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The map label for this gene is ychM [C]

Identifier: 37680332

GI number: 37680332

Start: 2163163

End: 2164926

Strand: Direct

Name: ychM [C]

Synonym: VV2148

Alternate gene names: 37680332

Gene position: 2163163-2164926 (Clockwise)

Preceding gene: 37680331

Following gene: 37680335

Centisome position: 64.49

GC content: 52.78

Gene sequence:

>1764_bases
TTGGCCAAAATAATCCTATCGCAGTGGTTCCCCGGACTCGTCCAATTACAACACTATCAAAAAGAGTGGCTCGCTGATGA
CGTTCGCGCCGCCTTTTCTGTGGTGGCCGTCGCGCTGCCTGTTGCTATCGCCTACGCCCAATTAACGGGGGTTTCTGCGA
TTGTCGGTCTCTATTCGTGCGTATTGCCAATGTTGGTTTACGCCTTAATGGGCACATCAAGGCAATTGATCGTCGGACCT
GATGCCGCAACGTGTGCAGTGATTGCCGCTGTGGTAACCCCGCTTGCGGCTGGTGATGCAACCAAACACTGGCAACTGGT
GATGACCATGACCGCGATGACCGGAATGTGGTGCGTACTGGCAAGCCGTCTGAAATTGGGCATTTTGGCTGATTTTCTTT
CACGTCCGATCCTCTTAGGGCTACTCAATGGTGTGGCACTCACCATCATCGTTGGCCAGTTTGCCAAGGTGGTAGGCTGG
AAATATGAGCAGCGCTACCTACTTGAACGTTTATGGGAAGCCCCACAGCGATTGGCAGATTTGCACTGGCCGACATTGGC
GCTCAGCGTGGCTACTGTGGTCGTCTATCTGATCACCAAGCGATTTCGCCCTAGTTGGCCTGCGGCGATGTTGGCGATCC
TCATCACCACCGCCTCCGTTTGGCTTTTGCGTTTGCAAGAAGTTGGGGTGTCGGTGGTTGGGCTGACACAAGGCGGGTTT
CCTAACTTCCAAACGCCAGAGTTTGAACTGGGCGTCACTCGTGAGTTGGTGGTACCAGCGCTCAACTTGGCGATGGTGAG
CTTTGTCAGCATGATGCTGACCGCCCGCAGCTTCGCGGCCAAAAACGGCTACGATATTGATGCCGACAAAGAATTCCGTG
CCTTAGGCTTTGCCAATATTGCCTCGGCCTTTTCACAAGGATTTGCCATCAGTGGTGCCGATTCCCGCACAGCAGTCAAC
GATGCCAATGGAGGAAAATCCCAACTGGTGTCCATTATTGCTGCCATCACCATTGCGGTGATCGCCGTGTTTATCTACCA
GCCATTGCAGTTTATTCCTATCGCCTCATTGGGAGTGGTCTTGATTATCGCCTCGCTGTCGCTGCTTGATCTTAAAGGCA
TTTGGATCTTACGAAAACGTGACAAAGACGCCTTCTATCTCGCCTCCATCACTTTTGTTTCTGTACTGGTGATTGGCGTA
ATACCGGGCATCACCTTGGCGGTGTTGTTGGGTCTGTTCCAGTTCTTGCGCATCGTTATGCGCCCAAGCGATCAATTGCT
TGGGTTGGATGAAGAAGGCACCATTCGCACCGTCGACGGCACAGGCAAAGCCACTCCGATCCCTGGCATGGTGATCTACC
GTTTTAACTCGCCACTCACCTACTTCAACGCACCGTATTTCAAGCGCCGTTTACTGGAACACGCGGAACACACCAAAGAC
GTGGGTTGTGTGGTGGTGGATGCGGTTTCTAGCTTCACTCACCTAGATTTGAGTGTAATGGCAACGCTCGCGGATGTGCA
TGAAACGCTGAAAAAACGAGGAATTCGCTTGATTCTAGCTGGCCGTAAACGACGCCTTCGTCAGTGGTGTGAATTGACGG
GCATCAGCACCAGTGAAGGCGGCATTTTGCTGCGCGCGGATATGTATCTCGCCATCAAACTCAGTGGCTGTTACCTCAGC
GCCGTGGGTGAAGGCCAAGTCCCTACTGTGCAAAAAGAACCCGATTTGGAAGAGCCGCCAAAAGCGATTCCTGAAGTGGC
ATAA

Upstream 100 bases:

>100_bases
GAAGAGAATTTACCCTCCGCTATCGATAAATAACTCACGAATGTTACAAAATAACGCTGTATACTTTACAGTAACTTAAC
CGCATTTATGGGTAGATCTG

Downstream 100 bases:

>100_bases
GTCTCTTCTCTATTCCCCGAATGCCGTTATTCAGCAGGACTCGTGTGAGCTTGTGCTTGCTGAAGCGCTAACCATTGAGC
CGGTGTGGTATCAAAACATC

Product: sulfate permease

Products: Proton [Cytoplasm]; SO42- [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 587; Mature: 586

Protein sequence:

>587_residues
MAKIILSQWFPGLVQLQHYQKEWLADDVRAAFSVVAVALPVAIAYAQLTGVSAIVGLYSCVLPMLVYALMGTSRQLIVGP
DAATCAVIAAVVTPLAAGDATKHWQLVMTMTAMTGMWCVLASRLKLGILADFLSRPILLGLLNGVALTIIVGQFAKVVGW
KYEQRYLLERLWEAPQRLADLHWPTLALSVATVVVYLITKRFRPSWPAAMLAILITTASVWLLRLQEVGVSVVGLTQGGF
PNFQTPEFELGVTRELVVPALNLAMVSFVSMMLTARSFAAKNGYDIDADKEFRALGFANIASAFSQGFAISGADSRTAVN
DANGGKSQLVSIIAAITIAVIAVFIYQPLQFIPIASLGVVLIIASLSLLDLKGIWILRKRDKDAFYLASITFVSVLVIGV
IPGITLAVLLGLFQFLRIVMRPSDQLLGLDEEGTIRTVDGTGKATPIPGMVIYRFNSPLTYFNAPYFKRRLLEHAEHTKD
VGCVVVDAVSSFTHLDLSVMATLADVHETLKKRGIRLILAGRKRRLRQWCELTGISTSEGGILLRADMYLAIKLSGCYLS
AVGEGQVPTVQKEPDLEEPPKAIPEVA

Sequences:

>Translated_587_residues
MAKIILSQWFPGLVQLQHYQKEWLADDVRAAFSVVAVALPVAIAYAQLTGVSAIVGLYSCVLPMLVYALMGTSRQLIVGP
DAATCAVIAAVVTPLAAGDATKHWQLVMTMTAMTGMWCVLASRLKLGILADFLSRPILLGLLNGVALTIIVGQFAKVVGW
KYEQRYLLERLWEAPQRLADLHWPTLALSVATVVVYLITKRFRPSWPAAMLAILITTASVWLLRLQEVGVSVVGLTQGGF
PNFQTPEFELGVTRELVVPALNLAMVSFVSMMLTARSFAAKNGYDIDADKEFRALGFANIASAFSQGFAISGADSRTAVN
DANGGKSQLVSIIAAITIAVIAVFIYQPLQFIPIASLGVVLIIASLSLLDLKGIWILRKRDKDAFYLASITFVSVLVIGV
IPGITLAVLLGLFQFLRIVMRPSDQLLGLDEEGTIRTVDGTGKATPIPGMVIYRFNSPLTYFNAPYFKRRLLEHAEHTKD
VGCVVVDAVSSFTHLDLSVMATLADVHETLKKRGIRLILAGRKRRLRQWCELTGISTSEGGILLRADMYLAIKLSGCYLS
AVGEGQVPTVQKEPDLEEPPKAIPEVA
>Mature_586_residues
AKIILSQWFPGLVQLQHYQKEWLADDVRAAFSVVAVALPVAIAYAQLTGVSAIVGLYSCVLPMLVYALMGTSRQLIVGPD
AATCAVIAAVVTPLAAGDATKHWQLVMTMTAMTGMWCVLASRLKLGILADFLSRPILLGLLNGVALTIIVGQFAKVVGWK
YEQRYLLERLWEAPQRLADLHWPTLALSVATVVVYLITKRFRPSWPAAMLAILITTASVWLLRLQEVGVSVVGLTQGGFP
NFQTPEFELGVTRELVVPALNLAMVSFVSMMLTARSFAAKNGYDIDADKEFRALGFANIASAFSQGFAISGADSRTAVND
ANGGKSQLVSIIAAITIAVIAVFIYQPLQFIPIASLGVVLIIASLSLLDLKGIWILRKRDKDAFYLASITFVSVLVIGVI
PGITLAVLLGLFQFLRIVMRPSDQLLGLDEEGTIRTVDGTGKATPIPGMVIYRFNSPLTYFNAPYFKRRLLEHAEHTKDV
GCVVVDAVSSFTHLDLSVMATLADVHETLKKRGIRLILAGRKRRLRQWCELTGISTSEGGILLRADMYLAIKLSGCYLSA
VGEGQVPTVQKEPDLEEPPKAIPEVA

Specific function: Expression in E.coli induces sulfate uptake during early-to mid-log phase growth. Uptake is maximal at pH 6.0, is sulfate-specific, requires E.coli CysA and the transmembrane segment but not the STAS domain of the protein [H]

COG id: COG0659

COG function: function code P; Sulfate permease and related transporters (MFS superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 STAS domain [H]

Homologues:

Organism=Homo sapiens, GI45827800, Length=511, Percent_Identity=26.614481409002, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI39752683, Length=511, Percent_Identity=26.614481409002, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI94721257, Length=504, Percent_Identity=26.3888888888889, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI94721259, Length=504, Percent_Identity=26.3888888888889, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI94721255, Length=504, Percent_Identity=26.3888888888889, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI94721253, Length=504, Percent_Identity=26.3888888888889, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI269784651, Length=503, Percent_Identity=25.4473161033797, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI4557535, Length=524, Percent_Identity=25.763358778626, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI47131207, Length=515, Percent_Identity=26.9902912621359, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI20336272, Length=515, Percent_Identity=26.9902912621359, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI4505697, Length=510, Percent_Identity=27.2549019607843, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI45827802, Length=451, Percent_Identity=26.6075388026608, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI100913030, Length=516, Percent_Identity=23.6434108527132, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI262206105, Length=551, Percent_Identity=23.2304900181488, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI262206075, Length=551, Percent_Identity=23.2304900181488, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI262206069, Length=551, Percent_Identity=23.2304900181488, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI262206063, Length=551, Percent_Identity=23.2304900181488, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI16418413, Length=516, Percent_Identity=23.4496124031008, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI217272867, Length=516, Percent_Identity=23.4496124031008, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI16306483, Length=608, Percent_Identity=21.0526315789474, Blast_Score=93, Evalue=9e-19,
Organism=Homo sapiens, GI20336282, Length=608, Percent_Identity=21.0526315789474, Blast_Score=93, Evalue=9e-19,
Organism=Homo sapiens, GI16418457, Length=511, Percent_Identity=22.5048923679061, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI301601599, Length=511, Percent_Identity=22.5048923679061, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI65506789, Length=401, Percent_Identity=26.6832917705736, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI301601602, Length=240, Percent_Identity=25.4166666666667, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI87081859, Length=436, Percent_Identity=23.1651376146789, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI86565215, Length=499, Percent_Identity=26.0521042084168, Blast_Score=143, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17551690, Length=595, Percent_Identity=24.0336134453782, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI86564196, Length=611, Percent_Identity=24.2225859247136, Blast_Score=132, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17562578, Length=621, Percent_Identity=23.3494363929147, Blast_Score=118, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17566848, Length=557, Percent_Identity=23.5188509874327, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI193203292, Length=532, Percent_Identity=23.1203007518797, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI86564876, Length=419, Percent_Identity=21.7183770883055, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI86565209, Length=241, Percent_Identity=27.3858921161826, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI86565211, Length=241, Percent_Identity=27.3858921161826, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6325260, Length=579, Percent_Identity=21.9343696027634, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6319771, Length=592, Percent_Identity=21.7905405405405, Blast_Score=88, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6323121, Length=157, Percent_Identity=29.2993630573248, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21358229, Length=470, Percent_Identity=26.1702127659574, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24666186, Length=631, Percent_Identity=22.1870047543582, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI85815873, Length=439, Percent_Identity=26.879271070615, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24649801, Length=457, Percent_Identity=25.8205689277899, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24651449, Length=490, Percent_Identity=23.469387755102, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI19922482, Length=407, Percent_Identity=27.5184275184275, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24663084, Length=450, Percent_Identity=22.8888888888889, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21357695, Length=450, Percent_Identity=22.8888888888889, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21358633, Length=514, Percent_Identity=21.9844357976654, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21355087, Length=546, Percent_Identity=22.1611721611722, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24647160, Length=546, Percent_Identity=22.1611721611722, Blast_Score=95, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002645
- InterPro:   IPR001902
- InterPro:   IPR011547 [H]

Pfam domain/function: PF01740 STAS; PF00916 Sulfate_transp [H]

EC number: NA

Molecular weight: Translated: 63770; Mature: 63639

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: PS50801 STAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIILSQWFPGLVQLQHYQKEWLADDVRAAFSVVAVALPVAIAYAQLTGVSAIVGLYSC
CCEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLPMLVYALMGTSRQLIVGPDAATCAVIAAVVTPLAAGDATKHWQLVMTMTAMTGMWCVL
HHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
ASRLKLGILADFLSRPILLGLLNGVALTIIVGQFAKVVGWKYEQRYLLERLWEAPQRLAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LHWPTLALSVATVVVYLITKRFRPSWPAAMLAILITTASVWLLRLQEVGVSVVGLTQGGF
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
PNFQTPEFELGVTRELVVPALNLAMVSFVSMMLTARSFAAKNGYDIDADKEFRALGFANI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
ASAFSQGFAISGADSRTAVNDANGGKSQLVSIIAAITIAVIAVFIYQPLQFIPIASLGVV
HHHHHCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHH
LIIASLSLLDLKGIWILRKRDKDAFYLASITFVSVLVIGVIPGITLAVLLGLFQFLRIVM
HHHHHHHHHHCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RPSDQLLGLDEEGTIRTVDGTGKATPIPGMVIYRFNSPLTYFNAPYFKRRLLEHAEHTKD
CCCHHHCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCC
VGCVVVDAVSSFTHLDLSVMATLADVHETLKKRGIRLILAGRKRRLRQWCELTGISTSEG
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHCCCCCCCC
GILLRADMYLAIKLSGCYLSAVGEGQVPTVQKEPDLEEPPKAIPEVA
CEEEEECEEEEEEEECEEEEECCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKIILSQWFPGLVQLQHYQKEWLADDVRAAFSVVAVALPVAIAYAQLTGVSAIVGLYSC
CEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLPMLVYALMGTSRQLIVGPDAATCAVIAAVVTPLAAGDATKHWQLVMTMTAMTGMWCVL
HHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
ASRLKLGILADFLSRPILLGLLNGVALTIIVGQFAKVVGWKYEQRYLLERLWEAPQRLAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LHWPTLALSVATVVVYLITKRFRPSWPAAMLAILITTASVWLLRLQEVGVSVVGLTQGGF
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
PNFQTPEFELGVTRELVVPALNLAMVSFVSMMLTARSFAAKNGYDIDADKEFRALGFANI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
ASAFSQGFAISGADSRTAVNDANGGKSQLVSIIAAITIAVIAVFIYQPLQFIPIASLGVV
HHHHHCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHH
LIIASLSLLDLKGIWILRKRDKDAFYLASITFVSVLVIGVIPGITLAVLLGLFQFLRIVM
HHHHHHHHHHCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RPSDQLLGLDEEGTIRTVDGTGKATPIPGMVIYRFNSPLTYFNAPYFKRRLLEHAEHTKD
CCCHHHCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCC
VGCVVVDAVSSFTHLDLSVMATLADVHETLKKRGIRLILAGRKRRLRQWCELTGISTSEG
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHCCCCCCCC
GILLRADMYLAIKLSGCYLSAVGEGQVPTVQKEPDLEEPPKAIPEVA
CEEEEECEEEEEEEECEEEEECCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; SO42- [Periplasm] [C]

Specific reaction: Proton [Periplasm] + SO42- [Periplasm] = Proton [Cytoplasm] + SO42- [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]