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The map label for this gene is clpB1

Identifier: 33862722

GI number: 33862722

Start: 506406

End: 509003

Strand: Direct

Name: clpB1

Synonym: PMT0449

Alternate gene names: 33862722

Gene position: 506406-509003 (Clockwise)

Preceding gene: 33862721

Following gene: 33862725

Centisome position: 21.01

GC content: 50.62

Gene sequence:

>2598_bases
ATGCAACCTACAGCGGATCAATTTACCGAAAAAGGCTGGGCAGCAATCGTTTTGGCCCAACAACTTGCCCAACAACGCAA
GCACCAGCAACTGGAAACAGAGCATTTGTTGTTGTCACTGCTCCAGCAAAACGCTTTGGCCGGAAGAATCCTGGAAAAAG
CAGGTGTGTCGATCGGCAACTTGCAAACAGCCGTGGAGGCACACCTGCAAGAACAGCCCACTATGCAGGCTGCGCCAGAC
TCTGTCTATCTGGGCAAGGGAGTCAATGATCTTCTCGATCAAGCTGAGAAACATAAGCAAGCTTTTGGCGATAGTTTCAT
CTCGATTGAACATCTGTTACTTGCATTGGCCGGGGACAATCGTTGCGGCCGTAAGTTGCTCAATCAAGCGGGCGTGGATG
CCGGCAAACTAAAGGTTGCAATTGACGCGGTACGCGGAAACCAGAAGGTGACCGATCAGAACCCAGAAGGAACTTACGAA
TCTCTCGAAAAATATGGCAGAGACCTGAGTGCTGCTGCTCGCGAAGGCAAACTCGACCCTGTCATCGGAAGGGACGATGA
GATTCGACGCACGATTCAGATTCTTAGTAGGCGCACCAAAAACAACCCTGTCCTCATTGGGGAGCCAGGGGTGGGAAAAA
CCGCAATTGTTGAAGGCCTCGCACAGCGGATTGTTAATGGCGATGTACCTGCAGCCCTTCAGAACAGACAGTTAATCACC
CTTGATATGGGTGCTTTGATTGCAGGGGCGAAATATCGAGGTGAATTCGAAGAGCGACTCAAGGCGGTGCTCAAAGAAGT
TACCGCCTCTGAAGGACAAATCGTACTTTTTATTGATGAAATCCATACTGTTGTAGGAGCTGGAGCGACCGGTGGGGCAA
TGGATGCCAGCAATCTGCTTAAGCCAATGCTGGCTCGAGGGGAACTGCGCTGCATTGGTGCAACGACCCTCGATGAGCAC
CGACAGCACATCGAAAAAGACCCCGCTTTAGAAAGAAGATTCCAACAAGTGCTTGTGGATCAACCCACAGTGCAAGACAC
GATCTCCATCCTGCGTGGTCTCAAAGAACGCTACGAAGTGCATCATGGTGTGCGCATTGCTGATAACGCCCTAGTTGCTG
CAGCTGTGCTCAGTAGCCGATATATTGCCGATCGCTTTTTGCCAGATAAAGCCATCGATTTGATGGATGAATCTGCTGCA
CGGCTGAAAATGGAAATCACTTCCAAGCCTGAGGAAATTGATGAAATCGATCGCAAGATTGTGCAGCTCGAGATGGAGAA
GCTTTCCCTAGGACGTGAGTCCGACTCCGTTAGCAAGGAAAGGTTGGAAAAACTAGAACGCGAACTTGCTGAATTAGCAG
AGCAACAAAGTGCCCTCAATGCACAGTGGCAACAAGAAAAAGGTGCGATTGACGACCTTTCTTCGCTCAAAGAAGAAATC
GAACGGGTGCAATTGCAAGTGGAGCAAGCCAAGCGCAGCTACGACCTCAACAAGGCAGCTGAACTGGAGTATGGAACTCT
GGCGGGATTGCAGAAACAACTCAGCGAGAAAGAAACTGCCCTGGCCCAAGATGGAGAGGCAGGCGATAAATCACTGCTGC
GAGAGGAGGTTACGGAAGATGATATTGCTGATGTCATCGCTAAATGGACCGGGATTCCCGTCGCCAAGCTTGTGCAGTCG
GAAATGGAAAAGCTGCTTGGACTTGAAGCAGAACTCCACCAACGTGTGATTGGCCAAGAACAGGCTGTGCAAGCTGTTGC
GGATGCGATTCAGCGTTCTAGGGCAGGTTTAAGTGATCCCAACCGCCCGATCGCAAGTTTTTTATTTCTAGGCCCCACTG
GTGTCGGTAAAACGGAGCTATCCAAGGCATTGGCCTCTCAACTGTTTGACAGCGAGGCGGCTTTGGTTCGAATCGATATG
TCTGAGTATATGGAGAAGCACAGTGTCAGCAGACTGATTGGGGCCCCTCCGGGTTATGTGGGCTATGAGGCCGGTGGACA
GCTCACCGAAGCCGTACGCAGACGCCCTTATGCGGTAATCCTGTTCGATGAAGTGGAGAAGGCACACCAAGATGTGTTCA
ATGTGATGTTACAGATCCTTGATGATGGACGTGTCACCGATGGTCAGGGTCGCACAGTTGATTTTACAAATACGGTGCTA
ATTCTTACCAGTAATATTGGCAGCCAGTCGATTCTCGACTTGGGAGGCGATGATAGTCAATACAGGGAAATGGAGCGGCG
AGTTCATGATGCTTTGCACGCTCATTTTAGGCCTGAGTTTCTCAACCGCCTGGATGAAACAATCATCTTTCATAGTCTCA
GGCGCGAGGAACTGCGTCAGATCGTTGCCCTTCAGGTCAATCGGCTGCGTGAGCGTCTTTGCGATCGCAAGCTTGGCCTA
GAGATCAGTGATACAGCAGCTGATTGGCTCGCCAATGCTGGCTATGACCCTGTTTATGGGGCTAGACCCCTTAAGCGAGC
GATACAACGCGAGCTTGAAACTCCAATAGCCAAAAGTATCCTGGCGGGCCTTTATGGAGATAGTCAGATTGTGCATGTGG
ATGTGGATGTGGATCAGGAGCGTCTGAGTTTTCGCTAA

Upstream 100 bases:

>100_bases
GCTTACCACACTCTGCCGAAAGAGCCGTACCAATCAGAACGGTTTACCGCTTGGCGCTAATGGTTAGTCGACATACGGTT
GAATCAACGTAAAAGACCAC

Downstream 100 bases:

>100_bases
TGCTTATCCCCTTCGCGCTCCCATTAGGGGAGTCGATCGAGCAAATTGATCAGAGCAAAGTCTTCGTCTCAAACCACGTA
GGTGTTGCTTCATAGCAAGC

Product: ATP-dependent Clp protease, Hsp 100, ATP-binding subunit ClpB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 865; Mature: 865

Protein sequence:

>865_residues
MQPTADQFTEKGWAAIVLAQQLAQQRKHQQLETEHLLLSLLQQNALAGRILEKAGVSIGNLQTAVEAHLQEQPTMQAAPD
SVYLGKGVNDLLDQAEKHKQAFGDSFISIEHLLLALAGDNRCGRKLLNQAGVDAGKLKVAIDAVRGNQKVTDQNPEGTYE
SLEKYGRDLSAAAREGKLDPVIGRDDEIRRTIQILSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGDVPAALQNRQLIT
LDMGALIAGAKYRGEFEERLKAVLKEVTASEGQIVLFIDEIHTVVGAGATGGAMDASNLLKPMLARGELRCIGATTLDEH
RQHIEKDPALERRFQQVLVDQPTVQDTISILRGLKERYEVHHGVRIADNALVAAAVLSSRYIADRFLPDKAIDLMDESAA
RLKMEITSKPEEIDEIDRKIVQLEMEKLSLGRESDSVSKERLEKLERELAELAEQQSALNAQWQQEKGAIDDLSSLKEEI
ERVQLQVEQAKRSYDLNKAAELEYGTLAGLQKQLSEKETALAQDGEAGDKSLLREEVTEDDIADVIAKWTGIPVAKLVQS
EMEKLLGLEAELHQRVIGQEQAVQAVADAIQRSRAGLSDPNRPIASFLFLGPTGVGKTELSKALASQLFDSEAALVRIDM
SEYMEKHSVSRLIGAPPGYVGYEAGGQLTEAVRRRPYAVILFDEVEKAHQDVFNVMLQILDDGRVTDGQGRTVDFTNTVL
ILTSNIGSQSILDLGGDDSQYREMERRVHDALHAHFRPEFLNRLDETIIFHSLRREELRQIVALQVNRLRERLCDRKLGL
EISDTAADWLANAGYDPVYGARPLKRAIQRELETPIAKSILAGLYGDSQIVHVDVDVDQERLSFR

Sequences:

>Translated_865_residues
MQPTADQFTEKGWAAIVLAQQLAQQRKHQQLETEHLLLSLLQQNALAGRILEKAGVSIGNLQTAVEAHLQEQPTMQAAPD
SVYLGKGVNDLLDQAEKHKQAFGDSFISIEHLLLALAGDNRCGRKLLNQAGVDAGKLKVAIDAVRGNQKVTDQNPEGTYE
SLEKYGRDLSAAAREGKLDPVIGRDDEIRRTIQILSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGDVPAALQNRQLIT
LDMGALIAGAKYRGEFEERLKAVLKEVTASEGQIVLFIDEIHTVVGAGATGGAMDASNLLKPMLARGELRCIGATTLDEH
RQHIEKDPALERRFQQVLVDQPTVQDTISILRGLKERYEVHHGVRIADNALVAAAVLSSRYIADRFLPDKAIDLMDESAA
RLKMEITSKPEEIDEIDRKIVQLEMEKLSLGRESDSVSKERLEKLERELAELAEQQSALNAQWQQEKGAIDDLSSLKEEI
ERVQLQVEQAKRSYDLNKAAELEYGTLAGLQKQLSEKETALAQDGEAGDKSLLREEVTEDDIADVIAKWTGIPVAKLVQS
EMEKLLGLEAELHQRVIGQEQAVQAVADAIQRSRAGLSDPNRPIASFLFLGPTGVGKTELSKALASQLFDSEAALVRIDM
SEYMEKHSVSRLIGAPPGYVGYEAGGQLTEAVRRRPYAVILFDEVEKAHQDVFNVMLQILDDGRVTDGQGRTVDFTNTVL
ILTSNIGSQSILDLGGDDSQYREMERRVHDALHAHFRPEFLNRLDETIIFHSLRREELRQIVALQVNRLRERLCDRKLGL
EISDTAADWLANAGYDPVYGARPLKRAIQRELETPIAKSILAGLYGDSQIVHVDVDVDQERLSFR
>Mature_865_residues
MQPTADQFTEKGWAAIVLAQQLAQQRKHQQLETEHLLLSLLQQNALAGRILEKAGVSIGNLQTAVEAHLQEQPTMQAAPD
SVYLGKGVNDLLDQAEKHKQAFGDSFISIEHLLLALAGDNRCGRKLLNQAGVDAGKLKVAIDAVRGNQKVTDQNPEGTYE
SLEKYGRDLSAAAREGKLDPVIGRDDEIRRTIQILSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGDVPAALQNRQLIT
LDMGALIAGAKYRGEFEERLKAVLKEVTASEGQIVLFIDEIHTVVGAGATGGAMDASNLLKPMLARGELRCIGATTLDEH
RQHIEKDPALERRFQQVLVDQPTVQDTISILRGLKERYEVHHGVRIADNALVAAAVLSSRYIADRFLPDKAIDLMDESAA
RLKMEITSKPEEIDEIDRKIVQLEMEKLSLGRESDSVSKERLEKLERELAELAEQQSALNAQWQQEKGAIDDLSSLKEEI
ERVQLQVEQAKRSYDLNKAAELEYGTLAGLQKQLSEKETALAQDGEAGDKSLLREEVTEDDIADVIAKWTGIPVAKLVQS
EMEKLLGLEAELHQRVIGQEQAVQAVADAIQRSRAGLSDPNRPIASFLFLGPTGVGKTELSKALASQLFDSEAALVRIDM
SEYMEKHSVSRLIGAPPGYVGYEAGGQLTEAVRRRPYAVILFDEVEKAHQDVFNVMLQILDDGRVTDGQGRTVDFTNTVL
ILTSNIGSQSILDLGGDDSQYREMERRVHDALHAHFRPEFLNRLDETIIFHSLRREELRQIVALQVNRLRERLCDRKLGL
EISDTAADWLANAGYDPVYGARPLKRAIQRELETPIAKSILAGLYGDSQIVHVDVDVDQERLSFR

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family

Homologues:

Organism=Homo sapiens, GI13540606, Length=309, Percent_Identity=38.5113268608414, Blast_Score=202, Evalue=1e-51,
Organism=Escherichia coli, GI1788943, Length=855, Percent_Identity=55.5555555555556, Blast_Score=936, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=408, Percent_Identity=40.9313725490196, Blast_Score=284, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6320464, Length=708, Percent_Identity=52.8248587570621, Blast_Score=765, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=859, Percent_Identity=43.0733410942957, Blast_Score=685, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): CLPB_PROMM (Q7V8B1)

Other databases:

- EMBL:   BX548175
- RefSeq:   NP_894282.1
- ProteinModelPortal:   Q7V8B1
- STRING:   Q7V8B1
- GeneID:   1729619
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT0449
- NMPDR:   fig|74547.1.peg.449
- eggNOG:   COG0542
- HOGENOM:   HBG413133
- OMA:   DVESTIA
- ProtClustDB:   CLSK825903
- BioCyc:   PMAR74547:PMT0449-MONOMER
- GO:   GO:0005737
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- Gene3D:   G3DSA:1.10.1780.10
- PRINTS:   PR00300
- SMART:   SM00382
- TIGRFAMs:   TIGR03346

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small

EC number: NA

Molecular weight: Translated: 95780; Mature: 95780

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00870 CLPAB_1; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPTADQFTEKGWAAIVLAQQLAQQRKHQQLETEHLLLSLLQQNALAGRILEKAGVSIGN
CCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LQTAVEAHLQEQPTMQAAPDSVYLGKGVNDLLDQAEKHKQAFGDSFISIEHLLLALAGDN
HHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
RCGRKLLNQAGVDAGKLKVAIDAVRGNQKVTDQNPEGTYESLEKYGRDLSAAAREGKLDP
HHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHCCCCCC
VIGRDDEIRRTIQILSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGDVPAALQNRQLIT
CCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHHCCCEEEE
LDMGALIAGAKYRGEFEERLKAVLKEVTASEGQIVLFIDEIHTVVGAGATGGAMDASNLL
EEHHHHHHCCHHCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCCCCCCCHHHHH
KPMLARGELRCIGATTLDEHRQHIEKDPALERRFQQVLVDQPTVQDTISILRGLKERYEV
HHHHHCCCEEEEECCHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
HHGVRIADNALVAAAVLSSRYIADRFLPDKAIDLMDESAARLKMEITSKPEEIDEIDRKI
HCCCEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHH
VQLEMEKLSLGRESDSVSKERLEKLERELAELAEQQSALNAQWQQEKGAIDDLSSLKEEI
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHH
ERVQLQVEQAKRSYDLNKAAELEYGTLAGLQKQLSEKETALAQDGEAGDKSLLREEVTED
HHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHH
DIADVIAKWTGIPVAKLVQSEMEKLLGLEAELHQRVIGQEQAVQAVADAIQRSRAGLSDP
HHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCC
NRPIASFLFLGPTGVGKTELSKALASQLFDSEAALVRIDMSEYMEKHSVSRLIGAPPGYV
CCHHHHHHEECCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHCCCCCCC
GYEAGGQLTEAVRRRPYAVILFDEVEKAHQDVFNVMLQILDDGRVTDGQGRTVDFTNTVL
CCCCCCHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEECCEEE
ILTSNIGSQSILDLGGDDSQYREMERRVHDALHAHFRPEFLNRLDETIIFHSLRREELRQ
EEEECCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IVALQVNRLRERLCDRKLGLEISDTAADWLANAGYDPVYGARPLKRAIQRELETPIAKSI
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCHHHHHH
LAGLYGDSQIVHVDVDVDQERLSFR
HHHHCCCCEEEEEECCCCHHHHCCC
>Mature Secondary Structure
MQPTADQFTEKGWAAIVLAQQLAQQRKHQQLETEHLLLSLLQQNALAGRILEKAGVSIGN
CCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LQTAVEAHLQEQPTMQAAPDSVYLGKGVNDLLDQAEKHKQAFGDSFISIEHLLLALAGDN
HHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
RCGRKLLNQAGVDAGKLKVAIDAVRGNQKVTDQNPEGTYESLEKYGRDLSAAAREGKLDP
HHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHCCCCCC
VIGRDDEIRRTIQILSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGDVPAALQNRQLIT
CCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHHCCCEEEE
LDMGALIAGAKYRGEFEERLKAVLKEVTASEGQIVLFIDEIHTVVGAGATGGAMDASNLL
EEHHHHHHCCHHCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCCCCCCCHHHHH
KPMLARGELRCIGATTLDEHRQHIEKDPALERRFQQVLVDQPTVQDTISILRGLKERYEV
HHHHHCCCEEEEECCHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
HHGVRIADNALVAAAVLSSRYIADRFLPDKAIDLMDESAARLKMEITSKPEEIDEIDRKI
HCCCEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHH
VQLEMEKLSLGRESDSVSKERLEKLERELAELAEQQSALNAQWQQEKGAIDDLSSLKEEI
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHH
ERVQLQVEQAKRSYDLNKAAELEYGTLAGLQKQLSEKETALAQDGEAGDKSLLREEVTED
HHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHH
DIADVIAKWTGIPVAKLVQSEMEKLLGLEAELHQRVIGQEQAVQAVADAIQRSRAGLSDP
HHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCC
NRPIASFLFLGPTGVGKTELSKALASQLFDSEAALVRIDMSEYMEKHSVSRLIGAPPGYV
CCHHHHHHEECCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHCCCCCCC
GYEAGGQLTEAVRRRPYAVILFDEVEKAHQDVFNVMLQILDDGRVTDGQGRTVDFTNTVL
CCCCCCHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEECCEEE
ILTSNIGSQSILDLGGDDSQYREMERRVHDALHAHFRPEFLNRLDETIIFHSLRREELRQ
EEEECCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IVALQVNRLRERLCDRKLGLEISDTAADWLANAGYDPVYGARPLKRAIQRELETPIAKSI
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCHHHHHH
LAGLYGDSQIVHVDVDVDQERLSFR
HHHHCCCCEEEEEECCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642