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The map label for this gene is bioF [C]

Identifier: 37519966

GI number: 37519966

Start: 418932

End: 420098

Strand: Reverse

Name: bioF [C]

Synonym: gvip033

Alternate gene names: 37519966

Gene position: 420098-418932 (Counterclockwise)

Preceding gene: 37519968

Following gene: 37519965

Centisome position: 9.02

GC content: 65.64

Gene sequence:

>1167_bases
GTGGCTGATCCTTACGGATGGATCCGGGCGGATCTTGAGAGCTTGCATCGGGTGGGCTGGTACCGGACGACGCGAACCCA
CAATGGTCTGGCCGGACCGCAAATGGATGTGGACGGCAAGCCGGTGCTTCAGTTTGCAAGCAACGACTATCTGGGCCTCA
GCGGCGATGAACGGCTCATCGAGGCGGCTTGCCGGGCCGTTCGGCTCTACGGCGCCGGGGCGACCGGCTCGCGGCTTCTC
AGTGGTGAGCGCGATGTGCACCGCGAGTTGGAGCAAGCCCTGGCCGGGTGGAAAGGCTGCGATGATTGCCTGGTCTTTTC
GTCGGGTTATCTGGCCAATCTCGGGACGATCCCGGCGCTGGTGGGCAAGCGCGATCTGGTGGTAGGCGACGAGTACAACC
ACGCCTGCCTGCGCGGGGGGGCCGAATTGAGCGGTGCCGTCCACCGGCTTTATCCCCACGGCGATTGCAGCGCCCTGGAA
AGCTTACTGATCGAGCAGCGCGAGCGCCACCGCCGCTGCTTGATCTGCACCGACTCGGTCTTCAGCATGGATGGCGATCT
GATCGATCTGGCCCGCATCGCGGATCTGGCCCGCCGCTACGGGTGCATGCTCTTGGTGGACGAAGCCCACGCTACCGGCG
TGCTCGGCCCTACCGGTGCTGGGGCGGTCGAGCAACTGGGTCTCACCCGCTCCCTGGTGCAGATGGGAACGCTCTCGAAG
GCATTGGGCAGCCAGGGCGGCTACGTCTGCGGCAGTGCTGAACTTGTCGACTATCTGCGCAACCGGGCGCGCAGCTTCGT
CTACACGACCGGCCTGGCTCCGGCTGCGGCAGCCGCGGCCCTGGAGGCGGTGCATATTGCCCGCACCGAGACCCCGCGCC
GCGCCCTGCTCCGGCAAAACATCGCTCGCCTGCGCGCGGGTATCGATGAAATCGGCATTGCACAGCTGCCGAGCGATGCG
GCCATCCTTTGCCTGTGGGTGGGCGATATCGAAGCCACCCACTGCTTTGCCGGCGAGCTGTTCGAAGAGGGCATTTTTGC
CCCGGCCGTCCGGCCTCCCACCGTACCGACCAGCCGCATCCGCCTGTCTTTGATGGCTACCCACACCGAGGCGATGATCG
ACTCGCTGATCGCGGCCCTTACACAGGTCTCGTCGCGCTTCTCCTGA

Upstream 100 bases:

>100_bases
GTGAATAAGCTCTCGCACTCTAAGTCGCCAGTCCCCCTGACCGAAAGCGCAGGCCAGTCGCCGTCCGCCGCCGGACATCT
GCAAGTCGGGGTAATGGGGC

Downstream 100 bases:

>100_bases
ATGGCATGCCCCCCTCGCTGAGGAGAAATCAGGCAGGTGCAGCCCCTTGACAGGCGACACGGTATCTTAGGCTACAACTT
CGAACTCACCCAGCGGCCTA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MADPYGWIRADLESLHRVGWYRTTRTHNGLAGPQMDVDGKPVLQFASNDYLGLSGDERLIEAACRAVRLYGAGATGSRLL
SGERDVHRELEQALAGWKGCDDCLVFSSGYLANLGTIPALVGKRDLVVGDEYNHACLRGGAELSGAVHRLYPHGDCSALE
SLLIEQRERHRRCLICTDSVFSMDGDLIDLARIADLARRYGCMLLVDEAHATGVLGPTGAGAVEQLGLTRSLVQMGTLSK
ALGSQGGYVCGSAELVDYLRNRARSFVYTTGLAPAAAAAALEAVHIARTETPRRALLRQNIARLRAGIDEIGIAQLPSDA
AILCLWVGDIEATHCFAGELFEEGIFAPAVRPPTVPTSRIRLSLMATHTEAMIDSLIAALTQVSSRFS

Sequences:

>Translated_388_residues
MADPYGWIRADLESLHRVGWYRTTRTHNGLAGPQMDVDGKPVLQFASNDYLGLSGDERLIEAACRAVRLYGAGATGSRLL
SGERDVHRELEQALAGWKGCDDCLVFSSGYLANLGTIPALVGKRDLVVGDEYNHACLRGGAELSGAVHRLYPHGDCSALE
SLLIEQRERHRRCLICTDSVFSMDGDLIDLARIADLARRYGCMLLVDEAHATGVLGPTGAGAVEQLGLTRSLVQMGTLSK
ALGSQGGYVCGSAELVDYLRNRARSFVYTTGLAPAAAAAALEAVHIARTETPRRALLRQNIARLRAGIDEIGIAQLPSDA
AILCLWVGDIEATHCFAGELFEEGIFAPAVRPPTVPTSRIRLSLMATHTEAMIDSLIAALTQVSSRFS
>Mature_387_residues
ADPYGWIRADLESLHRVGWYRTTRTHNGLAGPQMDVDGKPVLQFASNDYLGLSGDERLIEAACRAVRLYGAGATGSRLLS
GERDVHRELEQALAGWKGCDDCLVFSSGYLANLGTIPALVGKRDLVVGDEYNHACLRGGAELSGAVHRLYPHGDCSALES
LLIEQRERHRRCLICTDSVFSMDGDLIDLARIADLARRYGCMLLVDEAHATGVLGPTGAGAVEQLGLTRSLVQMGTLSKA
LGSQGGYVCGSAELVDYLRNRARSFVYTTGLAPAAAAAALEAVHIARTETPRRALLRQNIARLRAGIDEIGIAQLPSDAA
ILCLWVGDIEATHCFAGELFEEGIFAPAVRPPTVPTSRIRLSLMATHTEAMIDSLIAALTQVSSRFS

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI7657118, Length=389, Percent_Identity=34.1902313624679, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI284448556, Length=415, Percent_Identity=32.0481927710843, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI4758668, Length=364, Percent_Identity=33.2417582417582, Blast_Score=186, Evalue=5e-47,
Organism=Homo sapiens, GI119220554, Length=364, Percent_Identity=33.2417582417582, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI83977440, Length=356, Percent_Identity=32.8651685393258, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI83977444, Length=377, Percent_Identity=32.3607427055703, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI83977442, Length=353, Percent_Identity=33.1444759206799, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI4502025, Length=376, Percent_Identity=31.1170212765957, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI40316939, Length=376, Percent_Identity=31.1170212765957, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI5454084, Length=301, Percent_Identity=27.906976744186, Blast_Score=121, Evalue=1e-27,
Organism=Escherichia coli, GI1790046, Length=391, Percent_Identity=34.5268542199489, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1786993, Length=354, Percent_Identity=36.4406779661017, Blast_Score=184, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71994529, Length=388, Percent_Identity=35.3092783505155, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI32566772, Length=362, Percent_Identity=30.1104972375691, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17560912, Length=316, Percent_Identity=28.1645569620253, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17560914, Length=316, Percent_Identity=28.1645569620253, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI71982617, Length=277, Percent_Identity=29.6028880866426, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71982625, Length=277, Percent_Identity=29.6028880866426, Blast_Score=136, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6320438, Length=415, Percent_Identity=31.0843373493976, Blast_Score=176, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6320267, Length=368, Percent_Identity=30.1630434782609, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6323954, Length=254, Percent_Identity=29.9212598425197, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24662918, Length=378, Percent_Identity=34.1269841269841, Blast_Score=221, Evalue=6e-58,
Organism=Drosophila melanogaster, GI17137420, Length=379, Percent_Identity=31.1345646437995, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI17136286, Length=363, Percent_Identity=26.9972451790634, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24653280, Length=272, Percent_Identity=28.3088235294118, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24653276, Length=272, Percent_Identity=28.3088235294118, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24653278, Length=272, Percent_Identity=28.3088235294118, Blast_Score=135, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIKB_GLOVI (Q7NNL4)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_923343.1
- HSSP:   P12998
- ProteinModelPortal:   Q7NNL4
- GeneID:   2599701
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.397
- HOGENOM:   HBG649839
- OMA:   ANWYRSV
- ProtClustDB:   PRK05958
- BioCyc:   GVIO251221:GLL0397-MONOMER
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR00858

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.3.1.29; =2.3.1.47

Molecular weight: Translated: 41702; Mature: 41571

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: BINDING 22-22 BINDING 134-134 BINDING 182-182 BINDING 354-354

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADPYGWIRADLESLHRVGWYRTTRTHNGLAGPQMDVDGKPVLQFASNDYLGLSGDERLI
CCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCHHHEECCCCCCCCCCHHHHH
EAACRAVRLYGAGATGSRLLSGERDVHRELEQALAGWKGCDDCLVFSSGYLANLGTIPAL
HHHHHHHHEECCCCCCHHHHCCCHHHHHHHHHHHHCCCCCCHHEEECCCCHHHCCCHHHH
VGKRDLVVGDEYNHACLRGGAELSGAVHRLYPHGDCSALESLLIEQRERHRRCLICTDSV
HCCCCEEECCCCCHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEEEEECCH
FSMDGDLIDLARIADLARRYGCMLLVDEAHATGVLGPTGAGAVEQLGLTRSLVQMGTLSK
HHCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
ALGSQGGYVCGSAELVDYLRNRARSFVYTTGLAPAAAAAALEAVHIARTETPRRALLRQN
HHCCCCCEEECHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
IARLRAGIDEIGIAQLPSDAAILCLWVGDIEATHCFAGELFEEGIFAPAVRPPTVPTSRI
HHHHHCCCHHCCHHCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHE
RLSLMATHTEAMIDSLIAALTQVSSRFS
EEEHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ADPYGWIRADLESLHRVGWYRTTRTHNGLAGPQMDVDGKPVLQFASNDYLGLSGDERLI
CCCHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCHHHEECCCCCCCCCCHHHHH
EAACRAVRLYGAGATGSRLLSGERDVHRELEQALAGWKGCDDCLVFSSGYLANLGTIPAL
HHHHHHHHEECCCCCCHHHHCCCHHHHHHHHHHHHCCCCCCHHEEECCCCHHHCCCHHHH
VGKRDLVVGDEYNHACLRGGAELSGAVHRLYPHGDCSALESLLIEQRERHRRCLICTDSV
HCCCCEEECCCCCHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEEEEECCH
FSMDGDLIDLARIADLARRYGCMLLVDEAHATGVLGPTGAGAVEQLGLTRSLVQMGTLSK
HHCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
ALGSQGGYVCGSAELVDYLRNRARSFVYTTGLAPAAAAAALEAVHIARTETPRRALLRQN
HHCCCCCEEECHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
IARLRAGIDEIGIAQLPSDAAILCLWVGDIEATHCFAGELFEEGIFAPAVRPPTVPTSRI
HHHHHCCCHHCCHHCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHE
RLSLMATHTEAMIDSLIAALTQVSSRFS
EEEHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292