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The map label for this gene is ctaB [H]

Identifier: 38233887

GI number: 38233887

Start: 1310339

End: 1311271

Strand: Reverse

Name: ctaB [H]

Synonym: DIP1301

Alternate gene names: 38233887

Gene position: 1311271-1310339 (Counterclockwise)

Preceding gene: 38233893

Following gene: 38233882

Centisome position: 52.69

GC content: 47.48

Gene sequence:

>933_bases
TTGGAGACAATCAAGGCCTATGTAGCGTTAACAAAGCCTAGGGTCATTGAGCTCCTATTGGTAGCAACTATTCCGGCGAT
GCTTCAAGCAGAACGCGGAGAAAACAACATTGGGCTGATATTGCTTACGTTGTTGGGCGGTTGGATGGGAGCTGCAGCTG
CCAACACATTCAACATGGTTGCTGACTCGGATATCGACCAAAAGATGGGACGTACGCGAGCTCGTCCACTAGTACGTAAC
AAAGTTTCTAATCGACACGCTTCAGTGTTTGCGTGGACTCTCACTGTAGTGAGTTTTTTATGGCTATGGGTGTTATGCCG
ATCTGTACTCGCGGGATTATTCATCCTCCTTACGATCTTCTTTTATATTTTTGTCTACACAAAATATCTTAAGAGAAAAA
CCCATCTCAACATCGTTTGGGGCGGTGCAGCAGGTTGTATGCCCGTAGTCGTCGGGTGGGCAGTGATTACCGATAATCTT
CCAGCAGGTACACCAGCACAATGGTGGCAGGCGATTGTGCTTTTCATGGTGATCTTCTTCTGGACACCCCCACACACATG
GGCATTAGCCATGAAGTACAAAGATGATTACGCACGTGCAGGTGTTCCGATGCTGCCCGTGGTTCGTACTCCCGTGGAAG
TAACTCGCCAAATTGTGTGGTACACCGTTGCAACGGTACTCACCACGTTTCTTCTTATTCCTGCTGCCTCATGGATTCAC
GCAATCATCGCTGTCGTGTCGGGTGTGTGGTTCTTAGTTATGGCTGTCAGGCTACATAACGGGATTAAAAATGGTGGTGA
AGTCAAGCCTTTGAAACTATTCATCCTTTCCAACAATTACTTGGCTGTCTACTTTGTAGGATTGTCGATTGATGCAGTAC
TAGGCTGGGAAACAATCGGCGGTCACCTTGGTTGGACGACCACGTTCTTTTAA

Upstream 100 bases:

>100_bases
ATTGCTAAGGCCGTAGTGCTTTGTGAATGGCATGGCCAGTTAACATTGACAGGCCGGCTGTAGTTTACGCACTTAACTTT
TGAACATGTTGGAGGAAACC

Downstream 100 bases:

>100_bases
ATACGAATCAATTTAAATACTTTGGACAAAGTAAAAAGCCTCATGATGATTTATGGAACATCATGAGGCTTTAATTGTAT
GCGGGTTTCGACCTGTGAAT

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
METIKAYVALTKPRVIELLLVATIPAMLQAERGENNIGLILLTLLGGWMGAAAANTFNMVADSDIDQKMGRTRARPLVRN
KVSNRHASVFAWTLTVVSFLWLWVLCRSVLAGLFILLTIFFYIFVYTKYLKRKTHLNIVWGGAAGCMPVVVGWAVITDNL
PAGTPAQWWQAIVLFMVIFFWTPPHTWALAMKYKDDYARAGVPMLPVVRTPVEVTRQIVWYTVATVLTTFLLIPAASWIH
AIIAVVSGVWFLVMAVRLHNGIKNGGEVKPLKLFILSNNYLAVYFVGLSIDAVLGWETIGGHLGWTTTFF

Sequences:

>Translated_310_residues
METIKAYVALTKPRVIELLLVATIPAMLQAERGENNIGLILLTLLGGWMGAAAANTFNMVADSDIDQKMGRTRARPLVRN
KVSNRHASVFAWTLTVVSFLWLWVLCRSVLAGLFILLTIFFYIFVYTKYLKRKTHLNIVWGGAAGCMPVVVGWAVITDNL
PAGTPAQWWQAIVLFMVIFFWTPPHTWALAMKYKDDYARAGVPMLPVVRTPVEVTRQIVWYTVATVLTTFLLIPAASWIH
AIIAVVSGVWFLVMAVRLHNGIKNGGEVKPLKLFILSNNYLAVYFVGLSIDAVLGWETIGGHLGWTTTFF
>Mature_310_residues
METIKAYVALTKPRVIELLLVATIPAMLQAERGENNIGLILLTLLGGWMGAAAANTFNMVADSDIDQKMGRTRARPLVRN
KVSNRHASVFAWTLTVVSFLWLWVLCRSVLAGLFILLTIFFYIFVYTKYLKRKTHLNIVWGGAAGCMPVVVGWAVITDNL
PAGTPAQWWQAIVLFMVIFFWTPPHTWALAMKYKDDYARAGVPMLPVVRTPVEVTRQIVWYTVATVLTTFLLIPAASWIH
AIIAVVSGVWFLVMAVRLHNGIKNGGEVKPLKLFILSNNYLAVYFVGLSIDAVLGWETIGGHLGWTTTFF

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=190, Percent_Identity=33.6842105263158, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1786631, Length=255, Percent_Identity=30.9803921568627, Blast_Score=117, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI71998235, Length=196, Percent_Identity=30.6122448979592, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6325085, Length=288, Percent_Identity=27.0833333333333, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19921064, Length=270, Percent_Identity=27.037037037037, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 34613; Mature: 34613

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METIKAYVALTKPRVIELLLVATIPAMLQAERGENNIGLILLTLLGGWMGAAAANTFNMV
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ADSDIDQKMGRTRARPLVRNKVSNRHASVFAWTLTVVSFLWLWVLCRSVLAGLFILLTIF
CCCCHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYIFVYTKYLKRKTHLNIVWGGAAGCMPVVVGWAVITDNLPAGTPAQWWQAIVLFMVIFF
HHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
WTPPHTWALAMKYKDDYARAGVPMLPVVRTPVEVTRQIVWYTVATVLTTFLLIPAASWIH
CCCCCCEEEEEEECHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIIAVVSGVWFLVMAVRLHNGIKNGGEVKPLKLFILSNNYLAVYFVGLSIDAVLGWETIG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCEEEEEEEEEEHHHHCCHHHHC
GHLGWTTTFF
CCCCCEECCC
>Mature Secondary Structure
METIKAYVALTKPRVIELLLVATIPAMLQAERGENNIGLILLTLLGGWMGAAAANTFNMV
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ADSDIDQKMGRTRARPLVRNKVSNRHASVFAWTLTVVSFLWLWVLCRSVLAGLFILLTIF
CCCCHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYIFVYTKYLKRKTHLNIVWGGAAGCMPVVVGWAVITDNLPAGTPAQWWQAIVLFMVIFF
HHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
WTPPHTWALAMKYKDDYARAGVPMLPVVRTPVEVTRQIVWYTVATVLTTFLLIPAASWIH
CCCCCCEEEEEEECHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIIAVVSGVWFLVMAVRLHNGIKNGGEVKPLKLFILSNNYLAVYFVGLSIDAVLGWETIG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCEEEEEEEEEEHHHHCCHHHHC
GHLGWTTTFF
CCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14602910 [H]