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The map label for this gene is clcA [H]

Identifier: 33863034

GI number: 33863034

Start: 832281

End: 833648

Strand: Direct

Name: clcA [H]

Synonym: PMT0762

Alternate gene names: 33863034

Gene position: 832281-833648 (Clockwise)

Preceding gene: 33863033

Following gene: 33863035

Centisome position: 34.52

GC content: 49.49

Gene sequence:

>1368_bases
ATGAGTTTTGATCTACGACGGCTCGAACAATTAATCCCAGGAGTGATTGGAAGAAAACAATCTGAGATTATTCAGCTCTT
TCAACATCTTTTATGTCTTTTGATTATTGGCCTTCTAATCGGCCTTGCATGCCTGCCACTCAACCTGATTGATGGAATTC
AAAAGTCTCTATTTCAGCAGTTACCAGCAACAACAGGAAGTGCATGGCGGCCCATTGGTCTGATATTGGCACTTTTGCCG
ATAGGAGTGATGCCAATCCTCTTGTTACTGCAGCGGGGGCCATGGCGAGATGCAGCTGGCTCTGGGATACCCCAGACGAT
GAATGCTCTTGAAGATCACTCACAGCTAGCACCTGCTCTCGCTGCACCTAGAACGATTCAACGTGGCCTTCTCTGGACTA
TTGCAACGGTTGCCCTTTTCCCTCTTGGACGGGAAGGGCCAGTGGTGCATTTAGGAGCAGCTGTTGCACGTGCAATTCAC
AAACGTTTTAAGCGTTGGCTCCCTTCACTGAATGAGCGTCAGATTGTCGCTATTGGTGGCGGTGCCGGACTTGCAGGAGG
CTTCAATACGCCTCTACTAGCACCAATATTCATGATTGAGGAACTCACAACTGAATATTCCCTCACTTTGATTTGGCCTG
CTCTTGTGATTGGAATCTCCGCGGCTTGGTTTAGCAGCGTTGGCGGAGAACCAATCTTCGGTCTTGGCATGATCAATGTA
ATGGCTCCAGAATCCGAGCAGCTCTTAATTGCTATTCCAATTGGGATTTTGGCTGGGCTTGTGGGGGGATTCTTTAATCG
AGGCCTTATCTGGTGCTCTTCATTTCTTGAACCATGGGTGCGTCAACGACCAATCCGCACTGGGCTTTTGCTTGGAATAT
GCCTAAGCACCTTGGCTCTAAGCAGCTGGGGGACAAGCACAGGTGATGGAGAGGGGCTTCTGCAATTGTTGATTCAAGAA
GGCATGCCGAACCATTTCCCTGATGGTGGCTCTATTTCACAAGGAATAACGTCTATATGGATCACCTTGGTTCGCGTCTT
GGCTCCGATGATTGCACTTTCACCTGGTGTACCTGGAGGCCTTATTGACCCTTCACTTGCGTTTGGAGGCCTCCTCGGTT
ACACGTTCTGTGGATTGGTTGGTTCAAGCACTCATCTCGGCTTAGCGCTTGGAATGGCTGCTGGTTTGGCTGGTGCCACA
CAGCTTCCACTTGTCTCGATTGTGTTCGCCTGGAGACTAGTTGGCGATCAGCAACTTTTTGCAGGTGTGATTCTTTGTTC
AGTGCTGGCCGCCTACATAGGACGGTTGGTGGCACGTAAGCCCGTCTATCACGCTCTTGCCGAACTTCAAAGACCTAATC
GATTTTGA

Upstream 100 bases:

>100_bases
TGTCAAGCAATGGAAAGCTTAAATGCACTGACAGTCGAGCTAGACATCCTTACATTCATAACCTGATCGAAGAGGGATTA
ATAGGTCTGGGACTTCGCCC

Downstream 100 bases:

>100_bases
TAGAAGCATAGAAATATAATTGCTGGACCGGCTAGGGCGACTGCGCCAAGTGGCCCAAAGATCTCGAGAATGCGGATGGC
AGTGTCCATAGCGACTTAGA

Product: chloride channel

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MSFDLRRLEQLIPGVIGRKQSEIIQLFQHLLCLLIIGLLIGLACLPLNLIDGIQKSLFQQLPATTGSAWRPIGLILALLP
IGVMPILLLLQRGPWRDAAGSGIPQTMNALEDHSQLAPALAAPRTIQRGLLWTIATVALFPLGREGPVVHLGAAVARAIH
KRFKRWLPSLNERQIVAIGGGAGLAGGFNTPLLAPIFMIEELTTEYSLTLIWPALVIGISAAWFSSVGGEPIFGLGMINV
MAPESEQLLIAIPIGILAGLVGGFFNRGLIWCSSFLEPWVRQRPIRTGLLLGICLSTLALSSWGTSTGDGEGLLQLLIQE
GMPNHFPDGGSISQGITSIWITLVRVLAPMIALSPGVPGGLIDPSLAFGGLLGYTFCGLVGSSTHLGLALGMAAGLAGAT
QLPLVSIVFAWRLVGDQQLFAGVILCSVLAAYIGRLVARKPVYHALAELQRPNRF

Sequences:

>Translated_455_residues
MSFDLRRLEQLIPGVIGRKQSEIIQLFQHLLCLLIIGLLIGLACLPLNLIDGIQKSLFQQLPATTGSAWRPIGLILALLP
IGVMPILLLLQRGPWRDAAGSGIPQTMNALEDHSQLAPALAAPRTIQRGLLWTIATVALFPLGREGPVVHLGAAVARAIH
KRFKRWLPSLNERQIVAIGGGAGLAGGFNTPLLAPIFMIEELTTEYSLTLIWPALVIGISAAWFSSVGGEPIFGLGMINV
MAPESEQLLIAIPIGILAGLVGGFFNRGLIWCSSFLEPWVRQRPIRTGLLLGICLSTLALSSWGTSTGDGEGLLQLLIQE
GMPNHFPDGGSISQGITSIWITLVRVLAPMIALSPGVPGGLIDPSLAFGGLLGYTFCGLVGSSTHLGLALGMAAGLAGAT
QLPLVSIVFAWRLVGDQQLFAGVILCSVLAAYIGRLVARKPVYHALAELQRPNRF
>Mature_454_residues
SFDLRRLEQLIPGVIGRKQSEIIQLFQHLLCLLIIGLLIGLACLPLNLIDGIQKSLFQQLPATTGSAWRPIGLILALLPI
GVMPILLLLQRGPWRDAAGSGIPQTMNALEDHSQLAPALAAPRTIQRGLLWTIATVALFPLGREGPVVHLGAAVARAIHK
RFKRWLPSLNERQIVAIGGGAGLAGGFNTPLLAPIFMIEELTTEYSLTLIWPALVIGISAAWFSSVGGEPIFGLGMINVM
APESEQLLIAIPIGILAGLVGGFFNRGLIWCSSFLEPWVRQRPIRTGLLLGICLSTLALSSWGTSTGDGEGLLQLLIQEG
MPNHFPDGGSISQGITSIWITLVRVLAPMIALSPGVPGGLIDPSLAFGGLLGYTFCGLVGSSTHLGLALGMAAGLAGATQ
LPLVSIVFAWRLVGDQQLFAGVILCSVLAAYIGRLVARKPVYHALAELQRPNRF

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=446, Percent_Identity=26.9058295964126, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 48345; Mature: 48214

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFDLRRLEQLIPGVIGRKQSEIIQLFQHLLCLLIIGLLIGLACLPLNLIDGIQKSLFQQ
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPATTGSAWRPIGLILALLPIGVMPILLLLQRGPWRDAAGSGIPQTMNALEDHSQLAPAL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AAPRTIQRGLLWTIATVALFPLGREGPVVHLGAAVARAIHKRFKRWLPSLNERQIVAIGG
HCCHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
GAGLAGGFNTPLLAPIFMIEELTTEYSLTLIWPALVIGISAAWFSSVGGEPIFGLGMINV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHE
MAPESEQLLIAIPIGILAGLVGGFFNRGLIWCSSFLEPWVRQRPIRTGLLLGICLSTLAL
ECCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
SSWGTSTGDGEGLLQLLIQEGMPNHFPDGGSISQGITSIWITLVRVLAPMIALSPGVPGG
HHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LIDPSLAFGGLLGYTFCGLVGSSTHLGLALGMAAGLAGATQLPLVSIVFAWRLVGDQQLF
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCHHHHH
AGVILCSVLAAYIGRLVARKPVYHALAELQRPNRF
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SFDLRRLEQLIPGVIGRKQSEIIQLFQHLLCLLIIGLLIGLACLPLNLIDGIQKSLFQQ
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPATTGSAWRPIGLILALLPIGVMPILLLLQRGPWRDAAGSGIPQTMNALEDHSQLAPAL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AAPRTIQRGLLWTIATVALFPLGREGPVVHLGAAVARAIHKRFKRWLPSLNERQIVAIGG
HCCHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
GAGLAGGFNTPLLAPIFMIEELTTEYSLTLIWPALVIGISAAWFSSVGGEPIFGLGMINV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHE
MAPESEQLLIAIPIGILAGLVGGFFNRGLIWCSSFLEPWVRQRPIRTGLLLGICLSTLAL
ECCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
SSWGTSTGDGEGLLQLLIQEGMPNHFPDGGSISQGITSIWITLVRVLAPMIALSPGVPGG
HHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LIDPSLAFGGLLGYTFCGLVGSSTHLGLALGMAAGLAGATQLPLVSIVFAWRLVGDQQLF
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCHHHHH
AGVILCSVLAAYIGRLVARKPVYHALAELQRPNRF
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA