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The map label for this gene is pntB [H]

Identifier: 33863434

GI number: 33863434

Start: 1256072

End: 1257511

Strand: Reverse

Name: pntB [H]

Synonym: PMT1164

Alternate gene names: 33863434

Gene position: 1257511-1256072 (Counterclockwise)

Preceding gene: 33863435

Following gene: 33863433

Centisome position: 52.16

GC content: 55.35

Gene sequence:

>1440_bases
ATGAATATTGCTGAGACCCTCAAGTTCGCGATTGACCTGGTCGCGGTTTTACTCCTTGCCCTTGGGATCAAGGGCCTTTC
GAAGGTGCGCTCTGCTCGTGAGGCCAATCTCCTTGCAGCTTTTGCCATGGCGCTTGCCGTGGTGGGCTTGATCGTGAACT
ATCTCGGCACCAGCGGCATCGCTGCTGAAGCCTGGATTTGGATCATCTTCGGCACGGTGGTCGGTGGATGTCTCGGTGCG
ATCACAGCGCAGCGAGTGCCGATGACCTCCATGCCGGAGACCGTTGCTCTGTTTAACGGCTGCGGAGGCATGTCGTCGTT
GTTGGTGGCTTTCGGCGTTGCAATCTTCCCGACAGCCGCTGGTGCTGGCGAAGCAGGCAGCGCAGTGGTTGAAGACATCT
CGATTGTGGTGTCTGTTTTTGTTGGCTCGATCACCTTTTCAGGATCCATCGTGGCGATGGCAAAGCTGCAGGGCTGGCTG
TCAACACCCCCTTGGATGCAGAGCAGGGTTCGGCATGCCGTGAACATTGCGCTTGCTGTGATGTCTTTAGTGGCTGCCAT
CGAACTTGGCCGCCGTGGCGACAACGTCAGTGCGCTTTGGTTGCTGGTGATCGGGTCTGGTTTGTTGGGAATCGGCGTAA
CGCTACCGATCGGCGGCGCTGATATGCCAGTGGTGATCTCACTTTTGAACAGTTATTCGGGAGTTGCGGCGGCGGCGGCA
GGTTTCGTTGTTGGTAGTCAGTTGCTGATTGTGGCTGGCGCCATGGTTGGAGCTGCTGGTCTGATCCTTACTCAGGTGAT
GTGCAACGGCATGAATCGTTCGTTGGTATCCGTGTTGTTTGGTGGAGCGTTAGGAGCAAGCGCTGCTTCTGGCGGCGGTG
GTGAATATAAAAACATCACCAGTTGCAGCGCTGAAGAGTGTGCCCTCACCCTTGAGGCAGCAGAGCGGGTTGTCATCGTT
CCCGGTTACGGCCTGGCTGTAGCACAGGCCCAGCACACGCTTAGGGAAGTCACCCGTGCTTTGGAGGCAGCTGGAATTGA
GGTCACCTATGCCATCCATCCGGTTGCTGGTCGGATGCCTGGTCATATGAACGTTCTCTTGGCTGAGGCTGATGTTCCTT
ATGAGCAGCTCAAGGAGATGGATGTGATTAATCCTGAGTTCCCAGCCACTGACGTGGTGCTGGTGCTAGGGGCGAACGAT
GTTGTGAATCCTCAGGCCAAGACCGATACAAGTTCACCTCTTTATGGCATGCCTGTGCTTGATGTGCAGGAAGCTCGCAC
GGTGTTCGTGGTGAAGCGGGGCATGAGTGCGGGCTACTCAGGGATTAAGAATGATCTGTTTGAACTTGCCAATACTTCCA
TGGTGTTTGGTGATGCCAAGAAAGTGTTGGGTGATCTTTTGGTTGAACTAAAGGAGCTTGGTGTTGGCAAGAAGGGGTGA

Upstream 100 bases:

>100_bases
TTGGTTTCGCCTTGTTCAACGTGATTGGCGGATTTCTCGTGACTGATCGGATGCTGGCCATGTTCAGCCGCAAGTCCGCT
CGCCGTAAGGACAACCACTG

Downstream 100 bases:

>100_bases
ACCCCATCCCGAGCTGCTTCAGCAGCTCGGGATGCCTTCTTTTAGACAGAGATTGCCTTGGCTTGGCGGTGATTTGCAGA
CCCTCAGGGACACCCTGAGA

Product: nicotinamide nucleotide transhydrogenase, subunit beta

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Proton-translocating transhydrogenase NADP(H)-binding component; Pyridine nucleotide transhydrogenase subunit beta; dIII [H]

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MNIAETLKFAIDLVAVLLLALGIKGLSKVRSAREANLLAAFAMALAVVGLIVNYLGTSGIAAEAWIWIIFGTVVGGCLGA
ITAQRVPMTSMPETVALFNGCGGMSSLLVAFGVAIFPTAAGAGEAGSAVVEDISIVVSVFVGSITFSGSIVAMAKLQGWL
STPPWMQSRVRHAVNIALAVMSLVAAIELGRRGDNVSALWLLVIGSGLLGIGVTLPIGGADMPVVISLLNSYSGVAAAAA
GFVVGSQLLIVAGAMVGAAGLILTQVMCNGMNRSLVSVLFGGALGASAASGGGGEYKNITSCSAEECALTLEAAERVVIV
PGYGLAVAQAQHTLREVTRALEAAGIEVTYAIHPVAGRMPGHMNVLLAEADVPYEQLKEMDVINPEFPATDVVLVLGAND
VVNPQAKTDTSSPLYGMPVLDVQEARTVFVVKRGMSAGYSGIKNDLFELANTSMVFGDAKKVLGDLLVELKELGVGKKG

Sequences:

>Translated_479_residues
MNIAETLKFAIDLVAVLLLALGIKGLSKVRSAREANLLAAFAMALAVVGLIVNYLGTSGIAAEAWIWIIFGTVVGGCLGA
ITAQRVPMTSMPETVALFNGCGGMSSLLVAFGVAIFPTAAGAGEAGSAVVEDISIVVSVFVGSITFSGSIVAMAKLQGWL
STPPWMQSRVRHAVNIALAVMSLVAAIELGRRGDNVSALWLLVIGSGLLGIGVTLPIGGADMPVVISLLNSYSGVAAAAA
GFVVGSQLLIVAGAMVGAAGLILTQVMCNGMNRSLVSVLFGGALGASAASGGGGEYKNITSCSAEECALTLEAAERVVIV
PGYGLAVAQAQHTLREVTRALEAAGIEVTYAIHPVAGRMPGHMNVLLAEADVPYEQLKEMDVINPEFPATDVVLVLGAND
VVNPQAKTDTSSPLYGMPVLDVQEARTVFVVKRGMSAGYSGIKNDLFELANTSMVFGDAKKVLGDLLVELKELGVGKKG
>Mature_479_residues
MNIAETLKFAIDLVAVLLLALGIKGLSKVRSAREANLLAAFAMALAVVGLIVNYLGTSGIAAEAWIWIIFGTVVGGCLGA
ITAQRVPMTSMPETVALFNGCGGMSSLLVAFGVAIFPTAAGAGEAGSAVVEDISIVVSVFVGSITFSGSIVAMAKLQGWL
STPPWMQSRVRHAVNIALAVMSLVAAIELGRRGDNVSALWLLVIGSGLLGIGVTLPIGGADMPVVISLLNSYSGVAAAAA
GFVVGSQLLIVAGAMVGAAGLILTQVMCNGMNRSLVSVLFGGALGASAASGGGGEYKNITSCSAEECALTLEAAERVVIV
PGYGLAVAQAQHTLREVTRALEAAGIEVTYAIHPVAGRMPGHMNVLLAEADVPYEQLKEMDVINPEFPATDVVLVLGAND
VVNPQAKTDTSSPLYGMPVLDVQEARTVFVVKRGMSAGYSGIKNDLFELANTSMVFGDAKKVLGDLLVELKELGVGKKG

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=454, Percent_Identity=37.8854625550661, Blast_Score=281, Evalue=1e-75,
Organism=Homo sapiens, GI122939153, Length=454, Percent_Identity=37.8854625550661, Blast_Score=281, Evalue=1e-75,
Organism=Escherichia coli, GI1787886, Length=457, Percent_Identity=45.7330415754923, Blast_Score=357, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17550456, Length=406, Percent_Identity=41.3793103448276, Blast_Score=284, Evalue=9e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 49056; Mature: 49056

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIAETLKFAIDLVAVLLLALGIKGLSKVRSAREANLLAAFAMALAVVGLIVNYLGTSGI
CCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AAEAWIWIIFGTVVGGCLGAITAQRVPMTSMPETVALFNGCGGMSSLLVAFGVAIFPTAA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCC
GAGEAGSAVVEDISIVVSVFVGSITFSGSIVAMAKLQGWLSTPPWMQSRVRHAVNIALAV
CCCCCCHHHHHHHHHHHHHHHHHHEECCCEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHH
MSLVAAIELGRRGDNVSALWLLVIGSGLLGIGVTLPIGGADMPVVISLLNSYSGVAAAAA
HHHHHHHHHCCCCCCHHHHHHHHHHCCHHHCCEEEECCCCCHHHHHHHHHHCCHHHHHHH
GFVVGSQLLIVAGAMVGAAGLILTQVMCNGMNRSLVSVLFGGALGASAASGGGGEYKNIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
SCSAEECALTLEAAERVVIVPGYGLAVAQAQHTLREVTRALEAAGIEVTYAIHPVAGRMP
CCCHHHHHEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCC
GHMNVLLAEADVPYEQLKEMDVINPEFPATDVVLVLGANDVVNPQAKTDTSSPLYGMPVL
CCCEEEEEECCCCHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCC
DVQEARTVFVVKRGMSAGYSGIKNDLFELANTSMVFGDAKKVLGDLLVELKELGVGKKG
CHHHHHEEEEEECCCCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNIAETLKFAIDLVAVLLLALGIKGLSKVRSAREANLLAAFAMALAVVGLIVNYLGTSGI
CCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AAEAWIWIIFGTVVGGCLGAITAQRVPMTSMPETVALFNGCGGMSSLLVAFGVAIFPTAA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCC
GAGEAGSAVVEDISIVVSVFVGSITFSGSIVAMAKLQGWLSTPPWMQSRVRHAVNIALAV
CCCCCCHHHHHHHHHHHHHHHHHHEECCCEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHH
MSLVAAIELGRRGDNVSALWLLVIGSGLLGIGVTLPIGGADMPVVISLLNSYSGVAAAAA
HHHHHHHHHCCCCCCHHHHHHHHHHCCHHHCCEEEECCCCCHHHHHHHHHHCCHHHHHHH
GFVVGSQLLIVAGAMVGAAGLILTQVMCNGMNRSLVSVLFGGALGASAASGGGGEYKNIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
SCSAEECALTLEAAERVVIVPGYGLAVAQAQHTLREVTRALEAAGIEVTYAIHPVAGRMP
CCCHHHHHEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCC
GHMNVLLAEADVPYEQLKEMDVINPEFPATDVVLVLGANDVVNPQAKTDTSSPLYGMPVL
CCCEEEEEECCCCHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCC
DVQEARTVFVVKRGMSAGYSGIKNDLFELANTSMVFGDAKKVLGDLLVELKELGVGKKG
CHHHHHEEEEEECCCCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]