Click here to switch to the map view.

The map label for this gene is asnC

Identifier: 37680274

GI number: 37680274

Start: 2097945

End: 2099345

Strand: Direct

Name: asnC

Synonym: VV2090

Alternate gene names: 37680274

Gene position: 2097945-2099345 (Clockwise)

Preceding gene: 37680273

Following gene: 37680277

Centisome position: 62.54

GC content: 50.11

Gene sequence:

>1401_bases
ATGACTTACGCGCCTGTAAAAGACGTATTAAGCGGTAAGCTGGCAGTGGACAGTGAAGTCACTGTACGCGGCTGGATCCG
TACACGTCGTGATTCCAAAGCTGGAATCTCTTTCCTTGCCATCTACGACGGCTCTTGTTTCGACCCGATTCAGGCCGTGG
TCCCAAATAATCTTAATAATTACAACGACGAAGTACTCAAGCTAACGACTGGCTGCTCTGTTGAAGTAACGGGTAAGATT
GTGGCTTCGCCTGCTGCTGGTCAAGCGTTTGAGCTTGCAGCGACTGACGTGAAAGTGGTGGGTTGGGTTGAAGATGCAGA
TACCTACCCAATGGCGAAAACACGTCATTCTATCGAGTACCTACGCGAAGTGGCTCACCTACGTCCACGTACTAACGTGA
TCGGTGCAGTTGCACGTGTTCGTCACTCGTTGTCTCAAGCGATCCACCGTTTCTACCACGAGCAAGGCTACTACTGGCTG
TCTGCTCCACTAATCACCGCCTCTGACTGTGAAGGCGCTGGTGAAATGTTCCGCGTGTCAACACTGGATCTTGCGAACCT
ACCTCGCACTGAGAGCGGTGACGTTGATTTCAACGAAGATTTCTTCGGTAAAGAGACATTCCTAACCGTTTCTGGTCAGC
TAAACGGCGAAGCGTACGCGTGTGCATTAAGCAAAATCTACACATTCGGCCCGACTTTCCGTGCAGAAAACTCAAACACC
AGCCGCCACCTAGCAGAGTTCTGGATGGTTGAGCCAGAAGTCGCGTTTGCTGATCTGAACGACATCGCGAAGTTGGCTGA
AGACATGCTGAAATATGTGTTCGCAGCCGTACTTGAAGAGCGTCGTGATGATCTTGAGTTCTTTGCTAGCCGCATCGACA
AAGATGTCATCAATCGCTTAGAACAGTTTGTGAGTTCTGATTTCGCACAAGTGGATTACACAGACGCGATTCAAATCCTG
TTGGATTCTGGCCGTGAGTTCGAGTTCCCAGTTGAATGGGGTATCGACATGTCTTCTGAGCACGAGCGTTTCTTGGCAGA
AGAGCACTTTAAAGCTCCGGTTATCGTGAAAAACTACCCGAAAGACATCAAAGCGTTCTACATGCGTATGAATGAAGATG
GTAAAACGGTTGCGGCGATGGACGTTCTCGCACCGGGCATCGGCGAAATCATCGGTGGTTCACAACGTGAAGAGCGTTTA
GACGTACTGGATGCTCGTATGGTTGAAATGGGCATCGATCCAGAACACATGAACTGGTATCGCGATCTGCGCCGTTACGG
CACCGTACCGCACGCTGGTTTCGGTTTAGGCTTCGAGCGTCTTGTTTCTTACGTAACAGGCATGGGCAACGTACGTGACG
TGATCCCATTCCCACGTACACCACGTAACGCAAACTTCTAA

Upstream 100 bases:

>100_bases
TAAAATTCTATCCAACCCAATGTTTCGCTTAATTTTTGAACGCTTACGTTTTTGGCAAACATTGGGTTGTATGTTTACCT
CAATGGAGATTATTTAAAAC

Downstream 100 bases:

>100_bases
TCTTTTAGAATTGTCGTTGAAATGAAAAAGCCTCCCAAGTCGGAGGCTTTTGTTTTTTAAGGCAATATTACTCTTGTGCA
TCATTTTCGATATCCGCATT

Product: asparaginyl-tRNA synthetase

Products: NA

Alternate protein names: Asparagine--tRNA ligase; AsnRS

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MTYAPVKDVLSGKLAVDSEVTVRGWIRTRRDSKAGISFLAIYDGSCFDPIQAVVPNNLNNYNDEVLKLTTGCSVEVTGKI
VASPAAGQAFELAATDVKVVGWVEDADTYPMAKTRHSIEYLREVAHLRPRTNVIGAVARVRHSLSQAIHRFYHEQGYYWL
SAPLITASDCEGAGEMFRVSTLDLANLPRTESGDVDFNEDFFGKETFLTVSGQLNGEAYACALSKIYTFGPTFRAENSNT
SRHLAEFWMVEPEVAFADLNDIAKLAEDMLKYVFAAVLEERRDDLEFFASRIDKDVINRLEQFVSSDFAQVDYTDAIQIL
LDSGREFEFPVEWGIDMSSEHERFLAEEHFKAPVIVKNYPKDIKAFYMRMNEDGKTVAAMDVLAPGIGEIIGGSQREERL
DVLDARMVEMGIDPEHMNWYRDLRRYGTVPHAGFGLGFERLVSYVTGMGNVRDVIPFPRTPRNANF

Sequences:

>Translated_466_residues
MTYAPVKDVLSGKLAVDSEVTVRGWIRTRRDSKAGISFLAIYDGSCFDPIQAVVPNNLNNYNDEVLKLTTGCSVEVTGKI
VASPAAGQAFELAATDVKVVGWVEDADTYPMAKTRHSIEYLREVAHLRPRTNVIGAVARVRHSLSQAIHRFYHEQGYYWL
SAPLITASDCEGAGEMFRVSTLDLANLPRTESGDVDFNEDFFGKETFLTVSGQLNGEAYACALSKIYTFGPTFRAENSNT
SRHLAEFWMVEPEVAFADLNDIAKLAEDMLKYVFAAVLEERRDDLEFFASRIDKDVINRLEQFVSSDFAQVDYTDAIQIL
LDSGREFEFPVEWGIDMSSEHERFLAEEHFKAPVIVKNYPKDIKAFYMRMNEDGKTVAAMDVLAPGIGEIIGGSQREERL
DVLDARMVEMGIDPEHMNWYRDLRRYGTVPHAGFGLGFERLVSYVTGMGNVRDVIPFPRTPRNANF
>Mature_465_residues
TYAPVKDVLSGKLAVDSEVTVRGWIRTRRDSKAGISFLAIYDGSCFDPIQAVVPNNLNNYNDEVLKLTTGCSVEVTGKIV
ASPAAGQAFELAATDVKVVGWVEDADTYPMAKTRHSIEYLREVAHLRPRTNVIGAVARVRHSLSQAIHRFYHEQGYYWLS
APLITASDCEGAGEMFRVSTLDLANLPRTESGDVDFNEDFFGKETFLTVSGQLNGEAYACALSKIYTFGPTFRAENSNTS
RHLAEFWMVEPEVAFADLNDIAKLAEDMLKYVFAAVLEERRDDLEFFASRIDKDVINRLEQFVSSDFAQVDYTDAIQILL
DSGREFEFPVEWGIDMSSEHERFLAEEHFKAPVIVKNYPKDIKAFYMRMNEDGKTVAAMDVLAPGIGEIIGGSQREERLD
VLDARMVEMGIDPEHMNWYRDLRRYGTVPHAGFGLGFERLVSYVTGMGNVRDVIPFPRTPRNANF

Specific function: Unknown

COG id: COG0017

COG function: function code J; Aspartyl/asparaginyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI226491502, Length=463, Percent_Identity=41.9006479481641, Blast_Score=381, Evalue=1e-106,
Organism=Homo sapiens, GI4758762, Length=446, Percent_Identity=29.372197309417, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI45439306, Length=342, Percent_Identity=27.7777777777778, Blast_Score=122, Evalue=6e-28,
Organism=Escherichia coli, GI1787161, Length=466, Percent_Identity=79.6137339055794, Blast_Score=801, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17556372, Length=433, Percent_Identity=31.8706697459584, Blast_Score=198, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI71984122, Length=452, Percent_Identity=28.9823008849558, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17551876, Length=481, Percent_Identity=26.1954261954262, Blast_Score=115, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6319872, Length=469, Percent_Identity=37.5266524520256, Blast_Score=303, Evalue=5e-83,
Organism=Saccharomyces cerevisiae, GI6321807, Length=457, Percent_Identity=31.0722100656455, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6323011, Length=487, Percent_Identity=24.0246406570842, Blast_Score=113, Evalue=5e-26,
Organism=Drosophila melanogaster, GI19922416, Length=450, Percent_Identity=36.8888888888889, Blast_Score=285, Evalue=4e-77,
Organism=Drosophila melanogaster, GI19921528, Length=462, Percent_Identity=29.4372294372294, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI17136276, Length=494, Percent_Identity=25.5060728744939, Blast_Score=112, Evalue=7e-25,

Paralogues:

None

Copy number: 80 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SYN_VIBVU (Q8DAF0)

Other databases:

- EMBL:   AE016795
- RefSeq:   NP_761106.1
- ProteinModelPortal:   Q8DAF0
- SMR:   Q8DAF0
- GeneID:   1179134
- GenomeReviews:   AE016795_GR
- KEGG:   vvu:VV1_2254
- HOGENOM:   HBG745843
- OMA:   EPEMAFC
- ProtClustDB:   PRK03932
- BioCyc:   VVUL216895:VV1_2254-MONOMER
- BRENDA:   6.1.1.22
- GO:   GO:0005737
- HAMAP:   MF_00534
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR004522
- InterPro:   IPR002312
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PRINTS:   PR01042
- TIGRFAMs:   TIGR00457

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.22

Molecular weight: Translated: 52407; Mature: 52275

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYAPVKDVLSGKLAVDSEVTVRGWIRTRRDSKAGISFLAIYDGSCFDPIQAVVPNNLNN
CCCCCCHHHHCCCEEECCCEEEEHHHHHCCCCCCCEEEEEEECCCCCCHHHHHCCCCCCC
YNDEVLKLTTGCSVEVTGKIVASPAAGQAFELAATDVKVVGWVEDADTYPMAKTRHSIEY
CCCCEEEEECCCCEEECCEEEECCCCCCEEEEEECCEEEEEEEECCCCCCCHHHHHHHHH
LREVAHLRPRTNVIGAVARVRHSLSQAIHRFYHEQGYYWLSAPLITASDCEGAGEMFRVS
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCEEECCCCCCCCCEEEEE
TLDLANLPRTESGDVDFNEDFFGKETFLTVSGQLNGEAYACALSKIYTFGPTFRAENSNT
EECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEECCCCCC
SRHLAEFWMVEPEVAFADLNDIAKLAEDMLKYVFAAVLEERRDDLEFFASRIDKDVINRL
HHHHHHHHCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQFVSSDFAQVDYTDAIQILLDSGREFEFPVEWGIDMSSEHERFLAEEHFKAPVIVKNYP
HHHHHCCCCCCCHHHHHHHHHHCCCCEECCHHCCCCCCCHHHHHHHHHHCCCCEEECCCC
KDIKAFYMRMNEDGKTVAAMDVLAPGIGEIIGGSQREERLDVLDARMVEMGIDPEHMNWY
HHHHHHHHHCCCCCCEEEHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
RDLRRYGTVPHAGFGLGFERLVSYVTGMGNVRDVIPFPRTPRNANF
HHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TYAPVKDVLSGKLAVDSEVTVRGWIRTRRDSKAGISFLAIYDGSCFDPIQAVVPNNLNN
CCCCCHHHHCCCEEECCCEEEEHHHHHCCCCCCCEEEEEEECCCCCCHHHHHCCCCCCC
YNDEVLKLTTGCSVEVTGKIVASPAAGQAFELAATDVKVVGWVEDADTYPMAKTRHSIEY
CCCCEEEEECCCCEEECCEEEECCCCCCEEEEEECCEEEEEEEECCCCCCCHHHHHHHHH
LREVAHLRPRTNVIGAVARVRHSLSQAIHRFYHEQGYYWLSAPLITASDCEGAGEMFRVS
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCEEECCCCCCCCCEEEEE
TLDLANLPRTESGDVDFNEDFFGKETFLTVSGQLNGEAYACALSKIYTFGPTFRAENSNT
EECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEECCCCCC
SRHLAEFWMVEPEVAFADLNDIAKLAEDMLKYVFAAVLEERRDDLEFFASRIDKDVINRL
HHHHHHHHCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQFVSSDFAQVDYTDAIQILLDSGREFEFPVEWGIDMSSEHERFLAEEHFKAPVIVKNYP
HHHHHCCCCCCCHHHHHHHHHHCCCCEECCHHCCCCCCCHHHHHHHHHHCCCCEEECCCC
KDIKAFYMRMNEDGKTVAAMDVLAPGIGEIIGGSQREERLDVLDARMVEMGIDPEHMNWY
HHHHHHHHHCCCCCCEEEHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
RDLRRYGTVPHAGFGLGFERLVSYVTGMGNVRDVIPFPRTPRNANF
HHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA