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The map label for this gene is nhaB

Identifier: 37680307

GI number: 37680307

Start: 2132217

End: 2133806

Strand: Direct

Name: nhaB

Synonym: VV2123

Alternate gene names: 37680307

Gene position: 2132217-2133806 (Clockwise)

Preceding gene: 37680296

Following gene: 37680308

Centisome position: 63.56

GC content: 47.67

Gene sequence:

>1590_bases
ATGCCGATGTCGCTCGGAAACGCTTTTATTAAGAATTTTCTTGGTAAAGCGCCTGATTGGTATAAAGTTGCCATCATTTC
TTTTTTAATCATTAACCCGATTGTTTTCTTCTTCGTTGACCCATTTGTAGCAGGCTGGCTACTCGTCGTGGAATTTATTT
TCACCTTGGCAATGGCGCTCAAATGTTATCCTCTTCAACCTGGTGGTTTATTAGCCATTGAAGCCATCGCGATTGGCATG
ACTAGCCCTGAACAGGTTAAGCATGAGCTCGTCGCCAATATCGAAGTGTTGTTGTTACTGGTCTTCATGGTCGCTGGCAT
CTACTTCATGAAGCAGTTGCTACTCTTCATTTTCACCAAGATATTGCTTGGCATTCGCTCTAAAGCGATTTTGTCTTTAG
CGTTTTGTTTTGCCGCGGCCTTTCTTTCCGCTTTCTTAGACGCACTGACCGTTATCGCGGTTGTTATCAGCGTTGCCGTG
GGTTTTTATTCGATCTACCACAAAGTGGCATCGGGTAAGGGCGTCAGTTCCGATCATGACCATACACAAGACGATCATCT
TGCCGAGCTGACTCGTGACGACTTAGAAAACTACCGCGCATTTTTACGCTCACTGCTCATGCATGCGGGTGTTGGTACTG
CGCTCGGTGGCGTGACGACCATGGTAGGTGAACCTCAAAACTTGATCATTGCAGACCAAGCAAGTTGGTTGTTTGGTGAG
TTCTTGATTCGCATGGCTCCAGTTACGCTTCCTGTTTTCGTCTGTGGTTTGCTCACCTGTTTTGCGGTCGAAAAACTTAA
GGTGTTTGGCTACGGCGCTGAACTACCTGATAACGTTCGTCATATCCTTGTCGAATTCGACAAAGAAGAACGCAAGGCTC
GTACCAACCAAGATGTGGCCAAACTTTGGATTCAAGGTCTTATCGCCGTATGGCTGATTGTCGGCCTCGCACTGCACTTG
GCCGCGGTAGGTTTGATCGGTTTGTCCGTCATCATCCTAGCCACAGCCTTCACTGGTGTGATTGAAGAACACTCACTCGG
TAAAGCGTTTGAAGAAGCACTGCCATTTACGGCACTTCTTGCGGTTTTCTTCTCTATCGTGGCGGTAATCATCGACCAAG
AGTTGTTTAAGCCTGTTATCGATGCAGTTCTCGCGGTGGAAGACAAAGGCACGCAGTTGGCGATGTTCTACGTGGCAAAC
GGTTTGCTTTCGATGGTGTCTGACAACGTGTTCGTCGGTACGGTTTACATCAACGAAGTCAAAACTGCGCTAGTAGAAGG
CATTATTACACGTGACCAGTTTGATTTGCTGGCCGTGGCGATCAACACAGGAACTAACTTGCCATCAGTGGCAACACCAA
ACGGCCAAGCGGCGTTCCTATTTTTGTTGACTTCAGCACTAGCACCATTGATTCGTCTGTCTTACGGCAAGATGGTGATC
ATGGCTCTGCCATACACGATTGTACTGGCTCTGGTTGGCTTGTTTGGCATCGTCTTCTTACTTGAGCCTATGACAACTTG
GTTTTACGACGCAGGTTGGATTGCTCACCATGTGGGTGAGGCAACTCACGCAGTTTCCGGCGGACATTAA

Upstream 100 bases:

>100_bases
TAAGTTATTGTTTATAAAGATAGATATTTCTTCTTTAAAGCATAGGCTTAAGCACTATGTTGTAGTGTCTATTCATATAT
AAGTTAATAAGAGAATTATC

Downstream 100 bases:

>100_bases
ATTTTTAGTTTGCTAAAGAAACTTATCCGAGATAAAAAGCTCTGAGTATTCAGAGCTTTTTTATTGAACATACAAAGGAT
TTTAGAAGTGAATTTATTTG

Product: sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaB [H]

Number of amino acids: Translated: 529; Mature: 528

Protein sequence:

>529_residues
MPMSLGNAFIKNFLGKAPDWYKVAIISFLIINPIVFFFVDPFVAGWLLVVEFIFTLAMALKCYPLQPGGLLAIEAIAIGM
TSPEQVKHELVANIEVLLLLVFMVAGIYFMKQLLLFIFTKILLGIRSKAILSLAFCFAAAFLSAFLDALTVIAVVISVAV
GFYSIYHKVASGKGVSSDHDHTQDDHLAELTRDDLENYRAFLRSLLMHAGVGTALGGVTTMVGEPQNLIIADQASWLFGE
FLIRMAPVTLPVFVCGLLTCFAVEKLKVFGYGAELPDNVRHILVEFDKEERKARTNQDVAKLWIQGLIAVWLIVGLALHL
AAVGLIGLSVIILATAFTGVIEEHSLGKAFEEALPFTALLAVFFSIVAVIIDQELFKPVIDAVLAVEDKGTQLAMFYVAN
GLLSMVSDNVFVGTVYINEVKTALVEGIITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGKMVI
MALPYTIVLALVGLFGIVFLLEPMTTWFYDAGWIAHHVGEATHAVSGGH

Sequences:

>Translated_529_residues
MPMSLGNAFIKNFLGKAPDWYKVAIISFLIINPIVFFFVDPFVAGWLLVVEFIFTLAMALKCYPLQPGGLLAIEAIAIGM
TSPEQVKHELVANIEVLLLLVFMVAGIYFMKQLLLFIFTKILLGIRSKAILSLAFCFAAAFLSAFLDALTVIAVVISVAV
GFYSIYHKVASGKGVSSDHDHTQDDHLAELTRDDLENYRAFLRSLLMHAGVGTALGGVTTMVGEPQNLIIADQASWLFGE
FLIRMAPVTLPVFVCGLLTCFAVEKLKVFGYGAELPDNVRHILVEFDKEERKARTNQDVAKLWIQGLIAVWLIVGLALHL
AAVGLIGLSVIILATAFTGVIEEHSLGKAFEEALPFTALLAVFFSIVAVIIDQELFKPVIDAVLAVEDKGTQLAMFYVAN
GLLSMVSDNVFVGTVYINEVKTALVEGIITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGKMVI
MALPYTIVLALVGLFGIVFLLEPMTTWFYDAGWIAHHVGEATHAVSGGH
>Mature_528_residues
PMSLGNAFIKNFLGKAPDWYKVAIISFLIINPIVFFFVDPFVAGWLLVVEFIFTLAMALKCYPLQPGGLLAIEAIAIGMT
SPEQVKHELVANIEVLLLLVFMVAGIYFMKQLLLFIFTKILLGIRSKAILSLAFCFAAAFLSAFLDALTVIAVVISVAVG
FYSIYHKVASGKGVSSDHDHTQDDHLAELTRDDLENYRAFLRSLLMHAGVGTALGGVTTMVGEPQNLIIADQASWLFGEF
LIRMAPVTLPVFVCGLLTCFAVEKLKVFGYGAELPDNVRHILVEFDKEERKARTNQDVAKLWIQGLIAVWLIVGLALHLA
AVGLIGLSVIILATAFTGVIEEHSLGKAFEEALPFTALLAVFFSIVAVIIDQELFKPVIDAVLAVEDKGTQLAMFYVANG
LLSMVSDNVFVGTVYINEVKTALVEGIITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGKMVIM
ALPYTIVLALVGLFGIVFLLEPMTTWFYDAGWIAHHVGEATHAVSGGH

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3067

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaB Na(+)/H(+) (TC 2.A.34) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1787435, Length=515, Percent_Identity=68.9320388349515, Blast_Score=683, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004671 [H]

Pfam domain/function: PF06450 NhaB [H]

EC number: NA

Molecular weight: Translated: 57473; Mature: 57342

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PMSLGNAFIKNFLGKAPDWYKVAIISFLIINPIVFFFVDPFVAGWLLVVEFIFTLAMAL
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KCYPLQPGGLLAIEAIAIGMTSPEQVKHELVANIEVLLLLVFMVAGIYFMKQLLLFIFTK
HCCCCCCCCEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILLGIRSKAILSLAFCFAAAFLSAFLDALTVIAVVISVAVGFYSIYHKVASGKGVSSDHD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
HTQDDHLAELTRDDLENYRAFLRSLLMHAGVGTALGGVTTMVGEPQNLIIADQASWLFGE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCHHHHHHH
FLIRMAPVTLPVFVCGLLTCFAVEKLKVFGYGAELPDNVRHILVEFDKEERKARTNQDVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHCCHHHH
KLWIQGLIAVWLIVGLALHLAAVGLIGLSVIILATAFTGVIEEHSLGKAFEEALPFTALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
AVFFSIVAVIIDQELFKPVIDAVLAVEDKGTQLAMFYVANGLLSMVSDNVFVGTVYINEV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCCCEEEEEEEHHHH
KTALVEGIITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGKMVI
HHHHHHHHHCCCCHHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHH
MALPYTIVLALVGLFGIVFLLEPMTTWFYDAGWIAHHVGEATHAVSGGH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3 Proton [Periplasm]; Na (I) [Cytoplasm] [C]

Specific reaction: 3 Proton [Periplasm] + 2 Na (I) [Cytoplasm] = 2 Na (I) [Periplasm] + 3 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA