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The map label for this gene is 34498281

Identifier: 34498281

GI number: 34498281

Start: 3077863

End: 3078789

Strand: Reverse

Name: 34498281

Synonym: CV_2826

Alternate gene names: NA

Gene position: 3078789-3077863 (Counterclockwise)

Preceding gene: 34498283

Following gene: 34498280

Centisome position: 64.8

GC content: 68.18

Gene sequence:

>927_bases
ATGAAGCAGGTGGAGATCATCGACTCCCATACCGGGGGCGAACCCACTCGGCTGGTGTTGAGCGGGTTTCCCGCGCTGGC
GGGGGCCACTATGGCGGACAAGCGCGACGCGCTGCGCGAGCGGCACGACCAGTGGCGCCGCGCCTGCCTGCTGGAGCCGC
GCGGCAGCGATGTGCTGGTGGGCGCGCTGTATTGCGAGCCGGTGTCGCCCGACGCCGCCTGCGGGGTGATCTTCTTCAAC
AATACCGGCTACATCGGCATGTGCGGCCACGGCACCATAGGCCTGATCGCCTCCCTGCATTGCCTGGGGCGCATCGCGCC
CGGCGCGCACAAGATCGATACCCCGGTGGGGCCGGTGGACGCCGTCTTGCATGAAGACGGCTCGGTGACGCTGCGCAATG
TGCCGGCCTATCGCTACCGCCGGCAGGCGGCGGTGGAGGTGCCCGGCCATGGAACGGTGATCGGCGACATCGCCTGGGGC
GGCAACTGGTTCTTTCTGGTCGCCGAGCATGGCCTGAGCGTGCGGCTGGACAATGTCGCGGCGCTGAGCGCGTTCAGTTG
CGCCACGATGCAGGCGCTGGAAGAGCAGGGCATCACCGGCGCCGACGGCGCGCGCATCGATCATGTCGAGCTGTTCGCCG
ACGATGAGCAAGCCGACAGCCGCAACTTCGTCATGTGCCCGGGCAAGGCCTACGACCGTTCCCCTTGCGGCACCGGCACC
AGCGCCAAGCTGGCCTGCTTGGCGGCCGACGGCAAGCTGGCCGAAGGCGAGCAATGGGTGCAGGCCGGCATCACCGGCAG
CCGCTTCGTCGGCCATTACCAGCGCGAAGGCGACTTCATCCGCCCCTACATCACCGGCCGCGCCCATATCACGGCCCGCG
CCATGCTGCTGATAGACGAACAAGACCCTTTCGCGTGGGGCATCTGA

Upstream 100 bases:

>100_bases
ATCGAATACGGATGCGGCGCGGAGATTCAATGGAATCAACGGCCTGCGAGACGACGGCGCGGTCGGCCGGACTGGATGGG
GTTTCAGAATGGACAAGCGA

Downstream 100 bases:

>100_bases
GCCCGCGCCTCTCATGACCTCTACCACCTGAATGAATGCCGCAAGGAGCAAAACAATGAGCGATAACATTTTCACCGGCT
GCATCCCGGCCCTGATGACC

Product: proline racemace

Products: NA

Alternate protein names: Hydroxyproline-2-epimerase; PaHyPRE [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MKQVEIIDSHTGGEPTRLVLSGFPALAGATMADKRDALRERHDQWRRACLLEPRGSDVLVGALYCEPVSPDAACGVIFFN
NTGYIGMCGHGTIGLIASLHCLGRIAPGAHKIDTPVGPVDAVLHEDGSVTLRNVPAYRYRRQAAVEVPGHGTVIGDIAWG
GNWFFLVAEHGLSVRLDNVAALSAFSCATMQALEEQGITGADGARIDHVELFADDEQADSRNFVMCPGKAYDRSPCGTGT
SAKLACLAADGKLAEGEQWVQAGITGSRFVGHYQREGDFIRPYITGRAHITARAMLLIDEQDPFAWGI

Sequences:

>Translated_308_residues
MKQVEIIDSHTGGEPTRLVLSGFPALAGATMADKRDALRERHDQWRRACLLEPRGSDVLVGALYCEPVSPDAACGVIFFN
NTGYIGMCGHGTIGLIASLHCLGRIAPGAHKIDTPVGPVDAVLHEDGSVTLRNVPAYRYRRQAAVEVPGHGTVIGDIAWG
GNWFFLVAEHGLSVRLDNVAALSAFSCATMQALEEQGITGADGARIDHVELFADDEQADSRNFVMCPGKAYDRSPCGTGT
SAKLACLAADGKLAEGEQWVQAGITGSRFVGHYQREGDFIRPYITGRAHITARAMLLIDEQDPFAWGI
>Mature_308_residues
MKQVEIIDSHTGGEPTRLVLSGFPALAGATMADKRDALRERHDQWRRACLLEPRGSDVLVGALYCEPVSPDAACGVIFFN
NTGYIGMCGHGTIGLIASLHCLGRIAPGAHKIDTPVGPVDAVLHEDGSVTLRNVPAYRYRRQAAVEVPGHGTVIGDIAWG
GNWFFLVAEHGLSVRLDNVAALSAFSCATMQALEEQGITGADGARIDHVELFADDEQADSRNFVMCPGKAYDRSPCGTGT
SAKLACLAADGKLAEGEQWVQAGITGSRFVGHYQREGDFIRPYITGRAHITARAMLLIDEQDPFAWGI

Specific function: Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting 4- hydroxy-L-proline to 4-hydroxy-D-proline, which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases. Strong B-cell

COG id: COG3938

COG function: function code E; Proline racemase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the proline racemase family. 4- hydroxyproline epimerase subfamily [H]

Homologues:

Organism=Homo sapiens, GI21389361, Length=332, Percent_Identity=33.7349397590361, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008794 [H]

Pfam domain/function: PF05544 Pro_racemase [H]

EC number: =5.1.1.8 [H]

Molecular weight: Translated: 33030; Mature: 33030

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQVEIIDSHTGGEPTRLVLSGFPALAGATMADKRDALRERHDQWRRACLLEPRGSDVLV
CCCEEEEECCCCCCCEEEEEECCCHHHCCCHHHHHHHHHHHHHHHHHHEECCCCCCCEEE
GALYCEPVSPDAACGVIFFNNTGYIGMCGHGTIGLIASLHCLGRIAPGAHKIDTPVGPVD
EEEEECCCCCCCEEEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
AVLHEDGSVTLRNVPAYRYRRQAAVEVPGHGTVIGDIAWGGNWFFLVAEHGLSVRLDNVA
HEEECCCCEEEECCCHHHHHCCEEEECCCCCEEEEEEEECCCEEEEEEECCCEEEECCEE
ALSAFSCATMQALEEQGITGADGARIDHVELFADDEQADSRNFVMCPGKAYDRSPCGTGT
HHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCCEEECCCCCCCCCCCCCCC
SAKLACLAADGKLAEGEQWVQAGITGSRFVGHYQREGDFIRPYITGRAHITARAMLLIDE
CCEEEEEEECCCCCCCHHHHHHCCCHHHHHEEHHCCCCEEEEEECCCEEEEEEEEEEEEC
QDPFAWGI
CCCCCCCC
>Mature Secondary Structure
MKQVEIIDSHTGGEPTRLVLSGFPALAGATMADKRDALRERHDQWRRACLLEPRGSDVLV
CCCEEEEECCCCCCCEEEEEECCCHHHCCCHHHHHHHHHHHHHHHHHHEECCCCCCCEEE
GALYCEPVSPDAACGVIFFNNTGYIGMCGHGTIGLIASLHCLGRIAPGAHKIDTPVGPVD
EEEEECCCCCCCEEEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
AVLHEDGSVTLRNVPAYRYRRQAAVEVPGHGTVIGDIAWGGNWFFLVAEHGLSVRLDNVA
HEEECCCCEEEECCCHHHHHCCEEEECCCCCEEEEEEEECCCEEEEEEECCCEEEECCEE
ALSAFSCATMQALEEQGITGADGARIDHVELFADDEQADSRNFVMCPGKAYDRSPCGTGT
HHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCCEEECCCCCCCCCCCCCCC
SAKLACLAADGKLAEGEQWVQAGITGSRFVGHYQREGDFIRPYITGRAHITARAMLLIDE
CCEEEEEEECCCCCCCHHHHHHCCCHHHHHEEHHCCCCEEEEEECCCEEEEEEEEEEEEC
QDPFAWGI
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]