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The map label for this gene is bioF [H]

Identifier: 38233967

GI number: 38233967

Start: 1399385

End: 1400575

Strand: Direct

Name: bioF [H]

Synonym: DIP1382

Alternate gene names: 38233967

Gene position: 1399385-1400575 (Clockwise)

Preceding gene: 38233966

Following gene: 38233977

Centisome position: 56.23

GC content: 48.87

Gene sequence:

>1191_bases
ATGTCTCCATCGCTTGATTTTTATGCTCACCAACGCAACGTGGAGTGGCATGAACGAGGACTTGAGCGCACACCCGCGCA
GTTTTATTCACCTCAAACTCCACACGCAATAATCGATAATCGCCCTATGCTGCTATTTTCCAGCTCTGATTATTTAGGCC
TTAGCGAACATCCTTTCCTAAAAAACGCCGCAATCCAAGCAATCAGCTCTTTAGGTACAGGATCTGGGGGCTCCCGATTG
ACCACTGGCAGCAGCATTCACCGCAGCATCGAAATTCATCTCGCTCAATTTTTCGGCTCCCCCGACGCAGTGTTTTTCGC
TTCCGGCTATCAAGCAAATGTCACCATCATCTCTACACTTGCAGGACCACATTGCACCATTTATTCAGATTCACTCAATC
ACGCTTCCATCATTGACGGTTGTCGACTCAGCAAGTCTCAAGTAAAGACTTTTCCCACCGGAGATTATGAAGCTCTCGAT
GCCGCATTAGCTCATTGTGATACTACGAATTCGCTTATTATTACCGACGCGGTGTTTTCCATGTCTGGCACAATCGCAGA
TCTCGAACAGTTACGCCAAGTAGCAGCCCGACACGGCTCATGGTTACTTATCGACGACGCCCACGGAATCGGTTGCTTAG
GAAACGCAGGGCGTGGCACTGCGCATTTGTTCCCCCACGCACCGACCGATTTCTCGCAAGAAGTAATCGTCGGTACGTCA
AGTAAAGCCCTTGGAGGCGAAGGCGGCTTCGCTTTATGCTCTGAACAGGTTGCCACCTTGTTACGCAATCAAGGGCGCGG
GTATGTCTTTTCGACCGCTCCAGCACCAGCGACGATGGCAACTACCGATGCTGCGCTGACAGTTCTAGAACAAGAACCAG
ATCGTATTCGGAGGCTCCAATCCAATATTGCGTACTTCGCACAGCGAAGCTCAAACGTAGTCCCATTTCAGAAAAGCGGC
TTTTTCTCCCCTATCATTTCGTACACAATTGGAGACGAAAATGAAGCACTGAAGTCTGCACAGCTGCTTCGCGATAATGG
ATTTTTTATCCCAGCAATCAGGTACCCGACAGTAAGCCGTGGAAGTGCCATGTTGAGAATAACGATGACCGCAATGCATT
CTCACCACGATATTGATCAACTAGCTGATGCACTCAATCAATTAGAAAGTCACCGTTTAGATAACTCCTAG

Upstream 100 bases:

>100_bases
TCGGCGGGCGTGTTTTTCTATTGGATACTCGGGTGAGCACGCCTGAAGATACGATTAGTTATCTTGAACAAAAGCCAGTC
CTCATTACCGGAGTTAATTA

Downstream 100 bases:

>100_bases
TCATGAGTATTGGGCAACTCGAAAAAAATAGGAAGCCGTGCAGTTCCACCAAGCCGTAAACCTCGAACTAGTGGACGCAC
CCTAAGGGCTCGAGTATCTG

Product: putative aminotransferase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSPSLDFYAHQRNVEWHERGLERTPAQFYSPQTPHAIIDNRPMLLFSSSDYLGLSEHPFLKNAAIQAISSLGTGSGGSRL
TTGSSIHRSIEIHLAQFFGSPDAVFFASGYQANVTIISTLAGPHCTIYSDSLNHASIIDGCRLSKSQVKTFPTGDYEALD
AALAHCDTTNSLIITDAVFSMSGTIADLEQLRQVAARHGSWLLIDDAHGIGCLGNAGRGTAHLFPHAPTDFSQEVIVGTS
SKALGGEGGFALCSEQVATLLRNQGRGYVFSTAPAPATMATTDAALTVLEQEPDRIRRLQSNIAYFAQRSSNVVPFQKSG
FFSPIISYTIGDENEALKSAQLLRDNGFFIPAIRYPTVSRGSAMLRITMTAMHSHHDIDQLADALNQLESHRLDNS

Sequences:

>Translated_396_residues
MSPSLDFYAHQRNVEWHERGLERTPAQFYSPQTPHAIIDNRPMLLFSSSDYLGLSEHPFLKNAAIQAISSLGTGSGGSRL
TTGSSIHRSIEIHLAQFFGSPDAVFFASGYQANVTIISTLAGPHCTIYSDSLNHASIIDGCRLSKSQVKTFPTGDYEALD
AALAHCDTTNSLIITDAVFSMSGTIADLEQLRQVAARHGSWLLIDDAHGIGCLGNAGRGTAHLFPHAPTDFSQEVIVGTS
SKALGGEGGFALCSEQVATLLRNQGRGYVFSTAPAPATMATTDAALTVLEQEPDRIRRLQSNIAYFAQRSSNVVPFQKSG
FFSPIISYTIGDENEALKSAQLLRDNGFFIPAIRYPTVSRGSAMLRITMTAMHSHHDIDQLADALNQLESHRLDNS
>Mature_395_residues
SPSLDFYAHQRNVEWHERGLERTPAQFYSPQTPHAIIDNRPMLLFSSSDYLGLSEHPFLKNAAIQAISSLGTGSGGSRLT
TGSSIHRSIEIHLAQFFGSPDAVFFASGYQANVTIISTLAGPHCTIYSDSLNHASIIDGCRLSKSQVKTFPTGDYEALDA
ALAHCDTTNSLIITDAVFSMSGTIADLEQLRQVAARHGSWLLIDDAHGIGCLGNAGRGTAHLFPHAPTDFSQEVIVGTSS
KALGGEGGFALCSEQVATLLRNQGRGYVFSTAPAPATMATTDAALTVLEQEPDRIRRLQSNIAYFAQRSSNVVPFQKSGF
FSPIISYTIGDENEALKSAQLLRDNGFFIPAIRYPTVSRGSAMLRITMTAMHSHHDIDQLADALNQLESHRLDNS

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=365, Percent_Identity=33.6986301369863, Blast_Score=191, Evalue=7e-49,
Organism=Homo sapiens, GI284448556, Length=350, Percent_Identity=33.7142857142857, Blast_Score=188, Evalue=9e-48,
Organism=Homo sapiens, GI83977442, Length=363, Percent_Identity=30.5785123966942, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI83977444, Length=363, Percent_Identity=30.5785123966942, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI83977440, Length=363, Percent_Identity=30.5785123966942, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4502025, Length=347, Percent_Identity=30.835734870317, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI40316939, Length=347, Percent_Identity=30.835734870317, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI119220554, Length=368, Percent_Identity=25.2717391304348, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI4758668, Length=382, Percent_Identity=24.6073298429319, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI5454084, Length=275, Percent_Identity=24, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1786993, Length=353, Percent_Identity=37.3937677053824, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1790046, Length=366, Percent_Identity=33.6065573770492, Blast_Score=194, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI71994529, Length=350, Percent_Identity=34, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI32566772, Length=367, Percent_Identity=26.9754768392371, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17560912, Length=371, Percent_Identity=25.6064690026954, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17560914, Length=371, Percent_Identity=25.6064690026954, Blast_Score=121, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI71982617, Length=279, Percent_Identity=24.0143369175627, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71982625, Length=279, Percent_Identity=24.0143369175627, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320267, Length=365, Percent_Identity=27.9452054794521, Blast_Score=143, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6320438, Length=372, Percent_Identity=28.494623655914, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323954, Length=267, Percent_Identity=25.0936329588015, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24662918, Length=348, Percent_Identity=31.6091954022989, Blast_Score=185, Evalue=6e-47,
Organism=Drosophila melanogaster, GI17137420, Length=374, Percent_Identity=32.3529411764706, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI17136286, Length=318, Percent_Identity=24.2138364779874, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24653280, Length=285, Percent_Identity=24.5614035087719, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24653276, Length=285, Percent_Identity=24.5614035087719, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24653278, Length=285, Percent_Identity=24.5614035087719, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 42830; Mature: 42699

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPSLDFYAHQRNVEWHERGLERTPAQFYSPQTPHAIIDNRPMLLFSSSDYLGLSEHPFL
CCCCCCCEEECCCCCHHHCCCCCCCHHHCCCCCCCEEECCCCEEEEECCCCCCCCCCCCH
KNAAIQAISSLGTGSGGSRLTTGSSIHRSIEIHLAQFFGSPDAVFFASGYQANVTIISTL
HHHHHHHHHHCCCCCCCCEECCCHHHHHHHEEEEHHHHCCCCEEEEECCCCCCEEEEEEC
AGPHCTIYSDSLNHASIIDGCRLSKSQVKTFPTGDYEALDAALAHCDTTNSLIITDAVFS
CCCEEEEEECCCCCHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEEHHHH
MSGTIADLEQLRQVAARHGSWLLIDDAHGIGCLGNAGRGTAHLFPHAPTDFSQEVIVGTS
CCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEECC
SKALGGEGGFALCSEQVATLLRNQGRGYVFSTAPAPATMATTDAALTVLEQEPDRIRRLQ
CCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEECHHHHEEECCCHHHHHHHH
SNIAYFAQRSSNVVPFQKSGFFSPIISYTIGDENEALKSAQLLRDNGFFIPAIRYPTVSR
HHHHHHHHCCCCCCCCCCCCCCCHHEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCC
GSAMLRITMTAMHSHHDIDQLADALNQLESHRLDNS
CCEEEEEEEEHHHCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SPSLDFYAHQRNVEWHERGLERTPAQFYSPQTPHAIIDNRPMLLFSSSDYLGLSEHPFL
CCCCCCEEECCCCCHHHCCCCCCCHHHCCCCCCCEEECCCCEEEEECCCCCCCCCCCCH
KNAAIQAISSLGTGSGGSRLTTGSSIHRSIEIHLAQFFGSPDAVFFASGYQANVTIISTL
HHHHHHHHHHCCCCCCCCEECCCHHHHHHHEEEEHHHHCCCCEEEEECCCCCCEEEEEEC
AGPHCTIYSDSLNHASIIDGCRLSKSQVKTFPTGDYEALDAALAHCDTTNSLIITDAVFS
CCCEEEEEECCCCCHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEEHHHH
MSGTIADLEQLRQVAARHGSWLLIDDAHGIGCLGNAGRGTAHLFPHAPTDFSQEVIVGTS
CCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEECC
SKALGGEGGFALCSEQVATLLRNQGRGYVFSTAPAPATMATTDAALTVLEQEPDRIRRLQ
CCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEECHHHHEEECCCHHHHHHHH
SNIAYFAQRSSNVVPFQKSGFFSPIISYTIGDENEALKSAQLLRDNGFFIPAIRYPTVSR
HHHHHHHHCCCCCCCCCCCCCCCHHEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCC
GSAMLRITMTAMHSHHDIDQLADALNQLESHRLDNS
CCEEEEEEEEHHHCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]