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The map label for this gene is uvrB

Identifier: 37521424

GI number: 37521424

Start: 1976669

End: 1978711

Strand: Reverse

Name: uvrB

Synonym: gvip255

Alternate gene names: 37521424

Gene position: 1978711-1976669 (Counterclockwise)

Preceding gene: 37521431

Following gene: 37521423

Centisome position: 42.47

GC content: 62.07

Gene sequence:

>2043_bases
ATGACCGACGACCGCTTCGTAGTCTCGGCCCCATACCGGCCGACCGGGGACCAGCCCCGGGCGATTGCCCAGCTCAGTGC
CGGAGCGCTGGGCGGTGTCACTTTTCAGACGTTGTTGGGGGCGACTGGCACCGGCAAGACCTTCACGATCGCCAATGTGA
TCGAAAAGGTCGGTAAACCGACCCTGGTCCTGGCCCACAACAAGACCCTCGCCGCCCAGCTTTGCAACGAATTGCGCGAA
TTTTTTCCCGACAATGCTGTCGAATACTTTGTTTCTTATTACGACTACTACCAGCCCGAAGCGTACATCCCCCAGACCGA
CACCTATATCGAAAAATCGGCGAGCATCAACGACGAAATCGACATGCTGCGCCATTCGGCCACCCGCTCGCTCTTCGAGC
GGCGCGACGTGATTGTGGTGGCCTCCGTCAGCTGCATTTACGGCCTGGGTATGCCCGAGGAGTACCTGCGCGCCGCCATT
CCCCTCAAAGTCGGATCGAACATTGATCAGCGCGAGTTGCTGCGCCAGTTGGTCACGGTACAGTACGAGCGCAACGACAT
CGATCTGGGCCGCGGCCGCTTCAGAGTGCGCGGCGATGTGGTCGAGATCGGTCCCGCCTACGAGGATCGGATCATCCGGG
TCGAATTTTTTGGCGACGAAGTCGAGGCGGTGCGCTGGCTCGACCCGGTCACAGGCGAGGTGGTCCGCTCGGTCAACAGC
CTCAACATCTACCCGGCCAAGCACTTTGTGACACCTGAGGAGCAGCTGGAGCAGGCCTGCATCGCCATCGAACAGGAACT
GGAGGCGCGCGTGGCCGAACTGGAGGGCGAAAACAAGCTGCTGGAGGCCCAGCGCATCAAGCAGCGCACCCGCTACGACC
TGGAGATGCTGCGCGAGGTGGGTTACTGCAACGGCGTCGAAAATTATTCGCGCCACCTCGCCGCCCGCCGGCCGGGTGAA
GCGCCCTCTTGCCTCATCGATTATTTTCCGCAGGACTGGCTGTTGGTGGTCGACGAATCCCACGTCACCATCCCCCAGAT
CCGCGGCATGTACAACGGCGACGCCCAGCGCAAAAAAGTGCTCATCGATCACGGTTTCAGGCTCCCTTCGGCCGCCGACA
ACCGCCCGCTCAAAGCGCCCGAATTCTGGGATAAAGTCCGCCAGGCCATCTTCGTCTCGGCCACCCCGGGCGATTGGGAA
GTCGAACTCTCGGGCGGCGGTCGCGACCCCGAGACCGGCCGCATGGCAGGGGAGCACGTCGCCGAGCAGATTATCCGGCC
CACCGGCGTGCTCGACCCCGAGGTCTTTGTGCGGCCGGTGGCAGGTCAGGTGGACGACTTGCTCCACGAAATTCACGATC
GGGTCGCCCGCCGCGAGCGGGTATTGGTCACCACCCTCACCAAGCGCATGGCCGAGGATCTCACCGAGTACTTCCAAGAG
CGGGGGGTTAAAGTGCGCTATTTGCACTCAGAAATTCAGGCCATCGAGCGCATCGAGATTTTGCAGGCTCTGCGCCAGGG
CGATTTTGACGTGCTCATCGGCGTCAACTTACTTAGAGAAGGGCTCGATTTGCCCGAAGTGTCGCTGGTGGCGATTCTGG
ACGCTGATAAAGAAGGGTTCCTGCGCGCCGAGCGCTCGCTGATTCAGACGATTGGCCGGGCGGCGCGCCATGTGCGCGGA
CAGGTGATCATGTACGCCGACCGCCTCACCGCCTCGATGGACAAAGCGATCAGCGAGACCGAGCGGCGCCGCCAGATCCA
GAGGGCCTACAACGCAGCGCACGGCCTCACCCCCCAACCCATCGTCAAGCGCCTGGATGCCAACAGCATCCTCGACTATC
TGGCAGTTTCCCGCCGCCTCAACCAGCAGGAACTCGAAGCTGCCGCCGCCGCCCCGGCGGAAGTGGCCCTGGCCGATATT
CCCGAACTGGTGTCGCAGCTGGAGATCCAGATGCGCGATGCGGCCAAGAAGCTGGAGTTCGAGAAAGCCGCCGAGTACCG
CGATAAAATCCATAAGCTGCGCGAGCGGCTTTTGGGCAAGTAA

Upstream 100 bases:

>100_bases
AACACGAAGCGGGGGCGATGGAAACGGCCGCCGCCGATCCGGACGGCCGGGGGCGGCAGAGGCTACAATAGGAAACAGGT
TGTGAACTTTTGGACACGCA

Downstream 100 bases:

>100_bases
CGAGGCCATCAATTTTCGGGGGGTACTTGCTGCATCTGTGTTGCTGAGCGCTTTCCAGCCCGTGCCGGGTCGGTAGCGTT
CCCTCGCGGGCGCGCTTCCC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 680; Mature: 679

Protein sequence:

>680_residues
MTDDRFVVSAPYRPTGDQPRAIAQLSAGALGGVTFQTLLGATGTGKTFTIANVIEKVGKPTLVLAHNKTLAAQLCNELRE
FFPDNAVEYFVSYYDYYQPEAYIPQTDTYIEKSASINDEIDMLRHSATRSLFERRDVIVVASVSCIYGLGMPEEYLRAAI
PLKVGSNIDQRELLRQLVTVQYERNDIDLGRGRFRVRGDVVEIGPAYEDRIIRVEFFGDEVEAVRWLDPVTGEVVRSVNS
LNIYPAKHFVTPEEQLEQACIAIEQELEARVAELEGENKLLEAQRIKQRTRYDLEMLREVGYCNGVENYSRHLAARRPGE
APSCLIDYFPQDWLLVVDESHVTIPQIRGMYNGDAQRKKVLIDHGFRLPSAADNRPLKAPEFWDKVRQAIFVSATPGDWE
VELSGGGRDPETGRMAGEHVAEQIIRPTGVLDPEVFVRPVAGQVDDLLHEIHDRVARRERVLVTTLTKRMAEDLTEYFQE
RGVKVRYLHSEIQAIERIEILQALRQGDFDVLIGVNLLREGLDLPEVSLVAILDADKEGFLRAERSLIQTIGRAARHVRG
QVIMYADRLTASMDKAISETERRRQIQRAYNAAHGLTPQPIVKRLDANSILDYLAVSRRLNQQELEAAAAAPAEVALADI
PELVSQLEIQMRDAAKKLEFEKAAEYRDKIHKLRERLLGK

Sequences:

>Translated_680_residues
MTDDRFVVSAPYRPTGDQPRAIAQLSAGALGGVTFQTLLGATGTGKTFTIANVIEKVGKPTLVLAHNKTLAAQLCNELRE
FFPDNAVEYFVSYYDYYQPEAYIPQTDTYIEKSASINDEIDMLRHSATRSLFERRDVIVVASVSCIYGLGMPEEYLRAAI
PLKVGSNIDQRELLRQLVTVQYERNDIDLGRGRFRVRGDVVEIGPAYEDRIIRVEFFGDEVEAVRWLDPVTGEVVRSVNS
LNIYPAKHFVTPEEQLEQACIAIEQELEARVAELEGENKLLEAQRIKQRTRYDLEMLREVGYCNGVENYSRHLAARRPGE
APSCLIDYFPQDWLLVVDESHVTIPQIRGMYNGDAQRKKVLIDHGFRLPSAADNRPLKAPEFWDKVRQAIFVSATPGDWE
VELSGGGRDPETGRMAGEHVAEQIIRPTGVLDPEVFVRPVAGQVDDLLHEIHDRVARRERVLVTTLTKRMAEDLTEYFQE
RGVKVRYLHSEIQAIERIEILQALRQGDFDVLIGVNLLREGLDLPEVSLVAILDADKEGFLRAERSLIQTIGRAARHVRG
QVIMYADRLTASMDKAISETERRRQIQRAYNAAHGLTPQPIVKRLDANSILDYLAVSRRLNQQELEAAAAAPAEVALADI
PELVSQLEIQMRDAAKKLEFEKAAEYRDKIHKLRERLLGK
>Mature_679_residues
TDDRFVVSAPYRPTGDQPRAIAQLSAGALGGVTFQTLLGATGTGKTFTIANVIEKVGKPTLVLAHNKTLAAQLCNELREF
FPDNAVEYFVSYYDYYQPEAYIPQTDTYIEKSASINDEIDMLRHSATRSLFERRDVIVVASVSCIYGLGMPEEYLRAAIP
LKVGSNIDQRELLRQLVTVQYERNDIDLGRGRFRVRGDVVEIGPAYEDRIIRVEFFGDEVEAVRWLDPVTGEVVRSVNSL
NIYPAKHFVTPEEQLEQACIAIEQELEARVAELEGENKLLEAQRIKQRTRYDLEMLREVGYCNGVENYSRHLAARRPGEA
PSCLIDYFPQDWLLVVDESHVTIPQIRGMYNGDAQRKKVLIDHGFRLPSAADNRPLKAPEFWDKVRQAIFVSATPGDWEV
ELSGGGRDPETGRMAGEHVAEQIIRPTGVLDPEVFVRPVAGQVDDLLHEIHDRVARRERVLVTTLTKRMAEDLTEYFQER
GVKVRYLHSEIQAIERIEILQALRQGDFDVLIGVNLLREGLDLPEVSLVAILDADKEGFLRAERSLIQTIGRAARHVRGQ
VIMYADRLTASMDKAISETERRRQIQRAYNAAHGLTPQPIVKRLDANSILDYLAVSRRLNQQELEAAAAAPAEVALADIP
ELVSQLEIQMRDAAKKLEFEKAAEYRDKIHKLRERLLGK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=684, Percent_Identity=56.578947368421, Blast_Score=753, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_GLOVI (Q7NJH7)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_924801.1
- ProteinModelPortal:   Q7NJH7
- GeneID:   2600257
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.1855
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- ProtClustDB:   PRK05298
- BioCyc:   GVIO251221:GLL1855-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 76910; Mature: 76778

