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The map label for this gene is thiD [H]

Identifier: 37521080

GI number: 37521080

Start: 1629061

End: 1629867

Strand: Direct

Name: thiD [H]

Synonym: glr1511

Alternate gene names: 37521080

Gene position: 1629061-1629867 (Clockwise)

Preceding gene: 37521079

Following gene: 37521085

Centisome position: 34.97

GC content: 66.17

Gene sequence:

>807_bases
GTGACGATCGCCCGCGCGCTCACCATCGCCGGGTCCGATTCGGGCGGCGGGGCGGGTCTACAGGCCGACCTGCGCACCTT
CGCCTTTCACAAAGTGCACGGCATGTCCGCCGTCACCTGCCTGACCGCCCAGAACACCCTCGAGGTACAGGGGGTGGTGC
CGGTGGAGCCCGATTTCGTCGCCCTGCAAGTCAAAGCGGTGGTCGGGGATATTGGTCTGGATGCCGTCAAGACGGGCATG
CTGCTGAACGCCGGGATCATCGCCCGGGTCGCCAGGCTGGCTGTCGAGCTGCCTTTGCCGAATCTGGTGGTGGACCCGGT
GATGGTGTCGCGCACGGGTGCCCAGCTCATCGACGATGACGCCGTGGTGGCACTCAAGAGCAAACTGTTGCCTTTGGCGA
TCCTCGTGACGCCCAATTTGCACGAGGCGCGGCTGCTAAGCGGGATCGCCATCGAAACGATTGCCGATATGCAGATAGCT
GCCTACCGGATCGCAGAGCTTGGAGCACGCAGCGTGCTCATCAAAGGCGGTGCCCTCGCGGTCGGACGCGGCACGGATGT
CTGGTACGACGGCGGCGAATGCGTCGTGCTGACGGGCGATACGATCGACACCCCTCACACCCATGGCACCGGCTGCACCC
TGGCCGCGGCGATTGCCGCCAACCTCGCCCTCGGTCTTCCGCTGCGCGAGGCGATCGTGCAAGCCAAAGCCTACGTCACC
GCCGCGCTGCGCCATAGCCTGGCGATTGGCCGCGGCCAGGGACCGGTAGGCCACTTCTGGCCGTTGCTCGGCGATGCCGA
CGGTTAG

Upstream 100 bases:

>100_bases
CCATCGCTTCTCAGACCGACCGGGCACTAGTGATGGTCATGACCGTGGAGGCGATGCAGAAGGTGGCGACTCTCACCGCC
GCGCTCACAACCCTGCTCGC

Downstream 100 bases:

>100_bases
GTTTGGGCGTTCGGTTTGGCAGCCAGGGACTTCAGCGATTCCGCCTCTCGGACTCTGTAGCCGCCGGAGCCTACTTGCAA
GCTGCTTGTCCTGGCCCGGC

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MTIARALTIAGSDSGGGAGLQADLRTFAFHKVHGMSAVTCLTAQNTLEVQGVVPVEPDFVALQVKAVVGDIGLDAVKTGM
LLNAGIIARVARLAVELPLPNLVVDPVMVSRTGAQLIDDDAVVALKSKLLPLAILVTPNLHEARLLSGIAIETIADMQIA
AYRIAELGARSVLIKGGALAVGRGTDVWYDGGECVVLTGDTIDTPHTHGTGCTLAAAIAANLALGLPLREAIVQAKAYVT
AALRHSLAIGRGQGPVGHFWPLLGDADG

Sequences:

>Translated_268_residues
MTIARALTIAGSDSGGGAGLQADLRTFAFHKVHGMSAVTCLTAQNTLEVQGVVPVEPDFVALQVKAVVGDIGLDAVKTGM
LLNAGIIARVARLAVELPLPNLVVDPVMVSRTGAQLIDDDAVVALKSKLLPLAILVTPNLHEARLLSGIAIETIADMQIA
AYRIAELGARSVLIKGGALAVGRGTDVWYDGGECVVLTGDTIDTPHTHGTGCTLAAAIAANLALGLPLREAIVQAKAYVT
AALRHSLAIGRGQGPVGHFWPLLGDADG
>Mature_267_residues
TIARALTIAGSDSGGGAGLQADLRTFAFHKVHGMSAVTCLTAQNTLEVQGVVPVEPDFVALQVKAVVGDIGLDAVKTGML
LNAGIIARVARLAVELPLPNLVVDPVMVSRTGAQLIDDDAVVALKSKLLPLAILVTPNLHEARLLSGIAIETIADMQIAA
YRIAELGARSVLIKGGALAVGRGTDVWYDGGECVVLTGDTIDTPHTHGTGCTLAAAIAANLALGLPLREAIVQAKAYVTA
ALRHSLAIGRGQGPVGHFWPLLGDADG

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=262, Percent_Identity=40.4580152671756, Blast_Score=171, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6325378, Length=268, Percent_Identity=32.4626865671642, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324997, Length=273, Percent_Identity=34.0659340659341, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324517, Length=273, Percent_Identity=32.967032967033, Blast_Score=111, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 27506; Mature: 27375

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIARALTIAGSDSGGGAGLQADLRTFAFHKVHGMSAVTCLTAQNTLEVQGVVPVEPDFV
CCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCCCEE
ALQVKAVVGDIGLDAVKTGMLLNAGIIARVARLAVELPLPNLVVDPVMVSRTGAQLIDDD
EEEEEEECCCCCHHHHHHCHHCCHHHHHHHHHHHHCCCCCCCEECCEEEECCCCHHCCCC
AVVALKSKLLPLAILVTPNLHEARLLSGIAIETIADMQIAAYRIAELGARSVLIKGGALA
HHHEEHHCCCEEEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEE
VGRGTDVWYDGGECVVLTGDTIDTPHTHGTGCTLAAAIAANLALGLPLREAIVQAKAYVT
EECCCEEEECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
AALRHSLAIGRGQGPVGHFWPLLGDADG
HHHHHHHHCCCCCCCCCHHHHCCCCCCC
>Mature Secondary Structure 
TIARALTIAGSDSGGGAGLQADLRTFAFHKVHGMSAVTCLTAQNTLEVQGVVPVEPDFV
CCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCCCEE
ALQVKAVVGDIGLDAVKTGMLLNAGIIARVARLAVELPLPNLVVDPVMVSRTGAQLIDDD
EEEEEEECCCCCHHHHHHCHHCCHHHHHHHHHHHHCCCCCCCEECCEEEECCCCHHCCCC
AVVALKSKLLPLAILVTPNLHEARLLSGIAIETIADMQIAAYRIAELGARSVLIKGGALA
HHHEEHHCCCEEEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEE
VGRGTDVWYDGGECVVLTGDTIDTPHTHGTGCTLAAAIAANLALGLPLREAIVQAKAYVT
EECCCEEEECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
AALRHSLAIGRGQGPVGHFWPLLGDADG
HHHHHHHHCCCCCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA