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The map label for this gene is fbp

Identifier: 34497882

GI number: 34497882

Start: 2609934

End: 2610941

Strand: Reverse

Name: fbp

Synonym: CV_2427

Alternate gene names: 34497882

Gene position: 2610941-2609934 (Counterclockwise)

Preceding gene: 34497884

Following gene: 34497879

Centisome position: 54.95

GC content: 64.29

Gene sequence:

>1008_bases
ATGAGCCGCATCACCCTCTCCCGTTTTCTGATCGAACAACAGCGCAAGGCCGGCACGCTTCCACCGGAGCTGCGCCTGCT
GATCGAAACCGTGGGCCGCGCCTGCAAGGCCATCAGCTACTCGGTGAACAAGGGCGCGCTGGCCGACGTGCTGGGCGAGG
CCGGCACCGGCAACATCCAGGGCGAGGCGCAGAAGAAGCTGGACGTGATCGCCAACGACTTCCTGCTGGACGCCAACGAG
TGGGGCGGCAGCCTGGCCGCGATGGCGTCGGAAGAGATGGAGCTGCCCTACCACATCCCGGGCGAATACCCGAAGGGCGA
ATACCTGCTGATGTTCGACCCGCTGGACGGTTCGTCCAACATCGACGTCAACATCTCCGTCGGCACCATTTTCTCCATCC
TGCGCTGCCCCGAGGGCGTGACGCAGCCGACAGAAACCGATTTCCTGCAGCCTGGCACCCACCAAGTCGCCGCCGGCTAC
ACCGTGTACGGCCCGCAAACCATGCTGGTGCTGACCTTCGGCAGCGGCGTGCACGGCTTTACGCTGGACCGCGAGCACGG
CTCTTTCGTGCTGACCCACCCGGACATGAAAGTGCCGGAACGCACCGCCGAATTCGCGATCAACATGTCCAATATGCGCC
ACTGGGAAGCGCCGGTGCGCCGCTACGTGGAGGAGATGCTGGCCGGCAAGACCGGCCCGCGCGGCCGCGATTTCAACATG
CGCTGGGTGGCGTCGATGGTGGCCGAAGTGCATCGCATCATCACCCGCGGCGGCATCTTCATGTATCCGAAGGACGCGCG
CGATCCGTCCAAGGCCGGCAAGCTGCGGCTGATGTACGAAGGCAACCCGATGGCCTTCATCATCGAGCAAGCCGGCGGCG
CGGCCACCAACGGCCACCAGCGCATCCTGGACATCGTGCCGACCAAGCTGCACGAGCGCGTGGCGGTGTTCCTCGGCTCT
AAGGAAGAAGTGGAACTGGTGACGCGCTATCATAGCGAACAGCAATAA

Upstream 100 bases:

>100_bases
TCCCAACCGCCCCGTCTGCCGGCTTATTCGCTATAATCCCGCTTTGCGCCGCCAAGCCGTCGGCATTATCATTCGCGCAC
CTACCCATCTAAGGAACGTC

Downstream 100 bases:

>100_bases
GCCGCCAGTCGTCTTTCTGAACCAAGCCCGCGTCCTGCGGGCTTTTTGCCTTCAATCGAACAGCGATCCCTGCCGGGGCG
GATCGGCGATTTCGCCTTCC

Product: fructose-1,6-bisphosphatase

Products: NA

Alternate protein names: FBPase class 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MSRITLSRFLIEQQRKAGTLPPELRLLIETVGRACKAISYSVNKGALADVLGEAGTGNIQGEAQKKLDVIANDFLLDANE
WGGSLAAMASEEMELPYHIPGEYPKGEYLLMFDPLDGSSNIDVNISVGTIFSILRCPEGVTQPTETDFLQPGTHQVAAGY
TVYGPQTMLVLTFGSGVHGFTLDREHGSFVLTHPDMKVPERTAEFAINMSNMRHWEAPVRRYVEEMLAGKTGPRGRDFNM
RWVASMVAEVHRIITRGGIFMYPKDARDPSKAGKLRLMYEGNPMAFIIEQAGGAATNGHQRILDIVPTKLHERVAVFLGS
KEEVELVTRYHSEQQ

Sequences:

>Translated_335_residues
MSRITLSRFLIEQQRKAGTLPPELRLLIETVGRACKAISYSVNKGALADVLGEAGTGNIQGEAQKKLDVIANDFLLDANE
WGGSLAAMASEEMELPYHIPGEYPKGEYLLMFDPLDGSSNIDVNISVGTIFSILRCPEGVTQPTETDFLQPGTHQVAAGY
TVYGPQTMLVLTFGSGVHGFTLDREHGSFVLTHPDMKVPERTAEFAINMSNMRHWEAPVRRYVEEMLAGKTGPRGRDFNM
RWVASMVAEVHRIITRGGIFMYPKDARDPSKAGKLRLMYEGNPMAFIIEQAGGAATNGHQRILDIVPTKLHERVAVFLGS
KEEVELVTRYHSEQQ
>Mature_334_residues
SRITLSRFLIEQQRKAGTLPPELRLLIETVGRACKAISYSVNKGALADVLGEAGTGNIQGEAQKKLDVIANDFLLDANEW
GGSLAAMASEEMELPYHIPGEYPKGEYLLMFDPLDGSSNIDVNISVGTIFSILRCPEGVTQPTETDFLQPGTHQVAAGYT
VYGPQTMLVLTFGSGVHGFTLDREHGSFVLTHPDMKVPERTAEFAINMSNMRHWEAPVRRYVEEMLAGKTGPRGRDFNMR
WVASMVAEVHRIITRGGIFMYPKDARDPSKAGKLRLMYEGNPMAFIIEQAGGAATNGHQRILDIVPTKLHERVAVFLGSK
EEVELVTRYHSEQQ

Specific function: INVOLVED IN SEVERAL METABOLIC PATHWAYS. IN E.COLI AND YEAST IT IS NECESSARY FOR GROWTH ON SUBSTANCES SUCH AS GLYCEROL, SUCCINATE AND ACETATE. [C]

COG id: COG0158

COG function: function code G; Fructose-1,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FBPase class 1 family

Homologues:

Organism=Homo sapiens, GI189083692, Length=336, Percent_Identity=42.5595238095238, Blast_Score=248, Evalue=5e-66,
Organism=Homo sapiens, GI16579888, Length=336, Percent_Identity=42.5595238095238, Blast_Score=248, Evalue=5e-66,
Organism=Homo sapiens, GI22907028, Length=323, Percent_Identity=42.1052631578947, Blast_Score=236, Evalue=3e-62,
Organism=Escherichia coli, GI1790679, Length=331, Percent_Identity=45.3172205438066, Blast_Score=273, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17508131, Length=327, Percent_Identity=44.3425076452599, Blast_Score=272, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6323409, Length=324, Percent_Identity=41.0493827160494, Blast_Score=259, Evalue=5e-70,
Organism=Drosophila melanogaster, GI45550998, Length=327, Percent_Identity=45.565749235474, Blast_Score=267, Evalue=7e-72,
Organism=Drosophila melanogaster, GI19921562, Length=327, Percent_Identity=45.8715596330275, Blast_Score=267, Evalue=8e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): F16PA_CHRVO (Q7NVB6)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_902097.1
- HSSP:   P0A993
- ProteinModelPortal:   Q7NVB6
- SMR:   Q7NVB6
- GeneID:   2547041
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_2427
- NMPDR:   fig|243365.1.peg.2427
- HOGENOM:   HBG731261
- OMA:   ANEVDTC
- PhylomeDB:   Q7NVB6
- ProtClustDB:   PRK09293
- BioCyc:   CVIO243365:CV_2427-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01855
- InterPro:   IPR000146
- PANTHER:   PTHR11556
- PRINTS:   PR00115

Pfam domain/function: PF00316 FBPase

EC number: =3.1.3.11

Molecular weight: Translated: 37080; Mature: 36949

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00124 FBPASE

Important sites: BINDING 208-208 BINDING 274-274

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRITLSRFLIEQQRKAGTLPPELRLLIETVGRACKAISYSVNKGALADVLGEAGTGNIQ
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCC
GEAQKKLDVIANDFLLDANEWGGSLAAMASEEMELPYHIPGEYPKGEYLLMFDPLDGSSN
CHHHHHHHHHHHHEEEECCCCCCCEEEHHHHCCCCCEECCCCCCCCCEEEEEECCCCCCC
IDVNISVGTIFSILRCPEGVTQPTETDFLQPGTHQVAAGYTVYGPQTMLVLTFGSGVHGF
EEEEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCEEEECCCEEEEEEECCCCCCE
TLDREHGSFVLTHPDMKVPERTAEFAINMSNMRHWEAPVRRYVEEMLAGKTGPRGRDFNM
EEECCCCCEEEECCCCCCCCHHHHHEEEHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCH
RWVASMVAEVHRIITRGGIFMYPKDARDPSKAGKLRLMYEGNPMAFIIEQAGGAATNGHQ
HHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCHH
RILDIVPTKLHERVAVFLGSKEEVELVTRYHSEQQ
HHHHHHHHHHHHHHHEEECCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SRITLSRFLIEQQRKAGTLPPELRLLIETVGRACKAISYSVNKGALADVLGEAGTGNIQ
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCC
GEAQKKLDVIANDFLLDANEWGGSLAAMASEEMELPYHIPGEYPKGEYLLMFDPLDGSSN
CHHHHHHHHHHHHEEEECCCCCCCEEEHHHHCCCCCEECCCCCCCCCEEEEEECCCCCCC
IDVNISVGTIFSILRCPEGVTQPTETDFLQPGTHQVAAGYTVYGPQTMLVLTFGSGVHGF
EEEEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCEEEECCCEEEEEEECCCCCCE
TLDREHGSFVLTHPDMKVPERTAEFAINMSNMRHWEAPVRRYVEEMLAGKTGPRGRDFNM
EEECCCCCEEEECCCCCCCCHHHHHEEEHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCH
RWVASMVAEVHRIITRGGIFMYPKDARDPSKAGKLRLMYEGNPMAFIIEQAGGAATNGHQ
HHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCHH
RILDIVPTKLHERVAVFLGSKEEVELVTRYHSEQQ
HHHHHHHHHHHHHHHEEECCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782