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDDRFVVSAPYRPTGDQPRAIAQLSAGALGGVTFQTLLGATGTGKTFTIANVIEKVGKP
CCCCCEEEECCCCCCCCCCHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEHHHHHHHHCCC
TLVLAHNKTLAAQLCNELREFFPDNAVEYFVSYYDYYQPEAYIPQTDTYIEKSASINDEI
EEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCHHH
DMLRHSATRSLFERRDVIVVASVSCIYGLGMPEEYLRAAIPLKVGSNIDQRELLRQLVTV
HHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHHHHHCCHHCCCCCCHHHHHHHHHHH
QYERNDIDLGRGRFRVRGDVVEIGPAYEDRIIRVEFFGDEVEAVRWLDPVTGEVVRSVNS
HHCCCCCCCCCCEEEEECCEEEECCCCCCCEEEEEEECCHHHHHHHCCCHHHHHHHHHHC
LNIYPAKHFVTPEEQLEQACIAIEQELEARVAELEGENKLLEAQRIKQRTRYDLEMLREV
CEEECCHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
GYCNGVENYSRHLAARRPGEAPSCLIDYFPQDWLLVVDESHVTIPQIRGMYNGDAQRKKV
HCCCCHHHHHHHHHHCCCCCCCHHHHHCCCCCEEEEECCCCCCHHHHCCCCCCCHHHHHH
LIDHGFRLPSAADNRPLKAPEFWDKVRQAIFVSATPGDWEVELSGGGRDPETGRMAGEHV
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHEEEEECCCCEEEEECCCCCCCCCCHHHHHHH
AEQIIRPTGVLDPEVFVRPVAGQVDDLLHEIHDRVARRERVLVTTLTKRMAEDLTEYFQE
HHHHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGVKVRYLHSEIQAIERIEILQALRQGDFDVLIGVNLLREGLDLPEVSLVAILDADKEGF
CCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCCEEEEEEEECCCHHH
LRAERSLIQTIGRAARHVRGQVIMYADRLTASMDKAISETERRRQIQRAYNAAHGLTPQP
HHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IVKRLDANSILDYLAVSRRLNQQELEAAAAAPAEVALADIPELVSQLEIQMRDAAKKLEF
HHHHCCHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKAAEYRDKIHKLRERLLGK
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TDDRFVVSAPYRPTGDQPRAIAQLSAGALGGVTFQTLLGATGTGKTFTIANVIEKVGKP
CCCCEEEECCCCCCCCCCHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEHHHHHHHHCCC
TLVLAHNKTLAAQLCNELREFFPDNAVEYFVSYYDYYQPEAYIPQTDTYIEKSASINDEI
EEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCHHH
DMLRHSATRSLFERRDVIVVASVSCIYGLGMPEEYLRAAIPLKVGSNIDQRELLRQLVTV
HHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHHHHHCCHHCCCCCCHHHHHHHHHHH
QYERNDIDLGRGRFRVRGDVVEIGPAYEDRIIRVEFFGDEVEAVRWLDPVTGEVVRSVNS
HHCCCCCCCCCCEEEEECCEEEECCCCCCCEEEEEEECCHHHHHHHCCCHHHHHHHHHHC
LNIYPAKHFVTPEEQLEQACIAIEQELEARVAELEGENKLLEAQRIKQRTRYDLEMLREV
CEEECCHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
GYCNGVENYSRHLAARRPGEAPSCLIDYFPQDWLLVVDESHVTIPQIRGMYNGDAQRKKV
HCCCCHHHHHHHHHHCCCCCCCHHHHHCCCCCEEEEECCCCCCHHHHCCCCCCCHHHHHH
LIDHGFRLPSAADNRPLKAPEFWDKVRQAIFVSATPGDWEVELSGGGRDPETGRMAGEHV
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHEEEEECCCCEEEEECCCCCCCCCCHHHHHHH
AEQIIRPTGVLDPEVFVRPVAGQVDDLLHEIHDRVARRERVLVTTLTKRMAEDLTEYFQE
HHHHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGVKVRYLHSEIQAIERIEILQALRQGDFDVLIGVNLLREGLDLPEVSLVAILDADKEGF
CCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCCEEEEEEEECCCHHH
LRAERSLIQTIGRAARHVRGQVIMYADRLTASMDKAISETERRRQIQRAYNAAHGLTPQP
HHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IVKRLDANSILDYLAVSRRLNQQELEAAAAAPAEVALADIPELVSQLEIQMRDAAKKLEF
HHHHCCHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKAAEYRDKIHKLRERLLGK
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292