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The map label for this gene is ilvA [H]

Identifier: 33862956

GI number: 33862956

Start: 739154

End: 740698

Strand: Reverse

Name: ilvA [H]

Synonym: PMT0684

Alternate gene names: 33862956

Gene position: 740698-739154 (Counterclockwise)

Preceding gene: 33862959

Following gene: 33862955

Centisome position: 30.72

GC content: 52.04

Gene sequence:

>1545_bases
ATGGACGATTATCTACAGAGGATTCTGAGGGCACGTGTCTATGACGTAGCCCATGAAACCCCCCTGGAACTGGCCAAAAA
CCTCAGTCGCCGTTTTCAGAACAAGATCTGGTTGAAACGTGAGGACCTACAGCCAGTCTTCTCATTCAAGCTGCGTGGTG
CGTATAACCGCATGTCCCTTCTCAGCCAAGAAGAGTTGCAGCGTGGCGTGATTGCTTCAAGTGCTGGAAACCACGCTCAG
GGAGTGGCACTGAGCGCCTCTTATCTCAATTGCAGAGCTGTGATTGTGATGCCTATCACCACACCCGAAATGAAGGTACG
GGCAGTCCGTGCTCTTGGCGCTGAAGTCGCACTTCATGGAGAGACCTACGACGAGGCCTATCAAGAGGCCATGCGTCGCA
GTGAAAAAGATGGACTCACGTTTATCCACCCGTTTGATGATCCAGAGGTGATTGCTGGGCAAGGGACGATTGCTCTAGAA
ATCCTGCGCCAGATCCAAGATCCACCAGATGCAATCTATGTCGCAGTTGGCGGTGGCGGACTGATCGGAGGGATTGCCAC
CTATGTCAAAAGCTTGTGGCCGCAAGTCGAAATTATCGGTGTCGAGCCCTACGACGCTGCAGCAATGAAGCTCTCTCTTG
AGGCTGGTGAACGTATTCAGCTGCCCAATGTTGGCCTATTTGCCGACGGAGTCGCTGTACGTCAAGTAGGCAAACTCACC
TTCTCATTAGCCCAGATGCACGTAGACGCGATGGTGACGGTAAGCACTGATGAAATCTGTGCAGCGATCAAAGATGTTTT
TGAAGATACCCGCTCAATTCTTGAACCAGCTGGCGCACTGGCAATTGCTGGCATGAAGGCAGATATCGCCAAACGTGATC
TTCAAGACCGCACTCTTGTGGCCGTGGCCTGTGGCGCAAACATGAACTTTGAACGGCTTCGTTTTGTCGCCGAAAGAGCA
GAGCTAGGGGAAGAAAGGGAAGCAATACTCGCTGTGGAAATCCCAGAACAGGCAGGCAGCCTGCGAAAGCTCTGCAATGT
CCTTGCAGGGAAAAATCTCACCGAATTCAGTTACCGAATGGCAGAAGGGGATAGAGCACAAATATTCATCGGGGTACAGG
TTTTAGACCTGGATGATCGAACCAAGCTTTTAACGCGACTGCAGTCGTCAGGATTCGCATGCCTTGATCTCAGCAACGAC
GAGCTCACCAAAGGGCACCTTCGTCACATGGTGGGTGGTCGGCTTCCTGCCTCAGCCAAAACCCTTTGCCGAGATGGATG
TCGCGAACTGCTCTATCGCTTTGAGTTCCCTGAGCGACCAGGAGCTCTTATGACCTTTGTTAGTGCCCTTCACCCTGAAT
GGAGTATCAGCATCTTCCACTACCGCAATCACGGAGCAGATGTCGGCAGGATCGTTGTAGGTGTGTTGGTTCAGGACAAC
GAAATGGACGATTGGCAGCGCTTTCTTGAAGATCTGGGCTACCCAAACTGGGAAGAAACAAACAACCCCGCCTACTGCTT
ATTTCTGGGTGCACAGACCGTTTGA

Upstream 100 bases:

>100_bases
TCCAACCCATTCAATCTAGGTCTTCTCAGCTATAGAACGACGAAAGCAACCCTGGCAAGTGCAAACAGTTGACGGATCTG
AATATTGCAAGACTGTCGTG

Downstream 100 bases:

>100_bases
TCGCGGTAACTTGGCATATTCCATACCAGGGCCTGCCATGGCCACCGATTCCCCAGCTCAAGAGAGGGATGAGGTCTCCA
GCTTCTCCTTACCAGCACGT

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MDDYLQRILRARVYDVAHETPLELAKNLSRRFQNKIWLKREDLQPVFSFKLRGAYNRMSLLSQEELQRGVIASSAGNHAQ
GVALSASYLNCRAVIVMPITTPEMKVRAVRALGAEVALHGETYDEAYQEAMRRSEKDGLTFIHPFDDPEVIAGQGTIALE
ILRQIQDPPDAIYVAVGGGGLIGGIATYVKSLWPQVEIIGVEPYDAAAMKLSLEAGERIQLPNVGLFADGVAVRQVGKLT
FSLAQMHVDAMVTVSTDEICAAIKDVFEDTRSILEPAGALAIAGMKADIAKRDLQDRTLVAVACGANMNFERLRFVAERA
ELGEEREAILAVEIPEQAGSLRKLCNVLAGKNLTEFSYRMAEGDRAQIFIGVQVLDLDDRTKLLTRLQSSGFACLDLSND
ELTKGHLRHMVGGRLPASAKTLCRDGCRELLYRFEFPERPGALMTFVSALHPEWSISIFHYRNHGADVGRIVVGVLVQDN
EMDDWQRFLEDLGYPNWEETNNPAYCLFLGAQTV

Sequences:

>Translated_514_residues
MDDYLQRILRARVYDVAHETPLELAKNLSRRFQNKIWLKREDLQPVFSFKLRGAYNRMSLLSQEELQRGVIASSAGNHAQ
GVALSASYLNCRAVIVMPITTPEMKVRAVRALGAEVALHGETYDEAYQEAMRRSEKDGLTFIHPFDDPEVIAGQGTIALE
ILRQIQDPPDAIYVAVGGGGLIGGIATYVKSLWPQVEIIGVEPYDAAAMKLSLEAGERIQLPNVGLFADGVAVRQVGKLT
FSLAQMHVDAMVTVSTDEICAAIKDVFEDTRSILEPAGALAIAGMKADIAKRDLQDRTLVAVACGANMNFERLRFVAERA
ELGEEREAILAVEIPEQAGSLRKLCNVLAGKNLTEFSYRMAEGDRAQIFIGVQVLDLDDRTKLLTRLQSSGFACLDLSND
ELTKGHLRHMVGGRLPASAKTLCRDGCRELLYRFEFPERPGALMTFVSALHPEWSISIFHYRNHGADVGRIVVGVLVQDN
EMDDWQRFLEDLGYPNWEETNNPAYCLFLGAQTV
>Mature_514_residues
MDDYLQRILRARVYDVAHETPLELAKNLSRRFQNKIWLKREDLQPVFSFKLRGAYNRMSLLSQEELQRGVIASSAGNHAQ
GVALSASYLNCRAVIVMPITTPEMKVRAVRALGAEVALHGETYDEAYQEAMRRSEKDGLTFIHPFDDPEVIAGQGTIALE
ILRQIQDPPDAIYVAVGGGGLIGGIATYVKSLWPQVEIIGVEPYDAAAMKLSLEAGERIQLPNVGLFADGVAVRQVGKLT
FSLAQMHVDAMVTVSTDEICAAIKDVFEDTRSILEPAGALAIAGMKADIAKRDLQDRTLVAVACGANMNFERLRFVAERA
ELGEEREAILAVEIPEQAGSLRKLCNVLAGKNLTEFSYRMAEGDRAQIFIGVQVLDLDDRTKLLTRLQSSGFACLDLSND
ELTKGHLRHMVGGRLPASAKTLCRDGCRELLYRFEFPERPGALMTFVSALHPEWSISIFHYRNHGADVGRIVVGVLVQDN
EMDDWQRFLEDLGYPNWEETNNPAYCLFLGAQTV

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=284, Percent_Identity=35.5633802816901, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI33469958, Length=311, Percent_Identity=30.5466237942122, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI19923959, Length=317, Percent_Identity=29.6529968454259, Blast_Score=100, Evalue=5e-21,
Organism=Escherichia coli, GI1790207, Length=508, Percent_Identity=50.1968503937008, Blast_Score=483, Evalue=1e-138,
Organism=Escherichia coli, GI1789505, Length=315, Percent_Identity=38.4126984126984, Blast_Score=179, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI71991565, Length=330, Percent_Identity=34.8484848484849, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17537387, Length=325, Percent_Identity=36.3076923076923, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17508781, Length=303, Percent_Identity=30.03300330033, Blast_Score=132, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6320930, Length=524, Percent_Identity=47.9007633587786, Blast_Score=470, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6322631, Length=301, Percent_Identity=35.5481727574751, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6319788, Length=319, Percent_Identity=25.705329153605, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21355833, Length=314, Percent_Identity=36.3057324840764, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24645328, Length=252, Percent_Identity=35.7142857142857, Blast_Score=116, Evalue=5e-26,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 56986; Mature: 56986

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDYLQRILRARVYDVAHETPLELAKNLSRRFQNKIWLKREDLQPVFSFKLRGAYNRMSL
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEECCCCCHHHHHHHCCCHHHHHH
LSQEELQRGVIASSAGNHAQGVALSASYLNCRAVIVMPITTPEMKVRAVRALGAEVALHG
HHHHHHHCCHHHCCCCCCCCCEEEEEEEECEEEEEEEECCCCHHHHHHHHHHCCEEEECC
ETYDEAYQEAMRRSEKDGLTFIHPFDDPEVIAGQGTIALEILRQIQDPPDAIYVAVGGGG
CHHHHHHHHHHHCCCCCCEEEECCCCCCCEEECCCHHHHHHHHHHCCCCCEEEEEECCCC
LIGGIATYVKSLWPQVEIIGVEPYDAAAMKLSLEAGERIQLPNVGLFADGVAVRQVGKLT
HHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEECCCCEEECCCCCEEECCHHHHHHHHHH
FSLAQMHVDAMVTVSTDEICAAIKDVFEDTRSILEPAGALAIAGMKADIAKRDLQDRTLV
HHHHHHHEEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHCCCCCEEE
AVACGANMNFERLRFVAERAELGEEREAILAVEIPEQAGSLRKLCNVLAGKNLTEFSYRM
EEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCHHHHHHH
AEGDRAQIFIGVQVLDLDDRTKLLTRLQSSGFACLDLSNDELTKGHLRHMVGGRLPASAK
CCCCCEEEEEEEEEEECCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCCCHHH
TLCRDGCRELLYRFEFPERPGALMTFVSALHPEWSISIFHYRNHGADVGRIVVGVLVQDN
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCHHHEEEEEEEECC
EMDDWQRFLEDLGYPNWEETNNPAYCLFLGAQTV
CHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCC
>Mature Secondary Structure
MDDYLQRILRARVYDVAHETPLELAKNLSRRFQNKIWLKREDLQPVFSFKLRGAYNRMSL
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEECCCCCHHHHHHHCCCHHHHHH
LSQEELQRGVIASSAGNHAQGVALSASYLNCRAVIVMPITTPEMKVRAVRALGAEVALHG
HHHHHHHCCHHHCCCCCCCCCEEEEEEEECEEEEEEEECCCCHHHHHHHHHHCCEEEECC
ETYDEAYQEAMRRSEKDGLTFIHPFDDPEVIAGQGTIALEILRQIQDPPDAIYVAVGGGG
CHHHHHHHHHHHCCCCCCEEEECCCCCCCEEECCCHHHHHHHHHHCCCCCEEEEEECCCC
LIGGIATYVKSLWPQVEIIGVEPYDAAAMKLSLEAGERIQLPNVGLFADGVAVRQVGKLT
HHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEECCCCEEECCCCCEEECCHHHHHHHHHH
FSLAQMHVDAMVTVSTDEICAAIKDVFEDTRSILEPAGALAIAGMKADIAKRDLQDRTLV
HHHHHHHEEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHCCCCCEEE
AVACGANMNFERLRFVAERAELGEEREAILAVEIPEQAGSLRKLCNVLAGKNLTEFSYRM
EEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCHHHHHHH
AEGDRAQIFIGVQVLDLDDRTKLLTRLQSSGFACLDLSNDELTKGHLRHMVGGRLPASAK
CCCCCEEEEEEEEEEECCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCCCHHH
TLCRDGCRELLYRFEFPERPGALMTFVSALHPEWSISIFHYRNHGADVGRIVVGVLVQDN
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCHHHEEEEEEEECC
EMDDWQRFLEDLGYPNWEETNNPAYCLFLGAQTV
CHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA