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The map label for this gene is zwf [H]

Identifier: 38233890

GI number: 38233890

Start: 1315019

End: 1316668

Strand: Direct

Name: zwf [H]

Synonym: DIP1304

Alternate gene names: 38233890

Gene position: 1315019-1316668 (Clockwise)

Preceding gene: 38233889

Following gene: 38233891

Centisome position: 52.84

GC content: 50.55

Gene sequence:

>1650_bases
TTGCCCAACGTGAGTAAACCAGTGGCTAACGGAAACACCGTAGAAAGTAACAATGCTGAACTTGCTTTCGGCGGTGTTGA
TTTTTCCTATTCTGATACACATGAGAATTCGTGTAGTAGAACGTCAAGCAAATGGGTCAATCCCCTAAGGGATGCTGAGG
ACAAGCGCCTCCCCCGCATCGCGGGCCCGTGCGGAATGGTTATTTTTGGTGTAACTGGTGATCTCGCTCGGAAAAAGCTC
CTGCCAGCGATCTATGATCTTGCACACAGGGGCCTATTGCCTGCAGGTTTCAGTCTTGTCGGCTACGGTCGACGAGGCTG
GTCTAAGGCCGACTTTGAAAATTACGTCAAGCAAGCAGTTGTTGCCGGTGCCCGTACCGATTTCCGCGAAAATGTTTGGG
CACGACTTGCCGAAGGTATGCACTTCGTTCAAGGCAATTTCGATGATGATGCAGCATTTGATAGTTTGGCATCGCTTTTG
GCGGATCTTGATCAGACCCGTGGAACTGCCGGTAACTGGGCCTTTTATCTCTCTGTTCCACCAGATTATTTTTCGGATGT
TTGCCATCAACTTCAGCGCTCAGGCATGGCTACAGCCGAGGGCAATTCATGGCGTCGCGTCATTGTGGAAAAGCCTTTTG
GGCATGATCAAGAATCAGCACGTCAGCTAAACAACTTGATCAATTCAGTATTCCCTGAAAAGTCAGTATTTCGTATCGAC
CACTACTTGGGTAAAGAGACAGTGCAAAATATTATGGCACTGCGCTTTGCAAACCAGCTATTTGATCCGCTCTGGAATTC
TCACTATGTTGACCATGTCCAAATCACCATGGCTGAGGATATCGGTCTAGGCGGTCGCGCTGGTTACTATGATGGAATCG
GCGCCGCTAGAGACGTTATCCAAAACCACCTTATTCAGCTGTTGGCGCTGGTAGCTATGGAGGAACCCGTAGCTTTTACC
CCACAAGAGCTTCAGGCTGAAAAAATCAAGGTTCTTCGTGCCACTCGCCCAGTAGAACCTTTTGCTAAAACAACAGCCCG
AGGGCAATATTCGCGCGGTTGGCAGGGATCTGAGCTCGTCCAAGGTCTACGAGAAGAAGACGGATTTGATCCTAATTCCG
GAACTGAAACTTATGCTGCCTGCACACTCGAGATAAATTCGCGTCGTTGGGCCGGTGTGCCCTTTTATCTTCGGACTGGA
AAGCGTTTAGGACGCCGGGTGACTGAGATCGCCCTTGTATTCAAGGATGCGCCTCATCAGCCATTTAGCGAAGGTAGCCG
TCATTCCCAAGGCCGCAACGTCGTAGTGATCCGAGTCCAGCCTGATGAGGGTATGCTGATGCGTTTTGGTTCCAAGGTTC
CTGGTAACACGATGGAAGTACGCGACGTCAACATGGACTTCTCGTACTCAGAGGCATTTACCGAAGAATCACCGGAAGCC
TACGAACGACTCATTCTCGATGCACTTCTCGACGAAGCAAGTCTCTTCCCAACAAATGAAGAAGTTGAGCTTAGCTGGCA
GATCCTAGATCCGATATTGAACTTCTGGTCTGATCGTGGGCAACCGGAAGAATACCCCGCTGGCACCTGGGGCCCAGCTG
GTGCAGACAAGATGCTGGAGCGCGAAGGTCGCGCTTGGCGTCGACCTTAA

Upstream 100 bases:

>100_bases
AGCGATCTTCTTGATTCGATGGAATCTCGCTTGAAGTAATACAGTTTCAGCATAAAAATAATCGCGTTGGGTTCTGAGAA
CCACCTTCGAGAGGGTAAAC

Downstream 100 bases:

>100_bases
CGAGCGAGGAAGCTGAGATACGCCGTGATTTTTACACTGCCAAATACCACTACACAGGAAATCGCCAAGACTCTGGTAAA
AATTCGTGACACAGGAGGTC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 549; Mature: 548

Protein sequence:

>549_residues
MPNVSKPVANGNTVESNNAELAFGGVDFSYSDTHENSCSRTSSKWVNPLRDAEDKRLPRIAGPCGMVIFGVTGDLARKKL
LPAIYDLAHRGLLPAGFSLVGYGRRGWSKADFENYVKQAVVAGARTDFRENVWARLAEGMHFVQGNFDDDAAFDSLASLL
ADLDQTRGTAGNWAFYLSVPPDYFSDVCHQLQRSGMATAEGNSWRRVIVEKPFGHDQESARQLNNLINSVFPEKSVFRID
HYLGKETVQNIMALRFANQLFDPLWNSHYVDHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLIQLLALVAMEEPVAFT
PQELQAEKIKVLRATRPVEPFAKTTARGQYSRGWQGSELVQGLREEDGFDPNSGTETYAACTLEINSRRWAGVPFYLRTG
KRLGRRVTEIALVFKDAPHQPFSEGSRHSQGRNVVVIRVQPDEGMLMRFGSKVPGNTMEVRDVNMDFSYSEAFTEESPEA
YERLILDALLDEASLFPTNEEVELSWQILDPILNFWSDRGQPEEYPAGTWGPAGADKMLEREGRAWRRP

Sequences:

>Translated_549_residues
MPNVSKPVANGNTVESNNAELAFGGVDFSYSDTHENSCSRTSSKWVNPLRDAEDKRLPRIAGPCGMVIFGVTGDLARKKL
LPAIYDLAHRGLLPAGFSLVGYGRRGWSKADFENYVKQAVVAGARTDFRENVWARLAEGMHFVQGNFDDDAAFDSLASLL
ADLDQTRGTAGNWAFYLSVPPDYFSDVCHQLQRSGMATAEGNSWRRVIVEKPFGHDQESARQLNNLINSVFPEKSVFRID
HYLGKETVQNIMALRFANQLFDPLWNSHYVDHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLIQLLALVAMEEPVAFT
PQELQAEKIKVLRATRPVEPFAKTTARGQYSRGWQGSELVQGLREEDGFDPNSGTETYAACTLEINSRRWAGVPFYLRTG
KRLGRRVTEIALVFKDAPHQPFSEGSRHSQGRNVVVIRVQPDEGMLMRFGSKVPGNTMEVRDVNMDFSYSEAFTEESPEA
YERLILDALLDEASLFPTNEEVELSWQILDPILNFWSDRGQPEEYPAGTWGPAGADKMLEREGRAWRRP
>Mature_548_residues
PNVSKPVANGNTVESNNAELAFGGVDFSYSDTHENSCSRTSSKWVNPLRDAEDKRLPRIAGPCGMVIFGVTGDLARKKLL
PAIYDLAHRGLLPAGFSLVGYGRRGWSKADFENYVKQAVVAGARTDFRENVWARLAEGMHFVQGNFDDDAAFDSLASLLA
DLDQTRGTAGNWAFYLSVPPDYFSDVCHQLQRSGMATAEGNSWRRVIVEKPFGHDQESARQLNNLINSVFPEKSVFRIDH
YLGKETVQNIMALRFANQLFDPLWNSHYVDHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLIQLLALVAMEEPVAFTP
QELQAEKIKVLRATRPVEPFAKTTARGQYSRGWQGSELVQGLREEDGFDPNSGTETYAACTLEINSRRWAGVPFYLRTGK
RLGRRVTEIALVFKDAPHQPFSEGSRHSQGRNVVVIRVQPDEGMLMRFGSKVPGNTMEVRDVNMDFSYSEAFTEESPEAY
ERLILDALLDEASLFPTNEEVELSWQILDPILNFWSDRGQPEEYPAGTWGPAGADKMLEREGRAWRRP

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=482, Percent_Identity=37.551867219917, Blast_Score=313, Evalue=3e-85,
Organism=Homo sapiens, GI109389365, Length=482, Percent_Identity=37.551867219917, Blast_Score=313, Evalue=4e-85,
Organism=Homo sapiens, GI52145310, Length=368, Percent_Identity=32.8804347826087, Blast_Score=168, Evalue=1e-41,
Organism=Escherichia coli, GI1788158, Length=496, Percent_Identity=39.1129032258064, Blast_Score=366, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17538218, Length=516, Percent_Identity=36.8217054263566, Blast_Score=341, Evalue=5e-94,
Organism=Saccharomyces cerevisiae, GI6324088, Length=492, Percent_Identity=37.1951219512195, Blast_Score=313, Evalue=3e-86,
Organism=Drosophila melanogaster, GI24643350, Length=483, Percent_Identity=36.4389233954451, Blast_Score=301, Evalue=7e-82,
Organism=Drosophila melanogaster, GI24643352, Length=483, Percent_Identity=36.4389233954451, Blast_Score=301, Evalue=8e-82,
Organism=Drosophila melanogaster, GI221513548, Length=486, Percent_Identity=29.4238683127572, Blast_Score=219, Evalue=5e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 61438; Mature: 61306

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNVSKPVANGNTVESNNAELAFGGVDFSYSDTHENSCSRTSSKWVNPLRDAEDKRLPRI
CCCCCCCCCCCCEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCHHHCCHHHCCCCC
AGPCGMVIFGVTGDLARKKLLPAIYDLAHRGLLPAGFSLVGYGRRGWSKADFENYVKQAV
CCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHH
VAGARTDFRENVWARLAEGMHFVQGNFDDDAAFDSLASLLADLDQTRGTAGNWAFYLSVP
HHCCHHHHHHHHHHHHHHCHHEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
PDYFSDVCHQLQRSGMATAEGNSWRRVIVEKPFGHDQESARQLNNLINSVFPEKSVFRID
HHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
HYLGKETVQNIMALRFANQLFDPLWNSHYVDHVQITMAEDIGLGGRAGYYDGIGAARDVI
HHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHH
QNHLIQLLALVAMEEPVAFTPQELQAEKIKVLRATRPVEPFAKTTARGQYSRGWQGSELV
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHHH
QGLREEDGFDPNSGTETYAACTLEINSRRWAGVPFYLRTGKRLGRRVTEIALVFKDAPHQ
HHHHHHCCCCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
PFSEGSRHSQGRNVVVIRVQPDEGMLMRFGSKVPGNTMEVRDVNMDFSYSEAFTEESPEA
CCCCCCCCCCCCCEEEEEEECCCCHHHHCCCCCCCCCEEEEECCCCCCHHHHHCCCCHHH
YERLILDALLDEASLFPTNEEVELSWQILDPILNFWSDRGQPEEYPAGTWGPAGADKMLE
HHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
REGRAWRRP
HCCCCCCCC
>Mature Secondary Structure 
PNVSKPVANGNTVESNNAELAFGGVDFSYSDTHENSCSRTSSKWVNPLRDAEDKRLPRI
CCCCCCCCCCCEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCHHHCCHHHCCCCC
AGPCGMVIFGVTGDLARKKLLPAIYDLAHRGLLPAGFSLVGYGRRGWSKADFENYVKQAV
CCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHH
VAGARTDFRENVWARLAEGMHFVQGNFDDDAAFDSLASLLADLDQTRGTAGNWAFYLSVP
HHCCHHHHHHHHHHHHHHCHHEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
PDYFSDVCHQLQRSGMATAEGNSWRRVIVEKPFGHDQESARQLNNLINSVFPEKSVFRID
HHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
HYLGKETVQNIMALRFANQLFDPLWNSHYVDHVQITMAEDIGLGGRAGYYDGIGAARDVI
HHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHH
QNHLIQLLALVAMEEPVAFTPQELQAEKIKVLRATRPVEPFAKTTARGQYSRGWQGSELV
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHHH
QGLREEDGFDPNSGTETYAACTLEINSRRWAGVPFYLRTGKRLGRRVTEIALVFKDAPHQ
HHHHHHCCCCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
PFSEGSRHSQGRNVVVIRVQPDEGMLMRFGSKVPGNTMEVRDVNMDFSYSEAFTEESPEA
CCCCCCCCCCCCCEEEEEEECCCCHHHHCCCCCCCCCEEEEECCCCCCHHHHHCCCCHHH
YERLILDALLDEASLFPTNEEVELSWQILDPILNFWSDRGQPEEYPAGTWGPAGADKMLE
HHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
REGRAWRRP
HCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]