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The map label for this gene is ilvD [H]

Identifier: 33862833

GI number: 33862833

Start: 613587

End: 615257

Strand: Direct

Name: ilvD [H]

Synonym: PMT0560

Alternate gene names: 33862833

Gene position: 613587-615257 (Clockwise)

Preceding gene: 33862832

Following gene: 33862836

Centisome position: 25.45

GC content: 53.98

Gene sequence:

>1671_bases
ATGCTCAGATCCGCCGCCATCACAAAGGGAACTCAACGCTCTCCCAACCGAGCCATGCTTCGCGCAGTGGGCTTTGGCGA
CGAAGACTTCAATAAACCAATCATCGGTATAGCCAACGGCTACAGCACGATCACTCCTTGCAACATCGGTCTTAATGACC
TGGCGCGACGTTCAGAAGAAGCAGCCCGCCAGGCCGGTGCAATGCCCCAGATGTTCGGCACCATCACTGTCAGTGATGGC
ATCTCTATGGGCACCGAAGGGATGAAATATTCCCTGGTAAGTCGCGAGGTGATTGCTGATTCGATCGAGACAGCCTGCAA
CGCCCAAAGCATGGACGGCGTACTAGCAATCGGTGGCTGTGACAAAAACATGCCTGGAGCGATGATCGCCCTGGCCCGAA
TGAACATCCCAGGTGTCTTTGTCTATGGCGGAACGATCAAACCAGGAAAATTGGCTGACCGCGACCTCACTGTAGTCAGC
GCCTTTGAAGCTGTTGGTCAGCATGCCAGTGGCAAGATAAATGAGGAGCAACTCACCGCTATCGAGAAGAACGCTTGCCC
AGGAGCAGGAAGTTGCGGTGGCATGTTTACAGCCAACACGATGTCAGCCGCTATTGAAACATTGGGATTGAGTTTGCCTT
ACAGCTCAACGATGGCTGCAGAGGATGAGGAAAAAGCAAATAGCGCAGCCCGTAGTGCTGAAGTGCTTGTGGATGCCATT
AAGGCAAATATCTGTCCCCGCGATCTACTCACCAAGAACGCATTTGAAAACGCGATTAGCGTTGTCATGGCAGTGGGCGG
CTCCACCAATGCAGTTCTGCATCTGCTTGCGATTGCCCGTAGCGCAGGCGTAGACCTTTGCATCGATGACTTCGAGCGCA
TCCGCCAGCGTGTACCGGTGATTTGTGATCTAAAACCCAGCGGCCGTTACGTGACTGTTGATTTGCATAACGCAGGCGGC
ATTCCCCAAGTGATGAAACAGTTGCTTGATGCAGGCTTACTTCATGGAGACTGCCGCAATGTGGAAGGTAAAACCTTGAG
AGAACTGCTCAAGGATGTGCCATCCGAGCCTTCAGCAGAGCAAGACGTCATTCATCCCCTCTCGAAACCGGTCTATGCCA
AGGGGCACCTGGCGATCCTTAAAGGCAATCTGGCCAGCGAAGGATGCGTGGCCAAGATAAGCGGGATCAAAACCCCAGTA
CTTACTGGACCTGCAAGGGTTTTTGAAAGCGAGGAGGCCTGCCTTGCTGCCATTCTCAACAACAAGGTGAAGGCGGGAGA
TGTCGTCGTCATACGTAACGAAGGCCCGGTTGGCGGGCCTGGAATGCGAGAGATGCTTGCTCCTACATCTGCCATCGTCG
GTGAAGACCTTGGCGACAAGGTGGCCTTAATCACAGATGGACGCTTCAGCGGAGGTACCTATGGTTTGGTGGTGGGCCAT
GTGGCACCGGAAGCAGCCGTAGGCGGCATGATTGGCCTTGTGCAGGAAGGCGACAGCATCACCATCGATGCCAATCAACT
GCTGATCCAACTCAATGTCGAGAAGGATGAATTGGAGCGTCGCTCCAGCGCATGGGAAAAAACACAGCCGCGTTATCAAA
CAGGAGTTCTCGGTAAATACGCCCGAATGGTGAGTAGCGCCAGCAATGGTGCTGTCACCGACCAGCCCTGA

Upstream 100 bases:

>100_bases
CTCAATGCCGCCATTGCAGATGTGCGCAGACAGCTTGAAGATCTAGGGGCGCGGACCTAAGAGCTCGGTAAGTTGGCGAC
TGAGTGCCCCAGTCGCCACC

Downstream 100 bases:

>100_bases
ACTCTGATCAACTAGCTCTGCTCAGGCAAAACCAGCAGTGCTCTCAACCTACGAGCGAACGCTTCCAATGGTGCTCCATC
CTCAGGCGGCTGACAGCGTT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MLRSAAITKGTQRSPNRAMLRAVGFGDEDFNKPIIGIANGYSTITPCNIGLNDLARRSEEAARQAGAMPQMFGTITVSDG
ISMGTEGMKYSLVSREVIADSIETACNAQSMDGVLAIGGCDKNMPGAMIALARMNIPGVFVYGGTIKPGKLADRDLTVVS
AFEAVGQHASGKINEEQLTAIEKNACPGAGSCGGMFTANTMSAAIETLGLSLPYSSTMAAEDEEKANSAARSAEVLVDAI
KANICPRDLLTKNAFENAISVVMAVGGSTNAVLHLLAIARSAGVDLCIDDFERIRQRVPVICDLKPSGRYVTVDLHNAGG
IPQVMKQLLDAGLLHGDCRNVEGKTLRELLKDVPSEPSAEQDVIHPLSKPVYAKGHLAILKGNLASEGCVAKISGIKTPV
LTGPARVFESEEACLAAILNNKVKAGDVVVIRNEGPVGGPGMREMLAPTSAIVGEDLGDKVALITDGRFSGGTYGLVVGH
VAPEAAVGGMIGLVQEGDSITIDANQLLIQLNVEKDELERRSSAWEKTQPRYQTGVLGKYARMVSSASNGAVTDQP

Sequences:

>Translated_556_residues
MLRSAAITKGTQRSPNRAMLRAVGFGDEDFNKPIIGIANGYSTITPCNIGLNDLARRSEEAARQAGAMPQMFGTITVSDG
ISMGTEGMKYSLVSREVIADSIETACNAQSMDGVLAIGGCDKNMPGAMIALARMNIPGVFVYGGTIKPGKLADRDLTVVS
AFEAVGQHASGKINEEQLTAIEKNACPGAGSCGGMFTANTMSAAIETLGLSLPYSSTMAAEDEEKANSAARSAEVLVDAI
KANICPRDLLTKNAFENAISVVMAVGGSTNAVLHLLAIARSAGVDLCIDDFERIRQRVPVICDLKPSGRYVTVDLHNAGG
IPQVMKQLLDAGLLHGDCRNVEGKTLRELLKDVPSEPSAEQDVIHPLSKPVYAKGHLAILKGNLASEGCVAKISGIKTPV
LTGPARVFESEEACLAAILNNKVKAGDVVVIRNEGPVGGPGMREMLAPTSAIVGEDLGDKVALITDGRFSGGTYGLVVGH
VAPEAAVGGMIGLVQEGDSITIDANQLLIQLNVEKDELERRSSAWEKTQPRYQTGVLGKYARMVSSASNGAVTDQP
>Mature_556_residues
MLRSAAITKGTQRSPNRAMLRAVGFGDEDFNKPIIGIANGYSTITPCNIGLNDLARRSEEAARQAGAMPQMFGTITVSDG
ISMGTEGMKYSLVSREVIADSIETACNAQSMDGVLAIGGCDKNMPGAMIALARMNIPGVFVYGGTIKPGKLADRDLTVVS
AFEAVGQHASGKINEEQLTAIEKNACPGAGSCGGMFTANTMSAAIETLGLSLPYSSTMAAEDEEKANSAARSAEVLVDAI
KANICPRDLLTKNAFENAISVVMAVGGSTNAVLHLLAIARSAGVDLCIDDFERIRQRVPVICDLKPSGRYVTVDLHNAGG
IPQVMKQLLDAGLLHGDCRNVEGKTLRELLKDVPSEPSAEQDVIHPLSKPVYAKGHLAILKGNLASEGCVAKISGIKTPV
LTGPARVFESEEACLAAILNNKVKAGDVVVIRNEGPVGGPGMREMLAPTSAIVGEDLGDKVALITDGRFSGGTYGLVVGH
VAPEAAVGGMIGLVQEGDSITIDANQLLIQLNVEKDELERRSSAWEKTQPRYQTGVLGKYARMVSSASNGAVTDQP

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=607, Percent_Identity=40.8566721581549, Blast_Score=414, Evalue=1e-117,
Organism=Escherichia coli, GI2367371, Length=494, Percent_Identity=34.412955465587, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1788157, Length=507, Percent_Identity=30.7692307692308, Blast_Score=201, Evalue=8e-53,
Organism=Escherichia coli, GI1786464, Length=514, Percent_Identity=33.852140077821, Blast_Score=198, Evalue=9e-52,
Organism=Saccharomyces cerevisiae, GI6322476, Length=559, Percent_Identity=50.0894454382826, Blast_Score=536, Evalue=1e-153,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 58232; Mature: 58232

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRSAAITKGTQRSPNRAMLRAVGFGDEDFNKPIIGIANGYSTITPCNIGLNDLARRSEE
CCCCCCCCCCCCCCCCHHHHEEECCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHH
AARQAGAMPQMFGTITVSDGISMGTEGMKYSLVSREVIADSIETACNAQSMDGVLAIGGC
HHHHHCCCCHHHEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCEEEECCC
DKNMPGAMIALARMNIPGVFVYGGTIKPGKLADRDLTVVSAFEAVGQHASGKINEEQLTA
CCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHH
IEKNACPGAGSCGGMFTANTMSAAIETLGLSLPYSSTMAAEDEEKANSAARSAEVLVDAI
HHHCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
KANICPRDLLTKNAFENAISVVMAVGGSTNAVLHLLAIARSAGVDLCIDDFERIRQRVPV
HHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCE
ICDLKPSGRYVTVDLHNAGGIPQVMKQLLDAGLLHGDCRNVEGKTLRELLKDVPSEPSAE
EEEECCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCC
QDVIHPLSKPVYAKGHLAILKGNLASEGCVAKISGIKTPVLTGPARVFESEEACLAAILN
HHHHHHCCCCCCCCCCEEEEECCCCCCCCEEECCCCCCCCCCCHHHHHCCHHHHHHHHHC
NKVKAGDVVVIRNEGPVGGPGMREMLAPTSAIVGEDLGDKVALITDGRFSGGTYGLVVGH
CCCCCCCEEEEECCCCCCCCCHHHHHCCHHHHHCCCCCCEEEEEECCCCCCCEEEEEEEC
VAPEAAVGGMIGLVQEGDSITIDANQLLIQLNVEKDELERRSSAWEKTQPRYQTGVLGKY
CCCHHHHCCCEEEEECCCEEEEECCEEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHH
ARMVSSASNGAVTDQP
HHHHHCCCCCCCCCCC
>Mature Secondary Structure
MLRSAAITKGTQRSPNRAMLRAVGFGDEDFNKPIIGIANGYSTITPCNIGLNDLARRSEE
CCCCCCCCCCCCCCCCHHHHEEECCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHH
AARQAGAMPQMFGTITVSDGISMGTEGMKYSLVSREVIADSIETACNAQSMDGVLAIGGC
HHHHHCCCCHHHEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCEEEECCC
DKNMPGAMIALARMNIPGVFVYGGTIKPGKLADRDLTVVSAFEAVGQHASGKINEEQLTA
CCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHH
IEKNACPGAGSCGGMFTANTMSAAIETLGLSLPYSSTMAAEDEEKANSAARSAEVLVDAI
HHHCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
KANICPRDLLTKNAFENAISVVMAVGGSTNAVLHLLAIARSAGVDLCIDDFERIRQRVPV
HHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCE
ICDLKPSGRYVTVDLHNAGGIPQVMKQLLDAGLLHGDCRNVEGKTLRELLKDVPSEPSAE
EEEECCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCC
QDVIHPLSKPVYAKGHLAILKGNLASEGCVAKISGIKTPVLTGPARVFESEEACLAAILN
HHHHHHCCCCCCCCCCEEEEECCCCCCCCEEECCCCCCCCCCCHHHHHCCHHHHHHHHHC
NKVKAGDVVVIRNEGPVGGPGMREMLAPTSAIVGEDLGDKVALITDGRFSGGTYGLVVGH
CCCCCCCEEEEECCCCCCCCCHHHHHCCHHHHHCCCCCCEEEEEECCCCCCCEEEEEEEC
VAPEAAVGGMIGLVQEGDSITIDANQLLIQLNVEKDELERRSSAWEKTQPRYQTGVLGKY
CCCHHHHCCCEEEEECCCEEEEECCEEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHH
ARMVSSASNGAVTDQP
HHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA