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The map label for this gene is aqpZ

Identifier: 34498319

GI number: 34498319

Start: 3121368

End: 3122057

Strand: Reverse

Name: aqpZ

Synonym: CV_2864

Alternate gene names: 34498319

Gene position: 3122057-3121368 (Counterclockwise)

Preceding gene: 34498321

Following gene: 34498318

Centisome position: 65.71

GC content: 67.39

Gene sequence:

>690_bases
ATGAAATCGTATGGCGCGGAGTTTCTGGGCACTTTCTGGCTGGTGCTGGGCGGCTGCGGCAGCGCGGTGCTGGCGGCGGG
ATTTCCCAATCTGGGCATAGGCTTCGCCGGCGTGGCGCTGGCATTCGGCCTGACGGTGGTGACGATGGCTTACGCGATCG
GCCACATTTCCGGCTGCCACCTGAACCCGGCGGTATCCATCGGCCTGTGGGCGGGCGGGCGCTTTCCCGCCGGGCAATTG
GCGCCGTACATCGTGGCGCAGGTGCTGGGCGCCATCGCCGCGGGCGCGGTGCTGTACGTGATCGCCAGCGGCGGAGCCGG
CTTCGACGTGGCCAAGGGCTTCGCTTCCAACGGCTATGCCGAGCATTCGCCGGGCGGCTATTCGCTGCTGGCGGCCCTGG
TGTGCGAGGTGGTGATGACCATGTTTTTCTTATTGGTGATCATGGGCGCCACCGACAAGCGCGCGCCTGCCGGTTTCGCG
CCGTTGGCGATAGGCCTGGCGCTGACCCTGATCCACCTGATCAGCATCCCGGTCACCAATACCTCGGTCAACCCGGCGCG
CAGCACCGGCGTGGCCTTGTTCGTCGGCGGCTGGGCGGTGCAGCAGCTGTGGCTGTTCTGGCTGGCGCCCATCATCGGCG
CGGTGCTGGGCGCGAAGGTGTATCGCCTGATCGCCGGCGAGTCGGAGTAG

Upstream 100 bases:

>100_bases
AACGGCATCCGATCAGGCATCCAGTGCGCATCCGGCGCGCCCGGACGCGGTGAATGGCAGGGCGGGGCCTGGTCTTTTCG
CAACCTGGAGGGGAGAGAAG

Downstream 100 bases:

>100_bases
CCGCCCGCCATCCGGCAACCGCGGCCTAGGCCGCGGTTTTTTTTCGCGCTAAGTAGCTGCCCGCGTGCCGCCTGTTCCGT
GTTGTTCAGGGTATGTCAGG

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MKSYGAEFLGTFWLVLGGCGSAVLAAGFPNLGIGFAGVALAFGLTVVTMAYAIGHISGCHLNPAVSIGLWAGGRFPAGQL
APYIVAQVLGAIAAGAVLYVIASGGAGFDVAKGFASNGYAEHSPGGYSLLAALVCEVVMTMFFLLVIMGATDKRAPAGFA
PLAIGLALTLIHLISIPVTNTSVNPARSTGVALFVGGWAVQQLWLFWLAPIIGAVLGAKVYRLIAGESE

Sequences:

>Translated_229_residues
MKSYGAEFLGTFWLVLGGCGSAVLAAGFPNLGIGFAGVALAFGLTVVTMAYAIGHISGCHLNPAVSIGLWAGGRFPAGQL
APYIVAQVLGAIAAGAVLYVIASGGAGFDVAKGFASNGYAEHSPGGYSLLAALVCEVVMTMFFLLVIMGATDKRAPAGFA
PLAIGLALTLIHLISIPVTNTSVNPARSTGVALFVGGWAVQQLWLFWLAPIIGAVLGAKVYRLIAGESE
>Mature_229_residues
MKSYGAEFLGTFWLVLGGCGSAVLAAGFPNLGIGFAGVALAFGLTVVTMAYAIGHISGCHLNPAVSIGLWAGGRFPAGQL
APYIVAQVLGAIAAGAVLYVIASGGAGFDVAKGFASNGYAEHSPGGYSLLAALVCEVVMTMFFLLVIMGATDKRAPAGFA
PLAIGLALTLIHLISIPVTNTSVNPARSTGVALFVGGWAVQQLWLFWLAPIIGAVLGAKVYRLIAGESE

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family

Homologues:

Organism=Homo sapiens, GI4502179, Length=221, Percent_Identity=35.2941176470588, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI37694062, Length=226, Percent_Identity=37.1681415929204, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI4502183, Length=223, Percent_Identity=37.6681614349776, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI4755125, Length=230, Percent_Identity=33.9130434782609, Blast_Score=110, Evalue=8e-25,
Organism=Homo sapiens, GI4502181, Length=230, Percent_Identity=33.9130434782609, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI6912506, Length=221, Percent_Identity=34.3891402714932, Blast_Score=100, Evalue=9e-22,
Organism=Homo sapiens, GI157266307, Length=245, Percent_Identity=31.8367346938775, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI86792455, Length=223, Percent_Identity=30.4932735426009, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI22538420, Length=238, Percent_Identity=30.672268907563, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI45446752, Length=202, Percent_Identity=33.1683168316832, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI4826645, Length=249, Percent_Identity=29.3172690763052, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI4502187, Length=247, Percent_Identity=27.9352226720648, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI297307120, Length=91, Percent_Identity=38.4615384615385, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1787101, Length=230, Percent_Identity=70.8695652173913, Blast_Score=309, Evalue=1e-85,
Organism=Escherichia coli, GI1790362, Length=255, Percent_Identity=30.1960784313725, Blast_Score=81, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71993722, Length=231, Percent_Identity=31.1688311688312, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17558372, Length=229, Percent_Identity=30.5676855895196, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71992966, Length=240, Percent_Identity=29.1666666666667, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17531431, Length=244, Percent_Identity=29.9180327868852, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17531429, Length=244, Percent_Identity=29.9180327868852, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24652747, Length=229, Percent_Identity=36.6812227074236, Blast_Score=124, Evalue=4e-29,
Organism=Drosophila melanogaster, GI45551084, Length=229, Percent_Identity=36.6812227074236, Blast_Score=124, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24652751, Length=219, Percent_Identity=35.1598173515982, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI19922038, Length=219, Percent_Identity=35.1598173515982, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136672, Length=230, Percent_Identity=29.1304347826087, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24762342, Length=199, Percent_Identity=27.6381909547739, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45550503, Length=228, Percent_Identity=26.3157894736842, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AQPZ_CHRVO (Q7NU39)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_902534.1
- ProteinModelPortal:   Q7NU39
- SMR:   Q7NU39
- GeneID:   2548292
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_2864
- NMPDR:   fig|243365.1.peg.2864
- HOGENOM:   HBG705794
- OMA:   GFGEHSP
- PhylomeDB:   Q7NU39
- ProtClustDB:   PRK05420
- BioCyc:   CVIO243365:CV_2864-MONOMER
- HAMAP:   MF_01146
- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357
- PANTHER:   PTHR19139
- PRINTS:   PR00783
- TIGRFAMs:   TIGR00861

Pfam domain/function: PF00230 MIP

EC number: NA

Molecular weight: Translated: 23229; Mature: 23229

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS00221 MIP; PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1152e318)-; HASH(0x11bb4784)-; HASH(0x11d669e8)-; HASH(0xf91be7c)-; HASH(0x113e5b28)-; HASH(0x1143fd68)-;

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSYGAEFLGTFWLVLGGCGSAVLAAGFPNLGIGFAGVALAFGLTVVTMAYAIGHISGCH
CCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LNPAVSIGLWAGGRFPAGQLAPYIVAQVLGAIAAGAVLYVIASGGAGFDVAKGFASNGYA
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHCCCCC
EHSPGGYSLLAALVCEVVMTMFFLLVIMGATDKRAPAGFAPLAIGLALTLIHLISIPVTN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
TSVNPARSTGVALFVGGWAVQQLWLFWLAPIIGAVLGAKVYRLIAGESE
CCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
>Mature Secondary Structure
MKSYGAEFLGTFWLVLGGCGSAVLAAGFPNLGIGFAGVALAFGLTVVTMAYAIGHISGCH
CCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LNPAVSIGLWAGGRFPAGQLAPYIVAQVLGAIAAGAVLYVIASGGAGFDVAKGFASNGYA
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHCCCCC
EHSPGGYSLLAALVCEVVMTMFFLLVIMGATDKRAPAGFAPLAIGLALTLIHLISIPVTN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
TSVNPARSTGVALFVGGWAVQQLWLFWLAPIIGAVLGAKVYRLIAGESE
CCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14500782