAGGGCAAAGGATATGCCCCTGCTGAAAATGACG
TAGCTGAATTGATGCACTCGACGGGTGTTATCAATCCGAAGACCGGTGAACCAGTGGGCACCAAGAGCCCCGGATGGACA
TCAGTTTTTAGTAAAGAGCTTGTAAAAGCTGGAGAGACGCGCAAAGATATTGTTGCTATCACGGCTGCCATGGCTGGACC
GACAGGGCTTTCTGCCTTCGGTGAGAAATTCCCTGATCGATTGTTTGACGTTGGAATCGCAGAGCAACATGCTATGACAT
CTGCAGCCGGTTTGGCGCTAGGCGGTCTCCATCCAGTCGTTGCTATCTATTCGACATTTCTCAATAGAGCATTTGATCAA
TTACTCATGGATGTCGGTTTGCTCAATCTTCCGGTTACGATCGTTCTGGATCGTGCGGGAGTTACCGGCTCCGATGGTGC
AAGTCACAATGGCGTTTGGGATTTTGCAGTAGCAGGGATCGTACCAGGTATCCGAATTGCGGCACCGCGTGACGATGAGA
ATCTTAAGGAGCTGTTCGCTGAAGCACTTACTATTGACTCTCCAACTGTTGTGAGGTTCCCTAAGGGAGAGTTGCCGTCT
CGGCTGAGTGCACAGCAGCGTTTCGACGATGGTGCGGAACTATTGCATTATTCCGATTCTGATCATGAAGATTCGACACC
GAGCATTTTGGTCGTTGCGGTTGGTTCTCTCGTTTCATCTGTTATGGAAATCGTGTCCGACATTGAAGAGTGCGGTTGTA
ATGTGACTGTGGTTGATCCACGATGGGCAGTACCTGTTGCGCCATCAATCGTGGGATTGGCAGCAGATCATGAACTTGTT
ATAACTGTTGAAGATGGAATCATTCATGGCGGAGTGGGCGCGATGATTAATGAGGCGCTTAATGCCTCTGAAATAGATGT
ACCAGTTCGAAATTTGGCATTTCCTGAGGTATTCCCTGAGCATCAAAGTAGGAATCAACTACTTGATGCTGTGGGGTTAT
CTCCTCGAGGTATAAAGACTCAAATTATCGCAGCTGCAGAATCTCTTTACCTTTTAGACAAGGAATAG

Upstream 100 bases:

>100_bases
AAGGCAATCGTAGTCAAAGCTGTTGGACTTTCGCGCAGTTGAGTCTGTGCCTGATCTGTAAACCGCCAGTATTTTTATGA
AAGGGTGCAACTCAACGCGC

Downstream 100 bases:

>100_bases
CTTCTGTAAGCGAGGGACGGGCCTTGATTTTTTGGAATCTAGGCTCGTCCCTGTATTTCTCTATGAGGCGTGCTCAATTT
TGTTGAGTGTATCTGTAATT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 635; Mature: 634

Protein sequence:

>635_residues
MSILEHISSPADVKTLSYEQLDTLASEIREFLVEKVSATGGHLGPNLGVVELTLAIHRVFSSPSDPIIFDTSHQSYVHKI
LTGRAGAFDTLRQKDGLSGYTSRAESNHDWTESSHASASLSYADGLAKAFQLKGEKARNVVAVVGDGALTGGMCWEALNN
IATGTERNVVVVVNDNGRSYSPTIGGFADNLAALRMKPSYDRVMEQGKTTLKSLGWVGERTFEALHAFKEGVKSSVIPTE
MFPELGMKYIGPVNGHNTKAVEAALRYGRDHKGPLIVHVVTEKGKGYAPAENDVAELMHSTGVINPKTGEPVGTKSPGWT
SVFSKELVKAGETRKDIVAITAAMAGPTGLSAFGEKFPDRLFDVGIAEQHAMTSAAGLALGGLHPVVAIYSTFLNRAFDQ
LLMDVGLLNLPVTIVLDRAGVTGSDGASHNGVWDFAVAGIVPGIRIAAPRDDENLKELFAEALTIDSPTVVRFPKGELPS
RLSAQQRFDDGAELLHYSDSDHEDSTPSILVVAVGSLVSSVMEIVSDIEECGCNVTVVDPRWAVPVAPSIVGLAADHELV
ITVEDGIIHGGVGAMINEALNASEIDVPVRNLAFPEVFPEHQSRNQLLDAVGLSPRGIKTQIIAAAESLYLLDKE

Sequences:

>Translated_635_residues
MSILEHISSPADVKTLSYEQLDTLASEIREFLVEKVSATGGHLGPNLGVVELTLAIHRVFSSPSDPIIFDTSHQSYVHKI
LTGRAGAFDTLRQKDGLSGYTSRAESNHDWTESSHASASLSYADGLAKAFQLKGEKARNVVAVVGDGALTGGMCWEALNN
IATGTERNVVVVVNDNGRSYSPTIGGFADNLAALRMKPSYDRVMEQGKTTLKSLGWVGERTFEALHAFKEGVKSSVIPTE
MFPELGMKYIGPVNGHNTKAVEAALRYGRDHKGPLIVHVVTEKGKGYAPAENDVAELMHSTGVINPKTGEPVGTKSPGWT
SVFSKELVKAGETRKDIVAITAAMAGPTGLSAFGEKFPDRLFDVGIAEQHAMTSAAGLALGGLHPVVAIYSTFLNRAFDQ
LLMDVGLLNLPVTIVLDRAGVTGSDGASHNGVWDFAVAGIVPGIRIAAPRDDENLKELFAEALTIDSPTVVRFPKGELPS
RLSAQQRFDDGAELLHYSDSDHEDSTPSILVVAVGSLVSSVMEIVSDIEECGCNVTVVDPRWAVPVAPSIVGLAADHELV
ITVEDGIIHGGVGAMINEALNASEIDVPVRNLAFPEVFPEHQSRNQLLDAVGLSPRGIKTQIIAAAESLYLLDKE
>Mature_634_residues
SILEHISSPADVKTLSYEQLDTLASEIREFLVEKVSATGGHLGPNLGVVELTLAIHRVFSSPSDPIIFDTSHQSYVHKIL
TGRAGAFDTLRQKDGLSGYTSRAESNHDWTESSHASASLSYADGLAKAFQLKGEKARNVVAVVGDGALTGGMCWEALNNI
ATGTERNVVVVVNDNGRSYSPTIGGFADNLAALRMKPSYDRVMEQGKTTLKSLGWVGERTFEALHAFKEGVKSSVIPTEM
FPELGMKYIGPVNGHNTKAVEAALRYGRDHKGPLIVHVVTEKGKGYAPAENDVAELMHSTGVINPKTGEPVGTKSPGWTS
VFSKELVKAGETRKDIVAITAAMAGPTGLSAFGEKFPDRLFDVGIAEQHAMTSAAGLALGGLHPVVAIYSTFLNRAFDQL
LMDVGLLNLPVTIVLDRAGVTGSDGASHNGVWDFAVAGIVPGIRIAAPRDDENLKELFAEALTIDSPTVVRFPKGELPSR
LSAQQRFDDGAELLHYSDSDHEDSTPSILVVAVGSLVSSVMEIVSDIEECGCNVTVVDPRWAVPVAPSIVGLAADHELVI
TVEDGIIHGGVGAMINEALNASEIDVPVRNLAFPEVFPEHQSRNQLLDAVGLSPRGIKTQIIAAAESLYLLDKE

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI225637463, Length=538, Percent_Identity=23.7918215613383, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI225637461, Length=538, Percent_Identity=23.7918215613383, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI225637459, Length=538, Percent_Identity=23.7918215613383, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI133778974, Length=317, Percent_Identity=26.1829652996845, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI205277463, Length=536, Percent_Identity=22.2014925373134, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI4507521, Length=536, Percent_Identity=22.2014925373134, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786622, Length=626, Percent_Identity=36.2619808306709, Blast_Score=397, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17539652, Length=525, Percent_Identity=24.7619047619048, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45551847, Length=322, Percent_Identity=25.4658385093168, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45550715, Length=322, Percent_Identity=25.4658385093168, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24645119, Length=322, Percent_Identity=25.4658385093168, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_CORDI (Q6NGV3)

Other databases:

- EMBL:   BX248358
- RefSeq:   NP_939749.1
- HSSP:   P21874
- ProteinModelPortal:   Q6NGV3
- SMR:   Q6NGV3
- GeneID:   2649472
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1397
- NMPDR:   fig|257309.1.peg.1340
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- ProtClustDB:   PRK05444
- BioCyc:   CDIP257309:DIP1397-MONOMER
- BRENDA:   2.2.1.7
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 67667; Mature: 67536

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILEHISSPADVKTLSYEQLDTLASEIREFLVEKVSATGGHLGPNLGVVELTLAIHRVF
CCHHHHCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
SSPSDPIIFDTSHQSYVHKILTGRAGAFDTLRQKDGLSGYTSRAESNHDWTESSHASASL
CCCCCCEEEECCHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCH
SYADGLAKAFQLKGEKARNVVAVVGDGALTGGMCWEALNNIATGTERNVVVVVNDNGRSY
HHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCEE
SPTIGGFADNLAALRMKPSYDRVMEQGKTTLKSLGWVGERTFEALHAFKEGVKSSVIPTE
CCCCCCHHHCHHHEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHH
MFPELGMKYIGPVNGHNTKAVEAALRYGRDHKGPLIVHVVTEKGKGYAPAENDVAELMHS
HHHHCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHH
TGVINPKTGEPVGTKSPGWTSVFSKELVKAGETRKDIVAITAAMAGPTGLSAFGEKFPDR
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
LFDVGIAEQHAMTSAAGLALGGLHPVVAIYSTFLNRAFDQLLMDVGLLNLPVTIVLDRAG
HHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
VTGSDGASHNGVWDFAVAGIVPGIRIAAPRDDENLKELFAEALTIDSPTVVRFPKGELPS
CCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCH
RLSAQQRFDDGAELLHYSDSDHEDSTPSILVVAVGSLVSSVMEIVSDIEECGCNVTVVDP
HHHHHHHCCCCHHHEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCEEEECC
RWAVPVAPSIVGLAADHELVITVEDGIIHGGVGAMINEALNASEIDVPVRNLAFPEVFPE
CCCCCCCCHHHEEECCCEEEEEEECCEEECCHHHHHHHHCCCCCCCCCHHHCCCCHHCCC
HQSRNQLLDAVGLSPRGIKTQIIAAAESLYLLDKE
CCHHHHHHHHHCCCCCCCHHHHHHHHHHEEEEECC
>Mature Secondary Structure 
SILEHISSPADVKTLSYEQLDTLASEIREFLVEKVSATGGHLGPNLGVVELTLAIHRVF
CHHHHCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
SSPSDPIIFDTSHQSYVHKILTGRAGAFDTLRQKDGLSGYTSRAESNHDWTESSHASASL
CCCCCCEEEECCHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCH
SYADGLAKAFQLKGEKARNVVAVVGDGALTGGMCWEALNNIATGTERNVVVVVNDNGRSY
HHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCEE
SPTIGGFADNLAALRMKPSYDRVMEQGKTTLKSLGWVGERTFEALHAFKEGVKSSVIPTE
CCCCCCHHHCHHHEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHH
MFPELGMKYIGPVNGHNTKAVEAALRYGRDHKGPLIVHVVTEKGKGYAPAENDVAELMHS
HHHHCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHH
TGVINPKTGEPVGTKSPGWTSVFSKELVKAGETRKDIVAITAAMAGPTGLSAFGEKFPDR
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
LFDVGIAEQHAMTSAAGLALGGLHPVVAIYSTFLNRAFDQLLMDVGLLNLPVTIVLDRAG
HHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
VTGSDGASHNGVWDFAVAGIVPGIRIAAPRDDENLKELFAEALTIDSPTVVRFPKGELPS
CCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCH
RLSAQQRFDDGAELLHYSDSDHEDSTPSILVVAVGSLVSSVMEIVSDIEECGCNVTVVDP
HHHHHHHCCCCHHHEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCEEEECC
RWAVPVAPSIVGLAADHELVITVEDGIIHGGVGAMINEALNASEIDVPVRNLAFPEVFPE
CCCCCCCCHHHEEECCCEEEEEEECCEEECCHHHHHHHHCCCCCCCCCHHHCCCCHHCCC
HQSRNQLLDAVGLSPRGIKTQIIAAAESLYLLDKE
CCHHHHHHHHHCCCCCCCHHHHHHHHHHEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910