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The map label for this gene is gpmA2

Identifier: 37521444

GI number: 37521444

Start: 1993433

End: 1994092

Strand: Reverse

Name: gpmA2

Synonym: gll1875

Alternate gene names: 37521444

Gene position: 1994092-1993433 (Counterclockwise)

Preceding gene: 37521450

Following gene: 37521442

Centisome position: 42.8

GC content: 62.88

Gene sequence:

>660_bases
ATGGCACTACTGGTCATGGTCCGCCACGGTCAATCGATCTGGAACCTCGAAAACCGCTTCACCGGCTGGACTGACGTTCC
CCTGACCGAAAAAGGCCGCGCGGAAGCCCGCGCCTGCGGCGAGTTGATTTATTGCGTCCCCTTCGCCGTCGCCTTTACTT
CCAAACTGACGCGCGCCCAAGACACCTTGCGCCTCATTCTCGAAGCCGCCGACCAACCGGACGTGCCGGTGATCGAGGAT
CAGGCCCTCAATGAGCGCCACTACGGCGAGCTGCAGGGGCTCAACAAAGCCGAAACTGCCGCGAAGTACGGTGAGGAAAC
GGTCCGGCAGTGGCGGCGCAGCCTGGAGGGGCGTCCCCCCGGCGGCGAGAGCCTCAAGGACACCGCCCTGCGATCATTGC
GCTATTTCTACGAAAAAATTGTTCCCGAGTTGGAGGCGGGTAAGAACGTGCTCGTCAGTGCCCACGGCAACACGATCCGG
GCCATTTTGATGGAACTCGATCACCTGAGCCCCGAGCAGGTCGAAAAGGTCGAAATCGAATACTGCGTGCCGGTCGCCTT
CGAGCATCAGGCGGACGGCACCTTCTCGCAGGTGCTCATGCCCCGATGCGACATCATCCGGCCGCCGCAGCCGCCGGCCC
GCAGCATCGCCCGGCTCTAG

Upstream 100 bases:

>100_bases
CTCAGGGTAACACCCGCAAAGCTGAATATTTTGGGTAGTTCTATCCGAATGCGTCCCGGCCCTGTTAGAACAACCTTGTT
TGTTTTTGGCAGAGCACCAC

Downstream 100 bases:

>100_bases
CGGATGCGGTCGATGCGGGAGATGGCGGTGAGGGCGGCGGCACCGAGGGCAACCACCACGCCCCCCCAGAAGATGCTCCA
CAAAAAGTTGCTCAGCGTCG

Product: phosphoglycerate mutase

Products: NA

Alternate protein names: BPG-dependent PGAM 2; PGAM 2; Phosphoglyceromutase 2; dPGM 2

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MALLVMVRHGQSIWNLENRFTGWTDVPLTEKGRAEARACGELIYCVPFAVAFTSKLTRAQDTLRLILEAADQPDVPVIED
QALNERHYGELQGLNKAETAAKYGEETVRQWRRSLEGRPPGGESLKDTALRSLRYFYEKIVPELEAGKNVLVSAHGNTIR
AILMELDHLSPEQVEKVEIEYCVPVAFEHQADGTFSQVLMPRCDIIRPPQPPARSIARL

Sequences:

>Translated_219_residues
MALLVMVRHGQSIWNLENRFTGWTDVPLTEKGRAEARACGELIYCVPFAVAFTSKLTRAQDTLRLILEAADQPDVPVIED
QALNERHYGELQGLNKAETAAKYGEETVRQWRRSLEGRPPGGESLKDTALRSLRYFYEKIVPELEAGKNVLVSAHGNTIR
AILMELDHLSPEQVEKVEIEYCVPVAFEHQADGTFSQVLMPRCDIIRPPQPPARSIARL
>Mature_218_residues
ALLVMVRHGQSIWNLENRFTGWTDVPLTEKGRAEARACGELIYCVPFAVAFTSKLTRAQDTLRLILEAADQPDVPVIEDQ
ALNERHYGELQGLNKAETAAKYGEETVRQWRRSLEGRPPGGESLKDTALRSLRYFYEKIVPELEAGKNVLVSAHGNTIRA
ILMELDHLSPEQVEKVEIEYCVPVAFEHQADGTFSQVLMPRCDIIRPPQPPARSIARL

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI50593010, Length=214, Percent_Identity=43.4579439252336, Blast_Score=170, Evalue=8e-43,
Organism=Homo sapiens, GI4505753, Length=214, Percent_Identity=42.0560747663551, Blast_Score=164, Evalue=4e-41,
Organism=Homo sapiens, GI71274132, Length=214, Percent_Identity=39.2523364485981, Blast_Score=149, Evalue=1e-36,
Organism=Homo sapiens, GI4502445, Length=216, Percent_Identity=40.2777777777778, Blast_Score=148, Evalue=3e-36,
Organism=Homo sapiens, GI40353764, Length=216, Percent_Identity=40.2777777777778, Blast_Score=148, Evalue=3e-36,
Organism=Homo sapiens, GI310129614, Length=159, Percent_Identity=44.0251572327044, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI9966849, Length=188, Percent_Identity=30.3191489361702, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1786970, Length=212, Percent_Identity=44.3396226415094, Blast_Score=171, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6322697, Length=215, Percent_Identity=40.4651162790698, Blast_Score=146, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6320183, Length=266, Percent_Identity=27.0676691729323, Blast_Score=93, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6324516, Length=267, Percent_Identity=28.8389513108614, Blast_Score=92, Evalue=8e-20,
Organism=Drosophila melanogaster, GI85725270, Length=215, Percent_Identity=43.2558139534884, Blast_Score=163, Evalue=8e-41,
Organism=Drosophila melanogaster, GI85725272, Length=215, Percent_Identity=43.2558139534884, Blast_Score=163, Evalue=8e-41,
Organism=Drosophila melanogaster, GI24650981, Length=215, Percent_Identity=43.2558139534884, Blast_Score=163, Evalue=8e-41,
Organism=Drosophila melanogaster, GI24646216, Length=215, Percent_Identity=41.3953488372093, Blast_Score=161, Evalue=3e-40,
Organism=Drosophila melanogaster, GI28571815, Length=219, Percent_Identity=35.1598173515982, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI28571817, Length=219, Percent_Identity=35.1598173515982, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24648979, Length=219, Percent_Identity=35.1598173515982, Blast_Score=119, Evalue=2e-27,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA2_GLOVI (Q7NJF7)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_924821.1
- ProteinModelPortal:   Q7NJF7
- SMR:   Q7NJF7
- GeneID:   2600277
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:gll1875
- NMPDR:   fig|251221.1.peg.1875
- HOGENOM:   HBG658938
- OMA:   ELPACES
- BioCyc:   GVIO251221:GLL1875-MONOMER
- BRENDA:   5.4.2.1
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 24664; Mature: 24533

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 9-9 ACT_SITE 155-155

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLVMVRHGQSIWNLENRFTGWTDVPLTEKGRAEARACGELIYCVPFAVAFTSKLTRAQ
CEEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DTLRLILEAADQPDVPVIEDQALNERHYGELQGLNKAETAAKYGEETVRQWRRSLEGRPP
HHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
GGESLKDTALRSLRYFYEKIVPELEAGKNVLVSAHGNTIRAILMELDHLSPEQVEKVEIE
CCCHHHHHHHHHHHHHHHHHCCHHHCCCEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHE
YCVPVAFEHQADGTFSQVLMPRCDIIRPPQPPARSIARL
EECCEEECCCCCCHHHHHHHHHHCCCCCCCCCHHHHCCC
>Mature Secondary Structure 
ALLVMVRHGQSIWNLENRFTGWTDVPLTEKGRAEARACGELIYCVPFAVAFTSKLTRAQ
EEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DTLRLILEAADQPDVPVIEDQALNERHYGELQGLNKAETAAKYGEETVRQWRRSLEGRPP
HHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
GGESLKDTALRSLRYFYEKIVPELEAGKNVLVSAHGNTIRAILMELDHLSPEQVEKVEIE
CCCHHHHHHHHHHHHHHHHHCCHHHCCCEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHE
YCVPVAFEHQADGTFSQVLMPRCDIIRPPQPPARSIARL
EECCEEECCCCCCHHHHHHHHHHCCCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292