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The map label for this gene is lysC [H]

Identifier: 37521343

GI number: 37521343

Start: 1885007

End: 1886812

Strand: Reverse

Name: lysC [H]

Synonym: gll1774

Alternate gene names: 37521343

Gene position: 1886812-1885007 (Counterclockwise)

Preceding gene: 37521346

Following gene: 37521339

Centisome position: 40.5

GC content: 66.83

Gene sequence:

>1806_bases
GTGGGCCTCATCGTTCAGAAGTACGGCGGCACATCGGTGGGCAGCGCCGAACGGATGCGCTCGGTGGCCGAGCGCATCGC
CCGCACCCACCGCCAGGGACACGATCTGGTCGTGGTCGTCTCGGCGATGGGCCACACCACCGACGCCCTGGTCAAAATGG
CCTGCGAGATGCACGGCGAGCCGGACCCGCGCGAGATGGACATGCTGCTCACCACCGGCGAGCAGCAGAGCGTGGCGCTC
TTGACCATGGCGCTGCACGCCTTGGGTTGCAAGGCGATTTCGCTGACCGGTGCCCAGGTGGGTGTCGTCACCGAACCCAA
CCACACCCGGGCACGCATCCGCAGGGTGCAGACAGGCCGCATCAACGAGCTTCTGGCTGCCGGGTACGTGCTGGTGGTGG
CCGGCTTTCAGGGCATCTGCCACTCGCGCTTCTGGGAAATTACGACGCTGGGCCGGGGCGGGTCCGACACCAGCGCCGTG
GCTCTCGCGGCCGTGCTCAAGGCCAACCGCTGCGAAATTTATACCGACGTGCCGGGGGTACTGACCACCGATCCGCGCCT
GGTGGGCGATGCCGCCTTGCTCGAGGAAATCACCAGCGAGGAGATGCTGGAATTGGCGAGCCTGGGTGCCCAGGTGCTCC
ATCCGCGCGCCGTCGAGATTGCCCGCAACTACGCGGTGCCGTTGGTGGTGCGCTCCAGTTGGAGCGACGCCCCCGGTACG
ATTGTGCTCTCGCCCCGTCTGCCGGTGGACCGGGCCATCGACAATCTGGAGACCGAGCGGCCGGTAGACGCCGTCTACAT
CGACAACCATCAGGCAAAAATTGCGCTGTTGCGCGTTCCGGACCGTCCCGGTGTGGCGGCGGCCCTTTTTGGGCACCTGG
CCAAGGCGGGGATCGATGTGGACCTGATTATCCAGTCCATCCACCACCCGAATGCTCCGGAACCCACCAACGACATTGCC
TTTACGGTCCAGCGCTCGGATCTGGCCGCTGCGGTCGCCACGAGCGAAACGGCCGCCGCCGCGCTGGGCGGTTGCGCGGT
GGTGGTGGACCCGGTGCCCACCAAAGTGAGCATCCGCGGCGCCGGGATCATCGGACGACCGGGTGTGGTCGCCCAGATGT
TCAAAGCCCTAGCCGAGGCGCGGATCAATATCCAGATGATTTCGACTTCCGAAACCAGCCTCAGCTGCGTGATTGCAGGC
GAGCAGGCCGAGAAGGCGGGCGAGGTGCTCTGTGGCCAGTTCGGCCTGCGCGCGCCGGTCTACGAGGAACCGCCGGTGGT
GAGCGGCGCGCGGCCGGTCGCCCAGGCGGTGCGCGGCGTAGCCCTCGACACCAATCAAGCCCAGGTAGCGATTTTGCAGA
TACCCGACCGGCCCGGGGTGGCGGCGGAGATCTTTCAGTGTCTGGCCCAAGAAGGGATTGCCGTCGACATGATCGTCCAA
TCGCAGCGCGGGGCCGACACCAACGACATCGGCTTTACGGTCAGCCGCTCCGCCGTGCGCGCGGCCCAACGCGCCCTCGC
TTCTTTGTGCATGGGCTTCGCAGGCTGTGGCGGGGTGGTCGTGCGCGAATCGGTGGCCAAACTCAGCCTGGTGGGAGCGG
GCATCGTCGGCACCCCGGGGGTGGCCGCCCGCATGTTCGAGACGCTTGCGAGTCTCGGCACCAACATCGAGATGATCTCC
ACCTCGACTATCAAGGTGAGCTGCATCGTGGAGGCTGCTTGCTGCGAAGCGTCTCTCCAGGCGGTGCACCGGGCCTTCGG
CCTGGGTAGCGGGGCGATGGTCGCGGTGGAAGGCCGCAGCAGCTAG

Upstream 100 bases:

>100_bases
CAACATACTGCCCACCTGCGGGGAGGGTCGGTGAATCCCTTGTGTCCTGGAGCAGCGTACCGGTAGACTCGTGGGGATCT
GTCGGCAACCGAATTTTTCC

Downstream 100 bases:

>100_bases
AAAACCAAATGGGAATTCAACCCAGCCCACTTGGCAAACCGAACCGATCGGCAGATGGGGCTCCCAGACGTCGACGAGAC
GCTTGTTACCATCGTGTCGA

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 601; Mature: 600

Protein sequence:

>601_residues
MGLIVQKYGGTSVGSAERMRSVAERIARTHRQGHDLVVVVSAMGHTTDALVKMACEMHGEPDPREMDMLLTTGEQQSVAL
LTMALHALGCKAISLTGAQVGVVTEPNHTRARIRRVQTGRINELLAAGYVLVVAGFQGICHSRFWEITTLGRGGSDTSAV
ALAAVLKANRCEIYTDVPGVLTTDPRLVGDAALLEEITSEEMLELASLGAQVLHPRAVEIARNYAVPLVVRSSWSDAPGT
IVLSPRLPVDRAIDNLETERPVDAVYIDNHQAKIALLRVPDRPGVAAALFGHLAKAGIDVDLIIQSIHHPNAPEPTNDIA
FTVQRSDLAAAVATSETAAAALGGCAVVVDPVPTKVSIRGAGIIGRPGVVAQMFKALAEARINIQMISTSETSLSCVIAG
EQAEKAGEVLCGQFGLRAPVYEEPPVVSGARPVAQAVRGVALDTNQAQVAILQIPDRPGVAAEIFQCLAQEGIAVDMIVQ
SQRGADTNDIGFTVSRSAVRAAQRALASLCMGFAGCGGVVVRESVAKLSLVGAGIVGTPGVAARMFETLASLGTNIEMIS
TSTIKVSCIVEAACCEASLQAVHRAFGLGSGAMVAVEGRSS

Sequences:

>Translated_601_residues
MGLIVQKYGGTSVGSAERMRSVAERIARTHRQGHDLVVVVSAMGHTTDALVKMACEMHGEPDPREMDMLLTTGEQQSVAL
LTMALHALGCKAISLTGAQVGVVTEPNHTRARIRRVQTGRINELLAAGYVLVVAGFQGICHSRFWEITTLGRGGSDTSAV
ALAAVLKANRCEIYTDVPGVLTTDPRLVGDAALLEEITSEEMLELASLGAQVLHPRAVEIARNYAVPLVVRSSWSDAPGT
IVLSPRLPVDRAIDNLETERPVDAVYIDNHQAKIALLRVPDRPGVAAALFGHLAKAGIDVDLIIQSIHHPNAPEPTNDIA
FTVQRSDLAAAVATSETAAAALGGCAVVVDPVPTKVSIRGAGIIGRPGVVAQMFKALAEARINIQMISTSETSLSCVIAG
EQAEKAGEVLCGQFGLRAPVYEEPPVVSGARPVAQAVRGVALDTNQAQVAILQIPDRPGVAAEIFQCLAQEGIAVDMIVQ
SQRGADTNDIGFTVSRSAVRAAQRALASLCMGFAGCGGVVVRESVAKLSLVGAGIVGTPGVAARMFETLASLGTNIEMIS
TSTIKVSCIVEAACCEASLQAVHRAFGLGSGAMVAVEGRSS
>Mature_600_residues
GLIVQKYGGTSVGSAERMRSVAERIARTHRQGHDLVVVVSAMGHTTDALVKMACEMHGEPDPREMDMLLTTGEQQSVALL
TMALHALGCKAISLTGAQVGVVTEPNHTRARIRRVQTGRINELLAAGYVLVVAGFQGICHSRFWEITTLGRGGSDTSAVA
LAAVLKANRCEIYTDVPGVLTTDPRLVGDAALLEEITSEEMLELASLGAQVLHPRAVEIARNYAVPLVVRSSWSDAPGTI
VLSPRLPVDRAIDNLETERPVDAVYIDNHQAKIALLRVPDRPGVAAALFGHLAKAGIDVDLIIQSIHHPNAPEPTNDIAF
TVQRSDLAAAVATSETAAAALGGCAVVVDPVPTKVSIRGAGIIGRPGVVAQMFKALAEARINIQMISTSETSLSCVIAGE
QAEKAGEVLCGQFGLRAPVYEEPPVVSGARPVAQAVRGVALDTNQAQVAILQIPDRPGVAAEIFQCLAQEGIAVDMIVQS
QRGADTNDIGFTVSRSAVRAAQRALASLCMGFAGCGGVVVRESVAKLSLVGAGIVGTPGVAARMFETLASLGTNIEMIST
STIKVSCIVEAACCEASLQAVHRAFGLGSGAMVAVEGRSS

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=351, Percent_Identity=32.4786324786325, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1790455, Length=264, Percent_Identity=32.5757575757576, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1790376, Length=113, Percent_Identity=39.8230088495575, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320893, Length=382, Percent_Identity=25.9162303664921, Blast_Score=94, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 62719; Mature: 62588

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLIVQKYGGTSVGSAERMRSVAERIARTHRQGHDLVVVVSAMGHTTDALVKMACEMHGE
CCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCC
PDPREMDMLLTTGEQQSVALLTMALHALGCKAISLTGAQVGVVTEPNHTRARIRRVQTGR
CCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEECCCEEEEEECCCCHHHHHHHHCCCC
INELLAAGYVLVVAGFQGICHSRFWEITTLGRGGSDTSAVALAAVLKANRCEIYTDVPGV
HHHHHHHCHHHEEHHHHHHHHHHCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCCCC
LTTDPRLVGDAALLEEITSEEMLELASLGAQVLHPRAVEIARNYAVPLVVRSSWSDAPGT
EECCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHCCCCEEEEECCCCCCCCE
IVLSPRLPVDRAIDNLETERPVDAVYIDNHQAKIALLRVPDRPGVAAALFGHLAKAGIDV
EEECCCCCHHHHHHHCCCCCCCCEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCH
DLIIQSIHHPNAPEPTNDIAFTVQRSDLAAAVATSETAAAALGGCAVVVDPVPTKVSIRG
HHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHCCHHHHHHHCCCEEEECCCCCEEEEEC
AGIIGRPGVVAQMFKALAEARINIQMISTSETSLSCVIAGEQAEKAGEVLCGQFGLRAPV
CCCCCCCCHHHHHHHHHHHCEEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHCCCCCCC
YEEPPVVSGARPVAQAVRGVALDTNQAQVAILQIPDRPGVAAEIFQCLAQEGIAVDMIVQ
CCCCCCCCCCHHHHHHHHCEEEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEE
SQRGADTNDIGFTVSRSAVRAAQRALASLCMGFAGCGGVVVRESVAKLSLVGAGIVGTPG
CCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCH
VAARMFETLASLGTNIEMISTSTIKVSCIVEAACCEASLQAVHRAFGLGSGAMVAVEGRS
HHHHHHHHHHHHCCCEEEEEECEEEEEEEEEHHHHHHHHHHHHHHHCCCCCCEEEEECCC
S
C
>Mature Secondary Structure 
GLIVQKYGGTSVGSAERMRSVAERIARTHRQGHDLVVVVSAMGHTTDALVKMACEMHGE
CEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCC
PDPREMDMLLTTGEQQSVALLTMALHALGCKAISLTGAQVGVVTEPNHTRARIRRVQTGR
CCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEECCCEEEEEECCCCHHHHHHHHCCCC
INELLAAGYVLVVAGFQGICHSRFWEITTLGRGGSDTSAVALAAVLKANRCEIYTDVPGV
HHHHHHHCHHHEEHHHHHHHHHHCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCCCC
LTTDPRLVGDAALLEEITSEEMLELASLGAQVLHPRAVEIARNYAVPLVVRSSWSDAPGT
EECCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHCCCCEEEEECCCCCCCCE
IVLSPRLPVDRAIDNLETERPVDAVYIDNHQAKIALLRVPDRPGVAAALFGHLAKAGIDV
EEECCCCCHHHHHHHCCCCCCCCEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCH
DLIIQSIHHPNAPEPTNDIAFTVQRSDLAAAVATSETAAAALGGCAVVVDPVPTKVSIRG
HHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHCCHHHHHHHCCCEEEECCCCCEEEEEC
AGIIGRPGVVAQMFKALAEARINIQMISTSETSLSCVIAGEQAEKAGEVLCGQFGLRAPV
CCCCCCCCHHHHHHHHHHHCEEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHCCCCCCC
YEEPPVVSGARPVAQAVRGVALDTNQAQVAILQIPDRPGVAAEIFQCLAQEGIAVDMIVQ
CCCCCCCCCCHHHHHHHHCEEEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEE
SQRGADTNDIGFTVSRSAVRAAQRALASLCMGFAGCGGVVVRESVAKLSLVGAGIVGTPG
CCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCH
VAARMFETLASLGTNIEMISTSTIKVSCIVEAACCEASLQAVHRAFGLGSGAMVAVEGRS
HHHHHHHHHHHHCCCEEEEEECEEEEEEEEEHHHHHHHHHHHHHHHCCCCCCEEEEECCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]