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The map label for this gene is macA [H]

Identifier: 34498160

GI number: 34498160

Start: 2928570

End: 2929805

Strand: Reverse

Name: macA [H]

Synonym: CV_2705

Alternate gene names: 34498160

Gene position: 2929805-2928570 (Counterclockwise)

Preceding gene: 34498161

Following gene: 34498159

Centisome position: 61.67

GC content: 67.56

Gene sequence:

>1236_bases
TTGTTGGCAATGATGCGGTTAAGGCAATGGTTTGGCATTTTCTTGCTTCCCGCGCGCGGACTGGCCGCCTTGTGGCGGCG
CTTCCGGCGTCGGGGATTCGGCAAGCGGCCGTGGCGCAACGCCATGGCTTTGTTGGCGGTTCTGGCATTGGCGGCTTGGG
GCGCGCATCGGGGACTGGCGGAGGATCCGCCGCCGCCGGTGCTGACCGCCAAGGTGGAGCGCGGCGAGCTGGAGGATCTG
GTGCTGGCCAGCGGCATGATCCAGGCGCTGCGGCAGGTTGACGTCGGCGCCCAGACCAATGGCCAGCTGAAGTCGCTGAA
AGTGGAGGCCGGCGACAAGGTGAAACAGGGGCAGCTGCTGGCCGAGATCGATCCGGAAGACAGCCTGAACGCTTTGCGCG
CCGCCGAGGCCTCGCTGGACGCGCGCATCGCCCAGCGCCAGGCCAAGCAGGCTTCGCTGCGCCAGGCCGAGCAGGAACTG
GCGCGCCAGCGCCGCATGCATGCGGAGGGCTCCACCTCGGACAAGGACCTGCTGGCGGCCGACACCAGCTACCGGACGCT
GAAGGCAGGGCTGGCCGAGCTGCAGGCGCAGATTCGCCAGGACGAGTCGCAGCGGGACAGCAAGCGCACCCTGCTGGGCT
ATACCCGCATCTTGGCGCCGATGGACGGCGAAGTGCTCGAAATCGTCACCCAGCAGGGACAGACGGTGATCGCCACCCAG
ACGGCGCCGGTGATCCTGAAACTGGCGGACCTGAGCAAGGTGACGGTGCGCGCCGACGTGGCCGAGGCCGACGTGATCCG
CATCCAGGCCGGCCTGCCGGTGTACTTCACCGTGCTGGGCGCGCCGGACAAGCGCTACTGGGGCAAGCTGCGGGCGATTC
TGCCGATGCCGGAGAAGATCAACAACGCGATGTTCTACAAGGCCTTGTTCGATGTGCCCAATCCTGACGGCAAGCTGCGC
GTCAACATGACCACCCAGGTCAGCATCGTGCTTTCCCGCGTGGACAAGGCGCTGAGCATTCCCTTGTCCGCCTTGGGCGC
GGCCGGCAAGGACGGCCGCCACGCGGTGAAGGTGAAGGGCAAGGACGGCAGGCTGCAGGAGCGTCGGGTCCGCATCGGCC
TGAAGACGTCCACCCGGGTCCAGGTGCTGGATGGGCTGAAGGCGGGCGAGCAGGTGGTGACCGGCGAGCAAGGCGACAAG
CCCGAAGAGGGCGGCGCCGTGGTGATCGGCGCATGA

Upstream 100 bases:

>100_bases
GCTGGGGGCGTGAGCGCGTCGCTACGATCGCTCTGAAAAAGATAGCAAGTGGAACTGTTTTGTAAATTCATTGCCATAAC
AGCTTATTTTTGTAAATAAC

Downstream 100 bases:

>100_bases
GCGGGGCGGGTCTCGAGCTTGACGGCGTCTGGCGGCGTTTCCCGTCCGGCGAGGACGAGGTGGCGGTGCTGAAGAACGTG
ACGCTGAGCATCGCCCCTGG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MLAMMRLRQWFGIFLLPARGLAALWRRFRRRGFGKRPWRNAMALLAVLALAAWGAHRGLAEDPPPPVLTAKVERGELEDL
VLASGMIQALRQVDVGAQTNGQLKSLKVEAGDKVKQGQLLAEIDPEDSLNALRAAEASLDARIAQRQAKQASLRQAEQEL
ARQRRMHAEGSTSDKDLLAADTSYRTLKAGLAELQAQIRQDESQRDSKRTLLGYTRILAPMDGEVLEIVTQQGQTVIATQ
TAPVILKLADLSKVTVRADVAEADVIRIQAGLPVYFTVLGAPDKRYWGKLRAILPMPEKINNAMFYKALFDVPNPDGKLR
VNMTTQVSIVLSRVDKALSIPLSALGAAGKDGRHAVKVKGKDGRLQERRVRIGLKTSTRVQVLDGLKAGEQVVTGEQGDK
PEEGGAVVIGA

Sequences:

>Translated_411_residues
MLAMMRLRQWFGIFLLPARGLAALWRRFRRRGFGKRPWRNAMALLAVLALAAWGAHRGLAEDPPPPVLTAKVERGELEDL
VLASGMIQALRQVDVGAQTNGQLKSLKVEAGDKVKQGQLLAEIDPEDSLNALRAAEASLDARIAQRQAKQASLRQAEQEL
ARQRRMHAEGSTSDKDLLAADTSYRTLKAGLAELQAQIRQDESQRDSKRTLLGYTRILAPMDGEVLEIVTQQGQTVIATQ
TAPVILKLADLSKVTVRADVAEADVIRIQAGLPVYFTVLGAPDKRYWGKLRAILPMPEKINNAMFYKALFDVPNPDGKLR
VNMTTQVSIVLSRVDKALSIPLSALGAAGKDGRHAVKVKGKDGRLQERRVRIGLKTSTRVQVLDGLKAGEQVVTGEQGDK
PEEGGAVVIGA
>Mature_411_residues
MLAMMRLRQWFGIFLLPARGLAALWRRFRRRGFGKRPWRNAMALLAVLALAAWGAHRGLAEDPPPPVLTAKVERGELEDL
VLASGMIQALRQVDVGAQTNGQLKSLKVEAGDKVKQGQLLAEIDPEDSLNALRAAEASLDARIAQRQAKQASLRQAEQEL
ARQRRMHAEGSTSDKDLLAADTSYRTLKAGLAELQAQIRQDESQRDSKRTLLGYTRILAPMDGEVLEIVTQQGQTVIATQ
TAPVILKLADLSKVTVRADVAEADVIRIQAGLPVYFTVLGAPDKRYWGKLRAILPMPEKINNAMFYKALFDVPNPDGKLR
VNMTTQVSIVLSRVDKALSIPLSALGAAGKDGRHAVKVKGKDGRLQERRVRIGLKTSTRVQVLDGLKAGEQVVTGEQGDK
PEEGGAVVIGA

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=360, Percent_Identity=46.6666666666667, Blast_Score=295, Evalue=3e-81,
Organism=Escherichia coli, GI87082036, Length=371, Percent_Identity=29.3800539083558, Blast_Score=89, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 44873; Mature: 44873

Theoretical pI: Translated: 10.66; Mature: 10.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAMMRLRQWFGIFLLPARGLAALWRRFRRRGFGKRPWRNAMALLAVLALAAWGAHRGLA
CHHHHHHHHHHCEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
EDPPPPVLTAKVERGELEDLVLASGMIQALRQVDVGAQTNGQLKSLKVEAGDKVKQGQLL
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCEE
AEIDPEDSLNALRAAEASLDARIAQRQAKQASLRQAEQELARQRRMHAEGSTSDKDLLAA
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEC
DTSYRTLKAGLAELQAQIRQDESQRDSKRTLLGYTRILAPMDGEVLEIVTQQGQTVIATQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEC
TAPVILKLADLSKVTVRADVAEADVIRIQAGLPVYFTVLGAPDKRYWGKLRAILPMPEKI
CCCEEEEEECCCEEEEEECCCCCCEEEEECCCCEEEEEECCCCHHHHHHHHHCCCCCHHH
NNAMFYKALFDVPNPDGKLRVNMTTQVSIVLSRVDKALSIPLSALGAAGKDGRHAVKVKG
HHHHEEHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHCCHHHHCCCCCCCCEEEEEEC
KDGRLQERRVRIGLKTSTRVQVLDGLKAGEQVVTGEQGDKPEEGGAVVIGA
CCCCCCHHHEEEECCCCCHHHHHHCCCCCCEEECCCCCCCCCCCCEEEEEC
>Mature Secondary Structure
MLAMMRLRQWFGIFLLPARGLAALWRRFRRRGFGKRPWRNAMALLAVLALAAWGAHRGLA
CHHHHHHHHHHCEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
EDPPPPVLTAKVERGELEDLVLASGMIQALRQVDVGAQTNGQLKSLKVEAGDKVKQGQLL
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCEE
AEIDPEDSLNALRAAEASLDARIAQRQAKQASLRQAEQELARQRRMHAEGSTSDKDLLAA
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEC
DTSYRTLKAGLAELQAQIRQDESQRDSKRTLLGYTRILAPMDGEVLEIVTQQGQTVIATQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEC
TAPVILKLADLSKVTVRADVAEADVIRIQAGLPVYFTVLGAPDKRYWGKLRAILPMPEKI
CCCEEEEEECCCEEEEEECCCCCCEEEEECCCCEEEEEECCCCHHHHHHHHHCCCCCHHH
NNAMFYKALFDVPNPDGKLRVNMTTQVSIVLSRVDKALSIPLSALGAAGKDGRHAVKVKG
HHHHEEHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHCCHHHHCCCCCCCCEEEEEEC
KDGRLQERRVRIGLKTSTRVQVLDGLKAGEQVVTGEQGDKPEEGGAVVIGA
CCCCCCHHHEEEECCCCCHHHHHHCCCCCCEEECCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]