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The map label for this gene is tuaD [H]

Identifier: 37521367

GI number: 37521367

Start: 1916929

End: 1918305

Strand: Reverse

Name: tuaD [H]

Synonym: gll1798

Alternate gene names: 37521367

Gene position: 1918305-1916929 (Counterclockwise)

Preceding gene: 37521374

Following gene: 37521366

Centisome position: 41.17

GC content: 64.78

Gene sequence:

>1377_bases
ATGAGAGTCGGAGTCATCGGTACCGGGTATGTCGGTCTGGTCACGGGCGCCTGTCTGGCTGCAGTGGGCCATCGGGTGCG
CTGCATGGACAACGATGCGCTCAAAATCGAGCGTCTACGCCGCGGGGTGATTCCGATCCACGAACCCGGTCTGGAGGATA
TCGTTCAGCGTACCAGCGCGAACGGATCGCTCGAATTTACGGCGGATCTGGCGGAGGTGGCGCGTGGCAGCGAAATCATC
TTCATTACCGTCGGTACCCCATCGCGTGCGGACGGCTCGCCGGATCTGACGGCGGTGCGGGCGGTGGCCCGGGGTATCGG
CAGCCACCTCGATGGGAGCTACCGAGTGATTGTGAACAAGTCGACCGTCCCGGTCGGGTCGGGCAACTGGGTGCGGATGC
TCGTCGAAGAGGGAGCGCGGCAACTGGAAGGAGCGACGGTGGTCGGTGCGCCGGGAGTGAGTACTGCCCATCCGGTCGAG
CCCGCCTTCGATGTGGTGAGCAACCCCGAATTTTTGCGCGAAGGGTCGGCGGTCTGGGACACCTTCAATCCCGACCGCAT
CGTGATCGGGGCAGAATGTGAGCAGGCCGTGGCTGTGATGCGCGAACTGTATGCCCACTGGATTGCGCCCGAACCGCTGG
GTAGGGCCTTGCCGCTGGTGGTGACCGACCTCGCCTCCGCCGAGATGATCAAGTACGCCGCCAACGCCTTCCTGGCCACG
AAGATTTCCTTTGTCAACGAAATGGCCAACATCTGTGAGCGCGTCGGCGCCGATGTACAGCAGGTGGCCGAGGCCATCGG
CCTCGACAAGCGCATCGGTCGGGCGTTTTTGAACGCTGGGGCGGGCTGGGGCGGCTCGTGCTTTCCAAAAGATGTCTCAG
CCCTGGTCAGTACCGGCCGGGAGTACGGCTACGAGTGCGCGCTGCTCAAAGCGACCCTCTCCGTCAATGAGGCGCAGAAG
CAGAGCGTCGTCGAGAAGCTGCAGCGGGAATTGCGCATCCTCAAGGGGCGGACGGTGGCGATTTGGGGATTGGCCTTCAA
ACCCCACACCGATGACATTCGCTGCGCACCGGCGCTTGAGGTGGCCGAGCAGCTCGTCGCCCTGGGTTGCCGGGTGGTGG
CGCACGATCCGGTCGTACCCAGCGAGCGGGCGCGCGAACAGCTGCCGGAAATGCAGGTGGCGGCCGACCCACTCGCGGCT
GCAGCCCAGGCGGATGCCCTGGTGGTGATGACCGAATGGCCGCTCTACAGCGAGATTGATCTGAGTGTATTGCGCCGTCG
CCTGCGCCAGCCCATTCTCATTGACGGGCGCAACTGTCTCGACGCCGCCGCCGCTCGGGCGGCGGGCTTGACCTATATCG
GCGTCGGACGCCCCTGA

Upstream 100 bases:

>100_bases
AGGCTGTGCCTTGCCCCCGCCGGCAAAGACGTGGGGGGGGGGCTGACGAGCGCTCCCCGGGCGGGTCCGGACTTTGCTAA
ATCACACAGGAAGCAATCGC

Downstream 100 bases:

>100_bases
CTGAGGTCTCTAGGTCCGAATTGAGCAAGAGTTCAAAGGAGGAAGCCATGCAACGCGCTTGCCGGAACAAGCGTCGATTG
GGTATCGGATGGCTCGCGCT

Product: UDP-glucose dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; Teichuronic acid biosynthesis protein tuaD [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MRVGVIGTGYVGLVTGACLAAVGHRVRCMDNDALKIERLRRGVIPIHEPGLEDIVQRTSANGSLEFTADLAEVARGSEII
FITVGTPSRADGSPDLTAVRAVARGIGSHLDGSYRVIVNKSTVPVGSGNWVRMLVEEGARQLEGATVVGAPGVSTAHPVE
PAFDVVSNPEFLREGSAVWDTFNPDRIVIGAECEQAVAVMRELYAHWIAPEPLGRALPLVVTDLASAEMIKYAANAFLAT
KISFVNEMANICERVGADVQQVAEAIGLDKRIGRAFLNAGAGWGGSCFPKDVSALVSTGREYGYECALLKATLSVNEAQK
QSVVEKLQRELRILKGRTVAIWGLAFKPHTDDIRCAPALEVAEQLVALGCRVVAHDPVVPSERAREQLPEMQVAADPLAA
AAQADALVVMTEWPLYSEIDLSVLRRRLRQPILIDGRNCLDAAAARAAGLTYIGVGRP

Sequences:

>Translated_458_residues
MRVGVIGTGYVGLVTGACLAAVGHRVRCMDNDALKIERLRRGVIPIHEPGLEDIVQRTSANGSLEFTADLAEVARGSEII
FITVGTPSRADGSPDLTAVRAVARGIGSHLDGSYRVIVNKSTVPVGSGNWVRMLVEEGARQLEGATVVGAPGVSTAHPVE
PAFDVVSNPEFLREGSAVWDTFNPDRIVIGAECEQAVAVMRELYAHWIAPEPLGRALPLVVTDLASAEMIKYAANAFLAT
KISFVNEMANICERVGADVQQVAEAIGLDKRIGRAFLNAGAGWGGSCFPKDVSALVSTGREYGYECALLKATLSVNEAQK
QSVVEKLQRELRILKGRTVAIWGLAFKPHTDDIRCAPALEVAEQLVALGCRVVAHDPVVPSERAREQLPEMQVAADPLAA
AAQADALVVMTEWPLYSEIDLSVLRRRLRQPILIDGRNCLDAAAARAAGLTYIGVGRP
>Mature_458_residues
MRVGVIGTGYVGLVTGACLAAVGHRVRCMDNDALKIERLRRGVIPIHEPGLEDIVQRTSANGSLEFTADLAEVARGSEII
FITVGTPSRADGSPDLTAVRAVARGIGSHLDGSYRVIVNKSTVPVGSGNWVRMLVEEGARQLEGATVVGAPGVSTAHPVE
PAFDVVSNPEFLREGSAVWDTFNPDRIVIGAECEQAVAVMRELYAHWIAPEPLGRALPLVVTDLASAEMIKYAANAFLAT
KISFVNEMANICERVGADVQQVAEAIGLDKRIGRAFLNAGAGWGGSCFPKDVSALVSTGREYGYECALLKATLSVNEAQK
QSVVEKLQRELRILKGRTVAIWGLAFKPHTDDIRCAPALEVAEQLVALGCRVVAHDPVVPSERAREQLPEMQVAADPLAA
AAQADALVVMTEWPLYSEIDLSVLRRRLRQPILIDGRNCLDAAAARAAGLTYIGVGRP

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=477, Percent_Identity=31.6561844863732, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI296040438, Length=374, Percent_Identity=33.1550802139037, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI296040443, Length=304, Percent_Identity=35.5263157894737, Blast_Score=181, Evalue=1e-45,
Organism=Escherichia coli, GI1788340, Length=413, Percent_Identity=26.8765133171913, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI48994968, Length=369, Percent_Identity=28.9972899728997, Blast_Score=119, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17560350, Length=491, Percent_Identity=33.6048879837067, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI17136908, Length=490, Percent_Identity=32.6530612244898, Blast_Score=243, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 48937; Mature: 48937

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVGVIGTGYVGLVTGACLAAVGHRVRCMDNDALKIERLRRGVIPIHEPGLEDIVQRTSA
CEEEEEECCHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHCC
NGSLEFTADLAEVARGSEIIFITVGTPSRADGSPDLTAVRAVARGIGSHLDGSYRVIVNK
CCCEEEEHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEC
STVPVGSGNWVRMLVEEGARQLEGATVVGAPGVSTAHPVEPAFDVVSNPEFLREGSAVWD
CCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCHHHHHHCCHHHHHCCCCEEC
TFNPDRIVIGAECEQAVAVMRELYAHWIAPEPLGRALPLVVTDLASAEMIKYAANAFLAT
CCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KISFVNEMANICERVGADVQQVAEAIGLDKRIGRAFLNAGAGWGGSCFPKDVSALVSTGR
HHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCH
EYGYECALLKATLSVNEAQKQSVVEKLQRELRILKGRTVAIWGLAFKPHTDDIRCAPALE
HCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCHHHH
VAEQLVALGCRVVAHDPVVPSERAREQLPEMQVAADPLAAAAQADALVVMTEWPLYSEID
HHHHHHHHCCEEEECCCCCCCHHHHHHCCCHHHHHCHHHHHHCCCEEEEEECCCCCCCCC
LSVLRRRLRQPILIDGRNCLDAAAARAAGLTYIGVGRP
HHHHHHHHCCCEEECCCHHHHHHHHHHCCCEEEECCCC
>Mature Secondary Structure
MRVGVIGTGYVGLVTGACLAAVGHRVRCMDNDALKIERLRRGVIPIHEPGLEDIVQRTSA
CEEEEEECCHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHCC
NGSLEFTADLAEVARGSEIIFITVGTPSRADGSPDLTAVRAVARGIGSHLDGSYRVIVNK
CCCEEEEHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEC
STVPVGSGNWVRMLVEEGARQLEGATVVGAPGVSTAHPVEPAFDVVSNPEFLREGSAVWD
CCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCHHHHHHCCHHHHHCCCCEEC
TFNPDRIVIGAECEQAVAVMRELYAHWIAPEPLGRALPLVVTDLASAEMIKYAANAFLAT
CCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KISFVNEMANICERVGADVQQVAEAIGLDKRIGRAFLNAGAGWGGSCFPKDVSALVSTGR
HHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCH
EYGYECALLKATLSVNEAQKQSVVEKLQRELRILKGRTVAIWGLAFKPHTDDIRCAPALE
HCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCHHHH
VAEQLVALGCRVVAHDPVVPSERAREQLPEMQVAADPLAAAAQADALVVMTEWPLYSEID
HHHHHHHHCCEEEECCCCCCCHHHHHHCCCHHHHHCHHHHHHCCCEEEEEECCCCCCCCC
LSVLRRRLRQPILIDGRNCLDAAAARAAGLTYIGVGRP
HHHHHHHHCCCEEECCCHHHHHHHHHHCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10048024; 9384377; 10376820 [H]