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The map label for this gene is csd [H]

Identifier: 37680788

GI number: 37680788

Start: 2629054

End: 2630265

Strand: Direct

Name: csd [H]

Synonym: VV2604

Alternate gene names: 37680788

Gene position: 2629054-2630265 (Clockwise)

Preceding gene: 37680787

Following gene: 37680794

Centisome position: 78.37

GC content: 50.74

Gene sequence:

>1212_bases
ATGTTTGACGTTCAAGCCATTCGCCAACAATTTCCCGCCTTGGCGCAACAAGTCAATCAAAACGAACTGGTTTATCTAGA
TAGTGCCGCGACAACACAAAAGCCGCAGTGTGTGATTGACACAATTACACAGTATTACAGCAGCCAAAATGCGAACGTTC
ATCGCGGCAGCCATAGTTTGACCGCCAGTGCGACCAGTCAATTTGAAGCCGCACGCGACTGTGTCGCTCATTTTATTGGC
GCGCAAAGCAGTAAAGAGATCATTTGGACACGTGGCGCAACCGAAGCGCTCAATTTGATTGCTCAAACTTACGCCCGAAG
CACCCTTCAAGTTGGCGACGAAATTCTCGTCAGCGAAATGGAGCATCACGCCAATATTGTACCTTGGCAAATGGTGGCAG
AGCAGACGGGCGCTAACGTGGTCAAAATCCCCATGACCGCCGACTGTCAGTTGGACATCGAATCGTTTAAAACATTGATG
AATGAGCGAGTTAAGATTGTTGCGGTCGCTCAAACCACCAACGTCACGGCCACTCGTCAACCCATAGAGTCCATCATCGA
GTTGGCCCATCAACACGGTGCCATTGTGGTGGTGGATGGCGCTCAAGGCATCGTTCACGAACCTGTCGACATGCGCACAC
TGGACGCCGATTTCTATGTGTTCTCCGGCCACAAGCTCTATGCGCCGGCAGGAATTGGCGTGCTTTACGGCAAACTGGCG
CTGCTGGAAGCCATGCCGCCATGGCATGGAGGCGGTAAGATGGTGGAAAAAGTGTCGTTTGAGAAAACCACCTTTTCGGC
TCTACCGGGAAAATTCGAAGCTGGAACACCCAATGTCGCTGGTGCCATTGCGCTTGCTAAGGCAATAGAGTGGTATCAAG
GTTTTGCTCGAGACGAAGTGGAATCTCACCTGCACCAATTGCAATCAGCAACATACCGTGCACTGCGCGAGATGGAGGAT
ATCCGTGTGATCGGATATCAAAACAATGCATCGGTGATTACTTTTGTCATGGATGGCGTTCACCATCAAGACATTGCAAC
GCTGCTCGATCAGCAAGGTATCGCCGTGCGAGCTGGTCATCACTGTGCTCATCCGCTCATGGATGCGTTAGGTGTCAAAG
GCACCGTCCGAGTCTCTTTCGCCATTTACAACACCATGCAAGACGTCAAGAAATTGATTGCAGCCTTAGAGAAAGCGGTG
GATATGCTTTAA

Upstream 100 bases:

>100_bases
AAATTATTATCTTACTGTCTGGCAAACAGCACGCGCGCCAAGTAGCAGAGCCTATGGTGACAGTACCTGTACTCAACTAC
CACAAACTGGGTGAAGAGTA

Downstream 100 bases:

>100_bases
AAAAGTGGGCTGAGGTCTTCAGCGTCTTAGCCCATCTTTATTCACCGAAGTATTTCAACTCATGTTGATACTCTTCACCG
CCGCCATTCGCTTTAAAATG

Product: selenocysteine lyase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MFDVQAIRQQFPALAQQVNQNELVYLDSAATTQKPQCVIDTITQYYSSQNANVHRGSHSLTASATSQFEAARDCVAHFIG
AQSSKEIIWTRGATEALNLIAQTYARSTLQVGDEILVSEMEHHANIVPWQMVAEQTGANVVKIPMTADCQLDIESFKTLM
NERVKIVAVAQTTNVTATRQPIESIIELAHQHGAIVVVDGAQGIVHEPVDMRTLDADFYVFSGHKLYAPAGIGVLYGKLA
LLEAMPPWHGGGKMVEKVSFEKTTFSALPGKFEAGTPNVAGAIALAKAIEWYQGFARDEVESHLHQLQSATYRALREMED
IRVIGYQNNASVITFVMDGVHHQDIATLLDQQGIAVRAGHHCAHPLMDALGVKGTVRVSFAIYNTMQDVKKLIAALEKAV
DML

Sequences:

>Translated_403_residues
MFDVQAIRQQFPALAQQVNQNELVYLDSAATTQKPQCVIDTITQYYSSQNANVHRGSHSLTASATSQFEAARDCVAHFIG
AQSSKEIIWTRGATEALNLIAQTYARSTLQVGDEILVSEMEHHANIVPWQMVAEQTGANVVKIPMTADCQLDIESFKTLM
NERVKIVAVAQTTNVTATRQPIESIIELAHQHGAIVVVDGAQGIVHEPVDMRTLDADFYVFSGHKLYAPAGIGVLYGKLA
LLEAMPPWHGGGKMVEKVSFEKTTFSALPGKFEAGTPNVAGAIALAKAIEWYQGFARDEVESHLHQLQSATYRALREMED
IRVIGYQNNASVITFVMDGVHHQDIATLLDQQGIAVRAGHHCAHPLMDALGVKGTVRVSFAIYNTMQDVKKLIAALEKAV
DML
>Mature_403_residues
MFDVQAIRQQFPALAQQVNQNELVYLDSAATTQKPQCVIDTITQYYSSQNANVHRGSHSLTASATSQFEAARDCVAHFIG
AQSSKEIIWTRGATEALNLIAQTYARSTLQVGDEILVSEMEHHANIVPWQMVAEQTGANVVKIPMTADCQLDIESFKTLM
NERVKIVAVAQTTNVTATRQPIESIIELAHQHGAIVVVDGAQGIVHEPVDMRTLDADFYVFSGHKLYAPAGIGVLYGKLA
LLEAMPPWHGGGKMVEKVSFEKTTFSALPGKFEAGTPNVAGAIALAKAIEWYQGFARDEVESHLHQLQSATYRALREMED
IRVIGYQNNASVITFVMDGVHHQDIATLLDQQGIAVRAGHHCAHPLMDALGVKGTVRVSFAIYNTMQDVKKLIAALEKAV
DML

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=213, Percent_Identity=27.6995305164319, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI156713448, Length=429, Percent_Identity=23.7762237762238, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1789175, Length=403, Percent_Identity=49.6277915632754, Blast_Score=396, Evalue=1e-111,
Organism=Escherichia coli, GI1787970, Length=399, Percent_Identity=45.3634085213033, Blast_Score=387, Evalue=1e-109,
Organism=Escherichia coli, GI48994898, Length=400, Percent_Identity=24.25, Blast_Score=102, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI25143064, Length=213, Percent_Identity=29.5774647887324, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI193211090, Length=346, Percent_Identity=26.0115606936416, Blast_Score=89, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6319831, Length=393, Percent_Identity=23.1552162849873, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI20129463, Length=229, Percent_Identity=29.2576419213974, Blast_Score=111, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR022471
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 44106; Mature: 44106

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDVQAIRQQFPALAQQVNQNELVYLDSAATTQKPQCVIDTITQYYSSQNANVHRGSHSL
CCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEECCCCCE
TASATSQFEAARDCVAHFIGAQSSKEIIWTRGATEALNLIAQTYARSTLQVGDEILVSEM
EHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EHHANIVPWQMVAEQTGANVVKIPMTADCQLDIESFKTLMNERVKIVAVAQTTNVTATRQ
HHHCCCCHHHHHHHHCCCCEEEECCCCCCEECHHHHHHHHHCCEEEEEEEECCCCCHHHH
PIESIIELAHQHGAIVVVDGAQGIVHEPVDMRTLDADFYVFSGHKLYAPAGIGVLYGKLA
HHHHHHHHHHHCCCEEEEECCCCCEECCCCCEEECCCEEEEECCEEECCCCHHHHHHHHH
LLEAMPPWHGGGKMVEKVSFEKTTFSALPGKFEAGTPNVAGAIALAKAIEWYQGFARDEV
HHHCCCCCCCCCHHHHHHHHCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ESHLHQLQSATYRALREMEDIRVIGYQNNASVITFVMDGVHHQDIATLLDQQGIAVRAGH
HHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEECCCCHHHHHHHHHCCCCEEECCC
HCAHPLMDALGVKGTVRVSFAIYNTMQDVKKLIAALEKAVDML
HHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFDVQAIRQQFPALAQQVNQNELVYLDSAATTQKPQCVIDTITQYYSSQNANVHRGSHSL
CCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEECCCCCE
TASATSQFEAARDCVAHFIGAQSSKEIIWTRGATEALNLIAQTYARSTLQVGDEILVSEM
EHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EHHANIVPWQMVAEQTGANVVKIPMTADCQLDIESFKTLMNERVKIVAVAQTTNVTATRQ
HHHCCCCHHHHHHHHCCCCEEEECCCCCCEECHHHHHHHHHCCEEEEEEEECCCCCHHHH
PIESIIELAHQHGAIVVVDGAQGIVHEPVDMRTLDADFYVFSGHKLYAPAGIGVLYGKLA
HHHHHHHHHHHCCCEEEEECCCCCEECCCCCEEECCCEEEEECCEEECCCCHHHHHHHHH
LLEAMPPWHGGGKMVEKVSFEKTTFSALPGKFEAGTPNVAGAIALAKAIEWYQGFARDEV
HHHCCCCCCCCCHHHHHHHHCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ESHLHQLQSATYRALREMEDIRVIGYQNNASVITFVMDGVHHQDIATLLDQQGIAVRAGH
HHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEECCCCHHHHHHHHHCCCCEEECCC
HCAHPLMDALGVKGTVRVSFAIYNTMQDVKKLIAALEKAVDML
HHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]