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The map label for this gene is dfp [H]

Identifier: 38233912

GI number: 38233912

Start: 1338983

End: 1340227

Strand: Reverse

Name: dfp [H]

Synonym: DIP1326

Alternate gene names: 38233912

Gene position: 1340227-1338983 (Counterclockwise)

Preceding gene: 38233913

Following gene: 38233911

Centisome position: 53.85

GC content: 48.67

Gene sequence:

>1245_bases
ATGACGAATACTTCATTTGATAACAGCACAATTGTAGTAGGTGTTGCCGGCGGTATTGCTGCCTACAAATCCTGCCATGT
AGTGAGAGGATTTAAAGAGGATGGTGCGAACGTTGTTGTTGTACCAACTTCTGCAGCATTGAATTTTGTTGGTAAGGCAA
CTTTTGAAGCTCTTTCTGGAAATCCAGTTTCTACTACCGTTTTTGATGCTGTCGATGAGGTCCGCCATGTCAATGTTGGG
CAGCACGCTGATCTGATCGTCGTGGCTCCCGCCACAGCTGACCTGATTGCTCGAGTGGCTATGGGGCGAGCAGATGACCT
ATTGACTGCAACTTTACTTGTAGCTACTTGCCCAATTGTTTTGGTGCCAGCAATGCATGCAGAGATGTGGAGTAACGCCG
CTACCCGTGAAAACGTTGCTACGCTGCGTCGCCGGGGTATCATCGTTATGGATCCAGCTCACGGTCGTCTCACAGGCGCA
GATACTGGCCCAGGGCGTTTGCCTGATTCCGATCAAATTATCGATTTTGCTAAAACTGTGGCACGCACGAAAGTCATGCC
TCGCGATCTTGTGGGTAAGAAAGTGCTAATTTCGGCAGGAGGCACTCAAGAGAACATTGATCCTGTGCGTTATGTAGGCA
ATAGATCGTCAGGTAGGCAAGGATTCGCGTTAGCAGAGATCGCATCACAGCGTGGGGCCGAAGTTACCGTCGTTGCCGGT
GCGACAGATAAGCTTCCGGTTCCTTGTGGTGCACGAGTAGTGAATGTTACATCGGCGGTGGAAATGCAGCGGGAATGTAT
GCGGGAAGCACGTAACAGTGATGTTGTGATTATGGCTGCTGCGGTAGCGGATTTTCGTCCGCGTGAAATTGCCTCTGCAA
AGATGAAGAAGGGTACCGCTGACTCTTCGCTTCAGGTGATTTCGATGGTGGAAAATCCTGATATTTTGCGAGGACTTGTC
GAACAACGACAAGGTGAAAAACCTGTCATCGTTGGATTTGCAGCTGAGACTGGGGATGCGAATCATACGCCCTTGGAGTT
TGCTCGACAGAAGTTGAACAGAAAAAAGTGCGATCTTTTGATGTGTAATGAAGTCGGCGTCGACAAAGTATTCGGTAAGG
CGGATAACAGTGGATATCTATTGTCTCGTCAAGGAAACGTTGAGGAAATCTCGCAGGGGTCGAAACACTGGATTGCTTTT
AATATTTTAAATCACGTCGTGAGGTTGCTAGAAGCCGAGATGTGA

Upstream 100 bases:

>100_bases
GTCTTCGCGGCTTAGACGGACCATAGTTGAAGCAACCCCCTTTGCACTGTGTTTTAAACAGCAAAGGGGGTTCGTTTTAC
TCCAAAATAAGTGAGATTTT

Downstream 100 bases:

>100_bases
CTGATCTCGCGAATCTTGTCTTTTTAGACAGCTTGGTCTATATTGGGTGAAATCAGCTTAAACGGTGAGGTCTTTATTGC
GGAAAAGCTTTGTCTGACGG

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MTNTSFDNSTIVVGVAGGIAAYKSCHVVRGFKEDGANVVVVPTSAALNFVGKATFEALSGNPVSTTVFDAVDEVRHVNVG
QHADLIVVAPATADLIARVAMGRADDLLTATLLVATCPIVLVPAMHAEMWSNAATRENVATLRRRGIIVMDPAHGRLTGA
DTGPGRLPDSDQIIDFAKTVARTKVMPRDLVGKKVLISAGGTQENIDPVRYVGNRSSGRQGFALAEIASQRGAEVTVVAG
ATDKLPVPCGARVVNVTSAVEMQRECMREARNSDVVIMAAAVADFRPREIASAKMKKGTADSSLQVISMVENPDILRGLV
EQRQGEKPVIVGFAAETGDANHTPLEFARQKLNRKKCDLLMCNEVGVDKVFGKADNSGYLLSRQGNVEEISQGSKHWIAF
NILNHVVRLLEAEM

Sequences:

>Translated_414_residues
MTNTSFDNSTIVVGVAGGIAAYKSCHVVRGFKEDGANVVVVPTSAALNFVGKATFEALSGNPVSTTVFDAVDEVRHVNVG
QHADLIVVAPATADLIARVAMGRADDLLTATLLVATCPIVLVPAMHAEMWSNAATRENVATLRRRGIIVMDPAHGRLTGA
DTGPGRLPDSDQIIDFAKTVARTKVMPRDLVGKKVLISAGGTQENIDPVRYVGNRSSGRQGFALAEIASQRGAEVTVVAG
ATDKLPVPCGARVVNVTSAVEMQRECMREARNSDVVIMAAAVADFRPREIASAKMKKGTADSSLQVISMVENPDILRGLV
EQRQGEKPVIVGFAAETGDANHTPLEFARQKLNRKKCDLLMCNEVGVDKVFGKADNSGYLLSRQGNVEEISQGSKHWIAF
NILNHVVRLLEAEM
>Mature_413_residues
TNTSFDNSTIVVGVAGGIAAYKSCHVVRGFKEDGANVVVVPTSAALNFVGKATFEALSGNPVSTTVFDAVDEVRHVNVGQ
HADLIVVAPATADLIARVAMGRADDLLTATLLVATCPIVLVPAMHAEMWSNAATRENVATLRRRGIIVMDPAHGRLTGAD
TGPGRLPDSDQIIDFAKTVARTKVMPRDLVGKKVLISAGGTQENIDPVRYVGNRSSGRQGFALAEIASQRGAEVTVVAGA
TDKLPVPCGARVVNVTSAVEMQRECMREARNSDVVIMAAAVADFRPREIASAKMKKGTADSSLQVISMVENPDILRGLVE
QRQGEKPVIVGFAAETGDANHTPLEFARQKLNRKKCDLLMCNEVGVDKVFGKADNSGYLLSRQGNVEEISQGSKHWIAFN
ILNHVVRLLEAEM

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=183, Percent_Identity=28.9617486338798, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI87082301, Length=405, Percent_Identity=39.2592592592593, Blast_Score=251, Evalue=9e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44161; Mature: 44030

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNTSFDNSTIVVGVAGGIAAYKSCHVVRGFKEDGANVVVVPTSAALNFVGKATFEALSG
CCCCCCCCCEEEEECCCCHHHHHHHHHEECHHCCCCEEEEEECHHHHHHHHHHHHHHHCC
NPVSTTVFDAVDEVRHVNVGQHADLIVVAPATADLIARVAMGRADDLLTATLLVATCPIV
CCCCHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LVPAMHAEMWSNAATRENVATLRRRGIIVMDPAHGRLTGADTGPGRLPDSDQIIDFAKTV
HHHHHHHHHHCCCCHHHHHHHHHHCCEEEECCCCCEEECCCCCCCCCCCCHHHHHHHHHH
ARTKVMPRDLVGKKVLISAGGTQENIDPVRYVGNRSSGRQGFALAEIASQRGAEVTVVAG
HHHHCCCHHHCCCEEEEECCCCCCCCCHHHEECCCCCCCCCHHHHHHHHHCCCEEEEEEC
ATDKLPVPCGARVVNVTSAVEMQRECMREARNSDVVIMAAAVADFRPREIASAKMKKGTA
CCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEEEEHHCCCCHHHHHHHHHCCCC
DSSLQVISMVENPDILRGLVEQRQGEKPVIVGFAAETGDANHTPLEFARQKLNRKKCDLL
CCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHCHHCCCEE
MCNEVGVDKVFGKADNSGYLLSRQGNVEEISQGSKHWIAFNILNHVVRLLEAEM
EECCCCHHHHHCCCCCCCEEEECCCCHHHHHCCCCCEEHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TNTSFDNSTIVVGVAGGIAAYKSCHVVRGFKEDGANVVVVPTSAALNFVGKATFEALSG
CCCCCCCCEEEEECCCCHHHHHHHHHEECHHCCCCEEEEEECHHHHHHHHHHHHHHHCC
NPVSTTVFDAVDEVRHVNVGQHADLIVVAPATADLIARVAMGRADDLLTATLLVATCPIV
CCCCHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LVPAMHAEMWSNAATRENVATLRRRGIIVMDPAHGRLTGADTGPGRLPDSDQIIDFAKTV
HHHHHHHHHHCCCCHHHHHHHHHHCCEEEECCCCCEEECCCCCCCCCCCCHHHHHHHHHH
ARTKVMPRDLVGKKVLISAGGTQENIDPVRYVGNRSSGRQGFALAEIASQRGAEVTVVAG
HHHHCCCHHHCCCEEEEECCCCCCCCCHHHEECCCCCCCCCHHHHHHHHHCCCEEEEEEC
ATDKLPVPCGARVVNVTSAVEMQRECMREARNSDVVIMAAAVADFRPREIASAKMKKGTA
CCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEEEEHHCCCCHHHHHHHHHCCCC
DSSLQVISMVENPDILRGLVEQRQGEKPVIVGFAAETGDANHTPLEFARQKLNRKKCDLL
CCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHCHHCCCEE
MCNEVGVDKVFGKADNSGYLLSRQGNVEEISQGSKHWIAFNILNHVVRLLEAEM
EECCCCHHHHHCCCCCCCEEEECCCCHHHHHCCCCCEEHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]