Click here to switch to the map view.

The map label for this gene is cobH [H]

Identifier: 37519953

GI number: 37519953

Start: 405587

End: 406183

Strand: Reverse

Name: cobH [H]

Synonym: gvip030

Alternate gene names: 37519953

Gene position: 406183-405587 (Counterclockwise)

Preceding gene: 37519956

Following gene: 37519952

Centisome position: 8.72

GC content: 63.99

Gene sequence:

>597_bases
ATGGACCTTCACCCAATCACCGCCGAAAGTTTCGCCATCATCGATGCTGAAATCGGCGAGCACGCCTTCCCACCCGCCGA
ATATCAGATCGTGCGGCGGGTGATCCACGCGACGGCCGACTTCGAGTACCAACACCTGTTGCGCTTTGAGCACGGAGCGA
TCCCCGCCGCCCTTGCCGCCATTCGGGCACAAACCCCGGTGATCGTCGATGTGCAGATGGTCAAAGTCGGCGTGGCCGGC
AGCCTTGGAGATCATCCTCTTATTTGCGCGCTGGAAGCGGGGATTATCCCGCAGGCGGGTCAGACGCGCACGGAGGCAGG
CTTGCTCGGTCTTAGCGCCCGCTATCCCGAAGCCATTTACGTCATCGGTAACGCTCCTACGGCCCTGCTGGCGCTGGTGG
AGGCGATCCGTGCAGGCCGAGCACATCCGGCGCTGGTGGTGGGCGTGCCGGTGGGTTTTGTGCAGGTGATCCCCGCCAAA
AAAGCCCTCGCCAGTCTGGCTATTCCCCAGATCCGGGTGGAGGGGCGCAAAGGCGGCTCGCCGGTGGCGGCGGCCATCGT
CAACGCCTTGATGGCTCTGAGCACCGCCGCTTCCTGA

Upstream 100 bases:

>100_bases
ATTTTGAGTTTGTGGGCGGTGTCGGCATCGGTCATGGTCGGGCCTCGCGCTACCAGGCCATCGTGCCACCAATCGGGCGG
TCGTGGGATCATTAGAAGGC

Downstream 100 bases:

>100_bases
GGAAGAGCCGCGCTTTGGCTACCGTTGCACCGACGAGGCATTGATTAAGCTGGTGGCATGAATAGCGGTTTTCCTATTTG
TGCTTCTAGTCAGTGACCAG

Product: precorrin-8X methylmutase

Products: hydrogenobyrinate

Alternate protein names: Cobalt-precorrin isomerase; HBA synthase [H]

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MDLHPITAESFAIIDAEIGEHAFPPAEYQIVRRVIHATADFEYQHLLRFEHGAIPAALAAIRAQTPVIVDVQMVKVGVAG
SLGDHPLICALEAGIIPQAGQTRTEAGLLGLSARYPEAIYVIGNAPTALLALVEAIRAGRAHPALVVGVPVGFVQVIPAK
KALASLAIPQIRVEGRKGGSPVAAAIVNALMALSTAAS

Sequences:

>Translated_198_residues
MDLHPITAESFAIIDAEIGEHAFPPAEYQIVRRVIHATADFEYQHLLRFEHGAIPAALAAIRAQTPVIVDVQMVKVGVAG
SLGDHPLICALEAGIIPQAGQTRTEAGLLGLSARYPEAIYVIGNAPTALLALVEAIRAGRAHPALVVGVPVGFVQVIPAK
KALASLAIPQIRVEGRKGGSPVAAAIVNALMALSTAAS
>Mature_198_residues
MDLHPITAESFAIIDAEIGEHAFPPAEYQIVRRVIHATADFEYQHLLRFEHGAIPAALAAIRAQTPVIVDVQMVKVGVAG
SLGDHPLICALEAGIIPQAGQTRTEAGLLGLSARYPEAIYVIGNAPTALLALVEAIRAGRAHPALVVGVPVGFVQVIPAK
KALASLAIPQIRVEGRKGGSPVAAAIVNALMALSTAAS

Specific function: Catalyzes the conversion of cobalt-precorrin-8X to cobyrinic acid; a methyl migration reaction during the transformation of cobalt-precorrin-3 to form cobyrinic acid [H]

COG id: COG2082

COG function: function code H; Precorrin isomerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003722 [H]

Pfam domain/function: PF02570 CbiC [H]

EC number: 5.4.1.2

Molecular weight: Translated: 20548; Mature: 20548

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLHPITAESFAIIDAEIGEHAFPPAEYQIVRRVIHATADFEYQHLLRFEHGAIPAALAA
CCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHH
IRAQTPVIVDVQMVKVGVAGSLGDHPLICALEAGIIPQAGQTRTEAGLLGLSARYPEAIY
HHCCCCEEEEEEEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCHHHEECCCCCCCCEEE
VIGNAPTALLALVEAIRAGRAHPALVVGVPVGFVQVIPAKKALASLAIPQIRVEGRKGGS
EECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCEEHHCHHHHHHHHCCCEEEEECCCCCC
PVAAAIVNALMALSTAAS
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDLHPITAESFAIIDAEIGEHAFPPAEYQIVRRVIHATADFEYQHLLRFEHGAIPAALAA
CCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHH
IRAQTPVIVDVQMVKVGVAGSLGDHPLICALEAGIIPQAGQTRTEAGLLGLSARYPEAIY
HHCCCCEEEEEEEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCHHHEECCCCCCCCEEE
VIGNAPTALLALVEAIRAGRAHPALVVGVPVGFVQVIPAKKALASLAIPQIRVEGRKGGS
EECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCEEHHCHHHHHHHHCCCEEEEECCCCCC
PVAAAIVNALMALSTAAS
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Precorrin 8X

Specific reaction: precorrin-8X = hydrogenobyrinate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]