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The map label for this gene is galR [H]

Identifier: 37680818

GI number: 37680818

Start: 2663103

End: 2664104

Strand: Direct

Name: galR [H]

Synonym: VV2633

Alternate gene names: 37680818

Gene position: 2663103-2664104 (Clockwise)

Preceding gene: 37680815

Following gene: 37680824

Centisome position: 79.39

GC content: 50.9

Gene sequence:

>1002_bases
ATGGCCACAATTAAAGATGTCGCTCGCGAGGCTGGCGTTTCCATCGCCACCGTCTCACGAGTGATTAATAAATCGCCCAA
AGCCAGTAAAGCGTCGATTGAATCCGTCACTCAAGCAATGGCCAAACTGGGCTATCGCCCCAATGCCGCCGCCAAAGCGT
TGGTGAGTCAAAGCACCAATACCATGGGCGTATTGGTTGGTGATGTATCGGATCCCTTCTTCGGCACGCTGATTAAAGCC
GTCGATGAAGTGGCCCATGAAAATGGCAAACATCTACTGATTGGTAATGGCTATCACAATGCCGAGGAAGAGCGCAGAGC
CATTGAACTGCTGATCAATAGCCGTTGCGATGCACTGGTGATTCATTCGAAAGGCTTGAGCGATGAAGAGTTGCTGTCAT
ACGCGCAAGAAGTGCCAAGCTTAGTGATCATCAATCGTCATATTCCACAAATCGCGCAACGCTGCATTTCCCTCGATAAC
TACAAAGGGGCCTATTTGGCTACAGAGTATTTAATTCGCCATGGCCACCAACACATTGCCTGCATTTCATCGAGCCACAA
AATTGAAGACGCCGACGCGCGTATCGCTGGATATCTCGCCGCATTAAGAGATAATCACATCGAGCTCTCCAGTGCGTACA
TCGAACAAGGCGAGCCCAATAGCGATGGCGGAGAAACGGCAATGACTAACCTGCTGACAAAATCTCTGCCGATCACCGGC
GTGGTGGCTTACAACGACTACATGGCGGCGGGTGCGCTATCGGTATTGGATGAAAATGGCTTAAAGGTGCCAGAGCAAGT
GTCAATGATAGGATTCGATGATGGTTTGATTGCTCGCTATGTCAGCCCTCGCCTCACCACCGTGCGCTATCCAATACAGA
TGATGGCAGAGAAAGCCGCGAGACTGGCGATCGATTTGGCTCGCCAGCAAGAGGCCGACCACAGCACCATGATCTTCTCA
CCCACTTTGGTAAGAAGAGATTCTGTGGCCAAGCTCTCTTAG

Upstream 100 bases:

>100_bases
CAAGTGGTAAAGATCGCATTTTTAAAATGAAAACTCGCCGTTATTTGCCTAATTTACAGTTCAGAGGTTTAATGAGGGCA
GCATAGAAATGAGGTAACAC

Downstream 100 bases:

>100_bases
CGCCTTTGCCTCATCAAAGCTTAAATCGCGTCATCTTCTGATCAAGCTGGCGCGACAAATCGGCCAAGGTTTCACTCTCT
TCCGCTAAGAAGTTGGCCGC

Product: transcriptional regulator

Products: NA

Alternate protein names: Galactose operon repressor [H]

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MATIKDVAREAGVSIATVSRVINKSPKASKASIESVTQAMAKLGYRPNAAAKALVSQSTNTMGVLVGDVSDPFFGTLIKA
VDEVAHENGKHLLIGNGYHNAEEERRAIELLINSRCDALVIHSKGLSDEELLSYAQEVPSLVIINRHIPQIAQRCISLDN
YKGAYLATEYLIRHGHQHIACISSSHKIEDADARIAGYLAALRDNHIELSSAYIEQGEPNSDGGETAMTNLLTKSLPITG
VVAYNDYMAAGALSVLDENGLKVPEQVSMIGFDDGLIARYVSPRLTTVRYPIQMMAEKAARLAIDLARQQEADHSTMIFS
PTLVRRDSVAKLS

Sequences:

>Translated_333_residues
MATIKDVAREAGVSIATVSRVINKSPKASKASIESVTQAMAKLGYRPNAAAKALVSQSTNTMGVLVGDVSDPFFGTLIKA
VDEVAHENGKHLLIGNGYHNAEEERRAIELLINSRCDALVIHSKGLSDEELLSYAQEVPSLVIINRHIPQIAQRCISLDN
YKGAYLATEYLIRHGHQHIACISSSHKIEDADARIAGYLAALRDNHIELSSAYIEQGEPNSDGGETAMTNLLTKSLPITG
VVAYNDYMAAGALSVLDENGLKVPEQVSMIGFDDGLIARYVSPRLTTVRYPIQMMAEKAARLAIDLARQQEADHSTMIFS
PTLVRRDSVAKLS
>Mature_332_residues
ATIKDVAREAGVSIATVSRVINKSPKASKASIESVTQAMAKLGYRPNAAAKALVSQSTNTMGVLVGDVSDPFFGTLIKAV
DEVAHENGKHLLIGNGYHNAEEERRAIELLINSRCDALVIHSKGLSDEELLSYAQEVPSLVIINRHIPQIAQRCISLDNY
KGAYLATEYLIRHGHQHIACISSSHKIEDADARIAGYLAALRDNHIELSSAYIEQGEPNSDGGETAMTNLLTKSLPITGV
VAYNDYMAAGALSVLDENGLKVPEQVSMIGFDDGLIARYVSPRLTTVRYPIQMMAEKAARLAIDLARQQEADHSTMIFSP
TLVRRDSVAKLS

Specific function: Repressor of the galactose operon. Binds galactose as an inducer [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789202, Length=333, Percent_Identity=55.2552552552552, Blast_Score=357, Evalue=1e-100,
Organism=Escherichia coli, GI1788474, Length=330, Percent_Identity=53.030303030303, Blast_Score=350, Evalue=8e-98,
Organism=Escherichia coli, GI1789068, Length=334, Percent_Identity=37.125748502994, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1790369, Length=331, Percent_Identity=32.3262839879154, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1787948, Length=340, Percent_Identity=32.6470588235294, Blast_Score=184, Evalue=5e-48,
Organism=Escherichia coli, GI1790194, Length=339, Percent_Identity=32.7433628318584, Blast_Score=168, Evalue=4e-43,
Organism=Escherichia coli, GI1787906, Length=315, Percent_Identity=30.1587301587302, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1787580, Length=314, Percent_Identity=26.7515923566879, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786540, Length=331, Percent_Identity=26.5861027190332, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI48994940, Length=299, Percent_Identity=25.752508361204, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790715, Length=326, Percent_Identity=24.8466257668712, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1789456, Length=337, Percent_Identity=25.2225519287834, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786268, Length=281, Percent_Identity=22.7758007117438, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1790689, Length=291, Percent_Identity=23.0240549828179, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36097; Mature: 35965

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIKDVAREAGVSIATVSRVINKSPKASKASIESVTQAMAKLGYRPNAAAKALVSQSTN
CCCHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCC
TMGVLVGDVSDPFFGTLIKAVDEVAHENGKHLLIGNGYHNAEEERRAIELLINSRCDALV
CEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEE
IHSKGLSDEELLSYAQEVPSLVIINRHIPQIAQRCISLDNYKGAYLATEYLIRHGHQHIA
EECCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEE
CISSSHKIEDADARIAGYLAALRDNHIELSSAYIEQGEPNSDGGETAMTNLLTKSLPITG
EECCCCCCCCHHHHHHHHHHHHHCCCEEHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEE
VVAYNDYMAAGALSVLDENGLKVPEQVSMIGFDDGLIARYVSPRLTTVRYPIQMMAEKAA
EEEECCHHHHHHHHHHCCCCCCCCHHHHEEECCCCHHHHHCCCCCEEEHHHHHHHHHHHH
RLAIDLARQQEADHSTMIFSPTLVRRDSVAKLS
HHHHHHHHHHCCCCCEEEECCHHHCCCCHHCCC
>Mature Secondary Structure 
ATIKDVAREAGVSIATVSRVINKSPKASKASIESVTQAMAKLGYRPNAAAKALVSQSTN
CCHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCC
TMGVLVGDVSDPFFGTLIKAVDEVAHENGKHLLIGNGYHNAEEERRAIELLINSRCDALV
CEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEE
IHSKGLSDEELLSYAQEVPSLVIINRHIPQIAQRCISLDNYKGAYLATEYLIRHGHQHIA
EECCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEE
CISSSHKIEDADARIAGYLAALRDNHIELSSAYIEQGEPNSDGGETAMTNLLTKSLPITG
EECCCCCCCCHHHHHHHHHHHHHCCCEEHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEE
VVAYNDYMAAGALSVLDENGLKVPEQVSMIGFDDGLIARYVSPRLTTVRYPIQMMAEKAA
EEEECCHHHHHHHHHHCCCCCCCCHHHHEEECCCCHHHHHCCCCCEEEHHHHHHHHHHHH
RLAIDLARQQEADHSTMIFSPTLVRRDSVAKLS
HHHHHHHHHHCCCCCEEEECCHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6283521; 9278503; 6350601; 8188660; 8982002 [H]