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The map label for this gene is purR [H]

Identifier: 339905967

GI number: 339905967

Start: 2047218

End: 2048264

Strand: Reverse

Name: purR [H]

Synonym: NA

Alternate gene names: 339905967

Gene position: 2048264-2047218 (Counterclockwise)

Preceding gene: 238027463

Following gene: 238027461

Centisome position: 52.43

GC content: 68.96

Gene sequence:

>1047_bases
ATGGCGACGATCAAGGATGTGGCTGCCATGGCGGGCGTGTCGTTCACCACGGTGTCACACGTGGTGAACAATTCGCGGCC
GGTGTCGGCCGACGTGCGAGCGAAGGTGGAGCGGGCGATCATCCAGCTCAACTACGTCCCGTCGGCCGTCGCGCGATCCC
TGAAAGCCCGCGCGACGGCCACCATCGGCCTGGTCGTGCCGAACAGCACGAATCCGTATTTCGCCGAACTCGCGCGCGGC
ATCGAGGACCAGTGCGCGGCACGCGGGTATTGCGTGTTCTTCTGCAATTCCGACGACGATCCCGTCAAGCAGCGCAATTA
TCTGCGCGTGCTGCAGGAAAAGCGCATCGACGGGCTGATCATCGCCTCGGCGGGCGAGGATGCGGTGCTGGCCCACACGC
TCGCCGATTCGCGCGAGCCGCTGGTGGTGGTGGATCGCAACATCGAGGGGCTGTCCGCCGATCTGGTGCAGATCGACCAC
GAGCGCGGCGCCTACCTGGCCACGCGCCACCTGATCGAGCTCGGGCATTCGCGAATCGGCTGCATCACCGGCCCCATCGA
TACGGCGGTCAGCGCGATGCGCGTGCACGGCTTCATCCGCGCGATGGCCGAGCGCGGCCTCGACATCGCGCCCGGCGCGA
TCGCCGAGAGCGACTTCTCGTGCCTGGGCGGCCATCGCGGCGCGGCTGAGCTGCTCGACAAGCTGCAGCCCACGGCGATC
TTCGCGGGCAACGACCTGATGGGCATCGGCGCGCTGCGCGCGGTGGCCGAGCGCGGCCTGGGCGTGCCGCACGACTGCTC
GATCATCGGTTTCGACGACATCGAGATGTCGAGCTACACCTACCCGGCGCTGTCGACGGTTGGCCAGTCGGCGCGCGCCC
TCGGCGAGATCGCGGCGCAAACGCTGATCGAGCGGATCGCGGCCGGCTCGGCGGGCTCGGCAGCCATGACCAAGCGCCGC
CGCGTGGTGTCGCCGCGGCTGGTGCTGCGCGAATCGACCGCGGCCTACAAAGGCGAAGCCGGCCTCACGCCGGCCGTGCG
CGCATGA

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: transcriptional regulators

Products: NA

Alternate protein names: Pur regulon repressor; Purine nucleotide synthesis repressor [H]

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:
NA

Sequences:

>Translated_348_residues
MATIKDVAAMAGVSFTTVSHVVNNSRPVSADVRAKVERAIIQLNYVPSAVARSLKARATATIGLVVPNSTNPYFAELARG
IEDQCAARGYCVFFCNSDDDPVKQRNYLRVLQEKRIDGLIIASAGEDAVLAHTLADSREPLVVVDRNIEGLSADLVQIDH
ERGAYLATRHLIELGHSRIGCITGPIDTAVSAMRVHGFIRAMAERGLDIAPGAIAESDFSCLGGHRGAAELLDKLQPTAI
FAGNDLMGIGALRAVAERGLGVPHDCSIIGFDDIEMSSYTYPALSTVGQSARALGEIAAQTLIERIAAGSAGSAAMTKRR
RVVSPRLVLRESTAAYKGEAGLTPAVRA
>Mature_347_residues
ATIKDVAAMAGVSFTTVSHVVNNSRPVSADVRAKVERAIIQLNYVPSAVARSLKARATATIGLVVPNSTNPYFAELARGI
EDQCAARGYCVFFCNSDDDPVKQRNYLRVLQEKRIDGLIIASAGEDAVLAHTLADSREPLVVVDRNIEGLSADLVQIDHE
RGAYLATRHLIELGHSRIGCITGPIDTAVSAMRVHGFIRAMAERGLDIAPGAIAESDFSCLGGHRGAAELLDKLQPTAIF
AGNDLMGIGALRAVAERGLGVPHDCSIIGFDDIEMSSYTYPALSTVGQSARALGEIAAQTLIERIAAGSAGSAAMTKRRR
VVSPRLVLRESTAAYKGEAGLTPAVRA

Specific function: Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepre

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790194, Length=341, Percent_Identity=41.6422287390029, Blast_Score=257, Evalue=9e-70,
Organism=Escherichia coli, GI1787948, Length=337, Percent_Identity=40.3560830860534, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1790369, Length=337, Percent_Identity=33.5311572700297, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1788474, Length=345, Percent_Identity=35.3623188405797, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI1789202, Length=289, Percent_Identity=35.6401384083045, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1789068, Length=296, Percent_Identity=33.1081081081081, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1786540, Length=336, Percent_Identity=32.4404761904762, Blast_Score=154, Evalue=8e-39,
Organism=Escherichia coli, GI1787580, Length=323, Percent_Identity=28.7925696594427, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1787906, Length=319, Percent_Identity=27.5862068965517, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1789456, Length=327, Percent_Identity=28.7461773700306, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI48994940, Length=318, Percent_Identity=27.0440251572327, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790715, Length=312, Percent_Identity=25, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1786268, Length=339, Percent_Identity=24.4837758112094, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1790689, Length=316, Percent_Identity=24.0506329113924, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790192, Length=227, Percent_Identity=27.7533039647577, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36847; Mature: 36715

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIKDVAAMAGVSFTTVSHVVNNSRPVSADVRAKVERAIIQLNYVPSAVARSLKARATA
CCCHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHEECCCHHHHHHHHHHHCEE
TIGLVVPNSTNPYFAELARGIEDQCAARGYCVFFCNSDDDPVKQRNYLRVLQEKRIDGLI
EEEEEECCCCCHHHHHHHCCHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEE
IASAGEDAVLAHTLADSREPLVVVDRNIEGLSADLVQIDHERGAYLATRHLIELGHSRIG
EECCCCCCEEHHHHHCCCCCEEEEECCCCCCCHHHEEEECCCCHHHHHHHHHHHCCCCCE
CITGPIDTAVSAMRVHGFIRAMAERGLDIAPGAIAESDFSCLGGHRGAAELLDKLQPTAI
EEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHCCCCEE
FAGNDLMGIGALRAVAERGLGVPHDCSIIGFDDIEMSSYTYPALSTVGQSARALGEIAAQ
EECCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TLIERIAAGSAGSAAMTKRRRVVSPRLVLRESTAAYKGEAGLTPAVRA
HHHHHHHCCCCCHHHHHHHHHHCCCHHEEECCCHHHCCCCCCCCCCCC
>Mature Secondary Structure 
ATIKDVAAMAGVSFTTVSHVVNNSRPVSADVRAKVERAIIQLNYVPSAVARSLKARATA
CCHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHEECCCHHHHHHHHHHHCEE
TIGLVVPNSTNPYFAELARGIEDQCAARGYCVFFCNSDDDPVKQRNYLRVLQEKRIDGLI
EEEEEECCCCCHHHHHHHCCHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEE
IASAGEDAVLAHTLADSREPLVVVDRNIEGLSADLVQIDHERGAYLATRHLIELGHSRIG
EECCCCCCEEHHHHHCCCCCEEEEECCCCCCCHHHEEEECCCCHHHHHHHHHHHCCCCCE
CITGPIDTAVSAMRVHGFIRAMAERGLDIAPGAIAESDFSCLGGHRGAAELLDKLQPTAI
EEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHCCCCEE
FAGNDLMGIGALRAVAERGLGVPHDCSIIGFDDIEMSSYTYPALSTVGQSARALGEIAAQ
EECCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TLIERIAAGSAGSAAMTKRRRVVSPRLVLRESTAAYKGEAGLTPAVRA
HHHHHHHCCCCCHHHHHHHHHHCCCHHEEECCCHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA