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The map label for this gene is fadE [H]

Identifier: 34498178

GI number: 34498178

Start: 2951502

End: 2953955

Strand: Reverse

Name: fadE [H]

Synonym: CV_2723

Alternate gene names: 34498178

Gene position: 2953955-2951502 (Counterclockwise)

Preceding gene: 34498179

Following gene: 34498177

Centisome position: 62.17

GC content: 66.34

Gene sequence:

>2454_bases
ATGATTGCTGCCGTTCTTCTGGTCGTGCTGCTCGGCGCGCTGGCTTACTTCGCCGCGCCGGTGCTGGTCTGGACCGTGGG
TGTCGCCGCCTGGCTCGCCGCGCTCCAGTTCGTATTCCACTGTCCGCTGCCTGTCGCCGCCTGGGCGGTTTTCGCCGCGG
TCGCCGCGGTGCTCAACATCGTGCCGCTGCGCCGCGCCGTATTTACCGGCCCGGTATTCGGCGTGTTCAAGAAAATCACG
CCTGCGATGTCGCAGACCGAGCAGGAGGCCATCAACGCCGGCACGGTGTGGTGGGACCGCGACCTGTTCTCCGGCAAGCC
GGATTACCAGCGCCTGCTGTCTTTTCCGGATCCCAAGCTGTCTCCGGAAGAGCAGGCCTTCATCGACGGTCCGACCGAGC
AGCTGTGCGGCATGATCGACGACTGGAAGATCACCCACGAGCTGAAGGATCTGCCGCCGGAAGTTTGGCAGTTCATCAAG
GATCATGGCTTCCTGGGCATGATCGTCAAGAAGAAGTACGGCGGCCTGGAGTTCTCCAACTACGCGCACGCCAAGGTGGT
GACCAAGATCGCCACCCGCGGCGGCACGGCTGCCGTGTCGGTGATGGTGCCCAACTCGCTCGGACCGGGCGAGCTGCTGC
AGCATTACGGCACCGAGGAGCAGAAGGACTACTACCTGCCGCGCCTGGCCAAGGGCGTGGAAGTGCCGTGCTTCGCGCTG
ACCAGCCCGTATGCCGGCTCCGACGCCGGCGCCATCCCGGACTACGGCGTGGTCTGCCGCGGCTCCTACACCCATCCACG
CACCGGCGAACGTTTCGAGAACGTGCTGGGCGTGCGCATCAGCTGGGAGAAGCGCTGGATCACGCTGGCTCCGGTGGCCA
CCATTCTGGGTCTGGCGTTCAAGATGTACGACCCTGAGCATCTGCTGGGCGACAAGGAAGACATCGGCATCACCTGCGCG
CTGGTGCCGACGGAGCACGAGGGCGTCGAAATCGGCCGCCGCCACTTCCCGGGCGGCTCCGCCTTCATGAACGGCCCCAC
CTGGGGCAAGGATGTGTTCATTCCGCTGGACTGGATCATCGGCGGCCGCGACTACGCCGGCCAAGGCTGGCGCATGCTGG
TGGAATGCCTGTCGGTCGGCCGCTGCATCTCGCTGCCGGCGATGTCCGTGGCCTGCGGCAAGCTGACCACCTGGACCACG
GGCGCCTACGCCCGCATCCGCGACCAGTTCGGCCTGCCTATCGGCAAGTTCGAGGGCGTGGACGAGGCGATGGCCCGCAT
CGGCGGCTATACCTACCAGATGGAGGCGTCGCAGGACCTGGCCTTGACCGGCCTGGACAACGGCGAGAAGCCGTCGGTGC
TGTCCGCCATCCTGAAGTACCACAACACCGAGCGCATGCGCAAAACGCTGAACGACGCGATGGACGTGCATGGCGGCAAG
GCCGTGGTGCTGGGTCCGCGCAACTACCTGGCGCGCGGCTACCAGGCGATCCCGATCGGCATCACCGTGGAAGGCGCCAA
CATCCTGACCCGTTCGATGATCATCTACGGCCAGGGCGCGATCCGCTGCCACCCGTTCGTGCTGCGCGAGATGAAGTCGG
CGATGGCCAACGACGGCGCCGAGTTCGACAAGGCGATTACCGGCCACATCAACTTCGTGATCAGCAATTTCGTGCGCTCG
CTGTGGCTGGGCCTGACCGGCGCCTGCCTCGCGTCCAGCCCCAGGGGCGGCGCCACCGCGGCCTACTACAAGCGCGTCAC
CCGCTTGTCCAGCGCCTTCGCGCTGCTGTCCGACATGGCCATGTTCAGCCTGGGCGGCTCGCTGAAGTTCCGGGAGAAGC
TGTCCGCCCGCCTGGGCGACATGCTGTCCGGCCTGTACATCGCCACCGCGTCGCTGAAGCGCTTCGAGCGCGACGGCGCG
CCCAAGGAAGACATCGCCGTGATGAGCTGGGCGGTGGAGAACGCGCTGTACGACGTGCAGGTGGCGATGGACGGCTTCCT
GGCCAACCTGCCCAGCCGCGGCCTGGCCTGGATTCTGCGCCGCGTGATCTTCCCGTGGGGCCTGACGCTGAAGCCGGCGT
CCGACCGCACCGGCACCAAGGTGGCCCGCGCCATGATGGAGCCGGGCGCCACCCGCGAGCGCCTGACCCGCGGCATGTAC
GTGCCTAAGTCCGAGGCGGATCCGGTCGGCGTGCTGGACCACGCCTTGCAAGCCATCCTGGCCACCGAGCCGGTGGAGCA
GAAGCTGCGCAAGCTGGCGCGCGACGGCAAGTTCAAGTCCATCACCGCGCGCGAGCGCCTGGCGGAGGCCTTGCAGACCG
GCCTGATCAACCAGGAAGAATTCGACGCCGTCACCCGAGCCCGCAAGCTGAAGCGCGACGTGATCATGGTGGACGACTTC
GACAAGAAGCTGGAGCAGCATGACGACAAATTGCTGCAGCGCCTGATTTTCTAA

Upstream 100 bases:

>100_bases
GTCTGGTCGCGCCCGTCGAAAGCTGATTCCGCATCGCCCGCCAATTACAACAGCAAGGCGGCGCATGCGGAACTGAGGGG
TCAACACGAGGGTAAACACA

Downstream 100 bases:

>100_bases
TTCGGGCAACGTGGTACCATGCGCCGGATGCCGCATGCATCCGGCGTTGAGCAAAGCGGCCGCGTCCAGCGCGGCTGTTT
TTCTCAGCGCCAGGCTTTTT

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: ACDH [H]

Number of amino acids: Translated: 817; Mature: 817

Protein sequence:

>817_residues
MIAAVLLVVLLGALAYFAAPVLVWTVGVAAWLAALQFVFHCPLPVAAWAVFAAVAAVLNIVPLRRAVFTGPVFGVFKKIT
PAMSQTEQEAINAGTVWWDRDLFSGKPDYQRLLSFPDPKLSPEEQAFIDGPTEQLCGMIDDWKITHELKDLPPEVWQFIK
DHGFLGMIVKKKYGGLEFSNYAHAKVVTKIATRGGTAAVSVMVPNSLGPGELLQHYGTEEQKDYYLPRLAKGVEVPCFAL
TSPYAGSDAGAIPDYGVVCRGSYTHPRTGERFENVLGVRISWEKRWITLAPVATILGLAFKMYDPEHLLGDKEDIGITCA
LVPTEHEGVEIGRRHFPGGSAFMNGPTWGKDVFIPLDWIIGGRDYAGQGWRMLVECLSVGRCISLPAMSVACGKLTTWTT
GAYARIRDQFGLPIGKFEGVDEAMARIGGYTYQMEASQDLALTGLDNGEKPSVLSAILKYHNTERMRKTLNDAMDVHGGK
AVVLGPRNYLARGYQAIPIGITVEGANILTRSMIIYGQGAIRCHPFVLREMKSAMANDGAEFDKAITGHINFVISNFVRS
LWLGLTGACLASSPRGGATAAYYKRVTRLSSAFALLSDMAMFSLGGSLKFREKLSARLGDMLSGLYIATASLKRFERDGA
PKEDIAVMSWAVENALYDVQVAMDGFLANLPSRGLAWILRRVIFPWGLTLKPASDRTGTKVARAMMEPGATRERLTRGMY
VPKSEADPVGVLDHALQAILATEPVEQKLRKLARDGKFKSITARERLAEALQTGLINQEEFDAVTRARKLKRDVIMVDDF
DKKLEQHDDKLLQRLIF

Sequences:

>Translated_817_residues
MIAAVLLVVLLGALAYFAAPVLVWTVGVAAWLAALQFVFHCPLPVAAWAVFAAVAAVLNIVPLRRAVFTGPVFGVFKKIT
PAMSQTEQEAINAGTVWWDRDLFSGKPDYQRLLSFPDPKLSPEEQAFIDGPTEQLCGMIDDWKITHELKDLPPEVWQFIK
DHGFLGMIVKKKYGGLEFSNYAHAKVVTKIATRGGTAAVSVMVPNSLGPGELLQHYGTEEQKDYYLPRLAKGVEVPCFAL
TSPYAGSDAGAIPDYGVVCRGSYTHPRTGERFENVLGVRISWEKRWITLAPVATILGLAFKMYDPEHLLGDKEDIGITCA
LVPTEHEGVEIGRRHFPGGSAFMNGPTWGKDVFIPLDWIIGGRDYAGQGWRMLVECLSVGRCISLPAMSVACGKLTTWTT
GAYARIRDQFGLPIGKFEGVDEAMARIGGYTYQMEASQDLALTGLDNGEKPSVLSAILKYHNTERMRKTLNDAMDVHGGK
AVVLGPRNYLARGYQAIPIGITVEGANILTRSMIIYGQGAIRCHPFVLREMKSAMANDGAEFDKAITGHINFVISNFVRS
LWLGLTGACLASSPRGGATAAYYKRVTRLSSAFALLSDMAMFSLGGSLKFREKLSARLGDMLSGLYIATASLKRFERDGA
PKEDIAVMSWAVENALYDVQVAMDGFLANLPSRGLAWILRRVIFPWGLTLKPASDRTGTKVARAMMEPGATRERLTRGMY
VPKSEADPVGVLDHALQAILATEPVEQKLRKLARDGKFKSITARERLAEALQTGLINQEEFDAVTRARKLKRDVIMVDDF
DKKLEQHDDKLLQRLIF
>Mature_817_residues
MIAAVLLVVLLGALAYFAAPVLVWTVGVAAWLAALQFVFHCPLPVAAWAVFAAVAAVLNIVPLRRAVFTGPVFGVFKKIT
PAMSQTEQEAINAGTVWWDRDLFSGKPDYQRLLSFPDPKLSPEEQAFIDGPTEQLCGMIDDWKITHELKDLPPEVWQFIK
DHGFLGMIVKKKYGGLEFSNYAHAKVVTKIATRGGTAAVSVMVPNSLGPGELLQHYGTEEQKDYYLPRLAKGVEVPCFAL
TSPYAGSDAGAIPDYGVVCRGSYTHPRTGERFENVLGVRISWEKRWITLAPVATILGLAFKMYDPEHLLGDKEDIGITCA
LVPTEHEGVEIGRRHFPGGSAFMNGPTWGKDVFIPLDWIIGGRDYAGQGWRMLVECLSVGRCISLPAMSVACGKLTTWTT
GAYARIRDQFGLPIGKFEGVDEAMARIGGYTYQMEASQDLALTGLDNGEKPSVLSAILKYHNTERMRKTLNDAMDVHGGK
AVVLGPRNYLARGYQAIPIGITVEGANILTRSMIIYGQGAIRCHPFVLREMKSAMANDGAEFDKAITGHINFVISNFVRS
LWLGLTGACLASSPRGGATAAYYKRVTRLSSAFALLSDMAMFSLGGSLKFREKLSARLGDMLSGLYIATASLKRFERDGA
PKEDIAVMSWAVENALYDVQVAMDGFLANLPSRGLAWILRRVIFPWGLTLKPASDRTGTKVARAMMEPGATRERLTRGMY
VPKSEADPVGVLDHALQAILATEPVEQKLRKLARDGKFKSITARERLAEALQTGLINQEEFDAVTRARKLKRDVIMVDDF
DKKLEQHDDKLLQRLIF

Specific function: Catalyzes the dehydrogenation of acyl-CoA [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=562, Percent_Identity=26.5124555160142, Blast_Score=119, Evalue=9e-27,
Organism=Homo sapiens, GI4557235, Length=443, Percent_Identity=23.9277652370203, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI76496475, Length=383, Percent_Identity=25.3263707571802, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI4501859, Length=373, Percent_Identity=26.2734584450402, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI4557233, Length=356, Percent_Identity=26.4044943820225, Blast_Score=73, Evalue=1e-12,
Organism=Escherichia coli, GI87081702, Length=805, Percent_Identity=53.6645962732919, Blast_Score=859, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17506239, Length=277, Percent_Identity=28.158844765343, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17508101, Length=281, Percent_Identity=30.2491103202847, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI32563615, Length=273, Percent_Identity=27.4725274725275, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17538396, Length=339, Percent_Identity=25.0737463126844, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281363737, Length=448, Percent_Identity=24.1071428571429, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24646207, Length=339, Percent_Identity=25.6637168141593, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI21356377, Length=278, Percent_Identity=25.8992805755396, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100
- InterPro:   IPR015396 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N; PF09317 DUF1974 [H]

EC number: 1.3.99.3

Molecular weight: Translated: 89789; Mature: 89789

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAAVLLVVLLGALAYFAAPVLVWTVGVAAWLAALQFVFHCPLPVAAWAVFAAVAAVLNI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
VPLRRAVFTGPVFGVFKKITPAMSQTEQEAINAGTVWWDRDLFSGKPDYQRLLSFPDPKL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHCCCCCCC
SPEEQAFIDGPTEQLCGMIDDWKITHELKDLPPEVWQFIKDHGFLGMIVKKKYGGLEFSN
CCCCCCCCCCCHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHCCCEEEEEECCCCCCCCCC
YAHAKVVTKIATRGGTAAVSVMVPNSLGPGELLQHYGTEEQKDYYLPRLAKGVEVPCFAL
CHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHCCCCCCCCCCCHHHHCCCCCCEEEE
TSPYAGSDAGAIPDYGVVCRGSYTHPRTGERFENVLGVRISWEKRWITLAPVATILGLAF
CCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHCEEEEECCCEEEHHHHHHHHHHHH
KMYDPEHLLGDKEDIGITCALVPTEHEGVEIGRRHFPGGSAFMNGPTWGKDVFIPLDWII
HCCCHHHHCCCCCCCCEEEEEECCCCCCHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEEE
GGRDYAGQGWRMLVECLSVGRCISLPAMSVACGKLTTWTTGAYARIRDQFGLPIGKFEGV
CCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHCCCCEECCCCHHHHHHHHHCCCCHHCCCH
DEAMARIGGYTYQMEASQDLALTGLDNGEKPSVLSAILKYHNTERMRKTLNDAMDVHGGK
HHHHHHHCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCC
AVVLGPRNYLARGYQAIPIGITVEGANILTRSMIIYGQGAIRCHPFVLREMKSAMANDGA
EEEECCHHHHHCCCEEEEEEEEECCCHHHHHEEEEECCCCCEEHHHHHHHHHHHHHCCCH
EFDKAITGHINFVISNFVRSLWLGLTGACLASSPRGGATAAYYKRVTRLSSAFALLSDMA
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
MFSLGGSLKFREKLSARLGDMLSGLYIATASLKRFERDGAPKEDIAVMSWAVENALYDVQ
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
VAMDGFLANLPSRGLAWILRRVIFPWGLTLKPASDRTGTKVARAMMEPGATRERLTRGMY
HHHHHHHHCCCCHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHCCCCCHHHHHCCCC
VPKSEADPVGVLDHALQAILATEPVEQKLRKLARDGKFKSITARERLAEALQTGLINQEE
CCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHH
FDAVTRARKLKRDVIMVDDFDKKLEQHDDKLLQRLIF
HHHHHHHHHHHHCEEEECCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIAAVLLVVLLGALAYFAAPVLVWTVGVAAWLAALQFVFHCPLPVAAWAVFAAVAAVLNI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
VPLRRAVFTGPVFGVFKKITPAMSQTEQEAINAGTVWWDRDLFSGKPDYQRLLSFPDPKL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHCCCCCCC
SPEEQAFIDGPTEQLCGMIDDWKITHELKDLPPEVWQFIKDHGFLGMIVKKKYGGLEFSN
CCCCCCCCCCCHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHCCCEEEEEECCCCCCCCCC
YAHAKVVTKIATRGGTAAVSVMVPNSLGPGELLQHYGTEEQKDYYLPRLAKGVEVPCFAL
CHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHCCCCCCCCCCCHHHHCCCCCCEEEE
TSPYAGSDAGAIPDYGVVCRGSYTHPRTGERFENVLGVRISWEKRWITLAPVATILGLAF
CCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHCEEEEECCCEEEHHHHHHHHHHHH
KMYDPEHLLGDKEDIGITCALVPTEHEGVEIGRRHFPGGSAFMNGPTWGKDVFIPLDWII
HCCCHHHHCCCCCCCCEEEEEECCCCCCHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEEE
GGRDYAGQGWRMLVECLSVGRCISLPAMSVACGKLTTWTTGAYARIRDQFGLPIGKFEGV
CCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHCCCCEECCCCHHHHHHHHHCCCCHHCCCH
DEAMARIGGYTYQMEASQDLALTGLDNGEKPSVLSAILKYHNTERMRKTLNDAMDVHGGK
HHHHHHHCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCC
AVVLGPRNYLARGYQAIPIGITVEGANILTRSMIIYGQGAIRCHPFVLREMKSAMANDGA
EEEECCHHHHHCCCEEEEEEEEECCCHHHHHEEEEECCCCCEEHHHHHHHHHHHHHCCCH
EFDKAITGHINFVISNFVRSLWLGLTGACLASSPRGGATAAYYKRVTRLSSAFALLSDMA
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
MFSLGGSLKFREKLSARLGDMLSGLYIATASLKRFERDGAPKEDIAVMSWAVENALYDVQ
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
VAMDGFLANLPSRGLAWILRRVIFPWGLTLKPASDRTGTKVARAMMEPGATRERLTRGMY
HHHHHHHHCCCCHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHCCCCCHHHHHCCCC
VPKSEADPVGVLDHALQAILATEPVEQKLRKLARDGKFKSITARERLAEALQTGLINQEE
CCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHH
FDAVTRARKLKRDVIMVDDFDKKLEQHDDKLLQRLIF
HHHHHHHHHHHHCEEEECCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]