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The map label for this gene is dusC [H]

Identifier: 37680310

GI number: 37680310

Start: 2135257

End: 2136213

Strand: Direct

Name: dusC [H]

Synonym: VV2126

Alternate gene names: 37680310

Gene position: 2135257-2136213 (Clockwise)

Preceding gene: 37680308

Following gene: 37680317

Centisome position: 63.65

GC content: 49.32

Gene sequence:

>957_bases
ATGCGAGTGATATTGGGACCGATGGAAGGTGTGCTCGACCACCTGATGCGAGAGATGCTTACCGAAATCAATGACTACGA
TTTTTGTGTCACTGAGTTTGTTCGCATTGTCAGCCAACCACTCCCAGACCATGTGTTTTATCGCCTCTGCCCTGAACTGA
AACAAGGGTCAAAAACAAAAAATGGTGTTCCTGTCAAAGTGCAGCTGTTAGGCCAAGATCCCCATTGGATGGCCGAAAAT
GCTATCCGCGCCGCGCAGCTCGGTGCGCATGGTATCGATCTCAACTTTGGTTGTCCGGCAAAGATGGTTAATCAAAGCAA
AGGGGGCGCAGCGCTGCTGCAACACCCAGAACTGATCTATCAAGTGGTCAAAGCGTGTCGTGATGCAGTGCCCTCGCACA
TTCCAGTTTCCGCCAAAATTCGTTTGGGCTGGGAAAACCCGGAAGATTGTTTCGAGATTGTGGACGCGGTAGAGCAAGGC
AAAGCGGATGAATTAACCGTCCATGCAAGAACCAAAGCTGGCGGCTATAAAGCGAGTGAAATCAAATGGGATTACATTGA
CCAAATCCGCCAACGTTCCACGATTCCTTTGATTGCAAATGGCGAAATCTGGAACTATGCCGATGGTCAAGCCTGTATTG
AAACCACTGGCATCGATTCTTTGATGGTGTGCCGTGGCGCATTAAACGTGCCTAACTTGGGCAACATCGTTAAGCACAAT
CACCGTGCGATGCCGTGGCACGAAGTGGTGGATTTATTGCTCAAATACACCCAATACGAAGTGCGTGGCGACAAAGGGAA
ATATTACCCAAATCGTATCAAGCAGTGGTTTGCTTATTTGCGCCAAGCATACCCACAAGCGGCTGACCTATTCCGTGATA
TTCGCACCTTGACGCAAGTGGAAAGCATCGTTGAGCATCTGCATCACTATCGCGAACAGCTCGAGGTGGCACAGTAA

Upstream 100 bases:

>100_bases
GGATTAAATCATGAAAAGCCTCTCTCCTTGCCTCTTCTCGTGACAAGCTCTCGGTGAATCGCTACAATCGCGCCTCATTT
TTTGAGAGGCCAGAATAAAG

Downstream 100 bases:

>100_bases
ACAATTTTGTCTTTACCACTGTTTTTCGCTTGGTAAAGACTGTCATCGGCAGCTTTGAATAAAGCGTCAAAGCTGTCACC
TGCGCCCATTTCACGTATCA

Product: putative regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MRVILGPMEGVLDHLMREMLTEINDYDFCVTEFVRIVSQPLPDHVFYRLCPELKQGSKTKNGVPVKVQLLGQDPHWMAEN
AIRAAQLGAHGIDLNFGCPAKMVNQSKGGAALLQHPELIYQVVKACRDAVPSHIPVSAKIRLGWENPEDCFEIVDAVEQG
KADELTVHARTKAGGYKASEIKWDYIDQIRQRSTIPLIANGEIWNYADGQACIETTGIDSLMVCRGALNVPNLGNIVKHN
HRAMPWHEVVDLLLKYTQYEVRGDKGKYYPNRIKQWFAYLRQAYPQAADLFRDIRTLTQVESIVEHLHHYREQLEVAQ

Sequences:

>Translated_318_residues
MRVILGPMEGVLDHLMREMLTEINDYDFCVTEFVRIVSQPLPDHVFYRLCPELKQGSKTKNGVPVKVQLLGQDPHWMAEN
AIRAAQLGAHGIDLNFGCPAKMVNQSKGGAALLQHPELIYQVVKACRDAVPSHIPVSAKIRLGWENPEDCFEIVDAVEQG
KADELTVHARTKAGGYKASEIKWDYIDQIRQRSTIPLIANGEIWNYADGQACIETTGIDSLMVCRGALNVPNLGNIVKHN
HRAMPWHEVVDLLLKYTQYEVRGDKGKYYPNRIKQWFAYLRQAYPQAADLFRDIRTLTQVESIVEHLHHYREQLEVAQ
>Mature_318_residues
MRVILGPMEGVLDHLMREMLTEINDYDFCVTEFVRIVSQPLPDHVFYRLCPELKQGSKTKNGVPVKVQLLGQDPHWMAEN
AIRAAQLGAHGIDLNFGCPAKMVNQSKGGAALLQHPELIYQVVKACRDAVPSHIPVSAKIRLGWENPEDCFEIVDAVEQG
KADELTVHARTKAGGYKASEIKWDYIDQIRQRSTIPLIANGEIWNYADGQACIETTGIDSLMVCRGALNVPNLGNIVKHN
HRAMPWHEVVDLLLKYTQYEVRGDKGKYYPNRIKQWFAYLRQAYPQAADLFRDIRTLTQVESIVEHLHHYREQLEVAQ

Specific function: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs [H]

COG id: COG0042

COG function: function code J; tRNA-dihydrouridine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dus family. DusC subfamily [H]

Homologues:

Organism=Homo sapiens, GI31742496, Length=181, Percent_Identity=31.4917127071823, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI40807366, Length=192, Percent_Identity=28.125, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI239788483, Length=197, Percent_Identity=27.9187817258883, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI239788462, Length=197, Percent_Identity=27.9187817258883, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI8923374, Length=201, Percent_Identity=30.8457711442786, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1788462, Length=308, Percent_Identity=57.4675324675325, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1789660, Length=327, Percent_Identity=32.1100917431193, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI145693211, Length=182, Percent_Identity=30.2197802197802, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI25144369, Length=179, Percent_Identity=31.8435754189944, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17510279, Length=273, Percent_Identity=26.7399267399267, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17543114, Length=202, Percent_Identity=29.2079207920792, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17507177, Length=154, Percent_Identity=30.5194805194805, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6323560, Length=240, Percent_Identity=25.4166666666667, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19921524, Length=177, Percent_Identity=33.8983050847458, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24580595, Length=171, Percent_Identity=30.4093567251462, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19920448, Length=171, Percent_Identity=30.4093567251462, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24585320, Length=233, Percent_Identity=27.4678111587983, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001269
- InterPro:   IPR018517 [H]

Pfam domain/function: PF01207 Dus [H]

EC number: NA

Molecular weight: Translated: 36151; Mature: 36151

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS01136 UPF0034

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVILGPMEGVLDHLMREMLTEINDYDFCVTEFVRIVSQPLPDHVFYRLCPELKQGSKTK
CCEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHCHHHHCCCCCC
NGVPVKVQLLGQDPHWMAENAIRAAQLGAHGIDLNFGCPAKMVNQSKGGAALLQHPELIY
CCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCHHHHCCHHHHH
QVVKACRDAVPSHIPVSAKIRLGWENPEDCFEIVDAVEQGKADELTVHARTKAGGYKASE
HHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCC
IKWDYIDQIRQRSTIPLIANGEIWNYADGQACIETTGIDSLMVCRGALNVPNLGNIVKHN
CCHHHHHHHHHCCCCCEEECCCEECCCCCCHHHHHCCCCHHHHHHCCCCCCCCCHHHHCC
HRAMPWHEVVDLLLKYTQYEVRGDKGKYYPNRIKQWFAYLRQAYPQAADLFRDIRTLTQV
CCCCCHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
ESIVEHLHHYREQLEVAQ
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRVILGPMEGVLDHLMREMLTEINDYDFCVTEFVRIVSQPLPDHVFYRLCPELKQGSKTK
CCEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHCHHHHCCCCCC
NGVPVKVQLLGQDPHWMAENAIRAAQLGAHGIDLNFGCPAKMVNQSKGGAALLQHPELIY
CCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCHHHHCCHHHHH
QVVKACRDAVPSHIPVSAKIRLGWENPEDCFEIVDAVEQGKADELTVHARTKAGGYKASE
HHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCC
IKWDYIDQIRQRSTIPLIANGEIWNYADGQACIETTGIDSLMVCRGALNVPNLGNIVKHN
CCHHHHHHHHHCCCCCEEECCCEECCCCCCHHHHHCCCCHHHHHHCCCCCCCCCHHHHCC
HRAMPWHEVVDLLLKYTQYEVRGDKGKYYPNRIKQWFAYLRQAYPQAADLFRDIRTLTQV
CCCCCHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
ESIVEHLHHYREQLEVAQ
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA