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The map label for this gene is invC [H]

Identifier: 34498083

GI number: 34498083

Start: 2834493

End: 2835782

Strand: Reverse

Name: invC [H]

Synonym: CV_2628

Alternate gene names: 34498083

Gene position: 2835782-2834493 (Counterclockwise)

Preceding gene: 34498084

Following gene: 34498082

Centisome position: 59.69

GC content: 71.4

Gene sequence:

>1290_bases
ATGAAGCCGCCGCGGCTGCTGCGCAGGCTGGCCAACCCCCAGCGCCTGTCCGGCCCCATCCTGGAGGCGGTGCTGCCCGG
GGTGGCGGTAGGCGAGCTGTGCGAGATCCGCCGCAACTGGCAGGAGCGCGAGGTGGTGGCGCGGGCGCAGGTGGTCGGCT
TCCAGCATGAGCGGGCGGTGCTGAGCCTGATCGGCAACGCCAGGGGCTTGTCGCGAGAGGCGGTGCTGCAGCCGACCGGC
CGGGCTTTGTCCGCCTGGGTGGGCGAGGAGGCGCTGGGCGCGGTGCTGGACCCGACCGGCCGCGTCGTCGAACGCTTTTC
TCCGGCCGCGGCCGGCGGCGGCGAGGCGCGCGACATCGACAGCGATCCGCCGCCTTATTCCCGCCGGGTGGGCGTGCGCG
AACCGCTGGCCACCGGCGTACGGGCGATAGACGGCCTGCTGACCTGCGGCGTCGGCCAGCGAGTGGGCATCTTCGCCTCG
GCCGGCTGCGGCAAGACCATGCTGATGCACATGCTGATCGAACAGGCGGACGCCGATGTGTTCGTGATCGGCCTGATCGG
CGAACGCGGACGCGAAGTCACGGAATTCGCCGAGGCGCTGCGCGGCTCGGACAAGCGCGACCGCTGCGTGCTGGTATTCG
CCACCTCGGATTTCCCGTCGGTGGACCGCTGCAACGCGGCGCTGCTGGCCACCACGGTGGCCGAGTATTTCCGCGACCAG
GGCAAGAAGGTGGTGCTGTTCGTCGATTCGATGACCCGCTACGCCCGCGCGCTGCGCGACGTGGCGCTGGCCGCCGGCGA
GCCGCCGGCCCGGCGCGGCTATCCGGCCTCGGTGTTCGACAGCCTGCCGCGCCTGCTGGAGCGGCCGGGCGCCACCGGCG
CAGGCAGCATCACCGCTTTTTACACGGTGCTGCTGGAGAGCGACGACGAGCCGGACCCGATGGCGGACGAGATCCGCTCG
ATCCTGGACGGCCACATCTATCTGAGCCGCAAGCTGGCCGGCCAGGGCCATTACCCGGCGATAGACGTGCTCAAGAGCGC
GAGCCGCGTGGCCGGCCAAGTGACGGACACCGGCCAGCAGCAGGCGGCCGCCGCCGTGCGCGGCCTGCTGGCGCGGCTGG
AGGAGCTGCAGGTGTTCATCGACCTGGGCGAATACCGGCCAGGGGAGAACGCGGACAACGACAGGGCGATGAGCCTGCGC
GATCCGCTGCGGCGGTGGCTGCGCCAGCGCATGGACGAGCGAGCCGCTTACCGGGACACGCTGGAGAGCATGGATGGCTT
CCGCGCTTAA

Upstream 100 bases:

>100_bases
CGCTGGTGCGCTCCGACCGGCTGGAGGACGGCCGCGCCTTCTCCGACGCGCTGCACGGCTTCTTCGACAGCCTGGAGCGC
TGCTGCGAGACGGTGCTGCG

Downstream 100 bases:

>100_bases
GCTCGGACCGCTGCTGGCCCGTTGCCAGGCCGCGCAATCGCGCTGCCGCGCGGGCCTCGCGCAGCTGGCGCGGGGAGAGG
CGGAGATCGACAGGGAGCGC

Product: ATP synthase SpaL

Products: NA

Alternate protein names: Invasion protein InvC [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MKPPRLLRRLANPQRLSGPILEAVLPGVAVGELCEIRRNWQEREVVARAQVVGFQHERAVLSLIGNARGLSREAVLQPTG
RALSAWVGEEALGAVLDPTGRVVERFSPAAAGGGEARDIDSDPPPYSRRVGVREPLATGVRAIDGLLTCGVGQRVGIFAS
AGCGKTMLMHMLIEQADADVFVIGLIGERGREVTEFAEALRGSDKRDRCVLVFATSDFPSVDRCNAALLATTVAEYFRDQ
GKKVVLFVDSMTRYARALRDVALAAGEPPARRGYPASVFDSLPRLLERPGATGAGSITAFYTVLLESDDEPDPMADEIRS
ILDGHIYLSRKLAGQGHYPAIDVLKSASRVAGQVTDTGQQQAAAAVRGLLARLEELQVFIDLGEYRPGENADNDRAMSLR
DPLRRWLRQRMDERAAYRDTLESMDGFRA

Sequences:

>Translated_429_residues
MKPPRLLRRLANPQRLSGPILEAVLPGVAVGELCEIRRNWQEREVVARAQVVGFQHERAVLSLIGNARGLSREAVLQPTG
RALSAWVGEEALGAVLDPTGRVVERFSPAAAGGGEARDIDSDPPPYSRRVGVREPLATGVRAIDGLLTCGVGQRVGIFAS
AGCGKTMLMHMLIEQADADVFVIGLIGERGREVTEFAEALRGSDKRDRCVLVFATSDFPSVDRCNAALLATTVAEYFRDQ
GKKVVLFVDSMTRYARALRDVALAAGEPPARRGYPASVFDSLPRLLERPGATGAGSITAFYTVLLESDDEPDPMADEIRS
ILDGHIYLSRKLAGQGHYPAIDVLKSASRVAGQVTDTGQQQAAAAVRGLLARLEELQVFIDLGEYRPGENADNDRAMSLR
DPLRRWLRQRMDERAAYRDTLESMDGFRA
>Mature_429_residues
MKPPRLLRRLANPQRLSGPILEAVLPGVAVGELCEIRRNWQEREVVARAQVVGFQHERAVLSLIGNARGLSREAVLQPTG
RALSAWVGEEALGAVLDPTGRVVERFSPAAAGGGEARDIDSDPPPYSRRVGVREPLATGVRAIDGLLTCGVGQRVGIFAS
AGCGKTMLMHMLIEQADADVFVIGLIGERGREVTEFAEALRGSDKRDRCVLVFATSDFPSVDRCNAALLATTVAEYFRDQ
GKKVVLFVDSMTRYARALRDVALAAGEPPARRGYPASVFDSLPRLLERPGATGAGSITAFYTVLLESDDEPDPMADEIRS
ILDGHIYLSRKLAGQGHYPAIDVLKSASRVAGQVTDTGQQQAAAAVRGLLARLEELQVFIDLGEYRPGENADNDRAMSLR
DPLRRWLRQRMDERAAYRDTLESMDGFRA

Specific function: Necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase. May energize the protein export apparatus encoded in the inv locus which is required for the surface presentation of determ

COG id: COG1157

COG function: function code NU; Flagellar biosynthesis/type III secretory pathway ATPase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI50345984, Length=365, Percent_Identity=29.041095890411, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI4757810, Length=365, Percent_Identity=29.041095890411, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI32189394, Length=351, Percent_Identity=29.6296296296296, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI19913428, Length=319, Percent_Identity=29.153605015674, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI19913424, Length=241, Percent_Identity=31.9502074688797, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI19913426, Length=353, Percent_Identity=26.9121813031161, Blast_Score=112, Evalue=5e-25,
Organism=Escherichia coli, GI1788251, Length=435, Percent_Identity=39.7701149425287, Blast_Score=261, Evalue=6e-71,
Organism=Escherichia coli, GI1790170, Length=350, Percent_Identity=32.2857142857143, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1790172, Length=321, Percent_Identity=28.0373831775701, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1790217, Length=242, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25144756, Length=325, Percent_Identity=31.0769230769231, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71988080, Length=365, Percent_Identity=28.2191780821918, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71988063, Length=365, Percent_Identity=28.2191780821918, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17570191, Length=352, Percent_Identity=26.7045454545455, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71988074, Length=279, Percent_Identity=30.8243727598566, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17565854, Length=243, Percent_Identity=32.5102880658436, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17510931, Length=351, Percent_Identity=25.0712250712251, Blast_Score=111, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6322581, Length=354, Percent_Identity=29.9435028248588, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6319370, Length=335, Percent_Identity=28.6567164179104, Blast_Score=125, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6319603, Length=354, Percent_Identity=28.8135593220339, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6320016, Length=227, Percent_Identity=31.2775330396476, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24638766, Length=353, Percent_Identity=30.8781869688385, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24658560, Length=338, Percent_Identity=30.1775147928994, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI28574560, Length=333, Percent_Identity=31.5315315315315, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI281361666, Length=366, Percent_Identity=27.3224043715847, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24646341, Length=366, Percent_Identity=27.3224043715847, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI17136796, Length=366, Percent_Identity=27.3224043715847, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24583992, Length=243, Percent_Identity=32.5102880658436, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24583988, Length=243, Percent_Identity=32.5102880658436, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24583986, Length=243, Percent_Identity=32.5102880658436, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24583984, Length=243, Percent_Identity=32.5102880658436, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI20129479, Length=277, Percent_Identity=30.6859205776173, Blast_Score=112, Evalue=5e-25,

Paralogues:

None

Copy number: 10-20 (rich media) [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR003593
- InterPro:   IPR004100
- InterPro:   IPR005714 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 46689; Mature: 46689

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPPRLLRRLANPQRLSGPILEAVLPGVAVGELCEIRRNWQEREVVARAQVVGFQHERAV
CCCHHHHHHHCCCHHCCCHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHH
LSLIGNARGLSREAVLQPTGRALSAWVGEEALGAVLDPTGRVVERFSPAAAGGGEARDID
HHHHHCCCCCCHHHHCCCCCHHHHHHHCHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCC
SDPPPYSRRVGVREPLATGVRAIDGLLTCGVGQRVGIFASAGCGKTMLMHMLIEQADADV
CCCCCCHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCE
FVIGLIGERGREVTEFAEALRGSDKRDRCVLVFATSDFPSVDRCNAALLATTVAEYFRDQ
EEEEECCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
GKKVVLFVDSMTRYARALRDVALAAGEPPARRGYPASVFDSLPRLLERPGATGAGSITAF
CCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHH
YTVLLESDDEPDPMADEIRSILDGHIYLSRKLAGQGHYPAIDVLKSASRVAGQVTDTGQQ
HHHHCCCCCCCCHHHHHHHHHHCCHHEEEHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHH
QAAAAVRGLLARLEELQVFIDLGEYRPGENADNDRAMSLRDPLRRWLRQRMDERAAYRDT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LESMDGFRA
HHHHCCCCC
>Mature Secondary Structure
MKPPRLLRRLANPQRLSGPILEAVLPGVAVGELCEIRRNWQEREVVARAQVVGFQHERAV
CCCHHHHHHHCCCHHCCCHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHH
LSLIGNARGLSREAVLQPTGRALSAWVGEEALGAVLDPTGRVVERFSPAAAGGGEARDID
HHHHHCCCCCCHHHHCCCCCHHHHHHHCHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCC
SDPPPYSRRVGVREPLATGVRAIDGLLTCGVGQRVGIFASAGCGKTMLMHMLIEQADADV
CCCCCCHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCE
FVIGLIGERGREVTEFAEALRGSDKRDRCVLVFATSDFPSVDRCNAALLATTVAEYFRDQ
EEEEECCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
GKKVVLFVDSMTRYARALRDVALAAGEPPARRGYPASVFDSLPRLLERPGATGAGSITAF
CCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHH
YTVLLESDDEPDPMADEIRSILDGHIYLSRKLAGQGHYPAIDVLKSASRVAGQVTDTGQQ
HHHHCCCCCCCCHHHHHHHHHHCCHHEEEHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHH
QAAAAVRGLLARLEELQVFIDLGEYRPGENADNDRAMSLRDPLRRWLRQRMDERAAYRDT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LESMDGFRA
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]