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The map label for this gene is pphA [C]

Identifier: 33863361

GI number: 33863361

Start: 1182896

End: 1183801

Strand: Reverse

Name: pphA [C]

Synonym: PMT1090

Alternate gene names: 33863361

Gene position: 1183801-1182896 (Counterclockwise)

Preceding gene: 33863362

Following gene: 33863360

Centisome position: 49.1

GC content: 53.31

Gene sequence:

>906_bases
ATGGAGTCTGCATCCTCGCAACGCGCCAAAGCTTCATTGGTGCGCTCAGCACCATTGAGGGATTTGACGAGTAAGTCGAC
TCGTTTGATGACCGGCAACGTGCGTGGATCCAAATCAAACACTTCAAGACTGTTCACCGTACGCAGTAGCGCTGACATAT
GGCTACTGCCCAGCCAGAATCTTGAAGAGAATGCTGCTGCGATTGTGAAGTCACCCCGCGAATGTCACTGGGTGATTGGG
GATGTCCATGGCTGTTATCAATCCTTGATAGAGCTCATCGCCTTGCTCCCCAGCTCAGACCAGCTCGTGTTTTGTGGAGA
TGTGATCAATCGAGGGCCGGCCATTGAGGCCACCATGTTGCTTGCCTGGGAAATGGTCTGTGGCGGTCGTGCTCATTGGT
TGCGTGGAAACCATGAACAACACCTGATCGATTGTCTGGAGGTCGACCCTCAAGATGGCCAGGCTGCTTTGCTGGCGATT
GACACGTACAGGCAATTGGGTGATCGCCAGGCTCGAGAGTGGTTAAGCCGCTTGAAAGGGCTTCCTCTTGTTTACAAAGC
CAAGGGATGGATTGCGACTCACGCTGGCTTTGACCTCGATGGCAATCCTGATTTGAGCATTCGTCAGCGATTCTGGGAGG
ATTACGACGGTCGCTATGGACGCGTGATCGTTGCTCATACCCCTCGTCCGCAGGTGGAGCGCCATCGCCATATCGTGATG
ATTGATACGGGAGCTTGCTACGGGGGCTTGCTGAGCGCCTATTGCCCAGAACGCGATGCTGTTGTTCAGGTCTGCGGTGA
CCGCAAGTTGAATCAGTATCTTGCATGCGATGTCGACAAGCCCAAAGAGTCGTTCACTCAAGAGATGACTACATCATCAT
CCCTGGTTTCTACTAAGCCTTGCTGA

Upstream 100 bases:

>100_bases
CTTCCACCAGATCCAGTCACGGATTGGTGGTGTGGTCATCAAATCTTCCCGGGTGAGACCAAGCTCAAGCTGGGCTGCCG
CACCTAGAAGGACGTCAATC

Downstream 100 bases:

>100_bases
CGATCTACCGCAGCAACAGAGCGGAGTGGTTAGCTCGAGTGTTGGCGGAGCAGCTGCGTCTGGCACCACCAGGTCTATTT
GACTCAGTGGATGTCCTGGT

Product: Serine/threonine specific protein phosphatase

Products: A Protein; Orthophosphate. [C]

Alternate protein names: Serine/Threonine Specific Protein Phosphatase; Serine/Threonine Protein Phosphatase; Bis(5-Nucleosyl)-Tetraphosphatase; Phosphatase; Kinase; Phosphoprotein Phosphatase; Calcineurin-Like Phosphoesterase

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MESASSQRAKASLVRSAPLRDLTSKSTRLMTGNVRGSKSNTSRLFTVRSSADIWLLPSQNLEENAAAIVKSPRECHWVIG
DVHGCYQSLIELIALLPSSDQLVFCGDVINRGPAIEATMLLAWEMVCGGRAHWLRGNHEQHLIDCLEVDPQDGQAALLAI
DTYRQLGDRQAREWLSRLKGLPLVYKAKGWIATHAGFDLDGNPDLSIRQRFWEDYDGRYGRVIVAHTPRPQVERHRHIVM
IDTGACYGGLLSAYCPERDAVVQVCGDRKLNQYLACDVDKPKESFTQEMTTSSSLVSTKPC

Sequences:

>Translated_301_residues
MESASSQRAKASLVRSAPLRDLTSKSTRLMTGNVRGSKSNTSRLFTVRSSADIWLLPSQNLEENAAAIVKSPRECHWVIG
DVHGCYQSLIELIALLPSSDQLVFCGDVINRGPAIEATMLLAWEMVCGGRAHWLRGNHEQHLIDCLEVDPQDGQAALLAI
DTYRQLGDRQAREWLSRLKGLPLVYKAKGWIATHAGFDLDGNPDLSIRQRFWEDYDGRYGRVIVAHTPRPQVERHRHIVM
IDTGACYGGLLSAYCPERDAVVQVCGDRKLNQYLACDVDKPKESFTQEMTTSSSLVSTKPC
>Mature_301_residues
MESASSQRAKASLVRSAPLRDLTSKSTRLMTGNVRGSKSNTSRLFTVRSSADIWLLPSQNLEENAAAIVKSPRECHWVIG
DVHGCYQSLIELIALLPSSDQLVFCGDVINRGPAIEATMLLAWEMVCGGRAHWLRGNHEQHLIDCLEVDPQDGQAALLAI
DTYRQLGDRQAREWLSRLKGLPLVYKAKGWIATHAGFDLDGNPDLSIRQRFWEDYDGRYGRVIVAHTPRPQVERHRHIVM
IDTGACYGGLLSAYCPERDAVVQVCGDRKLNQYLACDVDKPKESFTQEMTTSSSLVSTKPC

Specific function: Plays A Key Role In Signaling Protein Misfolding Via The Cpxr/Cpxa Transducing System. It Also Modulates The Phosphorylated Status Of Many Phosphoproteins In E. coli, Some Of Which Acting As Major Chaperones. Has Been Shown, In Vitro, To Act On Ser, Thr A

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.1.3.16 [C]

Molecular weight: Translated: 33538; Mature: 33538

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS00125 SER_THR_PHOSPHATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESASSQRAKASLVRSAPLRDLTSKSTRLMTGNVRGSKSNTSRLFTVRSSADIWLLPSQN
CCCCCHHHHHHHHHHHCCCHHHHCCCCEEEECCCCCCCCCCCEEEEEECCCCEEEECCCC
LEENAAAIVKSPRECHWVIGDVHGCYQSLIELIALLPSSDQLVFCGDVINRGPAIEATML
CCHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHCCCCCCEEEECHHHCCCCCHHHHHH
LAWEMVCGGRAHWLRGNHEQHLIDCLEVDPQDGQAALLAIDTYRQLGDRQAREWLSRLKG
HHHHHHHCCCEEECCCCCHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCC
LPLVYKAKGWIATHAGFDLDGNPDLSIRQRFWEDYDGRYGRVIVAHTPRPQVERHRHIVM
CCEEEECCCEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHCCEEEE
IDTGACYGGLLSAYCPERDAVVQVCGDRKLNQYLACDVDKPKESFTQEMTTSSSLVSTKP
EECCCHHHHHHHHHCCCCHHHHEECCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCC
C
C
>Mature Secondary Structure
MESASSQRAKASLVRSAPLRDLTSKSTRLMTGNVRGSKSNTSRLFTVRSSADIWLLPSQN
CCCCCHHHHHHHHHHHCCCHHHHCCCCEEEECCCCCCCCCCCEEEEEECCCCEEEECCCC
LEENAAAIVKSPRECHWVIGDVHGCYQSLIELIALLPSSDQLVFCGDVINRGPAIEATML
CCHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHCCCCCCEEEECHHHCCCCCHHHHHH
LAWEMVCGGRAHWLRGNHEQHLIDCLEVDPQDGQAALLAIDTYRQLGDRQAREWLSRLKG
HHHHHHHCCCEEECCCCCHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCC
LPLVYKAKGWIATHAGFDLDGNPDLSIRQRFWEDYDGRYGRVIVAHTPRPQVERHRHIVM
CCEEEECCCEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHCCEEEE
IDTGACYGGLLSAYCPERDAVVQVCGDRKLNQYLACDVDKPKESFTQEMTTSSSLVSTKP
EECCCHHHHHHHHHCCCCHHHHEECCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCC
C
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Phosphoprotein; H2O [C]

Specific reaction: A Phosphoprotein + H2O = A Protein + Orthophosphate. [C]

General reaction: Phosphoric ester hydrolysis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA