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The map label for this gene is gcvR [H]

Identifier: 37680689

GI number: 37680689

Start: 2536111

End: 2536698

Strand: Direct

Name: gcvR [H]

Synonym: VV2505

Alternate gene names: 37680689

Gene position: 2536111-2536698 (Clockwise)

Preceding gene: 37680686

Following gene: 37680690

Centisome position: 75.6

GC content: 46.26

Gene sequence:

>588_bases
GTGTTACCATCCGGAAAAAACAAAATACACAATAAGAGCGAATCTATGACTCAACATCTGGTAATTACCGCAATGGGCAC
GGATCGGCCAGGCATCTGTAACCAGGTTGTCCAACTGGTGACGCGTGCGGGTTGTAACATTATTGACAGTCGAATCGCCA
TTTTTGGCAATGAGTTTACCCTCATCATGCTGCTGTCTGGCAACACCAATGGCGTCACTCGAGTCGAGACCACTTTACCA
CTGCTCGGCCAAGAACATGATCTCATCACCATAATGAAGCGAACGTCGGCTCATCATCCAACGACAAATTGCTACACCAT
TGAGGTGTTTGTTGAATCGGATGACCGCGTCGGCCTCACCGAAAAATTCACACAATTCTTTGCAGAAAAGCAAATCGGCT
TGAGCGCACTCAGTGCCCAAACCATCGATAAAGCCACGGTACAAATGGAGCAAGACCAGTTCCACATCGCGATTACGGCA
CACGTACAAAACGAATCCAATTTAATGCAGATTCAGGAAGATTTTAATGATCTTTGCCGCTCGCTGAACGTACAAGGCAC
GCTGAACTTTATAAAAAACACCCTTTAA

Upstream 100 bases:

>100_bases
AGGATGTAGGCTTGTCAGCGTCTGGTGAATTCCAAGACCATCAACACAGCGTTCCCTAACATAAAAAACGGAAGCGACTC
GACATTTTCCATAAACTTCT

Downstream 100 bases:

>100_bases
AAGGAATAACGACATGAATATGCTGCAAGCAGGCTCCCCTGCTCCAGAATTTTCTTTGCCTGATCAAAATGGAAATCTTG
TCTCGCTCAAAGACCTCAAA

Product: glycine cleavage system regulatory protein

Products: NA

Alternate protein names: Gcv operon repressor [H]

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MLPSGKNKIHNKSESMTQHLVITAMGTDRPGICNQVVQLVTRAGCNIIDSRIAIFGNEFTLIMLLSGNTNGVTRVETTLP
LLGQEHDLITIMKRTSAHHPTTNCYTIEVFVESDDRVGLTEKFTQFFAEKQIGLSALSAQTIDKATVQMEQDQFHIAITA
HVQNESNLMQIQEDFNDLCRSLNVQGTLNFIKNTL

Sequences:

>Translated_195_residues
MLPSGKNKIHNKSESMTQHLVITAMGTDRPGICNQVVQLVTRAGCNIIDSRIAIFGNEFTLIMLLSGNTNGVTRVETTLP
LLGQEHDLITIMKRTSAHHPTTNCYTIEVFVESDDRVGLTEKFTQFFAEKQIGLSALSAQTIDKATVQMEQDQFHIAITA
HVQNESNLMQIQEDFNDLCRSLNVQGTLNFIKNTL
>Mature_195_residues
MLPSGKNKIHNKSESMTQHLVITAMGTDRPGICNQVVQLVTRAGCNIIDSRIAIFGNEFTLIMLLSGNTNGVTRVETTLP
LLGQEHDLITIMKRTSAHHPTTNCYTIEVFVESDDRVGLTEKFTQFFAEKQIGLSALSAQTIDKATVQMEQDQFHIAITA
HVQNESNLMQIQEDFNDLCRSLNVQGTLNFIKNTL

Specific function: Negative transcriptional regulator of the glycine cleavage system operon (GCV). Does not autoregulate its own expression. It is not yet known how gcvR acts as a repressor. It does not seem to bind DNA. It could interact with gcvA and suppress its activato

COG id: COG2716

COG function: function code E; Glycine cleavage system regulatory protein

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI87082113, Length=177, Percent_Identity=41.8079096045198, Blast_Score=143, Evalue=9e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR016867 [H]

Pfam domain/function: PF01842 ACT [H]

EC number: NA

Molecular weight: Translated: 21721; Mature: 21721

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPSGKNKIHNKSESMTQHLVITAMGTDRPGICNQVVQLVTRAGCNIIDSRIAIFGNEFT
CCCCCCCCCCCCHHHHEEEEEEEEECCCCCCHHHHHHHHHHHCCCCEECCEEEEECCCEE
LIMLLSGNTNGVTRVETTLPLLGQEHDLITIMKRTSAHHPTTNCYTIEVFVESDDRVGLT
EEEEEECCCCCEEEEEEECCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEEECCCCCCHH
EKFTQFFAEKQIGLSALSAQTIDKATVQMEQDQFHIAITAHVQNESNLMQIQEDFNDLCR
HHHHHHHHHHHCCHHHHHHHHHHHHHEEEECCEEEEEEEEEECCCCHHHHHHHHHHHHHH
SLNVQGTLNFIKNTL
HCCCCEEHHHHHCCC
>Mature Secondary Structure
MLPSGKNKIHNKSESMTQHLVITAMGTDRPGICNQVVQLVTRAGCNIIDSRIAIFGNEFT
CCCCCCCCCCCCHHHHEEEEEEEEECCCCCCHHHHHHHHHHHCCCCEECCEEEEECCCEE
LIMLLSGNTNGVTRVETTLPLLGQEHDLITIMKRTSAHHPTTNCYTIEVFVESDDRVGLT
EEEEEECCCCCEEEEEEECCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEEECCCCCCHH
EKFTQFFAEKQIGLSALSAQTIDKATVQMEQDQFHIAITAHVQNESNLMQIQEDFNDLCR
HHHHHHHHHHHCCHHHHHHHHHHHHHEEEECCEEEEEEEEEECCCCHHHHHHHHHHHHHH
SLNVQGTLNFIKNTL
HCCCCEEHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537378; 9205837; 9278503; 2016588 [H]