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The map label for this gene is guaC [C]

Identifier: 37521172

GI number: 37521172

Start: 1718695

End: 1719852

Strand: Direct

Name: guaC [C]

Synonym: glr1603

Alternate gene names: 37521172

Gene position: 1718695-1719852 (Clockwise)

Preceding gene: 37521171

Following gene: 37521173

Centisome position: 36.89

GC content: 66.32

Gene sequence:

>1158_bases
GTGGATATACAAATTGGACGGAGCAAGACCGTTCGCCGCGCATATGGTATCGATGAAATTGCCCTGGTGCCGGGGCGGCG
CACCCTCGATCCCGATCTGGCCGATACCGGCTGGACCATCGGCAACGTCACCCGCGAGATCCCGATCATCGCCTCGGCCA
TGGACGGCGTGGTCGATGTGAAGATGGCCGTCGAGCTCTCCAGGCTCGGCGCCCTGGGCGTCATCAACCTCCAGGGGGTG
CAGACGCGCTACGAGAATCCGACCGAAGTGCTTGCGCGCATCGCCTCGGTGGGCAAAGAAGCGTTCGTCGGCCTGATGCA
GGAACTGTACGCCGAGCCGGTAAAGCCGGAACTGATCCGCCGTCGCATCGAAGAAATCAAAGCGCAAGGGGGCATCGCCT
GCGCCTCCGCCACGCCGCAGGTGGCCGGGCAGTACGGTCCCATCGCCGCCGAGGCGGGTTGCGATCTCTTTTTTGTGCAG
GCGACGGTGGTCTCCACCGCCCACCTGTCGAGCCACGAAACGCTCGATCTGGCCGAATTTTGCGCTGCGATGCCCATTCC
GGTGGTGCTGGGCAACGTCGTCACCTACGAAGTCGCCCTCGATTTGATGCAGGCCGGGGCGGCGGCGGTGCTGGTGGGGA
TCGGCCCGGGGGCCGCCTGCACCAGCCGCGGCGTGCTGGGTGTCGGCATTCCCCAGGCGACGGCGGTTAGCGATTGTGCC
GCGGCCCGCGACGATTATTTTGCCCAGACCGGCCGCTACGTGCCGGTGATTGCCGACGGCGGCCTGGTCACCGGCGGCGA
CATCTGCAAGTGCATCGCCTGCGGTGCCGACGGCGTGATGATCGGCTCGCCCTTCGCCCGGGCGGCCGAGGCTCCCGGCA
ACGGCTTCCACTGGGGCATGGCCACCCCAAGCCCGGTGCTGCCCCGCGGCACGCGCATCAAAGTGGGCACCACCGGCACC
CTCGCCGAGATCCTGCGCGGACCGGCGCGCCTCGACGACGGCACCCACAACCTGCTGGGATCGCTCAAGACTTCGATGGG
CACCCTCGGGGCCAAAGATCTCAAGGAGATGCAGCAAGTCGAGGTCGTCGTCGCCCCTTCGCTTTTGACCGAGGGCAAGG
TTTATCAGAAAGCCCAGCAATTGGGCATGGGCAAGTAG

Upstream 100 bases:

>100_bases
GTGATCCCCTCCCGGTCCTGTCGGCCTGGAGGGGTTTTGGGATCGCGAACGATTCTTGCTATGGTTGGGAAATAGGTGCT
GCCGGGCGGGAGACGAGGCT

Downstream 100 bases:

>100_bases
CAGCGATCCCCGGCCACCAAATCGGCGGGCCGATGGGGCTGGATTTCCCATAACATGGTAGTCATGGATACCCTACGTCC
CACTGCCTTATCCCGCGAAC

Product: inosine 5-monophosphate dehydrogenase

Products: xanthosine 5'-phosphate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MDIQIGRSKTVRRAYGIDEIALVPGRRTLDPDLADTGWTIGNVTREIPIIASAMDGVVDVKMAVELSRLGALGVINLQGV
QTRYENPTEVLARIASVGKEAFVGLMQELYAEPVKPELIRRRIEEIKAQGGIACASATPQVAGQYGPIAAEAGCDLFFVQ
ATVVSTAHLSSHETLDLAEFCAAMPIPVVLGNVVTYEVALDLMQAGAAAVLVGIGPGAACTSRGVLGVGIPQATAVSDCA
AARDDYFAQTGRYVPVIADGGLVTGGDICKCIACGADGVMIGSPFARAAEAPGNGFHWGMATPSPVLPRGTRIKVGTTGT
LAEILRGPARLDDGTHNLLGSLKTSMGTLGAKDLKEMQQVEVVVAPSLLTEGKVYQKAQQLGMGK

Sequences:

>Translated_385_residues
MDIQIGRSKTVRRAYGIDEIALVPGRRTLDPDLADTGWTIGNVTREIPIIASAMDGVVDVKMAVELSRLGALGVINLQGV
QTRYENPTEVLARIASVGKEAFVGLMQELYAEPVKPELIRRRIEEIKAQGGIACASATPQVAGQYGPIAAEAGCDLFFVQ
ATVVSTAHLSSHETLDLAEFCAAMPIPVVLGNVVTYEVALDLMQAGAAAVLVGIGPGAACTSRGVLGVGIPQATAVSDCA
AARDDYFAQTGRYVPVIADGGLVTGGDICKCIACGADGVMIGSPFARAAEAPGNGFHWGMATPSPVLPRGTRIKVGTTGT
LAEILRGPARLDDGTHNLLGSLKTSMGTLGAKDLKEMQQVEVVVAPSLLTEGKVYQKAQQLGMGK
>Mature_385_residues
MDIQIGRSKTVRRAYGIDEIALVPGRRTLDPDLADTGWTIGNVTREIPIIASAMDGVVDVKMAVELSRLGALGVINLQGV
QTRYENPTEVLARIASVGKEAFVGLMQELYAEPVKPELIRRRIEEIKAQGGIACASATPQVAGQYGPIAAEAGCDLFFVQ
ATVVSTAHLSSHETLDLAEFCAAMPIPVVLGNVVTYEVALDLMQAGAAAVLVGIGPGAACTSRGVLGVGIPQATAVSDCA
AARDDYFAQTGRYVPVIADGGLVTGGDICKCIACGADGVMIGSPFARAAEAPGNGFHWGMATPSPVLPRGTRIKVGTTGT
LAEILRGPARLDDGTHNLLGSLKTSMGTLGAKDLKEMQQVEVVVAPSLLTEGKVYQKAQQLGMGK

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. [C

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family [H]

Homologues:

Organism=Homo sapiens, GI156104880, Length=185, Percent_Identity=31.8918918918919, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI66933016, Length=216, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI50541954, Length=369, Percent_Identity=26.0162601626016, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI50541952, Length=369, Percent_Identity=26.0162601626016, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI50541948, Length=369, Percent_Identity=26.0162601626016, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI50541956, Length=369, Percent_Identity=26.0162601626016, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI217035152, Length=111, Percent_Identity=43.2432432432432, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI217035146, Length=111, Percent_Identity=43.2432432432432, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI34328930, Length=111, Percent_Identity=43.2432432432432, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI217035150, Length=111, Percent_Identity=43.2432432432432, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI34328928, Length=111, Percent_Identity=43.2432432432432, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI217035148, Length=111, Percent_Identity=43.2432432432432, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI156616279, Length=111, Percent_Identity=43.2432432432432, Blast_Score=75, Evalue=8e-14,
Organism=Escherichia coli, GI1786293, Length=205, Percent_Identity=35.1219512195122, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1788855, Length=236, Percent_Identity=33.4745762711864, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17560440, Length=188, Percent_Identity=36.1702127659575, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71994385, Length=224, Percent_Identity=32.5892857142857, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71994389, Length=224, Percent_Identity=32.5892857142857, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322012, Length=147, Percent_Identity=34.0136054421769, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323464, Length=147, Percent_Identity=31.9727891156463, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323585, Length=113, Percent_Identity=38.9380530973451, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28571163, Length=170, Percent_Identity=37.6470588235294, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24641071, Length=170, Percent_Identity=37.6470588235294, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24641073, Length=170, Percent_Identity=37.6470588235294, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001093
- InterPro:   IPR005992 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: 1.1.1.205

Molecular weight: Translated: 40009; Mature: 40009

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIQIGRSKTVRRAYGIDEIALVPGRRTLDPDLADTGWTIGNVTREIPIIASAMDGVVDV
CCCCCCCCHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCHHCHHHHCHHHHHHHCCHHHH
KMAVELSRLGALGVINLQGVQTRYENPTEVLARIASVGKEAFVGLMQELYAEPVKPELIR
HHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
RRIEEIKAQGGIACASATPQVAGQYGPIAAEAGCDLFFVQATVVSTAHLSSHETLDLAEF
HHHHHHHHCCCEEEECCCHHHCCCCCCEEHHCCCCEEEEHHHHHHHHHCCCCCCCCHHHH
CAAMPIPVVLGNVVTYEVALDLMQAGAAAVLVGIGPGAACTSRGVLGVGIPQATAVSDCA
HHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHCCCEEEECCCCHHHHHHHH
AARDDYFAQTGRYVPVIADGGLVTGGDICKCIACGADGVMIGSPFARAAEAPGNGFHWGM
HHHHHHHHHCCCEEEEEECCCEEECCHHHHHHCCCCCCEEECCCHHHHHCCCCCCEEECC
ATPSPVLPRGTRIKVGTTGTLAEILRGPARLDDGTHNLLGSLKTSMGTLGAKDLKEMQQV
CCCCCCCCCCCEEEECCCHHHHHHHCCCHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
EVVVAPSLLTEGKVYQKAQQLGMGK
EEEEECHHHHCCHHHHHHHHHCCCC
>Mature Secondary Structure
MDIQIGRSKTVRRAYGIDEIALVPGRRTLDPDLADTGWTIGNVTREIPIIASAMDGVVDV
CCCCCCCCHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCHHCHHHHCHHHHHHHCCHHHH
KMAVELSRLGALGVINLQGVQTRYENPTEVLARIASVGKEAFVGLMQELYAEPVKPELIR
HHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
RRIEEIKAQGGIACASATPQVAGQYGPIAAEAGCDLFFVQATVVSTAHLSSHETLDLAEF
HHHHHHHHCCCEEEECCCHHHCCCCCCEEHHCCCCEEEEHHHHHHHHHCCCCCCCCHHHH
CAAMPIPVVLGNVVTYEVALDLMQAGAAAVLVGIGPGAACTSRGVLGVGIPQATAVSDCA
HHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHCCCEEEECCCCHHHHHHHH
AARDDYFAQTGRYVPVIADGGLVTGGDICKCIACGADGVMIGSPFARAAEAPGNGFHWGM
HHHHHHHHHCCCEEEEEECCCEEECCHHHHHHCCCCCCEEECCCHHHHHCCCCCCEEECC
ATPSPVLPRGTRIKVGTTGTLAEILRGPARLDDGTHNLLGSLKTSMGTLGAKDLKEMQQV
CCCCCCCCCCCEEEECCCHHHHHHHCCCHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
EVVVAPSLLTEGKVYQKAQQLGMGK
EEEEECHHHHCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: inosine 5'-phosphate; NAD+; H2O

Specific reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA