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The map label for this gene is hisA [H]

Identifier: 33862793

GI number: 33862793

Start: 569319

End: 570086

Strand: Direct

Name: hisA [H]

Synonym: PMT0520

Alternate gene names: 33862793

Gene position: 569319-570086 (Clockwise)

Preceding gene: 33862791

Following gene: 33862794

Centisome position: 23.61

GC content: 55.99

Gene sequence:

>768_bases
ATGGAGATCATCCCAGCCATCGACCTACTGGACAGCGTGTGCGTGCGACTTCACCAGGGGGACTACGAGAAGGTGACTCG
CTTCAGCGAGGACCCCGTTGATCAAGCCCTTAGCTGGCAGAAGCAGGGGGCAACTCGCCTACACCTGGTGGATCTCGATG
GCGCCAAATCTGGTGAGCCGGTCAACGATTCCTGTGTGCGAGCTATTACCTCTGCCCTCAATATTCCTGTCCAGCTCGGG
GGTGGTGTGCGCACTCTCGAACGAGCCGAAGAACTCCTCGCCTACGGCCTTGAACAAGTCATCCTTGGCACCGTGGCAAT
AGAGCAACCCCAGCTAGTGAAACAGCTTGCCCAAAGGAATCCCGGTCGGATTATCGTCGGCATCGATGCCAAAAACGGCA
AGGTGGCAACGCGAGGATGGATTAGCCAAAGCGAGGTGAATGCAACAGACTTAGCCTCCGATTTCAATGCTGCCGGTATC
GCCGCAATCATCAGCACAGACATTGCAACTGATGGAACCCTTGAAGGGCCGAACCTAGAGTCACTACGTGCAATGGCAAA
CGCCAGCAGCGTTCCAGTAATCGCCTCCGGAGGCGTGGGTTGCATGGCCGATCTACTTAGTCTGCTGGCTCTTGAACCCT
ATGGAGTGAGTGGGGTGATTGTGGGAAGAGCTCTCTACGACGGCAAGGTGGATCTAAAAGAAGCAATCCGAGCCATTGGC
GATGGCCGACTGCAGGACCCACCAACTAGCAAACCACTGATGGCATGA

Upstream 100 bases:

>100_bases
AGCTGAATCATCAAACGCGCATATTGAAGCGCGTTCGATCAGCAACTGAAGGCCCTTCGCCCTGCAGGATGGAGGTCTAA
GGCAACGTTCTTTGCCAATC

Downstream 100 bases:

>100_bases
GGACCTTGGACTATGAATTGACCTTGCTGGAGCCGTAAATTGAATTCATTATCACTTCAGTTGTGATGCACACCGCTCCC
AAGATCAGCGGCTCAAGTGC

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MEIIPAIDLLDSVCVRLHQGDYEKVTRFSEDPVDQALSWQKQGATRLHLVDLDGAKSGEPVNDSCVRAITSALNIPVQLG
GGVRTLERAEELLAYGLEQVILGTVAIEQPQLVKQLAQRNPGRIIVGIDAKNGKVATRGWISQSEVNATDLASDFNAAGI
AAIISTDIATDGTLEGPNLESLRAMANASSVPVIASGGVGCMADLLSLLALEPYGVSGVIVGRALYDGKVDLKEAIRAIG
DGRLQDPPTSKPLMA

Sequences:

>Translated_255_residues
MEIIPAIDLLDSVCVRLHQGDYEKVTRFSEDPVDQALSWQKQGATRLHLVDLDGAKSGEPVNDSCVRAITSALNIPVQLG
GGVRTLERAEELLAYGLEQVILGTVAIEQPQLVKQLAQRNPGRIIVGIDAKNGKVATRGWISQSEVNATDLASDFNAAGI
AAIISTDIATDGTLEGPNLESLRAMANASSVPVIASGGVGCMADLLSLLALEPYGVSGVIVGRALYDGKVDLKEAIRAIG
DGRLQDPPTSKPLMA
>Mature_255_residues
MEIIPAIDLLDSVCVRLHQGDYEKVTRFSEDPVDQALSWQKQGATRLHLVDLDGAKSGEPVNDSCVRAITSALNIPVQLG
GGVRTLERAEELLAYGLEQVILGTVAIEQPQLVKQLAQRNPGRIIVGIDAKNGKVATRGWISQSEVNATDLASDFNAAGI
AAIISTDIATDGTLEGPNLESLRAMANASSVPVIASGGVGCMADLLSLLALEPYGVSGVIVGRALYDGKVDLKEAIRAIG
DGRLQDPPTSKPLMA

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=241, Percent_Identity=38.5892116182573, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1788336, Length=245, Percent_Identity=27.3469387755102, Blast_Score=84, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 26818; Mature: 26818

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIIPAIDLLDSVCVRLHQGDYEKVTRFSEDPVDQALSWQKQGATRLHLVDLDGAKSGEP
CCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCC
VNDSCVRAITSALNIPVQLGGGVRTLERAEELLAYGLEQVILGTVAIEQPQLVKQLAQRN
CCHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
PGRIIVGIDAKNGKVATRGWISQSEVNATDLASDFNAAGIAAIISTDIATDGTLEGPNLE
CCEEEEEEECCCCEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHH
SLRAMANASSVPVIASGGVGCMADLLSLLALEPYGVSGVIVGRALYDGKVDLKEAIRAIG
HHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCCCCCEEEEEEEHCCCCCCHHHHHHHHC
DGRLQDPPTSKPLMA
CCCCCCCCCCCCCCC
>Mature Secondary Structure
MEIIPAIDLLDSVCVRLHQGDYEKVTRFSEDPVDQALSWQKQGATRLHLVDLDGAKSGEP
CCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCC
VNDSCVRAITSALNIPVQLGGGVRTLERAEELLAYGLEQVILGTVAIEQPQLVKQLAQRN
CCHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
PGRIIVGIDAKNGKVATRGWISQSEVNATDLASDFNAAGIAAIISTDIATDGTLEGPNLE
CCEEEEEEECCCCEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHH
SLRAMANASSVPVIASGGVGCMADLLSLLALEPYGVSGVIVGRALYDGKVDLKEAIRAIG
HHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCCCCCEEEEEEEHCCCCCCHHHHHHHHC
DGRLQDPPTSKPLMA
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA