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The map label for this gene is ilvD

Identifier: 38233690

GI number: 38233690

Start: 1079011

End: 1080852

Strand: Reverse

Name: ilvD

Synonym: DIP1096

Alternate gene names: 38233690

Gene position: 1080852-1079011 (Counterclockwise)

Preceding gene: 38233691

Following gene: 38233687

Centisome position: 43.43

GC content: 52.77

Gene sequence:

>1842_bases
ATGTTTCCACTTCGTTCACGAGTAACCACTGTTGGCCGCAACGCCGCTGGAGCCCGCGCCCTTTGGCGAGCTACTGGTAC
CAAAGACAATGAGTTTGGCAAGCCCATTGTGGCTATTGTGAACTCCTATACCCAATTCGTTCCTGGTCACGTGCACCTTA
AAAACGTAGGAGACATTGTCGCCGAAGCAGTTCGCGCCGCAGGAGGCGTTCCCAAAGAATTCAACACCATTGCAGTTGAC
GATGGCATCGCTATGGGACACGGCGGAATGCTCTATTCACTTCCTTCTCGCGAAATCATCGCAGACTCCGTTGAATACAT
GGTGAATGCACACACAGCGGACGCCATGGTCTGCATCTCAAACTGTGACAAAATCACGCCGGGCATGCTCAATGCTGCTT
TGCGATTAAACATTCCAGCTGTTTTCGTCTCTGGTGGACCGATGGAAGCCGGCAAAGCAGTCGTAGCAGATGGCATAGCC
CACGCCCCCACGGATCTGATCACCGCAATCACCGCATCAGCCAAAGACAGCGTGAATGATGATCAATTGTTATCCATTGA
GCAATCTGCATGTCCCACCTGCGGTTCTTGCTCAGGAATGTTTACCGCTAATTCAATGAACTGCTTGACTGAAGCTCTAG
GGCTCTCATTGCCAGGAAATGGCACAACCCTAGCAACGCACACCGCACGTCGAGAGCTTTTTGAGACAGCCGGAAAGCTA
GTCGTAGACCTATGCCAGCGCTACTACGGAGAAGAAGACGAATCCGTTCTACCGCGAAACATTGCAACAAAAAAGGCCTT
TATCAACGCAATGGCTCTTGATATGGCGATGGGCGGATCCACAAACACAGTGTTGCACACCCTAGCGGCCGCCCAAGAAG
GAGAGATTGACTTTGATCTCTCCGACATCGATGCACTTTCTCACCGAATCCCATGCCTTTCTAAAGTCGCACCCAACGGC
AATTACCACATCGAAGATGTCCATCGCGCAGGAGGAATACCTGCAATTTTGGGAGAATTACGCCGACGCGATCTCCTAGA
AAAAGGTGTGCACACCGTACTGTACAAGGAAATGGATTCATGGCTTGATGACTGGGATATCCGTGGTGGAAAGGCAACAG
ACAAGGCCATCGAGCTCTTCCACGCAGCGCCAGGCGGCGTCCGCACGACCGAGCCATTTTCTCAATCAAATCGATGGGAT
TCACTCGACACGGATCAGGCCCGTGGGTGTATTCACGACGTTGACCACGCATACTCGGCCGATGGTGGCCTAGTTATTCT
GCGCGGCAATCTTGCCCCTGACGGAGCCGTTGTAAAAGCCGCCGGCGTTGACGAATCGATCTGGACTTTTTCCGGCCCAG
CACGCGTCGTGGAAAGCCAAGAAGAGGCCGTGTCGATCATCCTAGACAAGCAGGTTCAACCGGGTGATGTTGTCGTGATT
CGATATGAGGGACCAGCTGGTGGCCCTGGTATGCAAGAGATGCTCCACCCCACTTCCTTTTTAAAGGGTGCAGGTTTAGG
AAAAGCTTGTGCCCTGATCACCGATGGCCGATTCTCTGGTGGTACTTCTGGGCTTTCCATTGGCCATATCTCTCCAGAAG
CTGCACATGGCGGCCTGATTGGACTGGTGGAAAACGGCGACACAATCACCATCGATATTAGGAACCGCAGCCTCAATCTA
GATGTCGACGATGCCGTGATCGAACAGCGTCGTGCAGCTATGTTGGAACGTGAAAAACCATGGACCCCAACCAACCGCAA
TCGACCTGTATCCAAGGCATTGCGCGCGTACGCATCCATGGCAACATCCGCAGACAAAGGCGCCGTACGTCAGTTAGACT
AA

Upstream 100 bases:

>100_bases
CGCTTCACCATTATCTTCAACGAAGAGTCTCACCACCCCGCCTGCTCTTTCCGTCGAAGTTACGCACTGCTATGAATCTG
TTTCACAGGATCGAGAAATC

Downstream 100 bases:

>100_bases
CCCACTAAGTTAAAGGCCCTAACCCTCTCTAATTCCAGAGGGAACCAGGGCCTTTGACTATCTTGTTGTGATAAAACTAT
GCGAATGGGTTAACTGCTGC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 613; Mature: 613

Protein sequence:

>613_residues
MFPLRSRVTTVGRNAAGARALWRATGTKDNEFGKPIVAIVNSYTQFVPGHVHLKNVGDIVAEAVRAAGGVPKEFNTIAVD
DGIAMGHGGMLYSLPSREIIADSVEYMVNAHTADAMVCISNCDKITPGMLNAALRLNIPAVFVSGGPMEAGKAVVADGIA
HAPTDLITAITASAKDSVNDDQLLSIEQSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTTLATHTARRELFETAGKL
VVDLCQRYYGEEDESVLPRNIATKKAFINAMALDMAMGGSTNTVLHTLAAAQEGEIDFDLSDIDALSHRIPCLSKVAPNG
NYHIEDVHRAGGIPAILGELRRRDLLEKGVHTVLYKEMDSWLDDWDIRGGKATDKAIELFHAAPGGVRTTEPFSQSNRWD
SLDTDQARGCIHDVDHAYSADGGLVILRGNLAPDGAVVKAAGVDESIWTFSGPARVVESQEEAVSIILDKQVQPGDVVVI
RYEGPAGGPGMQEMLHPTSFLKGAGLGKACALITDGRFSGGTSGLSIGHISPEAAHGGLIGLVENGDTITIDIRNRSLNL
DVDDAVIEQRRAAMLEREKPWTPTNRNRPVSKALRAYASMATSADKGAVRQLD

Sequences:

>Translated_613_residues
MFPLRSRVTTVGRNAAGARALWRATGTKDNEFGKPIVAIVNSYTQFVPGHVHLKNVGDIVAEAVRAAGGVPKEFNTIAVD
DGIAMGHGGMLYSLPSREIIADSVEYMVNAHTADAMVCISNCDKITPGMLNAALRLNIPAVFVSGGPMEAGKAVVADGIA
HAPTDLITAITASAKDSVNDDQLLSIEQSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTTLATHTARRELFETAGKL
VVDLCQRYYGEEDESVLPRNIATKKAFINAMALDMAMGGSTNTVLHTLAAAQEGEIDFDLSDIDALSHRIPCLSKVAPNG
NYHIEDVHRAGGIPAILGELRRRDLLEKGVHTVLYKEMDSWLDDWDIRGGKATDKAIELFHAAPGGVRTTEPFSQSNRWD
SLDTDQARGCIHDVDHAYSADGGLVILRGNLAPDGAVVKAAGVDESIWTFSGPARVVESQEEAVSIILDKQVQPGDVVVI
RYEGPAGGPGMQEMLHPTSFLKGAGLGKACALITDGRFSGGTSGLSIGHISPEAAHGGLIGLVENGDTITIDIRNRSLNL
DVDDAVIEQRRAAMLEREKPWTPTNRNRPVSKALRAYASMATSADKGAVRQLD
>Mature_613_residues
MFPLRSRVTTVGRNAAGARALWRATGTKDNEFGKPIVAIVNSYTQFVPGHVHLKNVGDIVAEAVRAAGGVPKEFNTIAVD
DGIAMGHGGMLYSLPSREIIADSVEYMVNAHTADAMVCISNCDKITPGMLNAALRLNIPAVFVSGGPMEAGKAVVADGIA
HAPTDLITAITASAKDSVNDDQLLSIEQSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTTLATHTARRELFETAGKL
VVDLCQRYYGEEDESVLPRNIATKKAFINAMALDMAMGGSTNTVLHTLAAAQEGEIDFDLSDIDALSHRIPCLSKVAPNG
NYHIEDVHRAGGIPAILGELRRRDLLEKGVHTVLYKEMDSWLDDWDIRGGKATDKAIELFHAAPGGVRTTEPFSQSNRWD
SLDTDQARGCIHDVDHAYSADGGLVILRGNLAPDGAVVKAAGVDESIWTFSGPARVVESQEEAVSIILDKQVQPGDVVVI
RYEGPAGGPGMQEMLHPTSFLKGAGLGKACALITDGRFSGGTSGLSIGHISPEAAHGGLIGLVENGDTITIDIRNRSLNL
DVDDAVIEQRRAAMLEREKPWTPTNRNRPVSKALRAYASMATSADKGAVRQLD

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=613, Percent_Identity=67.373572593801, Blast_Score=825, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=550, Percent_Identity=29.2727272727273, Blast_Score=193, Evalue=3e-50,
Organism=Escherichia coli, GI2367371, Length=570, Percent_Identity=29.4736842105263, Blast_Score=186, Evalue=5e-48,
Organism=Escherichia coli, GI1786464, Length=535, Percent_Identity=28.2242990654206, Blast_Score=161, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6322476, Length=609, Percent_Identity=34.3185550082102, Blast_Score=318, Evalue=2e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_CORDI (Q6NHN6)

Other databases:

- EMBL:   BX248357
- RefSeq:   NP_939457.1
- GeneID:   2650838
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1096
- NMPDR:   fig|257309.1.peg.1048
- HOGENOM:   HBG671001
- OMA:   ERISHTV
- PhylomeDB:   Q6NHN6
- ProtClustDB:   PRK12448
- BioCyc:   CDIP257309:DIP1096-MONOMER
- BRENDA:   4.2.1.9
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 65025; Mature: 65025

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPLRSRVTTVGRNAAGARALWRATGTKDNEFGKPIVAIVNSYTQFVPGHVHLKNVGDIV
CCCCHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHH
AEAVRAAGGVPKEFNTIAVDDGIAMGHGGMLYSLPSREIIADSVEYMVNAHTADAMVCIS
HHHHHHHCCCCCCCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHCCCCCCEEEEEC
NCDKITPGMLNAALRLNIPAVFVSGGPMEAGKAVVADGIAHAPTDLITAITASAKDSVND
CCCCCCCHHHCEEEEEECCEEEEECCCCCCCCCHHHCCCCCCCHHHHHHHHHCCCCCCCC
DQLLSIEQSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTTLATHTARRELFETAGKL
CCEEEEHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHH
VVDLCQRYYGEEDESVLPRNIATKKAFINAMALDMAMGGSTNTVLHTLAAAQEGEIDFDL
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCH
SDIDALSHRIPCLSKVAPNGNYHIEDVHRAGGIPAILGELRRRDLLEKGVHTVLYKEMDS
HHHHHHHHCCCHHHHCCCCCCEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLDDWDIRGGKATDKAIELFHAAPGGVRTTEPFSQSNRWDSLDTDQARGCIHDVDHAYSA
HHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHCC
DGGLVILRGNLAPDGAVVKAAGVDESIWTFSGPARVVESQEEAVSIILDKQVQPGDVVVI
CCCEEEEECCCCCCCCEEEECCCCCCCEECCCHHHHHCCHHHHEEHHEECCCCCCCEEEE
RYEGPAGGPGMQEMLHPTSFLKGAGLGKACALITDGRFSGGTSGLSIGHISPEAAHGGLI
EECCCCCCCCHHHHHCHHHHHHCCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCEE
GLVENGDTITIDIRNRSLNLDVDDAVIEQRRAAMLEREKPWTPTNRNRPVSKALRAYASM
EEEECCCEEEEEEECCEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
ATSADKGAVRQLD
HCCCCCCCCCCCC
>Mature Secondary Structure
MFPLRSRVTTVGRNAAGARALWRATGTKDNEFGKPIVAIVNSYTQFVPGHVHLKNVGDIV
CCCCHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHH
AEAVRAAGGVPKEFNTIAVDDGIAMGHGGMLYSLPSREIIADSVEYMVNAHTADAMVCIS
HHHHHHHCCCCCCCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHCCCCCCEEEEEC
NCDKITPGMLNAALRLNIPAVFVSGGPMEAGKAVVADGIAHAPTDLITAITASAKDSVND
CCCCCCCHHHCEEEEEECCEEEEECCCCCCCCCHHHCCCCCCCHHHHHHHHHCCCCCCCC
DQLLSIEQSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTTLATHTARRELFETAGKL
CCEEEEHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHH
VVDLCQRYYGEEDESVLPRNIATKKAFINAMALDMAMGGSTNTVLHTLAAAQEGEIDFDL
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCH
SDIDALSHRIPCLSKVAPNGNYHIEDVHRAGGIPAILGELRRRDLLEKGVHTVLYKEMDS
HHHHHHHHCCCHHHHCCCCCCEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLDDWDIRGGKATDKAIELFHAAPGGVRTTEPFSQSNRWDSLDTDQARGCIHDVDHAYSA
HHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHCC
DGGLVILRGNLAPDGAVVKAAGVDESIWTFSGPARVVESQEEAVSIILDKQVQPGDVVVI
CCCEEEEECCCCCCCCEEEECCCCCCCEECCCHHHHHCCHHHHEEHHEECCCCCCCEEEE
RYEGPAGGPGMQEMLHPTSFLKGAGLGKACALITDGRFSGGTSGLSIGHISPEAAHGGLI
EECCCCCCCCHHHHHCHHHHHHCCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCEE
GLVENGDTITIDIRNRSLNLDVDDAVIEQRRAAMLEREKPWTPTNRNRPVSKALRAYASM
EEEECCCEEEEEEECCEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
ATSADKGAVRQLD
HCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910